Avoro Capital Advisors LLC Top Holdings and 13F Report (2026) About Avoro Capital Advisors LLCInvestment ActivityAvoro Capital Advisors LLC has $10.16 billion in total holdings as of March 31, 2026.Avoro Capital Advisors LLC owns shares of 30 different stocks, but just 12 companies or ETFs make up 80% of its holdings.Approximately 8.20% of the portfolio was purchased this quarter.About 10.34% of the portfolio was sold this quarter.This quarter, Avoro Capital Advisors LLC has purchased 33 new stocks and bought additional shares in 9 stocks.Avoro Capital Advisors LLC sold shares of 7 stocks and completely divested from 7 stocks this quarter.Largest Holdings United Therapeutics $1,569,833,400Ascendis Pharma A/S $1,157,945,625Madrigal Pharmaceuticals $951,763,208Krystal Biotech $746,257,548argenex $730,250,000 Largest New Holdings this Quarter 23282W605 - Cytokinetics $219,699,978 Holding36322Q206 - DAMORA THERAPEUTICS INC $97,979,700 Holding24477V105 - DEFINIUM THERAPEUTICS INC $94,500,000 Holding05338F306 - AVALO THERAPEUTICS $21,051,300 Holding Largest Purchases this Quarter Cytokinetics 3,333,333 shares (about $219.70M)United Therapeutics 403,940 shares (about $210.67M)DAMORA THERAPEUTICS INC 3,783,000 shares (about $97.98M)DEFINIUM THERAPEUTICS INC 5,000,000 shares (about $94.50M)Terns Pharmaceuticals 1,345,000 shares (about $70.91M) Largest Sales this Quarter Centessa Pharmaceuticals 3,125,100 shares (about $124.13M)Ascendis Pharma A/S 98,611 shares (about $22.56M)Soleno Therapeutics 600,000 shares (about $20.09M)LEXEO THERAPEUTICS INC 1,425,000 shares (about $8.18M)Alkermes 200,000 shares (about $7.07M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAvoro Capital Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorUTHRUnited Therapeutics$1,569,833,400$210,670,599 â–²15.5%3,010,00015.4%MedicalASNDAscendis Pharma A/S$1,157,945,625$22,555,294 â–¼-1.9%5,062,50011.4%MedicalMDGLMadrigal Pharmaceuticals$951,763,208$5,591,183 â–²0.6%1,818,1819.4%MedicalKRYSKrystal Biotech$746,257,5480.0%2,888,8887.3%MedicalARGXargenex$730,250,000$7,302,500 â–²1.0%1,000,0007.2%MedicalARWRArrowhead Pharmaceuticals$670,889,937$4,702,437 â–²0.7%10,699,9996.6%MedicalKYMRKymera Therapeutics$622,571,6780.0%7,474,7476.1%MedicalAPLSApellis Pharmaceuticals$491,699,9910.0%12,222,2224.8%MedicalCNTACentessa Pharmaceuticals$454,017,673$124,128,972 â–¼-21.5%11,430,4554.5%MedicalCELCCelcuity$388,272,500$50,381,914 â–²14.9%3,575,0003.8%MedicalXENEXenon Pharmaceuticals$335,977,733$20,546,314 â–²6.5%5,777,7773.3%MedicalGPCRStructure Therapeutics$315,977,7510.0%6,555,5553.1%MedicalTERNTerns Pharmaceuticals$300,240,400$70,908,400 â–²30.9%5,695,0003.0%MedicalVERAVera Therapeutics$236,909,9640.0%5,888,8882.3%MedicalRVMDRevolution Medicines$227,997,179$16,964,679 â–²8.0%2,344,4442.2%MedicalCYTKCytokinetics$219,699,978$219,699,978 â–²New Holding3,333,3332.2%MedicalOCULOcular Therapeutix$104,308,050$13,020,279 â–²14.3%12,315,0001.0%MedicalDAMORA THERAPEUTICS INC$97,979,700$97,979,700 â–²New Holding3,783,0001.0%CommonQUREuniQure$97,439,378$3,113,122 â–¼-3.1%5,959,5951.0%MedicalTSHATaysha Gene Therapies$96,999,0000.0%21,700,0001.0%MedicalDEFINIUM THERAPEUTICS INC$94,500,000$94,500,000 â–²New Holding5,000,0000.9%CommonSLNOSoleno Therapeutics$77,004,000$20,088,000 â–¼-20.7%2,300,0000.8%MedicalALKSAlkermes$42,432,000$7,072,000 â–¼-14.3%1,200,0000.4%MedicalSEPTERNA INC$32,140,1250.0%1,337,5000.3%CommonVRDNViridian Therapeutics$29,340,0000.0%1,500,0000.3%MedicalGHRSGH Research$25,308,0000.0%1,800,0000.2%MedicalAVALO THERAPEUTICS$21,051,300$21,051,300 â–²New Holding1,410,0000.2%CommonLEXEO THERAPEUTICS INC$10,762,500$8,179,500 â–¼-43.2%1,875,0000.1%CommonAADIAadi Bioscience$9,830,4370.0%2,849,4020.1%MedicalMNKDMannKind$5,390,000$5,498,888 â–¼-50.5%2,200,0000.1%MedicalRNAAvidity Biosciences$0$393,469,150 â–¼-100.0%00.0%MedicalXBISPDR S&P Biotech ETF$0$256,053,000 â–¼-100.0%00.0%ETFMNMDMind Medicine (MindMed)$0$66,950,000 â–¼-100.0%00.0%MedicalPTCTPTC Therapeutics$0$52,032,600 â–¼-100.0%00.0%MedicalORUKA THERAPEUTICS INC$0$40,413,535 â–¼-100.0%00.0%CommonAPOGEE THERAPEUTICS INC$0$37,740,000 â–¼-100.0%00.0%CommonINCYIncyte$0$13,333,950 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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