| 5/16/2025 | Goldman Sachs Group Inc. | 170,349 | $235K | 0.0% | +6.0% | 0.301% | |
| 5/16/2025 | EcoR1 Capital LLC | 662,833 | $915K | 0.1% | -86.7% | 1.171% | |
| 5/16/2025 | Checkpoint Capital L.P. | 2,017,650 | $2.78M | 1.5% | +14.9% | 3.565% | |
| 5/16/2025 | BVF Inc. IL | 4,889,474 | $6.75M | 0.3% | +63.6% | 8.640% | |
| 5/15/2025 | Troluce Capital Advisors LLC | 83,758 | $116K | 0.0% | +58.3% | 0.148% | |
| 5/15/2025 | Cubist Systematic Strategies LLC | 20,840 | $29K | 0.0% | -67.0% | 0.037% | |
| 5/14/2025 | Hsbc Holdings PLC | 35,042 | $49K | 0.0% | N/A | 0.062% | |
| 5/13/2025 | Tocqueville Asset Management L.P. | 27,000 | $37K | 0.0% | -89.7% | 0.048% | |
| 5/13/2025 | Aberdeen Group plc | 891,448 | $1.23M | 0.0% | +0.9% | 1.575% | |
| 5/12/2025 | Nuveen LLC | 69,962 | $97K | 0.0% | N/A | 0.124% | |
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| 5/9/2025 | Deutsche Bank AG | 52,559 | $73K | 0.0% | +149.4% | 0.093% | |
| 5/8/2025 | Letko Brosseau & Associates Inc. | 77,100 | $106K | 0.0% | +113.0% | 0.136% | |
| 3/24/2025 | Wellington Management Group LLP | 132,895 | $404K | 0.0% | +5.2% | 0.235% | |
| 2/25/2025 | Heck Capital Advisors LLC | 20,120 | $61K | 0.0% | N/A | 0.038% | |
| 2/17/2025 | Woodline Partners LP | 115,866 | $352K | 0.0% | +6.7% | 0.217% | |
| 2/17/2025 | Squarepoint Ops LLC | 19,461 | $59K | 0.0% | N/A | 0.036% | |
| 2/17/2025 | Tang Capital Management LLC | 117,847 | $358K | 0.0% | N/A | 0.221% | |
| 2/17/2025 | Shay Capital LLC | 21,363 | $65K | 0.0% | N/A | 0.040% | |
| 2/17/2025 | ProShare Advisors LLC | 13,140 | $40K | 0.0% | N/A | 0.025% | |
| 2/17/2025 | Letko Brosseau & Associates Inc. | 36,200 | $110K | 0.0% | +74.9% | 0.068% | |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 18,951 | $58K | 0.0% | -81.7% | 0.036% | |
| 2/17/2025 | Cubist Systematic Strategies LLC | 63,095 | $192K | 0.0% | +96.3% | 0.118% | |
| 2/17/2025 | Bridgeway Capital Management LLC | 105,900 | $322K | 0.0% | +176.5% | 0.198% | |
| 2/17/2025 | Bank of America Corp DE | 150,114 | $456K | 0.0% | +54.4% | 0.281% | |
| 2/17/2025 | BNP Paribas Financial Markets | 65,139 | $198K | 0.0% | N/A | 0.122% | |
| 2/14/2025 | Lynx1 Capital Management LP | 5,357,347 | $16.29M | 6.1% | +2.5% | 10.038% | |
| 2/14/2025 | Dauntless Investment Group LLC | 110,345 | $335K | 0.4% | N/A | 0.207% | |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 3,500,000 | $10.64M | 0.0% | -20.5% | 6.558% | |
| 2/14/2025 | Stifel Financial Corp | 109,700 | $333K | 0.0% | +10.7% | 0.206% | |
| 2/14/2025 | Dimensional Fund Advisors LP | 280,028 | $851K | 0.0% | +108.5% | 0.525% | |
| 2/13/2025 | Marshall Wace LLP | 43,969 | $134K | 0.0% | -73.4% | 0.082% | |
| 2/13/2025 | Barclays PLC | 67,508 | $206K | 0.0% | +16.3% | 0.126% | |
| 2/13/2025 | Renaissance Technologies LLC | 10,600 | $32K | 0.0% | -85.7% | 0.020% | |
| 2/13/2025 | Wells Fargo & Company MN | 19,540 | $59K | 0.0% | +41.1% | 0.037% | |
