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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:CKPTNASDAQ:ENTXNASDAQ:FULCNASDAQ:PRTA On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCKPTCheckpoint Therapeutics$4.26+0.7%$4.09$1.80▼$4.50$370.71M1.181.38 million shs8.63 million shsENTXEntera Bio$1.82-0.8%$1.93$1.41▼$2.79$82.72M1.5170,666 shs68,176 shsFULCFulcrum Therapeutics$7.07+2.5%$4.32$2.32▼$10.13$372.46M2.29971,501 shs752,851 shsPRTAProthena$4.70+2.2%$9.04$4.32▼$25.42$252.99M0.11681,430 shs5.38 million shsThese 7 Stocks Will Be Magnificent in 2025Discover the next wave of investment opportunities with our report, 7 Stocks That Will Be Magnificent in 2025. Explore companies poised to replicate the growth, innovation, and value creation of the tech giants dominating today's markets.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCKPTCheckpoint Therapeutics+0.71%+2.16%+3.90%+48.95%+132.79%ENTXEntera Bio-0.82%-7.57%-18.39%-1.62%-25.10%FULCFulcrum Therapeutics+2.46%+15.52%+93.70%+96.94%-9.01%PRTAProthena+2.17%-28.24%-51.50%-70.27%-76.12%Compare MarketRank™CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & ValuationCKPTCheckpoint Therapeutics2.452 of 5 stars1.24.00.04.22.70.80.0ENTXEntera Bio2.6581 of 5 stars3.55.00.00.02.90.80.0FULCFulcrum Therapeutics0.556 of 5 stars1.31.00.00.02.62.50.0PRTAProthena2.7827 of 5 stars4.21.00.00.02.11.71.3Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceCKPTCheckpoint Therapeutics 2.33Hold$4.331.72% UpsideENTXEntera Bio 3.00Buy$10.00449.45% UpsideFULCFulcrum Therapeutics 2.50Moderate Buy$6.29-11.09% DownsidePRTAProthena 2.33Hold$31.50570.21% UpsideCurrent Analyst Ratings BreakdownLatest ENTX, PRTA, CKPT, and FULC Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails5/29/2025FULCFulcrum TherapeuticsPiper SandlerSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingOverweight ➝ Overweight$6.00 ➝ $9.005/28/2025PRTAProthenaBank of AmericaSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingNeutral ➝ Underperform5/27/2025PRTAProthenaPiper SandlerSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetOverweight ➝ Overweight$110.00 ➝ $81.005/27/2025PRTAProthenaJMP SecuritiesSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetMarket Outperform ➝ Market Outperform$78.00 ➝ $29.005/27/2025PRTAProthenaCantor FitzgeraldSubscribe to MarketBeat All Access for the recommendation accuracy ratingDowngradeOverweight ➝ Neutral5/27/2025PRTAProthenaJefferies Financial GroupSubscribe to MarketBeat All Access for the recommendation accuracy ratingDowngradeBuy ➝ Hold$6.005/27/2025PRTAProthenaOppenheimerSubscribe to MarketBeat All Access for the recommendation accuracy ratingDowngradeOutperform ➝ Market Perform5/27/2025PRTAProthenaHC WainwrightSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetBuy ➝ Buy$30.00 ➝ $14.005/27/2025PRTAProthenaChardan CapitalSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetBuy ➝ Buy$40.00 ➝ $18.005/23/2025FULCFulcrum TherapeuticsLeerink PartnrsSubscribe to MarketBeat All Access for the recommendation accuracy ratingUpgradeHold ➝ Strong-Buy5/23/2025FULCFulcrum TherapeuticsLeerink PartnersSubscribe to MarketBeat All Access for the recommendation accuracy ratingUpgradeMarket Perform ➝ Outperform$4.00 ➝ $12.00(Data available from 5/30/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookCKPTCheckpoint Therapeutics$41K9,041.59N/AN/A($0.47) per share-9.06ENTXEntera Bio$223K370.95N/AN/A$0.36 per share5.06FULCFulcrum Therapeutics$80M4.77N/AN/A$3.80 per share1.86PRTAProthena$137.94M1.83N/AN/A$10.46 per share0.45Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateCKPTCheckpoint Therapeutics-$51.85M-$1.29N/A∞N/AN/AN/A-659.07%8/11/2025 (Estimated)ENTXEntera Bio-$8.89M-$0.26N/AN/AN/AN/A-107.24%-92.29%8/8/2025 (Estimated)FULCFulcrum Therapeutics-$97.33M-$0.07N/AN/AN/AN/A-7.31%-6.74%7/30/2025 (Estimated)PRTAProthena-$147.03M-$2.08N/AN/AN/A-90.50%-22.67%-19.68%8/14/2025 (Estimated)Latest ENTX, PRTA, CKPT, and FULC EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails5/13/2025Q1 2025CKPTCheckpoint Therapeutics-$0.10-$0.19-$0.09-$0.19$4.53 millionN/A5/9/2025Q1 2025ENTXEntera Bio-$0.07-$0.06+$0.01-$0.06N/A$0.04 million5/8/2025Q1 2025PRTAProthena-$0.92-$1.12-$0.20-$1.12$8.18 million$2.83 million5/1/2025Q1 2025FULCFulcrum Therapeutics-$0.29-$0.28+$0.01-$0.28N/AN/A3/28/2025Q4 2024CKPTCheckpoint