Avoro Capital Advisors LLC Top Holdings and 13F Report (2024)

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About Avoro Capital Advisors LLC

Investment Activity

Avoro Capital Advisors LLC has $8.57 billion in total holdings as of March 31, 2024.
Avoro Capital Advisors LLC owns shares of 46 different stocks, but just 18 companies or ETFs make up 80% of its holdings.
Approximately 19.87% of the portfolio was purchased this quarter.
About 10.19% of the portfolio was sold this quarter.
This quarter, Avoro Capital Advisors LLC has purchased 42 new stocks and bought additional shares in 15 stocks.
Avoro Capital Advisors LLC sold shares of 3 stocks and completely divested from 7 stocks this quarter.

Largest Holdings

United Therapeutics: $656,743,751
Apellis Pharmaceuticals: $653,111,105
Ascendis Pharma A/S: $599,640,899
Sarepta Therapeutics: $562,431,720
Madrigal Pharmaceuticals: $519,244,326

Largest New Holdings this Quarter

Viking Therapeutics: $294,380,000 Holding
Alpine Immune Sciences: $228,921,000 Holding
Vera Therapeutics: $227,026,800 Holding
MacroGenics: $90,528,000 Holding
Autolus Therapeutics: $78,765,426 Holding

Largest Purchases this Quarter

Viking Therapeutics: 3,590,000 shares (about $294.38M)
Alpine Immune Sciences: 5,775,000 shares (about $228.92M)
Vera Therapeutics: 5,265,000 shares (about $227.03M)
Arrowhead Pharmaceuticals: 7,425,555 shares (about $212.37M)
MacroGenics: 6,150,000 shares (about $90.53M)

