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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:DFFNNASDAQ:ITRMNASDAQ:PRLDNASDAQ:XLO On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeDFFNDiffusion Pharmaceuticals$4.64$2.76▼$7.40$8.98M1.7810,937 shs351,000 shsITRMIterum Therapeutics$1.06+14.4%$1.22$0.81▼$3.02$37.65M2.911.01 million shs1.01 million shsPRLDPrelude Therapeutics$0.82+7.0%$0.76$0.61▼$6.80$35.66M1.3268,925 shs73,482 shsXLOXilio Therapeutics$0.72+8.0%$0.76$0.62▼$1.70$37.28M-0.271.18 million shs175,220 shs13 Stocks Institutional Investors Won't Stop BuyingWhich stocks are hedge funds and endowments buying in today's market? Enter your email address and we'll send you MarketBeat's list of thirteen stocks that institutional investors are buying now.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceDFFNDiffusion Pharmaceuticals0.00%0.00%0.00%0.00%0.00%ITRMIterum Therapeutics-7.28%-17.50%-16.76%-37.99%-40.39%PRLDPrelude Therapeutics-3.98%-20.39%+17.93%-31.14%-79.34%XLOXilio Therapeutics-3.85%-12.96%-0.95%-3.41%-47.10%Compare MarketRank™CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & ValuationDFFNDiffusion PharmaceuticalsN/AN/AN/AN/AN/AN/AN/AN/AITRMIterum Therapeutics2.2232 of 5 stars3.55.00.00.02.40.00.0PRLDPrelude Therapeutics2.9201 of 5 stars3.22.00.00.02.65.00.6XLOXilio Therapeutics2.8268 of 5 stars3.55.00.00.01.10.81.3Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceDFFNDiffusion Pharmaceuticals 0.00N/AN/AN/AITRMIterum Therapeutics 3.00Buy$9.00753.08% UpsidePRLDPrelude Therapeutics 2.33Hold$4.00389.18% UpsideXLOXilio Therapeutics 3.00Buy$4.00455.56% UpsideCurrent Analyst Ratings BreakdownLatest DFFN, XLO, ITRM, and PRLD Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails5/8/2025ITRMIterum TherapeuticsHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy$9.005/5/2025PRLDPrelude TherapeuticsHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$5.00 ➝ $5.004/29/2025PRLDPrelude TherapeuticsJMP SecuritiesSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingMarket Outperform ➝ Market Outperform$4.00 ➝ $4.004/8/2025PRLDPrelude TherapeuticsHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$5.00 ➝ $5.00(Data available from 5/8/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookDFFNDiffusion PharmaceuticalsN/AN/AN/AN/A$6.97 per shareN/AITRMIterum TherapeuticsN/AN/AN/AN/A($0.12) per shareN/APRLDPrelude Therapeutics$7M5.09N/AN/A$4.32 per share0.19XLOXilio Therapeutics$6.34M5.88N/AN/A$1.34 per share0.54Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateDFFNDiffusion Pharmaceuticals-$15.59MN/A0.00N/AN/AN/A-69.96%-62.98%N/AITRMIterum Therapeutics-$24.77M-$1.31N/A∞N/AN/AN/A-90.85%5/12/2025 (Estimated)PRLDPrelude Therapeutics-$121.83M-$1.69N/AN/AN/AN/A-66.89%-55.59%N/AXLOXilio Therapeutics-$76.40M-$1.28N/AN/AN/AN/A-211.50%-80.31%5/13/2025 (Estimated)Latest DFFN, XLO, ITRM, and PRLD EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails5/13/2025Q1 2025XLOXilio Therapeutics$0.10-$0.18-$0.28-$0.18N/AN/A5/12/2025Q1 2025ITRMIterum Therapeutics-$0.23N/AN/AN/AN/AN/A5/6/2025Q1 2025PRLDPrelude Therapeutics-$0.47-$0.42+$0.05-$0.42N/AN/A3/11/2025Q4 2024XLOXilio Therapeutics-$0.22-$0.20+$0.02-$0.20$2.26 million$1.72 million3/10/2025Q4 2024PRLDPrelude Therapeutics-$0.49-$0.38+$0.11-$0.38N/A$4.00 millionCompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthDFFNDiffusion PharmaceuticalsN/AN/AN/AN/AN/AITRMIterum TherapeuticsN/AN/AN/AN/AN/APRLDPrelude TherapeuticsN/AN/AN/AN/AN/AXLOXilio TherapeuticsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioDFFNDiffusion PharmaceuticalsN/A10.7110.71ITRMIterum TherapeuticsN/A1.411.41PRLDPrelude TherapeuticsN/A7.047.04XLOXilio TherapeuticsN/A1.671.67Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipDFFNDiffusion Pharmaceuticals9.95%ITRMIterum Therapeutics9.21%PRLDPrelude Therapeutics79.72%XLOXilio Therapeutics54.29%Insider OwnershipCompanyInsider OwnershipDFFNDiffusion Pharmaceuticals1.80%ITRMIterum Therapeutics9.20%PRLDPrelude Therapeutics62.80%XLOXilio Therapeutics5.20%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableDFFNDiffusion Pharmaceuticals132.04 million2.00 millionNot OptionableITRMIterum Therapeutics1035.69 million31.40 millionNot OptionablePRLDPrelude Therapeutics12043.61 million20.47 millionOptionableXLOXilio Therapeutics7051.78 million41.67 millionNot OptionableDFFN, XLO, ITRM, and PRLD HeadlinesRecent News About These CompaniesXilio Therapeutics, Inc.: Xilio Therapeutics Announces Pipeline and Business Updates and First Quarter 2025 Financial ResultsMay 8 at 1:59 PM | finanznachrichten.deXilio Therapeutics Announces Pipeline and Business Updates and First Quarter 2025 Financial ResultsMay 8 at 8:59 AM | finance.yahoo.comXilio Therapeutics Announces Pipeline and Business Updates and First Quarter 2025 Financial ResultsMay 8 at 7:30 AM | globenewswire.comXilio Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)May 2, 2025 | globenewswire.comXilio Therapeutics to Present Updated Phase 2 Data for Vilastobart, a