Opaleye Management Inc. Top Holdings and 13F Report (2025) About Opaleye Management Inc.Investment ActivityOpaleye Management Inc. has $759.22 million in total holdings as of June 30, 2025.Opaleye Management Inc. owns shares of 54 different stocks, but just 19 companies or ETFs make up 80% of its holdings.Approximately 14.46% of the portfolio was purchased this quarter.About 23.38% of the portfolio was sold this quarter.This quarter, Opaleye Management Inc. has purchased 54 new stocks and bought additional shares in 18 stocks.Opaleye Management Inc. sold shares of 12 stocks and completely divested from 10 stocks this quarter.Largest Holdings Harrow $99,864,430Liquidia $88,820,500Eton Pharmaceuticals $70,584,800SOL-GEL TECHNOLOGIES LTD $39,610,000Rhythm Pharmaceuticals $35,323,200 Largest New Holdings this Quarter 04546C304 - ASSERTIO HOLDINGS INC $5,064,375 Holding28106W103 - Editas Medicine $4,759,683 Holding09075X207 - BIODESIX INC $3,451,682 Holding45826J105 - Intellia Therapeutics $3,140,900 Holding55083R203 - LYELL IMMUNOPHARMA INC $1,586,686 Holding Largest Purchases this Quarter Urogen Pharma 1,161,577 shares (about $20.89M)MeiraGTx 1,732,415 shares (about $15.00M)PERSPECTIVE THERAPEUTICS INC 3,490,500 shares (about $14.56M)Disc Medicine 221,000 shares (about $14.13M)Q32 BIO INC 1,042,865 shares (about $6.70M) Largest Sales this Quarter Rhythm Pharmaceuticals 207,000 shares (about $59.45M)Harrow 1,072,770 shares (about $37.83M)CG ONCOLOGY INC 315,200 shares (about $21.33M)Ocular Therapeutix 995,000 shares (about $8.43M)Protalix BioTherapeutics 2,138,176 shares (about $4.64M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOpaleye Management Inc. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorHROWHarrow$99,864,430$37,825,870 â–¼-27.5%2,832,23013.2%MedicalLQDALiquidia$88,820,500$3,839,000 â–²4.5%2,545,00011.7%MedicalETONEton Pharmaceuticals$70,584,8000.0%2,860,0009.3%MedicalSOL-GEL TECHNOLOGIES LTD$39,610,000$3,664,796 â–²10.2%500,0005.2%SHS NEWRYTMRhythm Pharmaceuticals$35,323,200$59,446,361 â–¼-62.7%123,0004.7%MedicalAPOGEE THERAPEUTICS INC$32,826,300$146,708 â–²0.4%390,0004.3%COMIRONDisc Medicine$26,918,740$14,130,740 â–²110.5%421,0003.5%MedicalURGNUrogen Pharma$25,711,400$20,885,154 â–²432.7%1,430,0003.4%MedicalCRESCENT BIOPHARMA INC.$24,112,738$2,467,367 â–²11.4%1,312,6153.2%COMSTOKStoke Therapeutics$22,792,000$162,800 â–²0.7%700,0003.0%MedicalPERSPECTIVE THERAPEUTICS INC$19,494,750$14,555,385 â–²294.7%4,675,0002.6%COM NEWRZLTRezolute$19,215,000$39,174 â–²0.2%6,300,0002.5%MedicalMGTXMeiraGTx$18,387,423$15,002,714 â–²443.2%2,123,2592.4%MedicalTGTXTG Therapeutics$17,772,7000.0%535,0002.3%MedicalSANUWAVE HEALTH INC$16,966,1060.0%981,2672.2%COMEWTXEdgewise Therapeutics$15,750,0000.0%500,0002.1%MedicalALPHA COGNITION INC$14,065,106$2,696,501 â–²23.7%2,561,9501.9%COM NEWANNXAnnexon$12,917,956$1,486,044 â–¼-10.3%2,331,7611.7%MedicalALUMIS