Upstream Bio (UPB) Institutional Ownership $9.04 -0.09 (-0.97%) As of 03:08 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Ownership Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock Institutional Ownership Changes (13F Filings) for Upstream Bio (NASDAQ:UPB)Number ofInstitutional Buyers(last 12 months)50TotalInstitutional Inflows(last 12 months)$621.16MNumber ofInstitutional Sellers(last 12 months)7TotalInstitutional Outflows(last 12 months)$1.89M Get UPB Insider Trade Alerts Want to know when executives and insiders are buying or selling Upstream Bio stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily. Email Address Skip Chart & View Institutional Buying and Selling Data UPB Institutional Buying and Selling by Quarter Upstream Bio Major Shareholders & Ownership History Export to ExcelReporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails5/16/2025 Woodline Partners LP557,063$3.41M0.0%+5.8%1.036% 5/16/2025 Goldman Sachs Group Inc.32,955$202K0.0%-25.9%0.061% 5/16/2025 Parkman Healthcare Partners LLC233,563$1.43M0.2%N/A0.434% 5/16/2025 AQR Capital Management LLC18,822$115K0.0%N/A0.035% 5/16/2025 ADAR1 Capital Management LLC15,000$92K0.0%N/A0.028% 5/15/2025 Nantahala Capital Management LLC594,971$3.64M0.1%-0.8%1.106% 5/15/2025 Velan Capital Investment Management LP107,000$655K0.7%N/A0.199% 5/15/2025 Siren L.L.C.788,450$4.83M0.3%-1.4%1.466% 5/14/2025 Wellington Management Group LLP1,313,457$8.03M0.0%-17.0%2.442% 5/12/2025 Nuveen LLC22,586$138K0.0%N/A0.042% Get the Latest News and Ratings for UPB and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 5/9/2025 Charles Schwab Investment Management Inc.132,173$809K0.0%-2.3%0.246% 5/8/2025 XTX Topco Ltd12,731$78K0.0%N/A0.024% 5/1/2025 New York State Common Retirement Fund4,700$29K0.0%N/A0.009% 4/30/2025 Alps Advisors Inc.39,079$239K0.0%-9.8%0.073% 4/8/2025 Rhumbline Advisers13,327$82K0.0%-20.3%0.025% 3/24/2025 Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.951% 2/17/2025 VR Adviser LLC2,295,319$37.74M2.6%N/A4.282% 2/17/2025 Woodline Partners LP526,511$8.66M0.1%N/A0.982% 2/17/2025 Sandia Investment Management LP10,000$164K0.4%N/A0.019% 2/17/2025Nuveen Asset Management LLC22,586$371K0.0%N/A0.042% 2/17/2025 Orbimed Advisors LLC5,693,589$93.60M2.1%N/A10.622% 2/17/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,828$162K0.0%N/A0.018% 2/17/2025 Enavate Sciences GP LLC2,459,703$40.44M29.0%N/A4.589% 2/17/2025 Deutsche Bank AG14,851$244K0.0%N/A0.028% 2/17/2025 Deep Track Capital LP1,000,000$16.44M0.6%N/A1.866% 2/17/2025 Balyasny Asset Management L.P.301,152$4.95M0.0%N/A0.562% 2/17/2025 Bank of America Corp DE13,963$230K0.0%N/A0.026% 2/17/2025 BNP Paribas Financial Markets1,511$25K0.0%N/A0.003% 2/17/2025 Alyeska Investment Group L.P.85,000$1.40M0.0%N/A0.159% 2/14/2025 Jane Street Group LLC45,549$749K0.0%N/A0.085% 2/14/2025 Samsara BioCapital LLC2,217,146$36.45M4.9%N/A4.136% 2/14/2025 Soros Fund Management LLC46,350$762K0.0%N/A0.086% 2/14/2025 TCG Crossover Management LLC2,801,763$44.86M4.4%N/A5.227% 2/14/2025 Nantahala Capital Management LLC600,000$9.86M0.4%N/A1.119% 2/14/2025 Northern Trust Corp143,721$2.36M0.0%N/A0.268% 2/14/2025 Lynx1 Capital Management LP240,042$3.95M1.5%N/A0.448% 2/14/2025 Decheng Capital LLC3,285,293$54.01M11.6%N/A6.129% 2/14/2025 Bain Capital Life Sciences Investors LLC2,295,322$37.74M4.4%N/A4.282% 2/14/2025 Tower Research Capital LLC TRC2,846$47K0.0%N/A0.005% 2/14/2025 MetLife Investment Management LLC11,034$181K0.0%N/A0.021% White House to reset Social Security? 