Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Sio Capital Management, LLC has $335.80 million in total holdings as of March 31, 2025.
Sio Capital Management, LLC owns shares of 54 different stocks, but just 18 companies or ETFs make up 80% of its holdings.
Approximately 42.19% of the portfolio was purchased this quarter.
About 31.43% of the portfolio was sold this quarter.
This quarter, Sio Capital Management, LLC has purchased 51 new stocks and bought additional shares in 15 stocks.
Sio Capital Management, LLC sold shares of 7 stocks and completely divested from 11 stocks this quarter.

Largest Holdings

ICON Public: $35,577,392
Maximus: $31,936,923
Merck & Co., Inc.: $24,288,697
Zimmer Biomet: $21,242,188
Neurocrine Biosciences: $20,745,574

Largest New Holdings this Quarter

58933Y105 - Merck & Co., Inc.: $24,288,697 Holding
64125C109 - Neurocrine Biosciences: $20,745,574 Holding
379577208 - Globus Medical: $15,152,400 Holding
09061G101 - BioMarin Pharmaceutical: $9,976,762 Holding
405024100 - Haemonetics: $8,513,539 Holding

Largest Purchases this Quarter

Merck & Co., Inc.: 270,596 shares (about $24.29M)
Neurocrine Biosciences: 187,573 shares (about $20.75M)
Globus Medical: 207,000 shares (about $15.15M)
BioMarin Pharmaceutical: 141,134 shares (about $9.98M)
Embecta: 682,039 shares (about $8.70M)

