Opaleye Management Inc. Top Holdings and 13F Report (2025) About Opaleye Management Inc.Investment ActivityOpaleye Management Inc. has $1.10 billion in total holdings as of June 30, 2025.Opaleye Management Inc. owns shares of 58 different stocks, but just 19 companies or ETFs make up 80% of its holdings.Approximately 14.19% of the portfolio was purchased this quarter.About 8.87% of the portfolio was sold this quarter.This quarter, Opaleye Management Inc. has purchased 54 new stocks and bought additional shares in 15 stocks.Opaleye Management Inc. sold shares of 13 stocks and completely divested from 9 stocks this quarter.Largest Holdings Liquidia $195,139,175Eton Pharmaceuticals $103,532,000Harrow $101,928,000Disc Medicine $62,534,700Urogen Pharma $52,991,853 Largest New Holdings this Quarter 45258H106 - Immix Biopharma $24,176,950 Holding61225M102 - Monte Rosa Therapeutics $18,029,000 Holding76029N106 - Replimune Group $15,331,873 Holding92337C203 - Verastem $6,876,000 Holding71722W107 - Phathom Pharmaceuticals $2,013,641 Holding Largest Purchases this Quarter Disc Medicine 434,000 shares (about $31.74M)Immix Biopharma 2,345,000 shares (about $24.18M)MeiraGTx 1,426,741 shares (about $19.28M)Monte Rosa Therapeutics 745,000 shares (about $18.03M)Replimune Group 1,384,993 shares (about $15.33M) Largest Sales this Quarter Harrow 432,230 shares (about $18.36M)Liquidia 97,500 shares (about $7.77M)SANUWAVE HEALTH INC 675,127 shares (about $6.75M)JADE BIOSCIENCES INC 282,608 shares (about $6.28M)CG ONCOLOGY INC 77,011 shares (about $5.47M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOpaleye Management Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorLQDALiquidia$195,139,175$7,773,675 â–¼-3.8%2,447,50017.7%HealthcareETONEton Pharmaceuticals$103,532,0000.0%2,860,0009.4%HealthcareHROWHarrow$101,928,000$18,356,808 â–¼-15.3%2,400,0009.2%HealthcareIRONDisc Medicine$62,534,700$31,742,760 â–²103.1%855,0005.7%HealthcareURGNUrogen Pharma$52,991,853$367,853 â–²0.7%1,439,9964.8%HealthcareAPOGEE THERAPEUTICS INC$51,764,7000.0%390,0004.7%COMMGTXMeiraGTx$47,960,500$19,275,271 â–²67.2%3,550,0004.3%HealthcareSOL-GEL TECHNOLOGIES LTD$37,070,0000.0%500,0003.4%SHS NEWRZLTRezolute$32,760,0000.0%6,300,0003.0%HealthcareTGTXTG Therapeutics$29,392,9000.0%535,0002.7%HealthcareIMMXImmix Biopharma$24,176,950$24,176,950 â–²New Holding2,345,0002.2%HealthcareCRESCENT BIOPHARMA INC.$23,748,318$121,248 â–²0.5%1,319,3512.2%COMSTOKStoke Therapeutics$22,904,0000.0%700,0002.1%HealthcareALPHA COGNITION INC$20,905,272$2,407,993 â–²13.0%2,895,4671.9%COM NEWEWTXEdgewise Therapeutics$20,315,0000.0%500,0001.8%HealthcareRVMDRevolution Medicines$18,728,0000.0%100,0001.7%HealthcareGLUEMonte Rosa Therapeutics$18,029,000$18,029,000 â–²New Holding745,0001.6%HealthcareALUMIS INC$15,477,0000.0%550,0001.4%COMCDXSCodexis$15,334,1000.0%6,785,0001.4%HealthcareREPLReplimune Group$15,331,873$15,331,873 â–²New Holding1,384,9931.4%HealthcareXOMAXOMA Royalty$14,380,895$1,630,895 â–²12.8%338,3741.3%HealthcareMBX BIOSCIENCES INC$14,352,0000.0%260,0001.3%COMRYTMRhythm