Therapeutics-$0.22-$0.69-$0.47-$0.69N/A$0.04 million3/28/2025Q4 2024ENTXEntera Bio-$0.08-$0.06+$0.02-$0.06$0.04 million$0.04 millionCompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthCKPTCheckpoint TherapeuticsN/AN/AN/AN/AN/AENTXEntera BioN/AN/AN/AN/AN/AFULCFulcrum TherapeuticsN/AN/AN/AN/AN/APRTAProthenaN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioCKPTCheckpoint TherapeuticsN/A0.290.29ENTXEntera BioN/A6.616.61FULCFulcrum TherapeuticsN/A18.4418.44PRTAProthenaN/A11.5211.52Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipCKPTCheckpoint Therapeutics22.00%ENTXEntera Bio14.11%FULCFulcrum Therapeutics89.83%PRTAProthena97.08%Insider OwnershipCompanyInsider OwnershipCKPTCheckpoint Therapeutics2.10%ENTXEntera Bio10.90%FULCFulcrum Therapeutics7.00%PRTAProthena9.20%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableCKPTCheckpoint Therapeutics1087.02 million47.81 millionOptionableENTXEntera Bio2045.45 million31.88 millionOptionableFULCFulcrum Therapeutics10053.98 million51.73 millionOptionablePRTAProthena13053.83 million38.64 millionOptionableENTX, PRTA, CKPT, and FULC HeadlinesRecent News About These CompaniesOppenheimer Downgrades Prothena Corporation (NASDAQ:PRTA) to Perform from OutperformMay 30 at 1:47 AM | finance.yahoo.comB of A Securities Downgrades Prothena (PRTA)May 29 at 9:48 AM | msn.comProthena (NASDAQ:PRTA) Lowered to Underperform Rating by Bank of AmericaMay 29 at 8:52 AM | marketbeat.comProthena (NASDAQ:PRTA) Price Target Cut to $81.00 by Analysts at Piper SandlerMay 29 at 2:38 AM | americanbankingnews.comProthena (NASDAQ:PRTA) Stock Rating Lowered by OppenheimerMay 29 at 2:03 AM | americanbankingnews.comChardan Capital Issues Pessimistic Forecast for Prothena (NASDAQ:PRTA) Stock PriceMay 29 at 1:15 AM | americanbankingnews.comJefferies Downgrades Prothena Corporation (PRTA) After Negative Trial ResultsMay 29 at 12:57 AM | finance.yahoo.comOppenheimer Downgrades Prothena Corporation (NASDAQ:PRTA) to Perform from OutperformMay 28 at 2:24 PM | insidermonkey.comPiper Sandler Issues Pessimistic Forecast for Prothena (NASDAQ:PRTA) Stock PriceMay 28 at 11:29 AM | marketbeat.comProthena Target of Unusually High Options Trading (NASDAQ:PRTA)May 28 at 10:38 AM | marketbeat.comJMP Securities Cuts Prothena (NASDAQ:PRTA) Price Target to $29.00May 28 at 9:30 AM | marketbeat.comProthena (NASDAQ:PRTA) Downgraded by Cantor Fitzgerald to NeutralMay 28 at 9:13 AM | marketbeat.comProthena (NASDAQ:PRTA) Downgraded by Jefferies Financial Group to HoldMay 28 at 9:13 AM | marketbeat.comProthena (NASDAQ:PRTA) Cut to Market Perform at OppenheimerMay 28 at 9:13 AM | marketbeat.comChardan Capital Lowers Prothena (NASDAQ:PRTA) Price Target to $18.00May 28 at 8:15 AM | marketbeat.comHC Wainwright Issues Pessimistic Forecast for Prothena (NASDAQ:PRTA) Stock PriceMay 28 at 8:15 AM | marketbeat.comAnalysts Offer Insights on Healthcare Companies: Prothena (PRTA) and Bristol-Myers Squibb (BMY)May 28 at 4:44 AM | theglobeandmail.comJMP Securities Lowers Prothena (NASDAQ:PRTA) Price Target to $29.00May 28 at 3:04 AM | americanbankingnews.comProthena (NASDAQ:PRTA) Downgraded to Neutral Rating by Cantor FitzgeraldMay 28 at 2:28 AM | americanbankingnews.comProthena (NASDAQ:PRTA) Downgraded to Hold Rating by Jefferies Financial GroupMay 28 at 2:28 AM | americanbankingnews.comHC Wainwright Lowers Prothena (NASDAQ:PRTA) Price Target to $14.00May 28 at 1:53 AM | americanbankingnews.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeENTX, PRTA, CKPT, and FULC Company DescriptionsCheckpoint Therapeutics NASDAQ:CKPT$4.26 +0.03 (+0.71%) Closing price 05/29/2025 04:00 PM EasternExtended Trading$4.29 +0.03 (+0.61%) As of 05/29/2025 07:37 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Checkpoint Therapeutics, Inc., a clinical-stage immunotherapy and targeted oncology company, focuses on the acquisition, development, and commercialization of novel treatments for patients with solid tumor cancers in the United States and internationally. The company's lead antibody product candidate is Cosibelimab, which is in Phase 1 clinical trial to treat patients with selected recurrent or metastatic cancers; and CK-302, a product candidate in preclinical trials for hematological malignancies and solid tumors. It is developing Olafertinib, which is in Phase 3 clinical trials for the treatment of adult patients