Avoro Capital Advisors LLC Top Holdings and 13F Report (2025) About Avoro Capital Advisors LLCInvestment ActivityAvoro Capital Advisors LLC has $6.41 billion in total holdings as of March 31, 2025.Avoro Capital Advisors LLC owns shares of 33 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 6.89% of the portfolio was purchased this quarter.About 9.66% of the portfolio was sold this quarter.This quarter, Avoro Capital Advisors LLC has purchased 39 new stocks and bought additional shares in 13 stocks.Avoro Capital Advisors LLC sold shares of 7 stocks and completely divested from 7 stocks this quarter.Largest Holdings United Therapeutics $824,622,250Ascendis Pharma A/S $813,277,480argenx $731,058,035Madrigal Pharmaceuticals $669,820,593Krystal Biotech $492,399,300 Largest New Holdings this Quarter 152309100 - Centessa Pharmaceuticals $58,239,000 Holding Largest Purchases this Quarter Blueprint Medicines 2,665,000 shares (about $235.88M)Centessa Pharmaceuticals 4,050,000 shares (about $58.24M)Merus 875,000 shares (about $36.83M)Kymera Therapeutics 1,310,000 shares (about $35.85M)Krystal Biotech 102,178 shares (about $18.42M) Largest Sales this Quarter Intra-Cellular Therapies 2,425,000 shares (about $319.91M)United Therapeutics 85,300 shares (about $26.30M)BioCryst Pharmaceuticals 3,165,000 shares (about $23.74M)Amicus Therapeutics 2,675,000 shares (about $21.83M)Vaxcyte 175,000 shares (about $6.61M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAvoro Capital Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorUTHRUnited Therapeutics$824,622,250$26,295,431 ▼-3.1%2,675,00012.9%MedicalASNDAscendis Pharma A/S$813,277,480$17,915,328 ▲2.3%5,218,00012.7%MedicalARGXargenx$731,058,035$1,947,236 ▼-0.3%1,235,17711.4%MedicalMDGLMadrigal Pharmaceuticals$669,820,593$2,245,077 ▼-0.3%2,022,22210.5%MedicalKRYSKrystal Biotech$492,399,300$18,422,693 ▲3.9%2,731,0007.7%MedicalBPMCBlueprint Medicines$340,763,500$235,879,150 ▲224.9%3,850,0005.3%MedicalAPLSApellis Pharmaceuticals$267,299,9950.0%12,222,2224.2%MedicalRNAAvidity Biosciences$225,090,000$3,690,000 ▲1.7%7,625,0003.5%MedicalXENEXenon Pharmaceuticals$192,632,894$2,516,250 ▲1.3%5,741,6663.0%MedicalSLNOSoleno Therapeutics$180,411,2500.0%2,525,0002.8%MedicalKYMRKymera Therapeutics$176,810,200$35,854,700 ▲25.4%6,460,0002.8%MedicalSRPTSarepta Therapeutics$170,707,970$7,612,450 ▲4.7%2,674,8352.7%MedicalFOLDAmicus Therapeutics$167,280,000$21,828,000 ▼-11.5%20,500,0002.6%MedicalARWRArrowhead Pharmaceuticals$141,555,5540.0%11,111,1112.2%MedicalVERAVera Therapeutics$136,959,638$2,207,438 ▲1.6%5,701,9002.1%MedicalMRUSMerus$126,270,000$36,828,750 ▲41.2%3,000,0002.0%MedicalMLTXMoonLake Immunotherapeutics$108,227,8070.0%2,770,1001.7%MedicalITCIIntra-Cellular Therapies$82,450,000$319,906,000 ▼-79.5%625,0001.3%MedicalALKSAlkermes$80,899,0000.0%2,450,0001.3%MedicalBCRXBioCryst Pharmaceuticals$65,250,000$23,737,500 ▼-26.7%8,700,0001.0%MedicalOCULOcular Therapeutix$59,079,8000.0%8,060,0000.9%MedicalCNTACentessa Pharmaceuticals$58,239,000$58,239,000 ▲New Holding4,050,0000.9%MedicalETNB89bio$46,164,500$16,357,500 ▲54.9%6,350,0000.7%MedicalMNKDMannKind$44,012,5000.0%8,750,0000.7%MedicalPCVXVaxcyte$37,760,000$6,608,000 ▼-14.9%1,000,0000.6%MedicalTOURMALINE BIO INC$36,884,250$3,084,253 ▲9.1%2,425,0000.6%CommonRAREUltragenyx Pharmaceutical$30,054,3000.0%830,0000.5%MedicalTSHATaysha Gene Therapies$27,799,9990.0%19,999,9990.4%MedicalQUREuniQure$23,055,0000.0%2,175,0000.4%MedicalGLUEMonte Rosa Therapeutics$21,555,343$1,394,543 ▲6.9%4,645,5480.3%MedicalAUTLAutolus Therapeutics$15,361,4950.0%9,910,6420.2%MedicalSEPTERNA INC$7,744,125$1,317,225 ▲20.5%1,337,5000.1%CommonAADIAadi Bioscience$5,071,9360.0%2,849,4020.1%MedicalBMRNBioMarin Pharmaceutical$0$96,130,125 ▼-100.0%00.0%MedicalSNDXSyndax Pharmaceuticals$0$30,075,500 ▼-100.0%00.0%MedicalIOVAIovance Biotherapeutics$0$25,900,000 ▼-100.0%00.0%MedicalCG ONCOLOGY INC$0$20,076,000 ▼-100.0%00.0%CommonKURAKura Oncology$0$19,597,500 ▼-100.0%00.0%MedicalRCKTRocket Pharmaceuticals$0$15,084,000 ▼-100.0%00.0%MedicalOLMAOlema Pharmaceuticals$0$9,631,055 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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