Pharmaceuticals$13,601,175$55,515 â–¼-0.4%122,5001.2%HealthcareEDITEditas Medicine$12,512,653$6,269,183 â–²100.4%3,861,9301.1%HealthcarePTGXProtagonist Therapeutics$12,258,0000.0%100,0001.1%HealthcareCABACabaletta Bio$12,016,418$7,724,618 â–²180.0%3,863,8001.1%HealthcareQ32 BIO INC$11,860,940$4,143,405 â–¼-25.9%931,0001.1%COMANNXAnnexon$9,789,515$3,524,840 â–¼-26.5%1,714,4510.9%HealthcareVSTMVerastem$6,876,000$6,876,000 â–²New Holding1,800,0000.6%HealthcareZNTLZentalis Pharmaceuticals$6,851,3820.0%1,412,6560.6%HealthcareRLMDRelmada Therapeutics$6,470,2000.0%935,0000.6%HealthcareOCULOcular Therapeutix$5,892,0000.0%600,0000.5%HealthcareTRVITrevi Therapeutics$5,781,500$654,615 â–¼-10.2%310,0000.5%HealthcareBRIDGEBIO ONCOLOGY THERAPEUT$5,334,000$4,927,991 â–²1,213.8%700,0000.5%COM NEWLYELL IMMUNOPHARMA INC$4,833,551$3,722,238 â–²334.9%344,0250.4%COM NEWOPUS GENETICS INC$4,623,750$20,550 â–²0.4%1,125,0000.4%COMFDMT4D Molecular Therapeutics$4,448,012$2,954,542 â–²197.8%334,4370.4%HealthcareNTLAIntellia Therapeutics$4,230,000$84,600 â–²2.0%250,0000.4%HealthcareVYGRVoyager Therapeutics$4,147,500$122,500 â–²3.0%1,185,0000.4%HealthcareBIODESIX INC$4,059,000$1,308,960 â–¼-24.4%180,0000.4%COMRCKTRocket Pharmaceuticals$3,420,000$153,900 â–²4.7%1,000,0000.3%HealthcareJADE BIOSCIENCES INC$3,221,900$6,279,550 â–¼-66.1%145,0000.3%COM NEWSANUWAVE HEALTH INC$3,061,400$6,751,270 â–¼-68.8%306,1400.3%COMFORTRESS BIOTECH INC$2,723,400$465,120 â–¼-14.6%890,0000.2%COM NEWDERMJourney Medical$2,478,000$4,318,800 â–¼-63.5%350,0000.2%HealthcarePHATPhathom Pharmaceuticals$2,013,641$2,013,641 â–²New Holding185,5890.2%HealthcareINHIBRX BIOSCIENCES INC$1,922,572$1,922,572 â–²New Holding20,2910.2%COMENTAEnanta Pharmaceuticals$1,822,5000.0%125,0000.2%HealthcareHEMAB THERAPEUTICS HLDGS INC$1,750,258$1,750,258 â–²New Holding47,6520.2%COM SHSFIRST TRACKS BIOTHERAPEUTICS$1,307,800$1,307,800 â–²New Holding65,0000.1%ORD SHSCG ONCOLOGY INC$1,263,908$5,471,630 â–¼-81.2%17,7890.1%COMBHVNBiohaven$1,159,375$1,159,375 â–²New Holding77,9150.1%HealthcareAVIRAtea Pharmaceuticals$1,092,750$407,340 â–¼-27.2%235,0000.1%HealthcarePASITHEA THERAPEUTICS CORP$1,056,570$1,056,570 â–²New Holding2,050,0000.1%COM NEWADCTADC Therapeutics$749,000$749,000 â–²New Holding700,0000.1%HealthcareOKYOOKYO Pharma$562,806$562,806 â–²New Holding375,2040.1%HealthcarePALATIN TECHNOLOGIES INC$221,195$221,195 â–²New Holding20,5000.0%COM NEWADAGIO MED HLDGS INC$13,3530.0%18,4440.0%COMPERSPECTIVE THERAPEUTICS INC$0$19,494,750 â–¼-100.0%00.0%COM NEWASSERTIO HOLDINGS INC$0$5,064,375 â–¼-100.0%00.0%COM NEWSUTRO BIOPHARMA INC$0$4,749,615 â–¼-100.0%00.0%COM SHSTECTONIC THERAPEUTIC INC$0$3,801,930 â–¼-100.0%00.0%COMRIGEL PHARMACEUTICALS INC$0$1,892,800 â–¼-100.0%00.0%COMNEXTCURE INC$0$1,507,813 â–¼-100.0%00.0%COM NEWPERSPECTIVE THERAPEUTICS INC$0$834,000 â–¼-100.0%00.0%CALLPLXProtalix BioTherapeutics$0$737,800 â–¼-100.0%00.0%HealthcareLB PHARMACEUTICALS INC$0$357,718 â–¼-100.0%00.0%COM SHSShowing largest 100 holdings. 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