Tempus AI Q4 2025 Earnings Report

Tempus AI EPS Results

• Actual EPS: N/A
• Consensus EPS: -$0.05
• Beat/Miss: N/A
• One Year Ago EPS: -$0.18

Tempus AI Revenue Results

• Actual Revenue: N/A
• Expected Revenue: $362.55 million
• Beat/Miss: N/A
• YoY Revenue Growth: N/A

Tempus AI Announcement Details

• Quarter: Q4 2025
• Date: 2/24/2026
• Time: After Market Closes
• Conference Call Date: Tuesday, February 24, 2026
• Conference Call Time: 4:30PM ET

Tempus AI (NASDAQ:TEM) is a healthcare technology company focused on applying artificial intelligence and data analytics to precision medicine. The company combines molecular testing, clinical data and machine learning to help physicians make more informed treatment decisions and support the development of new therapies.

Tempus provides genomic and diagnostic testing services, including testing intended to identify clinically relevant mutations and other biomarkers. Its technology platform also organizes and analyzes clinical and molecular data, while its AI-enabled tools are designed to assist healthcare professionals with patient care, research and workflow management.

The company serves healthcare providers, patients, pharmaceutical companies and biotechnology researchers, primarily in the United States. Tempus was founded in 2015 by Eric Lefkofsky, who serves as its chief executive officer. The company became publicly traded on the Nasdaq under the symbol TEM in 2024.

Tempus AI Q4 2025 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: Tempus reported a strong 2025 with its core business revenue up >33%, guided 2026 revenue to $1.59 billion (~25% growth) and ~ $65 million of adjusted EBITDA, and said the balance sheet is in great shape.
• Positive Sentiment: The data/licensing business is accelerating — Insights grew ~69% in the quarter, total contract value is >$1.1 billion and net revenue retention is 126%, giving unusually high visibility into 2026 revenue.
• Positive Sentiment: Diagnostics momentum remains robust with oncology unit growth of 29% (MRD up 56% quarter‑over‑quarter) and hereditary units up 23%; MRD demand is described as highly constrained today but could be materially larger once reimbursement and go‑to‑market gating are removed.
• Positive Sentiment: AI investments are advancing — Tempus says it met AstraZeneca benchmarks for its first oncology foundation model, has deployed large GPU clusters, and expects these models to accelerate diagnostic insights and the data product roadmap.
• Negative Sentiment: Timing and reimbursement remain key risks — ASPs were ~$1,640 in Q4 with ~+$500 upside possible from FDA xT CDx migration and other initiatives, but MolDx/CRC reimbursement and lumpiness in hereditary revenue create near‑term variability and uncertain gross‑margin timing.

Presentation

[Operator]

Good day, and thank you for standing by. My name is Tina, and I will be your conference operator today. At this time, I would like to welcome everyone to the Tempus AI Q4 2025 Fiscal Results Conference Call. At this time, all lines are in a listen-only mode to prevent any background noise. After the speaker's remarks, there will be a question-and-answer session. We respectfully request that you limit questions to one. To ask a question, simply press star one on your touchtone phone. To re-withdraw your question, star one again. It is now my pleasure to turn today's call over to Liz Krutoholow, Vice President of Investor Relations. Please go ahead.

[Elizabeth Krutoholow, VP of Investor Relations at Tempus AI]

Thank you, Tina. Good afternoon, welcome to Tempus's Q4 2025 and full year 2025 conference call. This afternoon, Tempus released results for the quarter and year ended December 31st, 2025. The press release, an overview of the quarter, and our latest presentation are available on our IR website. Joining me today from Tempus are Eric Lefkofsky, founder and CEO of Tempus, and Jim Rogers, CFO. Before we begin, I would like to remind you that during this call, management may make forward-looking statements that are subject to risks and uncertainties that could cause actual results to differ materially. For a discussion of these risks, please refer to our Form 10-K and other subsequent filings with the SEC. During the call, we will discuss non-GAAP financial measures, which are not prepared in accordance with generally accepted accounting principles.

[Elizabeth Krutoholow, VP of Investor Relations at Tempus AI]

Definitions of these non-GAAP financial measures, along with reconciliations to the most directly comparable GAAP financial measures, are included in our earnings release, which is available on our IR page. I would now like to turn the call over to Eric.

