Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2026) About Frazier Life Sciences Management, L.P.Investment ActivityFrazier Life Sciences Management, L.P. has $3.89 billion in total holdings as of March 31, 2026.Frazier Life Sciences Management, L.P. owns shares of 38 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 6.20% of the portfolio was purchased this quarter.About 5.18% of the portfolio was sold this quarter.This quarter, Frazier Life Sciences Management, L.P. has purchased 40 new stocks and bought additional shares in 8 stocks.Frazier Life Sciences Management, L.P. sold shares of 9 stocks and completely divested from 6 stocks this quarter.Largest Holdings Mirum Pharmaceuticals $709,449,208NewAmsterdam Pharma $542,370,206Erasca $399,244,542BridgeBio Pharma $256,058,802Arcutis Biotherapeutics $232,643,479 Largest New Holdings this Quarter 09058V103 - BioCryst Pharmaceuticals $38,167,965 Holding00461U105 - Aclaris Therapeutics $18,470,153 Holding61225M102 - Monte Rosa Therapeutics $16,450,000 Holding98422T209 - XILIO THERAPEUTICS INC $3,553,267 Holding Largest Purchases this Quarter Mirum Pharmaceuticals 884,563 shares (about $81.72M)BioCryst Pharmaceuticals 4,009,240 shares (about $38.17M)Erasca 1,945,752 shares (about $31.48M)PALVELLA THERAPEUTICS INC NE 160,000 shares (about $19.94M)Aclaris Therapeutics 4,925,374 shares (about $18.47M) Largest Sales this Quarter Revolution Medicines 121,769 shares (about $11.84M)BridgeBio Pharma 97,418 shares (about $7.23M)Trevi Therapeutics 319,862 shares (about $3.82M)Krystal Biotech 7,153 shares (about $1.85M)KalVista Pharmaceuticals 78,759 shares (about $1.59M) Sector Allocation Over TimeMap of 500 Largest Holdings ofFrazier Life Sciences Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorMIRMMirum Pharmaceuticals$709,449,208$81,715,930 â–²13.0%7,679,68418.3%MedicalNAMSNewAmsterdam Pharma$542,370,2060.0%16,943,77414.0%MedicalERASErasca$399,244,542$31,482,267 â–²8.6%24,675,18810.3%MedicalBBIOBridgeBio Pharma$256,058,802$7,234,261 â–¼-2.7%3,448,1396.6%MedicalARQTArcutis Biotherapeutics$232,643,4790.0%9,874,5116.0%MedicalMBX BIOSCIENCES INC$198,562,5880.0%6,652,0135.1%COMPHATPhathom Pharmaceuticals$138,502,6930.0%12,466,4893.6%MedicalMAZE THERAPEUTICS INC$136,333,1290.0%4,567,2743.5%COMKRYSKrystal Biotech$124,331,224$1,847,763 â–¼-1.5%481,3073.2%MedicalTRVITrevi Therapeutics$118,578,796$3,815,954 â–¼-3.1%9,939,5473.1%MedicalPALVELLA THERAPEUTICS INC NE$109,991,160$19,944,000 â–²22.1%882,4002.8%COMKALVKalVista Pharmaceuticals$99,867,104$1,585,419 â–¼-1.6%4,961,1082.6%MedicalIRONDisc Medicine$86,629,237$6,064,837 â–²7.5%1,354,8522.2%MedicalCYTKCytokinetics$76,447,625$14,845,371 â–²24.1%1,159,8792.0%MedicalRVMDRevolution Medicines$65,710,464$11,842,035 â–¼-15.3%675,6861.7%MedicalDYNE THERAPEUTICS INC$57,165,3770.0%3,153,0821.5%COMSVRASavara$53,075,852$772,312 â–¼-1.4%9,720,8521.4%MedicalTARSTarsus Pharmaceuticals$51,114,3770.0%728,6441.3%MedicalVOR BIOPHARMA INC$45,383,8720.0%2,543,9391.2%COM NEWAGIOAgios Pharmaceuticals$42,493,186$800,891 â–¼-1.8%1,256,0801.1%MedicalBCRXBioCryst Pharmaceuticals$38,167,965$38,167,965 â–²New Holding4,009,2401.0%MedicalZLABZai Lab$35,782,6390.0%1,902,3200.9%MedicalAURAAura Biosciences$34,119,0000.0%5,100,0000.9%MedicalACADACADIA Pharmaceuticals$32,014,287$3,138,660 â–²10.9%1,438,1980.8%MedicalASNDAscendis Pharma A/S$30,497,2570.0%133,3330.8%MedicalLEXEO THERAPEUTICS INC$25,397,9220.0%4,424,7250.7%COMALKSAlkermes$24,774,8780.0%700,6470.6%MedicalACRSAclaris Therapeutics$18,470,153$18,470,153 â–²New Holding4,925,3740.5%MedicalGLUEMonte Rosa Therapeutics$16,450,000$16,450,000 â–²New Holding1,000,0000.4%MedicalIMCRImmunocore$14,616,177$3,015,000 â–²26.0%484,7820.4%MedicalMNKDMannKind$14,455,000$4,103,750 â–²39.6%5,900,0000.4%MedicalVALNValneva$14,322,9130.0%2,291,6660.4%MedicalEOLSEvolus$10,812,0330.0%2,630,6650.3%MedicalNAMSWNewAmsterdam Pharma$10,026,6730.0%500,3330.3%MedicalALLOAllogene Therapeutics$9,263,870$175,880 â–¼-1.9%3,796,6680.2%MedicalAUTLAutolus Therapeutics$6,138,116$242,071 â–¼-3.8%4,447,9100.2%MedicalIBIO INC$3,711,5870.0%1,953,4670.1%COM NEWXILIO THERAPEUTICS INC$3,553,267$3,553,267 â–²New Holding422,5050.1%COMRNAAvidity Biosciences$0$70,912,806 â–¼-100.0%00.0%MedicalABIVAX SA$0$51,015,647 â–¼-100.0%00.0%SPONSORED ADSRAPT THERAPEUTICS INC$0$33,305,489 â–¼-100.0%00.0%COM NEWTVTXTravere Therapeutics$0$9,231,230 â–¼-100.0%00.0%MedicalDSGNDesign Therapeutics$0$4,886,980 â–¼-100.0%00.0%MedicalXLOXilio Therapeutics$0$3,786,841 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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