Frazier Life Sciences Management, L.P. Top Holdings and 13F Report (2026) About Frazier Life Sciences Management, L.P.Investment ActivityFrazier Life Sciences Management, L.P. has $4.59 billion in total holdings as of June 30, 2026.Frazier Life Sciences Management, L.P. owns shares of 41 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 7.37% of the portfolio was purchased this quarter.About 7.61% of the portfolio was sold this quarter.This quarter, Frazier Life Sciences Management, L.P. has purchased 38 new stocks and bought additional shares in 8 stocks.Frazier Life Sciences Management, L.P. sold shares of 2 stocks and completely divested from 3 stocks this quarter.Largest Holdings Mirum Pharmaceuticals $899,060,606NewAmsterdam Pharma $613,032,889Erasca $457,545,444MBX BIOSCIENCES INC $367,191,118Arcutis Biotherapeutics $258,909,678 Largest New Holdings this Quarter 698955101 - PARABILIS MEDICINES INC $52,572,433 Holding004468500 - Achieve Life Sciences $49,724,879 Holding25056L103 - Design Therapeutics $26,188,587 Holding82024L103 - Shattuck Labs $26,025,000 Holding482931102 - KAILERA THERAPEUTICS INC $24,233,000 Holding Largest Purchases this Quarter PARABILIS MEDICINES INC 1,920,805 shares (about $52.57M)Achieve Life Sciences 7,614,836 shares (about $49.72M)NewAmsterdam Pharma 1,145,128 shares (about $38.81M)Allogene Therapeutics 18,650,000 shares (about $38.79M)Design Therapeutics 1,809,854 shares (about $26.19M) Largest Sales this Quarter BridgeBio Pharma 1,900,000 shares (about $141.51M)Trevi Therapeutics 100 shares (about $1.87K) Sector Allocation Over TimeMap of 500 Largest Holdings ofFrazier Life Sciences Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorMIRMMirum Pharmaceuticals$899,060,6060.0%7,679,68419.6%HealthcareNAMSNewAmsterdam Pharma$613,032,889$38,808,388 â–²6.8%18,088,90213.3%HealthcareERASErasca$457,545,444$5,496,000 â–²1.2%24,975,18810.0%HealthcareMBX BIOSCIENCES INC$367,191,1180.0%6,652,0138.0%COMARQTArcutis Biotherapeutics$258,909,6780.0%9,874,5115.6%HealthcareTRVITrevi Therapeutics$185,370,687$1,865 â–¼0.0%9,939,4474.0%HealthcareKRYSKrystal Biotech$178,887,3730.0%481,3073.9%HealthcareMAZE THERAPEUTICS INC$150,182,184$13,894,727 â–²10.2%5,032,9153.3%COMPHATPhathom Pharmaceuticals$135,261,4060.0%12,466,4892.9%HealthcarePALVELLA THERAPEUTICS INC NE$134,848,3680.0%882,4002.9%COMBBIOBridgeBio Pharma$115,305,393$141,512,000 â–¼-55.1%1,548,1392.5%HealthcareIRONDisc Medicine$99,093,8750.0%1,354,8522.2%HealthcareCYTKCytokinetics$98,810,0920.0%1,159,8792.2%HealthcareDYNE THERAPEUTICS INC$70,029,9510.0%3,153,0821.5%COMASNDAscendis Pharma A/S$60,053,342$24,490,764 â–²68.9%225,1551.3%HealthcareSVRASavara$59,880,4480.0%9,720,8521.3%HealthcarePARABILIS MEDICINES INC$52,572,433$52,572,433 â–²New Holding1,920,8051.1%COMAURAAura Biosciences$50,410,000$14,200,000 â–²39.2%7,100,0001.1%HealthcareACHVAchieve Life Sciences$49,724,879$49,724,879 â–²New Holding7,614,8361.1%HealthcareVOR BIOPHARMA INC$46,833,9170.0%2,543,9391.0%COM NEWALLOAllogene Therapeutics$46,689,069$38,792,000 â–²491.2%22,446,6681.0%HealthcareTARSTarsus Pharmaceuticals$45,860,8530.0%728,6441.0%HealthcareBCRXBioCryst Pharmaceuticals$40,092,4000.0%4,009,2400.9%HealthcareALKSAlkermes$36,710,4000.0%700,6470.8%HealthcareACADACADIA Pharmaceuticals$36,386,4090.0%1,438,1980.8%HealthcareZLABZai Lab$36,144,0800.0%1,902,3200.8%HealthcareMNKDMannKind$28,116,000$2,982,000 â–²11.9%6,600,0000.6%HealthcareDSGNDesign Therapeutics$26,188,587$26,188,587 â–²New Holding1,809,8540.6%HealthcareACRSAclaris Therapeutics$26,055,2280.0%4,925,3740.6%HealthcareSTTKShattuck Labs$26,025,000$26,025,000 â–²New Holding3,750,0000.6%HealthcareKAILERA THERAPEUTICS INC$24,233,000$24,233,000 â–²New Holding1,100,0000.5%COMMON STOCKGLUEMonte Rosa Therapeutics$24,200,0000.0%1,000,0000.5%HealthcareLEXEO THERAPEUTICS INC$22,459,095$1,862,000 â–²9.0%4,824,7250.5%COMRLAYRelay Therapeutics$19,003,616$19,003,616 â–²New Holding1,015,6930.4%HealthcareEOLSEvolus$18,256,8150.0%2,630,6650.4%HealthcareIMCRImmunocore$15,391,8290.0%484,7820.3%HealthcareVALNValneva$11,985,4130.0%2,291,6660.3%HealthcareNAMSWNewAmsterdam Pharma$10,692,1160.0%500,3330.2%HealthcareAUTLAutolus Therapeutics$7,116,6560.0%4,447,9100.2%HealthcareXILIO THERAPEUTICS INC$4,047,5980.0%422,5050.1%COMIBIO INC$3,418,5670.0%1,953,4670.1%COM NEWKALVKalVista Pharmaceuticals$0$99,867,104 â–¼-100.0%00.0%HealthcareRVMDRevolution Medicines$0$65,710,464 â–¼-100.0%00.0%HealthcareAGIOAgios Pharmaceuticals$0$42,493,186 â–¼-100.0%00.0%HealthcareShowing largest 100 holdings. 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