[Eric Lefkofsky, CEO at Tempus AI]

Thanks, Liz. 2025 was an exceptional year for Tempus, with both of our businesses growing rapidly and performing well above expectation. Total revenue of our core business was up over 33%. You factor in the acquisition of Ambry, obviously much higher. You look at our two main businesses, I'll start with diagnostics. In oncology, we had unit growth of 29%, which was and has been accelerating throughout the year. We called out that our MRD growth rate was actually 56% quarter-over-quarter, which is extraordinary. Hereditary held up well with 23% unit growth. All in our diagnostic business is accelerating and performing above expectation. In terms of data, that business is growing even faster. It's made up of really the 2 product lines, our licensing business and our applications.

[Eric Lefkofsky, CEO at Tempus AI]

Our licensing business, or Insights, was up 69% in the quarter when you factor in the one-time impact of the AstraZeneca warrant, and we're projecting roughly 40% growth this quarter. Total contract value was greater than $1.1 billion, and most importantly, has been rising faster than revenue over the past several quarters. Net revenue retention was 126%, which is super strong, all things considered. We guided to $1.59 billion, which is in line with our 25% long-term growth expectations and approximately $65 million of positive adjusted EBITDA. Our balance sheet is in great shape. Our products are resonating. Our AI advantages are continuing to take hold, so all in, we're poised for a phenomenal 2026. With that, happy to take questions.

[Operator]

As a reminder, to ask a question, simply press star one on your telephone keypad. Our first question comes from Callum Titchmarsh with Morgan Stanley. Please go ahead.

[Callum Titchmarsh, VP and Equity Research Analyst at Morgan Stanley]

Yeah, thanks a lot for the question, guys. Eric, I wanted to zoom out from the financials. I'm sure that'll be covered and go a bit broader. You know, the markets are a bit anxious around AI and how value is getting distributed within that ecosystem, and we're now obviously seeing kind of traditional AI players push into the healthcare sphere. I'm curious how you feel your position is protected on the data side. I guess to that point, why you expect the large pharma companies you work with, particularly within Insights, to keep coming back for more. You know, the Q1 guide's obviously strong, I'm kind of looking on that. Finally, just on that point, I'm interested whether the feedback you're receiving from these customers suggests that they're getting better at what they do because of what you're providing them.

[Callum Titchmarsh, VP and Equity Research Analyst at Morgan Stanley]

Just, you know, any sense of success stories and what you're hearing on the ground would be appreciated. Thanks a lot.

[Eric Lefkofsky, CEO at Tempus AI]

Yeah. I mean, I think the most interesting business models, I believe, surrounding AI, in particular, large language or large multimodal models, really center around access to proprietary data to train models and proprietary distribution once you have a model that generates insight. As we've talked about historically, Tempus is uniquely positioned in that we have both of those at scale. We have over 450 petabytes of connected multimodal data, which flows from our diagnostic business, which has real-time insights, real-time connection to outcome and response, is able to track patients longitudinally, rich molecular data, rich imaging data. We have this really unique proprietary data set that you can use to train AI, to train models.

[Eric Lefkofsky, CEO at Tempus AI]

Once we generate Insights or some kind of contextualization that we want to put in the hands of a doctor, because we're connected to more than 5,500 hospitals, because we have more than 8,500 regularly ordering oncologists, you know, thousands of other physicians in other areas, we can deliver these Insights in real time as part of routine clinical care. That's what makes us unique, that if somebody wanted to replicate our data business, they'd have to go reproduce all that real-time data, which is quite hard to do. You have to enter into contracts with providers, you have to get the data, you have to work through IT issues, you have to structure the data, you have to build technology to make the data useful.

[Eric Lefkofsky, CEO at Tempus AI]

It's an enormous lift that we've been on over the last 10 years. I think because of that, because of the work we've done to build the data pipes, to harmonize and structure the data, to build technology that wraps around the data, we just have a unique offering, and other people have been unable to replicate it. If you look at our-- the scale of our data business, I mean, you know, a few years ago, people thought we couldn't hit $100 million of data revenue, we're now, you know, 4 times that and projecting to grow 40% even at this scale.

[Eric Lefkofsky, CEO at Tempus AI]

We have 126% net revenue retention, which means, on average, our clients are ordering significantly more year after year than they ordered the year before. All kinds of proof points. Our largest clients continue to re-up. Those contracts get extended. We've announced a bunch of them over the last several years. It's because we're demonstrating real value, where these clients are able to use our data and our technology to be more intelligent about what assets to go forward with, refine their early stage discovery of, you know, projects, design more intelligent phase 2s and phase 3s, recruit the right populations at the right time, and get their drugs approved and in market faster. That is why the data business is just kind of having a moment, and the growth is actually accelerating.