INC$12,116,500$330,450 â–²2.8%550,0001.6%COMCDXSCodexis$11,059,550$7,723 â–¼-0.1%6,785,0001.5%MedicalPTGXProtagonist Therapeutics$10,540,000$527,000 â–¼-4.8%100,0001.4%MedicalRVMDRevolution Medicines$9,725,0000.0%100,0001.3%MedicalXOMAXOMA Royalty$9,411,000$232,452 â–²2.5%300,0001.2%MedicalQ32 BIO INC$8,064,984$6,695,193 â–²488.8%1,256,2281.1%COMMBX BIOSCIENCES INC$7,761,0000.0%260,0001.0%COMRLMDRelmada Therapeutics$6,507,6000.0%935,0000.9%MedicalCG ONCOLOGY INC$6,416,064$21,332,736 â–¼-76.9%94,8000.8%COMJADE BIOSCIENCES INC$6,007,8920.0%427,6080.8%COM NEWOCULOcular Therapeutix$5,082,000$8,427,650 â–¼-62.4%600,0000.7%MedicalASSERTIO HOLDINGS INC$5,064,375$5,064,375 â–²New Holding265,7070.7%COM NEWEDITEditas Medicine$4,759,683$4,759,683 â–²New Holding1,926,9970.6%MedicalSUTRO BIOPHARMA INC$4,749,6150.0%190,6710.6%COM SHSDERMJourney Medical$4,502,400$70,350 â–¼-1.5%960,0000.6%MedicalVYGRVoyager Therapeutics$4,439,000$181,049 â–¼-3.9%1,150,0000.6%MedicalTRVITrevi Therapeutics$4,117,0430.0%345,1000.5%MedicalTECTONIC THERAPEUTIC INC$3,801,930$2,835,900 â–¼-42.7%123,0000.5%COMCABACabaletta Bio$3,712,200$1,291,200 â–²53.3%1,380,0000.5%MedicalBIODESIX INC$3,451,682$3,451,682 â–²New Holding238,0470.5%COMRCKTRocket Pharmaceuticals$3,418,9000.0%955,0000.5%MedicalZNTLZentalis Pharmaceuticals$3,305,615$27,495 â–²0.8%1,412,6560.4%MedicalNTLAIntellia Therapeutics$3,140,900$3,140,900 â–²New Holding245,0000.4%MedicalFORTRESS BIOTECH INC$2,907,180$133,920 â–¼-4.4%1,042,0000.4%COM NEWOPUS GENETICS INC$2,251,2000.0%1,120,0000.3%COMRIGEL PHARMACEUTICALS INC$1,892,8000.0%70,0000.2%COMAVIRAtea Pharmaceuticals$1,735,588$768,183 â–²79.4%322,6000.2%MedicalLYELL IMMUNOPHARMA INC$1,586,686$1,586,686 â–²New Holding79,0970.2%COM NEWENTAEnanta Pharmaceuticals$1,578,750$631,500 â–²66.7%125,0000.2%MedicalNEXTCURE INC$1,507,813$1,507,813 â–²New Holding141,1810.2%COM NEWFDMT4D Molecular Therapeutics$1,045,429$1,045,429 â–²New Holding112,2910.1%MedicalPERSPECTIVE THERAPEUTICS INC$834,000$834,000 â–²New Holding200,0000.1%CALLPLXProtalix BioTherapeutics$737,800$4,639,842 â–¼-86.3%340,0000.1%MedicalBRIDGEBIO ONCOLOGY THERAPEUT$476,874$476,874 â–²New Holding53,2820.1%COM NEWLB PHARMACEUTICALS INC$357,718$357,718 â–²New Holding14,5060.0%COM SHSADAGIO MED HLDGS INC$21,2110.0%18,4440.0%COMALKSAlkermes$0$13,710,200 â–¼-100.0%00.0%MedicalGOSSGossamer Bio$0$8,432,000 â–¼-100.0%00.0%MedicalKARYOPHARM THERAPEUTICS INC$0$6,844,800 â–¼-100.0%00.0%COM NEWZYMEWORKS INC$0$2,868,101 â–¼-100.0%00.0%COMASRTAssertio$0$2,584,950 â–¼-100.0%00.0%MedicalVTYXVentyx Biosciences$0$2,274,946 â–¼-100.0%00.0%MedicalGENERATION BIO CO$0$1,760,800 â–¼-100.0%00.0%COM NEWBBIOBridgeBio Pharma$0$1,401,220 â–¼-100.0%00.0%MedicalSLNSilence Therapeutics$0$479,870 â–¼-100.0%00.0%MedicalRAPT THERAPEUTICS INC$0$213,363 â–¼-100.0%00.0%COM NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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