| 2/12/2025 | Geode Capital Management LLC | 963,257 | $2.93M | 0.0% | -1.0% | 1.805% | |
| 2/12/2025 | Wellington Management Group LLP | 132,895 | $404K | 0.0% | +5.2% | 0.249% | |
| 2/12/2025 | JPMorgan Chase & Co. | 66,756 | $203K | 0.0% | +109.9% | 0.125% | |
| 2/11/2025 | Prudential Financial Inc. | 10,415 | $32K | 0.0% | N/A | 0.020% | |
| 2/10/2025 | Tocqueville Asset Management L.P. | 260,870 | $793K | 0.0% | +26.8% | 0.489% | |
| 1/24/2025 | abrdn plc | 883,704 | $2.69M | 0.0% | +137.8% | 1.656% | |
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| 1/24/2025 | China Universal Asset Management Co. Ltd. | 10,410 | $32K | 0.0% | N/A | 0.020% | |
| 1/23/2025 | Heck Capital Advisors LLC | 20,120 | $61K | 0.0% | N/A | 0.038% | |
| 1/17/2025 | SG Americas Securities LLC | 20,415 | $62K | 0.0% | +31.2% | 0.038% | |
| 12/26/2024 | JPMorgan Chase & Co. | 31,805 | $158K | 0.0% | +94.4% | 0.060% | |
| 11/19/2024 | Barclays PLC | 58,067 | $289K | 0.0% | +341.1% | 0.109% | |
| 11/16/2024 | Geode Capital Management LLC | 973,466 | $4.85M | 0.0% | +8.1% | 1.838% | |
| 11/15/2024 | Barclays PLC | 58,067 | $289K | 0.0% | +341.1% | 0.110% | |
| 11/15/2024 | XTX Topco Ltd | 22,438 | $112K | 0.0% | N/A | 0.042% | |
| 11/15/2024 | Jane Street Group LLC | 93,876 | $468K | 0.0% | -5.2% | 0.177% | |
| 11/15/2024 | Wellington Management Group LLP | 126,345 | $629K | 0.0% | +38.9% | 0.239% | |
| 11/15/2024 | State Street Corp | 756,499 | $3.77M | 0.0% | +24.4% | 1.428% | |
| 11/15/2024 | Stifel Financial Corp | 99,133 | $494K | 0.0% | +3.9% | 0.187% | |
| 11/15/2024 | Jacobs Levy Equity Management Inc. | 103,440 | $515K | 0.0% | N/A | 0.195% | |
| 11/15/2024 | Checkpoint Capital L.P. | 825,341 | $4.11M | 2.0% | N/A | 1.558% | |
| 11/14/2024 | Walleye Capital LLC | 84,699 | $422K | 0.0% | -21.3% | 0.160% | |
| 11/14/2024 | MetLife Investment Management LLC | 23,363 | $116K | 0.0% | +129.1% | 0.044% | |
| 11/13/2024 | Great Point Partners LLC | 1,016,375 | $5.06M | 1.5% | +8.0% | 1.919% | |
| 11/13/2024 | Brown Brothers Harriman & Co. | 143,051 | $712K | 0.0% | +88.2% | 0.270% | |
| 11/7/2024 | LMR Partners LLP | 71,800 | $358K | 0.0% | -89.2% | 0.136% | |
| 11/6/2024 | Cornercap Investment Counsel Inc. | 10,788 | $54K | 0.0% | -53.0% | 0.020% | |
| 10/25/2024 | abrdn plc | 371,655 | $1.85M | 0.0% | +27.2% | 0.702% | |
| 10/3/2024 | SG Americas Securities LLC | 15,563 | $78K | 0.0% | N/A | 0.029% | |
| 8/15/2024 | The Manufacturers Life Insurance Company | 15,383 | $90K | 0.0% | N/A | 0.029% | |
| 8/15/2024 | Troluce Capital Advisors LLC | 92,832 | $543K | 0.1% | N/A | 0.176% | |
| 8/14/2024 | Great Point Partners LLC | 940,831 | $5.50M | 1.1% | N/A | 1.780% | |
| 8/14/2024 | Marshall Wace LLP | 307,487 | $1.80M | 0.0% | +60.8% | 0.582% | |
| 8/14/2024 | Bank of Montreal Can | 120,454 | $749K | 0.0% | N/A | 0.228% | |