[Operator]

Your next question comes from the line of Subbu Nambi with Guggenheim. Please go ahead.

[Subbu Nambi, Senior Managing Director at Guggenheim Securities]

Hey, guys. Thank you for taking my question. Earlier in Q1, you launched Paige Predict. Given we previously discussed that you don't expect this to contribute meaningfully to revenue this year, can you discuss the strategic value of the added capability when samples are QNS? How often is this case with xT and xR? A quick one for Jim. Jim, ASPs are expected to reach over $2,200 in the coming years, but what are you expecting in 2026 guidance? Thank you so much.

[Eric Lefkofsky, CEO at Tempus AI]

Yes, I'll start with Paige Predict. You know, we have. I think I'd encourage you to read the letter. We tried to spell some of this out in the letter we published. We've long talked about how there's enormous benefits to the contextualization of these diagnostics and the technology we wrap around them. It's not just about having, you know, the next version of an assay or running a study that produces, you know, some kind of wet lab improvement. Like, that only means so much.

[Eric Lefkofsky, CEO at Tempus AI]

If you look at our growth and the fact that our growth is this strong at this scale, it's in large part driven by the fact that we just have a technology advantage that makes physicians want to order our products because they get greater insights from those products. Those insights, If you look at just a few that we called out, one is Paige Predict, another is what we call our Immune Profile Score, and there are dozens of others. If you look at Paige Predict, here's an example of we've built technology that, at scale, allows us to digitize pathology slides and generate insights from those pathology slides by which we can predict mutations that exist, that will show up when we do the next-generation sequencing.

[Eric Lefkofsky, CEO at Tempus AI]

The benefit of having a system where you're sequencing tons of patients and following mutations, and you're digitizing pathology slides and tracking those, is you can begin to correlate these things. All next-generation sequencing has some amount of error. It's just inherent to the process of using Illumina and other sequencing companies, where you don't get 100% output when you sequence a patient. Some percentage of the time, it's a small %, but some percentage of the time you have results that can't be returned to a physician. Being able to digitize a pathology slide and render Insights, even when sequencing fails, just makes our tests a little better than somebody else. The fact that we can also render those results in hours makes us a little faster to deliver those Insights.

[Eric Lefkofsky, CEO at Tempus AI]

It's the same thing if you look at our Immune Profile Score. We're able to look at lots of different multimodal data we generate. Could be digitized pathology slides, could be transcriptomic data from RNA, could be DNA data, and refine what have historically been traditional biomarkers, like tumor mutational burden or others. Each of these Insights that we can generate, again, it's not that one of them alone is the reason that a physician would use us, but they just keep stacking up, and if you look at the foundation model efforts that we're engaged in, that's gonna do nothing, we think, but accelerate that dramatically.

[Eric Lefkofsky, CEO at Tempus AI]

To the extent today that we're, you know, X% better than somebody else because we can generate Y% more Insights, you know, you should expect that to grow, quite a bit over the next several years.

[James William Rogers, CFO at Tempus AI]

In response to the ASP question, ASPs in Q4 were around $1,640. That was up about $40 quarter-over-quarter. As you noted in our investor deck and kind of what was discussed at JPM, we think that there's about $500 or greater than $500 of upside to ASP based on the current mix, driven by a couple of factors. One is the continued migration of xT CDx from the LDT version to the FDA-approved version. As we previously stated, that we plan by the end of 2026 to be exiting with the vast majority of volume on that FDA-approved version. That's kind of the biggest impact from an ASP perspective in 2026.

[James William Rogers, CFO at Tempus AI]

We also announced that we've submitted our xF, which is our liquid biopsy, to the FDA. That will unlikely to have much of a 2026 impact from ASP, but as we get into 2027, we'll start to contribute. Lastly, there's still some upside from commercial payers, as we kind of chip away at those. That's kind of the build. Those three initiatives kind of get you that upside of $500, with xT CDx being the biggest driver, and that will play out over the course of 2026.

[Operator]

Your next question is from the line of Ryan MacDonald with Needham & Company. Please go ahead.

[Ryan MacDonald, Senior Analyst at Needham & Company]

All right, thanks for taking my questions. You know, my question for Eric, you know, you just sort of talked about the foundation model and how that can sort of exponentially, sort of help the stacking initiative and sort of development of additional algorithms, different additional modules over time. Can you just give us an update on sort of where things sort of stand on sort of the development of that foundation model? I think you mentioned last quarter, you're hoping to have the first version of the model ready in the Q1 of 2026 here, just curious if that's launched yet, how it's performing relative to expectations.