with metastatic non-small cell lung cancer; CK-103 for the treatment of various advanced and metastatic solid tumor cancers; and Anti-Carbonic Anhydrase IX (CAIX) antibody, a product candidate in preclinical trials to recognize CAIX expressing cells and kill them via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. The company has licensing and collaboration agreements with Adimab, LLC for the development of Cosibelimab; NeuPharma, Inc., to develop and commercialize Olafertinib; and Jubilant Biosys Limited for the development and commercialization of novel compounds that inhibit BET bromodomains. The company was incorporated in 2014 and is based in Waltham, Massachusetts. Checkpoint Therapeutics, Inc. is a subsidiary of Fortress Biotech, Inc.Entera Bio NASDAQ:ENTX$1.83 -0.01 (-0.49%) As of 05/29/2025 04:00 PM Eastern This is a fair market value price provided by Polygon.io. Learn more.Entera Bio Ltd., a clinical-stage company, focuses on the development and commercialization of orally delivered peptide and protein therapeutics for unmet medical needs. The company's product candidates include the EB612, which is in Phase II clinical trials for the treatment of hypoparathyroidism; and EB613 that has completed Phase II clinical trials for the treatment of osteoporosis, as well as is in Phase I clinical trials for the treatment of stress fractures. Its other product candidate is GLP-2, which is in preclinical trial for the treatment of short bowl syndrome; and OXM for the treatment of obesity and metabolic diseases. The company has a research collaboration and license agreement with the Amgen Inc. for the development and discovery of clinical candidates in the field of inflammatory disease and other serious illnesses. Entera Bio Ltd. was incorporated in 2009 and is based in Jerusalem, Israel.Fulcrum Therapeutics NASDAQ:FULC$7.07 +0.17 (+2.46%) Closing price 05/29/2025 04:00 PM EasternExtended Trading$7.06 0.00 (-0.07%) As of 05/29/2025 05:33 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing products for improving the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its product candidates are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy is under phase III clinical trial; and pociredir, a fetal hemoglobin inducer for the treatment of sickle cell disease and beta-thalassemia is under phase I clinical trial. The company is also discovering drug targets for the treatments of rare neuromuscular, muscular, central nervous system, and hematologic disorders, as well as cardiomyopathies and pulmonary diseases. Fulcrum Therapeutics, Inc. has collaboration and license agreement with Acceleron Pharma Inc. to identify biological targets to modulate specific pathways associated with a targeted indication within the pulmonary disease space; and MyoKardia, Inc. to discover and develop therapies for the treatment of genetic cardiomyopathies. Fulcrum Therapeutics, Inc. was Incorporated in 2015 and is headquartered in Cambridge, Massachusetts.Prothena NASDAQ:PRTA$4.70 +0.10 (+2.17%) Closing price 05/29/2025 04:00 PM EasternExtended Trading$4.62 -0.08 (-1.68%) As of 05/29/2025 07:45 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation in the United States. The company is involved in developing birtamimab, an investigational humanized antibody that is in Phase III clinical trial for the treatment of AL amyloidosis; Prasinezumab, a humanized monoclonal antibody, for the treatment of Parkinson's disease and other related synucleinopathies which is in Phase IIb clinical trial; NNC6019 that is in Phase lI clinical trial for the treatment of ATTR amyloidosis; and BMS-986446 and PRX012, which is in Phase I clinical trial for the treatment of Alzheimer's disease. Its discovery and preclinical programs include PRX123, a dual Aß-Tau vaccine for the treatment and prevention of Alzheimer's disease; and PRX019 for the treatment of neurogenerative diseases, as well as TDP-43 for the treatment of amyotrophic lateral sclerosis. Prothena Corporation plc has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target a-synuclein, including prasinezumab; and a collaboration agreement with Bristol-Myers Squibb to develop and commercialize antibodies targeting tau, TDP-43. The company was incorporated in 2012 and is based in Dublin, Ireland. 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