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And it could have a major impact on how you collect Social Security - Click here to understand what'2/13/2025 Marshall Wace LLP290,734$4.78M0.0%N/A0.542% 2/13/2025 Walleye Capital LLC10,000$164K0.0%N/A0.019% 2/13/2025 Barclays PLC27,017$445K0.0%N/A0.050% 2/13/2025 Summit Investment Advisors Inc.1,822$30K0.0%N/A0.003% 2/13/2025 Legal & General Group Plc1,734$28K0.0%N/A0.003% 2/13/2025 Invesco Ltd.15,602$256K0.0%N/A0.029% 2/13/2025 FMR LLC7,176,187$117.98M0.0%N/A13.388% 2/13/2025 Wells Fargo & Company MN9,047$149K0.0%N/A0.017% 2/12/2025 Geode Capital Management LLC363,269$5.97M0.0%N/A0.678% 2/12/2025 Alliancebernstein L.P.1,111,337$18.27M0.0%N/A2.073% 2/12/2025 Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.954% 2/12/2025 Norges Bank1,000,000$16.44M0.0%N/A1.866% 2/12/2025 JPMorgan Chase & Co.47,792$786K0.0%N/A0.089% 2/11/2025 Corebridge Financial Inc.8,660$142K0.0%N/A0.016% 2/6/2025 Charles Schwab Investment Management Inc.135,323$2.23M0.0%N/A0.252% 2/5/2025 US Bancorp DE1,660$27K0.0%N/A0.003% 2/4/2025 Bank of New York Mellon Corp36,913$607K0.0%N/A0.069% 1/30/2025 Rhumbline Advisers16,721$275K0.0%N/A0.031% 1/23/2025 Moody Aldrich Partners LLC74,773$1.23M0.2%N/A0.140% (Data available from 1/1/2016 forward) UPB Institutional Ownership - Frequently Asked Questions Who are the largest shareholders of UPB shares? During the previous two years, 53 institutional investors and hedge funds held shares of Upstream Bio. The most heavily invested institutionals were FMR LLC ($117.98M), Orbimed Advisors LLC ($93.60M), Decheng Capital LLC ($54.01M), TCG Crossover Management LLC ($44.86M), Enavate Sciences GP LLC ($40.44M), VR Adviser LLC ($37.74M), and Bain Capital Life Sciences Investors LLC ($37.74M).Learn more on UPB's institutional investors. Which institutional investors have been buying Upstream Bio stock? Of the 50 institutional investors that purchased Upstream Bio stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: FMR LLC ($7.18M), Orbimed Advisors LLC ($5.69M), Decheng Capital LLC ($3.29M), Wellington Management Group LLP ($3.17M), TCG Crossover Management LLC ($2.80M), Enavate Sciences GP LLC ($2.46M), and Bain Capital Life Sciences Investors LLC ($2.30M). How much institutional buying is happening at Upstream Bio? Institutional investors have bought a total of 38,062,932 shares in the last 24 months. This purchase volume represents approximately $621.16M in transactions. Which Upstream Bio major shareholders have been selling company stock? The following institutional investors have sold Upstream Bio stock in the last 24 months: Wellington Management Group LLP ($269.70K), Siren L.L.C. ($11.55K), Goldman Sachs Group Inc. ($11.54K), Nantahala Capital Management LLC ($5.03K), Alps Advisors Inc. ($4.26K), Rhumbline Advisers ($3.39K), and Charles Schwab Investment Management Inc. ($3.15K). How much institutional selling is happening at Upstream Bio? Institutional investors have sold a total of 308,616 shares in the last 24 months. This volume of shares sold represents approximately $1.89M in transactions. 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