Largest Sales this Quarter

LABCORP HOLDINGS INC: 29,420 shares (about $6.85M)
ANI Pharmaceuticals: 72,753 shares (about $4.87M)
Vir Biotechnology: 581,044 shares (about $3.77M)
Vaxart: 5,931,867 shares (about $2.41M)
Ventyx Biosciences: 1,464,142 shares (about $1.68M)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
ICLR ICON Public	$35,577,392	$1,366,847 ▲	4.0%	203,311	10.6%	Medical
MMS Maximus	$31,936,923	$5,927,689 ▲	22.8%	468,352	9.5%	Business Services
MRK Merck & Co., Inc.	$24,288,697	$24,288,697 ▲	New Holding	270,596	7.2%	Medical
ZBH Zimmer Biomet	$21,242,188	$1,457,079 ▲	7.4%	187,685	6.3%	Medical
NBIX Neurocrine Biosciences	$20,745,574	$20,745,574 ▲	New Holding	187,573	6.2%	Medical
LABCORP HOLDINGS INC	$19,520,602	$6,847,211 ▼	-26.0%	83,873	5.8%	COM SHS
BRIGHT MINDS BIOSCIENCES INC	$18,307,761	$2,011,588 ▲	12.3%	507,562	5.5%	COM NEW
GMED Globus Medical	$15,152,400	$15,152,400 ▲	New Holding	207,000	4.5%	Medical
TFX Teleflex	$14,894,118	$5,666,895 ▲	61.4%	107,780	4.4%	Medical
EMBC Embecta	$14,122,066	$8,695,997 ▲	160.3%	1,107,613	4.2%	Medical
BMRN BioMarin Pharmaceutical	$9,976,762	$9,976,762 ▲	New Holding	141,134	3.0%	Medical
ANTERIS TECHNOLOGIES GLOBAL	$8,626,654	$146 ▼	0.0%	2,369,960	2.6%	COM
HAE Haemonetics	$8,513,539	$8,513,539 ▲	New Holding	133,966	2.5%	Medical
ANNX Annexon	$6,557,727	$1,989,403 ▲	43.5%	3,397,786	2.0%	Medical
TARA Protara Therapeutics	$6,450,918	$327,168 ▲	5.3%	1,514,300	1.9%	Medical
ANIP ANI Pharmaceuticals	$5,844,601	$4,870,813 ▼	-45.5%	87,298	1.7%	Medical
SLNO Soleno Therapeutics	$5,594,535	$5,594,535 ▲	New Holding	78,300	1.7%	Medical
SEPTERNA INC	$4,566,399	$2,993,331 ▲	190.3%	788,670	1.4%	COM
PRAXIS PRECISION MEDICINES INC I	$4,260,375	$4,260,375 ▲	New Holding	112,500	1.3%	COM NEW
AVNS Avanos Medical	$4,098,222	$4,098,222 ▲	New Holding	285,989	1.2%	Medical
PMVP PMV Pharmaceuticals	$4,071,582	$177,920 ▲	4.6%	3,735,396	1.2%	Medical
TYRA Tyra Biosciences	$3,874,538	$1,634,447 ▲	73.0%	416,617	1.2%	Medical
IRON Disc Medicine	$3,649,086		0.0%	73,511	1.1%	Medical
ETNB 89bio	$3,635,000	$3,635,000 ▲	New Holding	500,000	1.1%	Medical
AKRO Akero Therapeutics	$3,440,800	$3,440,800 ▲	New Holding	85,000	1.0%	Medical
VIR Vir Biotechnology	$3,068,973	$3,765,165 ▼	-55.1%	473,607	0.9%	Medical
AORT Artivion	$2,978,555		0.0%	121,178	0.9%	Medical
VTYX Ventyx Biosciences	$2,970,053	$1,683,763 ▼	-36.2%	2,582,655	0.9%	Medical
PRQR ProQR Therapeutics	$2,732,609		0.0%	2,054,593	0.8%	Medical
VXRT Vaxart	$2,272,463	$2,414,270 ▼	-51.5%	5,583,448	0.7%	Medical
TVTX Travere Therapeutics	$2,168,320	$2,168,320 ▲	New Holding	121,000	0.6%	Medical
DIANTHUS THERAPEUTICS INC	$2,122,326	$2,122,326 ▲	New Holding	116,997	0.6%	COM
IDYA IDEAYA Biosciences	$2,014,740		0.0%	123,000	0.6%	Medical
SVRA Savara	$1,993,442	$1,983,063 ▲	19,106.1%	719,654	0.6%	Medical
ERAS Erasca	$1,857,975		0.0%	1,356,186	0.6%	Medical
ATXS Astria Therapeutics	$1,682,661	$1,013,436 ▼	-37.6%	315,105	0.5%	Medical
IRWD Ironwood Pharmaceuticals	$1,495,896	$161,455 ▲	12.1%	1,017,616	0.4%	Medical
ALIGOS THERAPEUTICS INC	$1,490,940	$1,490,940 ▲	New Holding	180,720	0.4%	COM NEW
AQST Aquestive Therapeutics	$1,135,724	$1,135,724 ▲	New Holding	391,629	0.3%	Medical
ALEC Alector	$1,029,706	$272,483 ▲	36.0%	837,159	0.3%	Medical
ENTA Enanta Pharmaceuticals	$977,062		0.0%	177,004	0.3%	Medical
CNTX Context Therapeutics	$812,951		0.0%	1,328,352	0.2%	Medical
TELA TELA Bio	$768,600		0.0%	630,000	0.2%	Medical
OVID Ovid Therapeutics	$696,161	$384,261 ▲	123.2%	2,232,000	0.2%	Medical
AVALO THERAPEUTICS INC	$572,379		0.0%	71,458	0.2%	COM NEW
APRE Aprea Therapeutics	$564,270		0.0%	276,603	0.2%	Medical
FHTX Foghorn Therapeutics	$444,103		0.0%	121,672	0.1%	Medical
NYXH Nyxoah	$354,856		0.0%	50,839	0.1%	Medical
MODD Modular Medical	$274,669		0.0%	251,990	0.1%	Medical
BOUNDLESS BIO INC	$244,708		0.0%	162,058	0.1%	COM
NXTC NextCure	$62,439		0.0%	130,000	0.0%	Medical
TERN Terns Pharmaceuticals	$27,600		0.0%	10,000	0.0%	Medical
HUMAW Humacyte	$18,124		0.0%	49,998	0.0%	Medical
RCKTW Rocket Pharmaceuticals	$17,120		0.0%	400,000	0.0%	Medical
CI The Cigna Group	$0	$27,062,548 ▼	-100.0%	0	0.0%	Medical
SNY Sanofi	$0	$18,665,010 ▼	-100.0%	0	0.0%	Medical
VTRS Viatris	$0	$9,088,500 ▼	-100.0%	0	0.0%	Medical
OGN Organon & Co.	$0	$9,047,637 ▼	-100.0%	0	0.0%	Medical
CARGO THERAPEUTICS INC	$0	$6,824,871 ▼	-100.0%	0	0.0%	COM
NEUMORA THERAPEUTICS INC.	$0	$6,744,780 ▼	-100.0%	0	0.0%	COM
ALPHA COGNITION INC	$0	$2,560,383 ▼	-100.0%	0	0.0%	COM NEW
Q32 BIO INC	$0	$2,399,101 ▼	-100.0%	0	0.0%	COM
NUVB Nuvation Bio	$0	$1,777,186 ▼	-100.0%	0	0.0%	Medical
CCCC C4 Therapeutics	$0	$558,000 ▼	-100.0%	0	0.0%	Medical
MESOBLAST LTD	$0	$229,680 ▼	-100.0%	0	0.0%	SPONS ADR

Showing largest 100 holdings. View all holdings.

More Institutional Buying and Selling Information

SEC Filings and Trading Data

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Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Sio Capital Management, LLC Top Holdings and 13F Report (2025)

About Sio Capital Management, LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofSio Capital Management, LLC

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools