Ishara Investments Lp Top Holdings and 13F Report (2026) About Ishara Investments LpInvestment ActivityIshara Investments Lp has $105.63 million in total holdings as of March 31, 2026.Ishara Investments Lp owns shares of 36 different stocks, but just 20 companies or ETFs make up 80% of its holdings.Approximately 52.84% of the portfolio was purchased this quarter.About 36.06% of the portfolio was sold this quarter.This quarter, Ishara Investments Lp has purchased 38 new stocks and bought additional shares in 11 stocks.Ishara Investments Lp sold shares of 8 stocks and completely divested from 19 stocks this quarter.Largest Holdings PRAXIS PRECISION MEDICINES I $13,870,280Axsome Therapeutics $6,929,820Xeris Biopharma $5,945,000KalVista Pharmaceuticals $5,570,978Amicus Therapeutics $5,335,740 Largest New Holdings this Quarter 05464T104 - Axsome Therapeutics $6,929,820 Holding483497103 - KalVista Pharmaceuticals $5,570,978 Holding04280A100 - Arrowhead Pharmaceuticals $3,470,445 Holding92337R101 - Vera Therapeutics $3,298,860 Holding89422G107 - Travere Therapeutics $3,288,897 Holding Largest Purchases this Quarter Axsome Therapeutics 41,000 shares (about $6.93M)KalVista Pharmaceuticals 276,750 shares (about $5.57M)Arrowhead Pharmaceuticals 55,350 shares (about $3.47M)Vera Therapeutics 82,000 shares (about $3.30M)Travere Therapeutics 110,700 shares (about $3.29M) Largest Sales this Quarter Annexon 575,750 shares (about $3.19M)PTC Therapeutics 25,750 shares (about $1.75M)BioMarin Pharmaceutical 18,000 shares (about $1.02M)ACADIA Pharmaceuticals 37,000 shares (about $823.62K)Oric Pharmaceuticals 57,500 shares (about $728.53K) Sector Allocation Over TimeMap of 500 Largest Holdings ofIshara Investments Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorPRAXIS PRECISION MEDICINES I$13,870,280$982,680 â–²7.6%43,05013.1%COM NEWAXSMAxsome Therapeutics$6,929,820$6,929,820 â–²New Holding41,0006.6%MedicalXERSXeris Biopharma$5,945,000$1,305,000 â–²28.1%1,025,0005.6%MedicalKALVKalVista Pharmaceuticals$5,570,978$5,570,978 â–²New Holding276,7505.3%MedicalFOLDAmicus Therapeutics$5,335,740$130,140 â–²2.5%369,0005.1%MedicalBMRNBioMarin Pharmaceutical$4,632,180$1,016,820 â–¼-18.0%82,0004.4%MedicalVSTMVerastem$4,346,000$2,915,000 â–²203.7%820,0004.1%MedicalRAREUltragenyx Pharmaceutical$3,650,538$2,603,038 â–²248.5%174,2503.5%MedicalARWRArrowhead Pharmaceuticals$3,470,445$3,470,445 â–²New Holding55,3503.3%MedicalPCVXVaxcyte$3,335,514$430,014 â–²14.8%57,4003.2%MedicalVERAVera Therapeutics$3,298,860$3,298,860 â–²New Holding82,0003.1%MedicalTVTXTravere Therapeutics$3,288,897$3,288,897 â–²New Holding110,7003.1%MedicalMLTXMoonLake Immunotherapeutics$3,248,020$3,248,020 â–²New Holding174,2503.1%MedicalZNTLZentalis