[Ryan MacDonald, Senior Analyst at Needham & Company]

You know, for Jim, just curious in terms of, you talked about ASPs just now, but just curious of how you're thinking about sort of underlying assumptions for volume growth, across oncology in particular, but hereditary as well, in the 2026 guide? Thanks.

[Eric Lefkofsky, CEO at Tempus AI]

I'll start. The foundation model had a deliverable in Q1, where we had to hit certain benchmarks that AstraZeneca had established. We think we've hit all those benchmarks. We've submitted all that to AZ. They're testing the model now, but we feel great about the model's performance, and so those efforts will go on. That was a particular cluster we set up of about a little over 1,000 H200s dedicated to that oncology foundation model. We've also procured a second cluster of more than 500 GB200. In terms of actual compute power, it's greater than the first cluster.

[Eric Lefkofsky, CEO at Tempus AI]

We're running additional models internal, not just in oncology, but across all of our data, 'cause we have enormous amounts of radiology data and pathology data and cardiology data, neuropsych, and so on and so forth. We're, you know, incredibly long on the value that these models are gonna deliver, and we're, you know, doubling down on those efforts. We think they'll be catalytic both to our diagnostic business, as we keep dropping insights into our tests that make our tests smarter and better than others, and so that should be an accelerant to growth. We also intend to propagate these insights throughout our data business so that our clients get more value.

[James William Rogers, CFO at Tempus AI]

Yeah. Then in terms of the kind of underlying volume assumptions in the diagnostics business, you know, oncology, as Eric mentioned, had 29% growth in Q4. The Q1, you know, is off to a good start, so we're not seeing kind of that pace slow down. On the hereditary side, volume growth was 23% in Q4. As we've talked about previously, what we highlight in the letter is we do anticipate that continuing to moderate as we lap some of the share gains that they had. There likely will also be some lumpiness in the hereditary growth rates in 2026. So in the letter, we've called out, you know, kind of this high teens, you know, longer term growth rates.

[James William Rogers, CFO at Tempus AI]

It might be a little bit lower in Q1 and then kind of pick up throughout the year. There'll probably be some lumpiness, but we think that that high teens is still, you know, achievable. Oncology, you know, again, we feel really strong about where the oncology business is at. On the hereditary side, you know, again, we were anticipating some of this slowdown, giving the lapping of some of the share gains.

[Operator]

Next question comes from the line of Mark Massaro with BTIG. Please go ahead.

[Mark Massaro, Director at BTIG]

Hey, guys, congrats on a strong year. Thanks for taking my questions. I think in your letter, you talk about MRD volumes came in around 4,700 tests in the quarter. I think you made a reference that that level could have been 20 times higher if the entire sales force had been selling it. Am I understanding it correctly that approximately 5% of your sales force was selling MRD in Q4? Is the right way to interpret this, that, you know, if everyone sold it could be 20x higher in the Q4, or was the 20x higher more of an aspirational, longer-term outlook?

[Eric Lefkofsky, CEO at Tempus AI]

Yeah, I mean, so the, it's obviously, it's just a, it's a hypothetical, so it's impossible to say what could have happened in Q1. We were simply highlighting the really unbelievable strength of our MRD offering on, you know, the main vector being we ran 4,700 tests. It's 56% quarter-over-quarter, not year-over-year, but quarter-over-quarter growth, and we are highly constraining this effort. Yes, we have a very small percentage of our cumulative sales force that is currently selling MRD, and if we were to let everyone sell it and completely unblock it could be 20 times higher.

[Eric Lefkofsky, CEO at Tempus AI]

Whether it would be, you know, you only know that when you unblock it, but our point is, the growth is just really amazingly strong with a highly constrained, sales effort. We will eventually unblock that sales effort. It's a, it's a function of reimbursement, it's a function of the appropriate timing, but we intend to, over time, ungate this and be in market fully. It, you know, it took other companies that have really strong reimbursement, like, for example, Natera, it took them quite some time to establish coverage in a broad enough way that this made financial sense. We're fortunate that we can kind of ungate this in an intelligent, appropriate manner and not kind of wreak financial havoc.

[Eric Lefkofsky, CEO at Tempus AI]

What we are calling out is when you look at our diagnostic platform, which is, you know, obviously broadly connected for hereditary profiling, broadly connected for therapy selection, both in solid tumor profiling and liquid biopsy. When you look at the number of EHR connections we have and the number of integrations we have, and the number of feet we have on the street, deeply embedded within the workflows of such a large percentage of the U.S. oncology market, I would suspect when we ungate this, we will become a very large MRD supplier.

