Upstream Bio (UPB) Institutional Ownership $11.41 +0.66 (+6.14%) As of 11:00 AM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Ownership Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock Institutional Ownership Changes (13F Filings) for Upstream Bio (NASDAQ:UPB)Number ofInstitutional Buyers(last 12 months)50TotalInstitutional Inflows(last 12 months)$621.16MNumber ofInstitutional Sellers(last 12 months)7TotalInstitutional Outflows(last 12 months)$2.05M Get UPB Insider Trade Alerts Want to know when executives and insiders are buying or selling Upstream Bio stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily. Email Address Skip Chart & View Institutional Buying and Selling Data UPB Institutional Buying and Selling by Quarter Upstream Bio Major Shareholders & Ownership History Export to ExcelReporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails6/27/2025Goldman Sachs Group Inc.32,955$202K0.0%-25.9%0.061% 5/29/2025Rhumbline Advisers13,327$82K0.0%-20.3%0.025% 5/23/2025Siren L.L.C.788,450$4.83M0.3%-1.4%1.466% 5/16/2025Woodline Partners LP557,063$3.41M0.0%+5.8%1.036% 5/16/2025Goldman Sachs Group Inc.32,955$202K0.0%-25.9%0.061% 5/16/2025Parkman Healthcare Partners LLC233,563$1.43M0.2%N/A0.434% 5/16/2025AQR Capital Management LLC18,822$115K0.0%N/A0.035% 5/16/2025ADAR1 Capital Management LLC15,000$92K0.0%N/A0.028% 5/15/2025Nantahala Capital Management LLC594,971$3.64M0.1%-0.8%1.106% 5/15/2025Velan Capital Investment Management LP107,000$655K0.7%N/A0.199% Get the Latest News and Ratings for UPB and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 5/15/2025Siren L.L.C.788,450$4.83M0.3%-1.4%1.466% 5/14/2025Wellington Management Group LLP1,313,457$8.03M0.0%-17.0%2.442% 5/12/2025Nuveen LLC22,586$138K0.0%N/A0.042% 5/9/2025Charles Schwab Investment Management Inc.132,173$809K0.0%-2.3%0.246% 5/8/2025XTX Topco Ltd12,731$78K0.0%N/A0.024% 5/1/2025New York State Common Retirement Fund4,700$29K0.0%N/A0.009% 4/30/2025Alps Advisors Inc.39,079$239K0.0%-9.8%0.073% 4/8/2025Rhumbline Advisers13,327$82K0.0%-20.3%0.025% 3/24/2025Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.951% 2/17/2025VR Adviser LLC2,295,319$37.74M2.6%N/A4.282% 2/17/2025Woodline Partners LP526,511$8.66M0.1%N/A0.982% 2/17/2025Sandia Investment Management LP10,000$164K0.4%N/A0.019% 2/17/2025Nuveen Asset Management LLC22,586$371K0.0%N/A0.042% 2/17/2025Orbimed Advisors LLC5,693,589$93.60M2.1%N/A10.622% 2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,828$162K0.0%N/A0.018% 2/17/2025Enavate Sciences GP LLC2,459,703$40.44M29.0%N/A4.589% 2/17/2025Deutsche Bank AG14,851$244K0.0%N/A0.028% 2/17/2025Deep Track Capital LP1,000,000$16.44M0.6%N/A1.866% 2/17/2025Balyasny Asset Management L.P.301,152$4.95M0.0%N/A0.562% 2/17/2025Bank of America Corp DE13,963$230K0.0%N/A0.026% 2/17/2025BNP Paribas Financial Markets1,511$25K0.0%N/A0.003% 2/17/2025Alyeska Investment Group L.P.85,000$1.40M0.0%N/A0.159% 2/14/2025Jane Street Group LLC45,549$749K0.0%N/A0.085% 2/14/2025Samsara BioCapital LLC2,217,146$36.45M4.9%N/A4.136% 2/14/2025Soros Fund Management LLC46,350$762K0.0%N/A0.086% 2/14/2025TCG Crossover Management LLC2,801,763$44.86M4.4%N/A5.227% 2/14/2025Nantahala Capital Management LLC600,000$9.86M0.4%N/A1.119% 2/14/2025Northern Trust Corp143,721$2.36M0.0%N/A0.268% 2/14/2025Lynx1 Capital Management LP240,042$3.95M1.5%N/A0.448% 2/14/2025Decheng Capital LLC3,285,293$54.01M11.6%N/A6.129% 🚀 3 Crypto Picks Every Growth Investor Should See (Free Ebook) (Ad)Are you curious about how experienced investors approach crypto? Our free 30‑page ebook, Crypto Boom Strategy, outlines a three‑step framework they use to navigate the market, ideal for those with a growth-focused mindset.