Pharmaceuticals$2,878,200$210,600 â–¼-6.8%1,230,0002.7%MedicalSRRKScholar Rock$2,821,784$2,821,784 â–²New Holding57,4002.7%MedicalACADACADIA Pharmaceuticals$2,737,980$823,620 â–¼-23.1%123,0002.6%MedicalARDXArdelyx$2,701,490$2,701,490 â–²New Holding451,0002.6%MedicalMLYSMineralys Therapeutics$2,221,380$2,221,380 â–²New Holding82,0002.1%MedicalGMABGenmab A/S$2,200,060$321,960 â–²17.1%82,0002.1%MedicalDBV TECHNOLOGIES S A$2,141,225$2,141,225 â–²New Holding102,5002.0%SPONSORED ADSCPRXCatalyst Pharmaceuticals$2,030,320$2,030,320 â–²New Holding82,0001.9%MedicalSIONNA THERAPEUTICS INC$1,972,428$1,972,428 â–²New Holding49,2001.9%COMCONTINEUM THERAPEUTICS INC$1,854,520$1,854,520 â–²New Holding142,0001.8%CL AALNYAlnylam Pharmaceuticals$1,695,709$1,695,709 â–²New Holding5,1251.6%MedicalLGNDLigand Pharmaceuticals$1,637,130$1,637,130 â–²New Holding8,2001.5%MedicalEWTXEdgewise Therapeutics$1,549,800$277,200 â–¼-15.2%49,2001.5%MedicalIMTXImmatics$1,512,900$725,700 â–²92.2%153,7501.4%MedicalLXRXLexicon Pharmaceuticals$1,407,120$34,320 â–²2.5%902,0001.3%MedicalBEAMBeam Therapeutics$1,367,842$176,342 â–²14.8%57,4001.3%MedicalORICOric Pharmaceuticals$1,298,675$728,525 â–¼-35.9%102,5001.2%MedicalNAMSNewAmsterdam Pharma$1,181,169$220,869 â–²23.0%36,9001.1%MedicalANNXAnnexon$965,345$3,189,655 â–¼-76.8%174,2500.9%MedicalIDYAIDEAYA Biosciences$819,672$819,672 â–²New Holding24,6000.8%MedicalSLNSilence Therapeutics$740,435$524,365 â–¼-41.5%140,5000.7%MedicalPTCTPTC Therapeutics$698,333$1,754,349 â–¼-71.5%10,2500.7%MedicalGOSSGossamer Bio$269,370$269,370 â–²New Holding820,0000.3%MedicalNUVBNuvation Bio$0$3,584,000 â–¼-100.0%00.0%MedicalBBIOBridgeBio Pharma$0$2,753,640 â–¼-100.0%00.0%MedicalUTHRUnited Therapeutics$0$2,679,875 â–¼-100.0%00.0%MedicalBCRXBioCryst Pharmaceuticals$0$2,340,000 â–¼-100.0%00.0%MedicalSNDXSyndax Pharmaceuticals$0$2,101,000 â–¼-100.0%00.0%MedicalTARSTarsus Pharmaceuticals$0$1,965,120 â–¼-100.0%00.0%MedicalAPOGApogee Enterprises$0$1,887,000 â–¼-100.0%00.0%IndustrialsINSMInsmed$0$1,740,400 â–¼-100.0%00.0%MedicalCORTCorcept Therapeutics$0$1,531,200 â–¼-100.0%00.0%MedicalAPLSApellis Pharmaceuticals$0$1,256,000 â–¼-100.0%00.0%MedicalDNLIDenali Therapeutics$0$1,155,700 â–¼-100.0%00.0%MedicalASNDAscendis Pharma A/S$0$1,066,200 â–¼-100.0%00.0%MedicalBHVNBiohaven$0$993,520 â–¼-100.0%00.0%MedicalDIANTHUS THERAPEUTICS INC$0$989,040 â–¼-100.0%00.0%COMNEKTAR THERAPEUTICS$0$845,600 â–¼-100.0%00.0%COM NEWAGIOAgios Pharmaceuticals$0$816,600 â–¼-100.0%00.0%MedicalIMVTImmunovant$0$762,600 â–¼-100.0%00.0%MedicalOLMAOlema Pharmaceuticals$0$750,000 â–¼-100.0%00.0%MedicalARQTArcutis Biotherapeutics$0$348,480 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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