[Operator]

Your next question comes from the line of Kyle Mikson with Canaccord Genuity. Please go ahead.

[Jesse Case, Managing Director at Canaccord Genuity]

Hi, it's Jesse Case the line for Kyle Mikson. Thank you for taking our questions. Just taking a step back, in oncology, I was wondering if you could provide a bit of more clarity on your tests. You briefly touched on ASP and volume dynamics, but could you just kind of walk through what each of the main growth drivers will be for xT, xR, xF, xH, and xE in 2026 and beyond? Thank you.

[Eric Lefkofsky, CEO at Tempus AI]

I don't even know how to answer that question. It's a fairly broad question, I would say, in the letter we call out, I think our main platform advantage that has been kind of fueling our growth. That platform advantage, the fact that we contextualize diagnostics, the fact that we're marrying clinical data with molecular data, the fact that we have such a comprehensive profile, the insights we can generate by virtue of that advantage exists in xT, which is our DNA profiling. It exists in xR, which is our RNA profiling. It exists in xA, xF, which are liquid biopsies. It exists in xH, which is our heme offering, which, by the way, we have a whole genome heme offering that goes live this year.

[Eric Lefkofsky, CEO at Tempus AI]

It exists in xE, which is our whole exome offering. It's across our entire platform. It's not as if we've got, like, one driver driving DNA and another driver driving RNA. Our core technology advantage drives the growth of all five of those assays.

[James William Rogers, CFO at Tempus AI]

The other thing I would add is, obviously, the market itself is also growing. You know, amongst our peers, everyone is experiencing kind of healthy growth rates. Clearly, sequencing is becoming more prevalent amongst our ordering physicians and ultimately patients. As Eric noted, kind of that data advantage is what allows us to kind of capture additional market share.

[Eric Lefkofsky, CEO at Tempus AI]

Yeah. With us, obviously, in solid tumor growing, you know, it looks like at this point, faster than others.

[James William Rogers, CFO at Tempus AI]

Yeah.

[Operator]

Our next question comes from the line of Casey Woodring with JPMorgan. Please go ahead.

[Casey Woodring, VP of Equity Research at JPMorgan Securities]

Great. Thank you for taking my questions. Can you walk us through what the guide embeds for data and services revenue in 2026? I know that you pointed to $350 million of current TCV being tied to 2026, so can you just talk about the visibility into in-year bookings to get to that guide and the timing around that? Maybe as just a follow-up, can you split out the guide of the 40% growth you're assuming in data in 1Q? Maybe just talk through how that will shake out across Insights and trials and any contribution embedded from the current foundation model with PathAI and AstraZeneca. Thank you.

[Eric Lefkofsky, CEO at Tempus AI]

As we called out, I think, during the JPM conference, the bookings have been so strong that we start the year with greater visibility into the 2026 revenue build than we've ever had, by a long shot. We called out again at JPM that it is normal for us to generate about $100 million of revenue within a given year from bookings in the year, meaning we, you know, somebody wanted data, and we delivered it within the year.

[Eric Lefkofsky, CEO at Tempus AI]

The fact that we have such a high percentage of our revenue already committed for 2026, means that we expect to be, you know, doing our best to manage the growth of the data business because it has just such systemic growth drivers going into 2026, and that's directly a correlation between bookings and revenue. We just have greater than $1.1 billion in the tank. A bunch of that applies to 2026, we just are starting the year super strong, we just have got crazy amounts of demand for our data products. Feels like we are in a unique spot in that we're just pulling further and further away from the competition, that business just is having a moment.

[Eric Lefkofsky, CEO at Tempus AI]

As it relates to, like, how the rest of it stacks up, the, you know, the vast majority of our data and apps is data licensing. It represents the biggest chunk of it, and so, everything else is kind of relatively small, but it all adds up. to the other piece, and that's our clinical trial matching business TIME, our care gap product called Next, and a few of the ancillary products that are connected to that.

[Operator]

Our next question comes from the line of Doug Schenkel with Wolfe Research. Please go ahead.

[Colleen Kusy, Research Analyst at Wolfe Research]

Hi, thank you for the question. This is Colleen on for Doug. You delivered high 20s clinical oncology volume growth exiting 2025. How should we think about the durability of that volume growth into this year and next? How should we be thinking about liquid versus tissue CGP growth throughout this year? Any color you can share on repeat testing with xF, If we should continue to think about xF being about 25% of total clinical oncology volume going forward.