| 8/12/2024 | Marathon Trading Investment Management LLC | 13,600 | $80K | 0.0% | -73.3% | 0.026% | |
| 8/9/2024 | Renaissance Technologies LLC | 80,000 | $468K | 0.0% | +70.2% | 0.151% | |
| 8/9/2024 | Dimensional Fund Advisors LP | 11,882 | $70K | 0.0% | N/A | 0.022% | |
| 8/9/2024 | Brown Brothers Harriman & Co. | 76,024 | $445K | 0.0% | N/A | 0.144% | |
| 8/8/2024 | Cornercap Investment Counsel Inc. | 22,940 | $134K | 0.0% | N/A | 0.043% | |
| 8/8/2024 | American Century Companies Inc. | 47,481 | $278K | 0.0% | +48.9% | 0.090% | |
| 8/2/2024 | Privium Fund Management UK Ltd | 12,103 | $69K | 0.0% | -23.5% | 0.023% | |
| 8/1/2024 | Rhumbline Advisers | 46,867 | $274K | 0.0% | N/A | 0.089% | |
| 7/26/2024 | Bank of New York Mellon Corp | 116,658 | $682K | 0.0% | N/A | 0.221% | |
| 5/10/2024 | Vanguard Group Inc. | 1,808,152 | $14.36M | 0.0% | +1.1% | 3.776% | |
| 5/10/2024 | Tocqueville Asset Management L.P. | 212,200 | $1.69M | 0.0% | N/A | 0.443% | |
| 4/17/2024 | Cannon Global Investment Management LLC | 17,500 | $139K | 0.4% | N/A | 0.037% | |
| 2/14/2024 | Pale Fire Capital SE | 21,573 | $126K | 0.0% | +30.2% | 0.045% | |
| 2/12/2024 | Letko Brosseau & Associates Inc. | 20,700 | $121K | 0.0% | -36.1% | 0.043% | |
| 1/31/2024 | abrdn plc | 200,000 | $1.17M | 0.0% | N/A | 0.418% | |
| 11/14/2023 | Pale Fire Capital SE | 16,575 | $42K | 0.0% | N/A | 0.035% | |
| 11/9/2023 | Letko Brosseau & Associates Inc. | 32,400 | $83K | 0.0% | N/A | 0.068% | |
| 8/15/2023 | BVF Inc. IL | 2,989,474 | $7.47M | 0.2% | N/A | 12.338% | |
| 8/10/2023 | Monashee Investment Management LLC | 400,000 | $1M | 0.2% | N/A | 1.651% | |
| 7/26/2023 | Privium Fund Management B.V. | 15,825 | $40K | 0.0% | N/A | 0.065% | |
| 5/10/2023 | Simplify Asset Management Inc. | 546,916 | $1.15M | 0.2% | N/A | 2.257% | |
| 2/15/2023 | Tang Capital Management LLC | 514,655 | $798K | 0.1% | -7.8% | 2.137% | |
| 11/16/2022 | Alphabet Inc. | 1,077,080 | $3.29M | 0.2% | N/A | 4.482% | |
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| 11/15/2022 | Tang Capital Management LLC | 557,915 | $1.70M | 0.2% | -25.4% | 2.322% | |
| 11/4/2022 | Prudential Financial Inc. | 11,000 | $34K | 0.0% | N/A | 0.046% | |
| 11/1/2022 | Privium Fund Management UK Ltd | 15,825 | $48K | 0.1% | N/A | 0.066% | |
| 5/17/2022 | RA Capital Management L.P. | 1,021,764 | $2.86M | 0.1% | -18.6% | 4.299% | |
| 5/17/2022 | Hhlr Advisors LTD. | 669,513 | $1.88M | 0.0% | -47.8% | 2.817% | |
| 4/26/2022 | Marquette Asset Management LLC | 28,895 | $81K | 0.0% | +33.7% | 0.122% | |
| 2/15/2022 | Deer Management Co. LLC | 1,245,505 | $5.61M | 0.1% | N/A | 5.240% | |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 550,000 | $2.48M | 0.0% | +10.8% | 2.314% | |
| 1/19/2022 | Marquette Asset Management LLC | 21,618 | $97K | 0.0% | N/A | 0.091% | |
| 11/16/2021 | Schonfeld Strategic Advisors LLC | 22,200 | $185K | 0.0% | N/A | 0.093% | |