Tumor-Activated, Fc-Enhanced Anti-CTLA-4, in Combination with Atezolizumab in Patients with Microsatellite Stable Colorectal Cancer at the 2025 ASCO Annual MeetingApril 23, 2025 | globenewswire.comXilio Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)April 4, 2025 | globenewswire.comXilio Therapeutics reports Q4 EPS (20c) vs (64c) last yearMarch 11, 2025 | markets.businessinsider.comXilio Therapeutics files $250M mixed securities shelfMarch 11, 2025 | markets.businessinsider.comXilio Therapeutics, Inc. (XLO) Reports Q4 Loss, Lags Revenue EstimatesMarch 11, 2025 | zacks.comXilio Therapeutics Announces Pipeline and Business Updates and Fourth Quarter and Full Year 2024 Financial ResultsMarch 11, 2025 | globenewswire.comXilio Therapeutics to Present at TD Cowen 45th Annual Health Care ConferenceFebruary 24, 2025 | globenewswire.comXilio Therapeutics, Inc.: Xilio Therapeutics Announces Multiple Masked T Cell Engager ProgramsFebruary 12, 2025 | finanznachrichten.deXilio Therapeutics Shares Surge Premarket on AbbVie DealFebruary 12, 2025 | marketwatch.comAbbVie, Xilio Hook upFebruary 12, 2025 | baystreet.caAbbVie signs heavily backloaded $2.1B Xilio biobucks pact in Big Pharma's latest T-cell engager dealFebruary 12, 2025 | fiercebiotech.comAbbVie expands oncology R&D with Xilio dealFebruary 12, 2025 | thepharmaletter.comXilio Therapeutics Announces Multiple Masked T Cell Engager ProgramsFebruary 12, 2025 | globenewswire.comAbbVie and Xilio Therapeutics Announce Collaboration and Option Agreement to Develop Novel Tumor-Activated ImmunotherapiesFebruary 12, 2025 | globenewswire.comAbbVie and Xilio Therapeutics Announce Collaboration and Option Agreement to Develop Novel Tumor-Activated ImmunotherapiesFebruary 12, 2025 | prnewswire.comXilio Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)February 3, 2025 | globenewswire.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeDFFN, XLO, ITRM, and PRLD Company DescriptionsDiffusion Pharmaceuticals NASDAQ:DFFNDiffusion Pharmaceuticals Inc., a biopharmaceutical company, develops novel therapies that enhance the body's ability to deliver oxygen. Its lead product candidate is Trans Sodium Crocetinate that is developed to enhance the diffusion of oxygen to tissues, as well as to treat COVID-19 disease. The company was founded in 2001 and is based in Charlottesville, Virginia.Iterum Therapeutics NASDAQ:ITRM$1.06 +0.13 (+14.41%) Closing price 03:58 PM EasternExtended Trading$1.07 +0.02 (+1.42%) As of 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Iterum Therapeutics plc, a clinical-stage pharmaceutical company, engages in developing and commercializing anti-infectives in Ireland, Bermuda, and the United States. It is developing sulopenem, a novel anti-infective compound with oral and intravenous formulations that is in Phase III clinical trials for the treatment of uncomplicated urinary tract infections, complicated urinary tract infections, and complicated intra-abdominal infections. The company was incorporated in 2015 and is headquartered in Dublin, Ireland.Prelude Therapeutics NASDAQ:PRLD$0.82 +0.05 (+6.99%) Closing price 04:00 PM EasternExtended Trading$0.82 +0.00 (+0.04%) As of 05:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Prelude Therapeutics Incorporated, a clinical-stage biopharmaceutical company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT1419, a myeloid cell leukemia-1 inhibitor, which is in Phase 1 clinical trial for the treatment of selected relapsed/refractory myeloid or B-cell malignancies; PRT2527, a cyclin-dependent kinase, which is in Phase 1 clinical trial for the treatment of advanced solid tumors; PRT3645, a cyclin-dependent kinase 4/6 inhibitor, which is in Phase 1 clinical trial for the treatment of advanced and metastatic solid tumors; and PRT3879, a SMARCA2 selective protein degrader, which is in Phase 2/3 clinical trial for the treatment of advanced and metastatic solid tumors with loss of SMARCA4 due to truncating mutation and/or deletion. The company's CDK9 program is a regulator of cancer-promoting transcriptional programs, including MCL1, MYC and MYB. Prelude Therapeutics Incorporated was incorporated in 2016 and is based in Wilmington, Delaware.Xilio Therapeutics NASDAQ:XLO$0.72 +0.05 (+8.03%) Closing price 03:58 PM EasternExtended Trading$0.72 0.00 (-0.28%) As of 07:51 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of tumor-activated immuno-oncology therapies. The company's checkpoint inhibitor program includes XTX101, an investigational Fc-enhanced, tumor-activated anti-CTLA-4 mAb that is in Phase 2 clinical trial for patients with advanced solid tumors. It also develops cytokine programs, which comprises XTX202, a tumor-activated beta-gamma biased IL-2, currently under Phase 2 clinal trials; and XTX301, an investigational tumor-activated, engineered IL-12 molecule, currently under Phase 1 studies. The company was founded in 2016 and is headquartered in Waltham, Massachusetts. 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