Largest Sales this Quarter

Alnylam Pharmaceuticals: 811,111 shares (about $121.22M)
SPDR S&P Biotech ETF: 144,444 shares (about $13.71M)
Krystal Biotech: 10,000 shares (about $1.78M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
UTHR United Therapeutics	$656,743,751		0.0%	2,858,888	7.7%	Medical
APLS Apellis Pharmaceuticals	$653,111,105		0.0%	11,111,111	7.6%	Medical
ASND Ascendis Pharma A/S	$599,640,899	$31,913,650 ▲	5.6%	3,966,666	7.0%	Medical
SRPT Sarepta Therapeutics	$562,431,720		0.0%	4,344,444	6.6%	Medical
MDGL Madrigal Pharmaceuticals	$519,244,326	$14,835,674 ▲	2.9%	1,944,444	6.1%	Medical
ARGX argenx	$487,609,227	$1,535,508 ▲	0.3%	1,238,467	5.7%	Medical
KRYS Krystal Biotech	$454,709,901	$1,779,300 ▼	-0.4%	2,555,555	5.3%	Medical
XBI SPDR S&P Biotech ETF	$408,027,000	$13,706,291 ▼	-3.2%	4,300,000	4.8%	ETF
BMRN BioMarin Pharmaceutical	$381,239,100	$5,677,100 ▲	1.5%	4,365,000	4.4%	Medical
FOLD Amicus Therapeutics	$322,772,000		0.0%	27,400,000	3.8%	Medical
CERE Cerevel Therapeutics	$319,373,310		0.0%	7,555,555	3.7%	Medical
VKTX Viking Therapeutics	$294,380,000	$294,380,000 ▲	New Holding	3,590,000	3.4%	Medical
ARWR Arrowhead Pharmaceuticals	$244,688,873	$212,370,873 ▲	657.1%	8,555,555	2.9%	Medical
XENE Xenon Pharmaceuticals	$243,949,971		0.0%	5,666,666	2.8%	Medical
ALPN Alpine Immune Sciences	$228,921,000	$228,921,000 ▲	New Holding	5,775,000	2.7%	Medical
VERA Vera Therapeutics	$227,026,800	$227,026,800 ▲	New Holding	5,265,000	2.6%	Medical
IOVA Iovance Biotherapeutics	$173,394,000	$74,100,000 ▲	74.6%	11,700,000	2.0%	Medical
ITCI Intra-Cellular Therapies	$171,270,000	$15,185,594 ▲	9.7%	2,475,000	2.0%	Medical
KYMR Kymera Therapeutics	$156,333,298	$4,578,298 ▲	3.0%	3,888,888	1.8%	Medical
RNA Avidity Biosciences	$148,654,000	$84,598,800 ▲	132.1%	5,825,000	1.7%	Medical
MLTX MoonLake Immunotherapeutics	$129,593,400		0.0%	2,580,000	1.5%	Medical
SNDX Syndax Pharmaceuticals	$100,488,884		0.0%	4,222,222	1.2%	Medical
MGNX MacroGenics	$90,528,000	$90,528,000 ▲	New Holding	6,150,000	1.1%	Medical
KURA Kura Oncology	$82,120,500	$18,557,100 ▲	29.2%	3,850,000	1.0%	Medical
AUTL Autolus Therapeutics	$78,765,426	$78,765,426 ▲	New Holding	12,345,678	0.9%	Medical
SPYRE THERAPEUTICS INC	$69,758,504		0.0%	1,839,138	0.8%	Common
SLNO Soleno Therapeutics	$69,550,000	$35,952,000 ▲	107.0%	1,625,000	0.8%	Medical
BCRX BioCryst Pharmaceuticals	$66,294,000		0.0%	13,050,000	0.8%	Medical
OCUL Ocular Therapeutix	$65,055,318	$65,055,318 ▲	New Holding	7,148,936	0.8%	Medical
TSHA Taysha Gene Therapies	$53,525,500	$41,025,057 ▲	328.2%	18,650,000	0.6%	Medical
TOURMALINE BIO INC	$50,888,884	$31,002,364 ▲	155.9%	2,222,222	0.6%	Common
ROIV Roivant Sciences	$49,023,247		0.0%	4,651,162	0.6%	Medical
ALNY Alnylam Pharmaceuticals	$44,835,000	$121,220,539 ▼	-73.0%	300,000	0.5%	Medical
MNKD MannKind	$40,770,000		0.0%	9,000,000	0.5%	Medical
MRUS Merus	$40,026,627		0.0%	888,888	0.5%	Medical
PCVX Vaxcyte	$39,278,250	$39,278,250 ▲	New Holding	575,000	0.5%	Medical
RARE Ultragenyx Pharmaceutical	$38,752,700	$22,411,200 ▲	137.1%	830,000	0.5%	Medical
MRNS Marinus Pharmaceuticals	$37,431,087	$8,955,087 ▲	31.4%	4,140,607	0.4%	Medical
RCKT Rocket Pharmaceuticals	$33,968,646		0.0%	1,260,900	0.4%	Medical
GLUE Monte Rosa Therapeutics	$31,971,750		0.0%	4,535,000	0.4%	Medical
CG ONCOLOGY INC	$30,730,000	$30,730,000 ▲	New Holding	700,000	0.4%	Common
CRSP CRISPR Therapeutics	$28,598,573	$28,598,573 ▲	New Holding	419,580	0.3%	Medical
VRCA Verrica Pharmaceuticals	$23,679,994		0.0%	3,999,999	0.3%	Medical
KYVERNA THERAPEUTICS INC	$11,799,000	$11,799,000 ▲	New Holding	475,000	0.1%	Common
AADI Aadi Bioscience	$6,667,601		0.0%	2,849,402	0.1%	Medical
ADVERUM BIOTECHNOLOGIES INC	$5,891,657	$5,891,657 ▲	New Holding	416,666	0.1%	Common
MRTX Mirati Therapeutics	$0	$287,101,850 ▼	-100.0%	0	0.0%	Medical
CBAY CymaBay Therapeutics	$0	$262,444,442 ▼	-100.0%	0	0.0%	Medical
GPCR Structure Therapeutics	$0	$95,106,653 ▼	-100.0%	0	0.0%	Medical
KRTX Karuna Therapeutics	$0	$39,563,750 ▼	-100.0%	0	0.0%	Medical
IMGN ImmunoGen	$0	$25,943,750 ▼	-100.0%	0	0.0%	Medical
FENC Fennec Pharmaceuticals	$0	$13,464,000 ▼	-100.0%	0	0.0%	Medical
NUVL Nuvalent	$0	$13,166,796 ▼	-100.0%	0	0.0%	Medical