👉 Click here to download your free ebook now!2/14/2025Bain Capital Life Sciences Investors LLC2,295,322$37.74M4.4%N/A4.282% 2/14/2025Tower Research Capital LLC TRC2,846$47K0.0%N/A0.005% 2/14/2025MetLife Investment Management LLC11,034$181K0.0%N/A0.021% 2/13/2025Marshall Wace LLP290,734$4.78M0.0%N/A0.542% 2/13/2025Walleye Capital LLC10,000$164K0.0%N/A0.019% 2/13/2025Barclays PLC27,017$445K0.0%N/A0.050% 2/13/2025Summit Investment Advisors Inc.1,822$30K0.0%N/A0.003% 2/13/2025Legal & General Group Plc1,734$28K0.0%N/A0.003% 2/13/2025Invesco Ltd.15,602$256K0.0%N/A0.029% 2/13/2025FMR LLC7,176,187$117.98M0.0%N/A13.388% 2/13/2025Wells Fargo & Company MN9,047$149K0.0%N/A0.017% 2/12/2025Geode Capital Management LLC363,269$5.97M0.0%N/A0.678% 2/12/2025Alliancebernstein L.P.1,111,337$18.27M0.0%N/A2.073% 2/12/2025Wellington Management Group LLP1,583,154$25.63M0.0%N/A2.954% 2/12/2025Norges Bank1,000,000$16.44M0.0%N/A1.866% 2/12/2025JPMorgan Chase & Co.47,792$786K0.0%N/A0.089% 2/11/2025Corebridge Financial Inc.8,660$142K0.0%N/A0.016% 2/6/2025Charles Schwab Investment Management Inc.135,323$2.23M0.0%N/A0.252% 2/5/2025US Bancorp DE1,660$27K0.0%N/A0.003% 2/4/2025Bank of New York Mellon Corp36,913$607K0.0%N/A0.069% 1/30/2025Rhumbline Advisers16,721$275K0.0%N/A0.031% 1/23/2025Moody Aldrich Partners LLC74,773$1.23M0.2%N/A0.140% (Data available from 1/1/2016 forward) UPB Institutional Ownership - Frequently Asked Questions Who are the largest shareholders of UPB shares? During the previous two years, 53 institutional investors and hedge funds held shares of Upstream Bio. The most heavily invested institutionals were FMR LLC ($117.98M), Orbimed Advisors LLC ($93.60M), Decheng Capital LLC ($54.01M), TCG Crossover Management LLC ($44.86M), Enavate Sciences GP LLC ($40.44M), VR Adviser LLC ($37.74M), and Bain Capital Life Sciences Investors LLC ($37.74M).Learn more on Upstream Bio's institutional investors. Which institutional investors have been buying Upstream Bio's stock? Of the 50 institutional investors that purchased Upstream Bio's stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: FMR LLC ($7.18M), Orbimed Advisors LLC ($5.69M), Decheng Capital LLC ($3.29M), Wellington Management Group LLP ($3.17M), TCG Crossover Management LLC ($2.80M), Enavate Sciences GP LLC ($2.46M), and Bain Capital Life Sciences Investors LLC ($2.30M). How much institutional buying is happening at Upstream Bio? Institutional investors have bought a total of 38,062,932 shares in the last 24 months. This purchase volume represents approximately $621.16M in transactions. Which of Upstream Bio's major shareholders have been selling company stock? The following institutional investors have sold Upstream Bio stock in the last 24 months: Wellington Management Group LLP ($269.70K), Siren L.L.C. ($23.10K), Goldman Sachs Group Inc. ($23.07K), Rhumbline Advisers ($6.79K), Nantahala Capital Management LLC ($5.03K), Alps Advisors Inc. ($4.26K), and Charles Schwab Investment Management Inc. ($3.15K). How much institutional selling is happening at Upstream Bio? Institutional investors have sold a total of 335,095 shares in the last 24 months. This volume of shares sold represents approximately $2.05M in transactions. 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