Upstream Bio (UPB) Institutional Ownership $9.26 +0.28 (+3.12%) As of 04:00 PM Eastern Add Compare Share Share Ownership Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock Institutional Ownership Changes (13F Filings) for Upstream Bio (NASDAQ:UPB)Number ofInstitutional Buyers(last 12 months)43TotalInstitutional Inflows(last 12 months)$618.44MNumber ofInstitutional Sellers(last 12 months)2TotalInstitutional Outflows(last 12 months)$46.85K Get UPB Insider Trade Alerts Want to know when executives and insiders are buying or selling Upstream Bio stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily. Email Address Skip Chart & View Institutional Buying and Selling Data UPB Institutional Buying and Selling by Quarter Upstream Bio Major Shareholders & Ownership History Export to ExcelReporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails4/30/2025Alps Advisors Inc.39,079$239K0.0%-9.8%0.073% 4/8/2025 Rhumbline Advisers13,327$82K0.0%-20.3%0.025% 3/24/2025Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.951% 2/17/2025VR Adviser LLC2,295,319$37.74M2.6%N/A4.282% 2/17/2025Woodline Partners LP526,511$8.66M0.1%N/A0.982% 2/17/2025Sandia Investment Management LP10,000$164K0.4%N/A0.019% 2/17/2025Nuveen Asset Management LLC22,586$371K0.0%N/A0.042% 2/17/2025Orbimed Advisors LLC5,693,589$93.60M2.1%N/A10.622% 2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,828$162K0.0%N/A0.018% 2/17/2025Enavate Sciences GP LLC2,459,703$40.44M29.0%N/A4.589% Get the Latest News and Ratings for UPB and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 2/17/2025Deutsche Bank AG14,851$244K0.0%N/A0.028% 2/17/2025Deep Track Capital LP1,000,000$16.44M0.6%N/A1.866% 2/17/2025Balyasny Asset Management L.P.301,152$4.95M0.0%N/A0.562% 2/17/2025Bank of America Corp DE13,963$230K0.0%N/A0.026% 2/17/2025BNP Paribas Financial Markets1,511$25K0.0%N/A0.003% 2/17/2025Alyeska Investment Group L.P.85,000$1.40M0.0%N/A0.159% 2/14/2025Jane Street Group LLC45,549$749K0.0%N/A0.085% 2/14/2025Samsara BioCapital LLC2,217,146$36.45M4.9%N/A4.136% 2/14/2025Soros Fund Management LLC46,350$762K0.0%N/A0.086% 2/14/2025TCG Crossover Management LLC2,801,763$44.86M4.4%N/A5.227% 2/14/2025Nantahala Capital Management LLC600,000$9.86M0.4%N/A1.119% 2/14/2025Northern Trust Corp143,721$2.36M0.0%N/A0.268% 2/14/2025Lynx1 Capital Management LP240,042$3.95M1.5%N/A0.448% 2/14/2025Decheng Capital LLC3,285,293$54.01M11.6%N/A6.129% 2/14/2025Bain Capital Life Sciences Investors LLC2,295,322$37.74M4.4%N/A4.282% 2/14/2025Tower Research Capital LLC TRC 2,846$47K0.0%N/A0.005% 2/14/2025MetLife Investment Management LLC11,034$181K0.0%N/A0.021% 2/13/2025Marshall Wace LLP290,734$4.78M0.0%N/A0.542% 2/13/2025Walleye Capital LLC10,000$164K0.0%N/A0.019% 2/13/2025Barclays PLC27,017$445K0.0%N/A0.050% 2/13/2025Summit Investment Advisors Inc.1,822$30K0.0%N/A0.003% 2/13/2025Legal & General Group Plc1,734$28K0.0%N/A0.003% 2/13/2025Invesco Ltd.15,602$256K0.0%N/A0.029% 2/13/2025FMR LLC7,176,187$117.98M0.0%N/A13.388% 2/13/2025Wells Fargo & Company MN9,047$149K0.0%N/A0.017% 2/12/2025Geode Capital Management LLC363,269$5.97M0.0%N/A0.678% 2/12/2025Alliancebernstein L.P.1,111,337$18.27M0.0%N/A2.073% 2/12/2025Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.954% 2/12/2025Norges Bank1,000,000$16.44M0.0%N/A1.866% 2/12/2025JPMorgan Chase & Co.47,792$786K0.0%N/A0.089% URGENT: Someone's Moving Gold Out of London... (Ad)People who don’t understand the gold market are about to lose a lot of money. Unfortunately, most so-called “gold analysts” have it all wrong… They tell you to invest in gold ETFs - because the popular mining ETFs will someday catch fire and close the price gap with spot gold. Go here to learn about my Top Four picks for the coming bull mania.2/11/2025Corebridge Financial Inc.8,660$142K0.0%N/A0.016% 2/6/2025Charles Schwab Investment Management Inc.135,323$2.23M0.0%N/A0.252% 2/5/2025US Bancorp DE1,660$27K0.0%N/A0.003% 2/4/2025 Bank of New York Mellon Corp36,913$607K0.0%N/A0.069% 1/30/2025 Rhumbline Advisers16,721$275K0.0%N/A0.031% 1/23/2025 Moody Aldrich Partners LLC74,773$1.23M0.2%N/A0.140% (Data available from 1/1/2016 forward) UPB Institutional Ownership - Frequently Asked Questions Who are the largest shareholders of UPB shares? During the previous two years, 44 institutional investors and hedge funds held shares of Upstream Bio. The most heavily invested institutionals were FMR LLC ($117.98M), Orbimed Advisors LLC ($93.60M), Decheng Capital LLC ($54.01M), TCG Crossover Management LLC ($44.86M), Enavate Sciences GP LLC ($40.44M), VR Adviser LLC ($37.74M), and Bain Capital Life Sciences Investors LLC ($37.74M).Learn more on UPB's institutional investors. Which institutional investors have been buying Upstream Bio stock? Of the 43 institutional investors that purchased Upstream Bio stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: FMR LLC ($7.18M), Orbimed Advisors LLC ($5.69M), Decheng Capital LLC ($3.29M), Wellington Management Group LLP ($3.17M), TCG Crossover Management LLC ($2.80M), Enavate Sciences GP LLC ($2.46M), and Bain Capital Life Sciences Investors LLC ($2.30M). How much institutional buying is happening at Upstream Bio? Institutional investors have bought a total of 37,617,978 shares in the last 24 months. This purchase volume represents approximately $618.44M in transactions. Which Upstream Bio major shareholders have been selling company stock? The following institutional investors have sold Upstream Bio stock in the last 24 months: Alps Advisors Inc. ($4.26K), and Rhumbline Advisers ($3.39K). How much institutional selling is happening at Upstream Bio? Institutional investors have sold a total of 7,655 shares in the last 24 months. This volume of shares sold represents approximately $46.85K in transactions. 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