[James William Rogers, CFO at Tempus AI]

Yeah, I'll start, and then, Eric, you can chime in. You know, in terms of the 29% growth and how that stacks up, again, as I mentioned before, we're off to a good start in the Q1 here, and so, you know, we don't see a massive slowdown in the oncology growth rates. Obviously, you're getting to larger and larger scales, so there, it's tough to continue growing at the same rate, but we're off to a good start. In terms of the breakdown, you know, outside of MRD growing dramatically faster than the rest of the portfolio, we see, you know, strong growth across both xT and xF.

[James William Rogers, CFO at Tempus AI]

You know, xF may be growing slightly faster than solid, but not, you know, there's not a dramatic variation there. We don't see kind of that trend that we've seen for quite some time. We don't see a lot of variation in kind of the product mix, as we look in 2026.

[Eric Lefkofsky, CEO at Tempus AI]

I'll just add to that. Like, so we, our guide implies 25% growth year-over-year. We've called out that our hereditary business is growing slower. It's, you know, kind of like for the year, we think, kind of high teens, mid high teens, around that range. We have a few other businesses that we historically have called out are also not growing. Like, for example, we've de-emphasized, we have a little, relatively small, but maybe a $20 million CRO business that we don't spend time on, things of that nature. You have a little bit of revenue or indicate...

[Eric Lefkofsky, CEO at Tempus AI]

With Ambry, a lot of, decent amount of revenue that's growing kind of significantly less than 25%, which means that our data business and our core oncology diagnostic business are growing 30%+ percent, right? Just as we told the world, we expected to grow at 30% or so last year in our core business and ended up growing at 33, I suspect something similar this year, right? If you do the math, we're gonna be growing in the roughly 30% range plus in those businesses. They're super healthy. Liquid is growing a little faster than solid, so that's been a long-term trend for us. We don't disclose breakdowns of each and so on and so forth, but liquid is growing a little faster.

[Eric Lefkofsky, CEO at Tempus AI]

Both are super healthy, there's just no one driver of the growth. It's not as if, like, it's not as if repetitive testing or concurrent testing or this kind of testing or that kind of testing are having an outsized impact. We're just seeing really good, solid growth. We're seeing really good liquid growth, slightly better, but that's been a long-term trend. More and more people want the benefits of tumor normal profiling. More and more people want the benefits of DNA and RNA. More and more people want our connected platform that's intelligent. Our unit growth in oncology is just really strong and showing no signs of slowing down.

[Operator]

Next question comes from the line of Andrew Brackmann with William Blair. Please go ahead.

[Andrew Brackmann, Equity Research Analyst at William Blair & Company]

Hey, guys. Good afternoon. Thanks for taking the questions. Eric, it's sort of been just over a year since you closed on Ambry, and if we sort of go back to when that acquisition was announced, sort of a big part of that thesis was really around the data that you would be able to sort of generate across the entire sort of oncology testing spectrum. Can you maybe just sort of talk about the acquisition in that lens, now that it's sort of been a part of the company for some time, just sort of what you're seeing in that regard and how that's led to growth in the data business as well? Thanks.

[Eric Lefkofsky, CEO at Tempus AI]

I think we called out, you know, multiple reasons to acquire Ambry. The, the first, by far, was to broaden the comprehensive nature of our testing compendium. If someone said to me, "Why did you buy Ambry?" I wouldn't say data. I would say the number one reason we bought Ambry was they had a very strong hereditary profile. More and more of our clients want a comprehensive solution. I think we've said this historically, you know, I very much believe that over the long term, when it comes to treating cancer patients, it's gonna be like e-commerce shoppers, going online. I don't go to one e-commerce site for books and another for clothes and another for, you know, consumer electronics and so on and so forth.

[Eric Lefkofsky, CEO at Tempus AI]

I go to Amazon because they have kind of everything I need in one place, and I believe that's gonna be the case as it relates to sequencing. You know, more and more providers want somebody who can help them manage risk, help them treat patients once they've been diagnosed, and help them monitor those patients post-treatment. We want to have a broad menu. That said, we're also seeing a trend of more and more of our provider partners, and certainly, obviously, to the benefit of patients, wanting to contribute deidentified data to platforms like ours to be used to accelerate research and to accelerate drug discovery and development. This is a very big trend that I don't see stopping. We still have 600,000 people a year that die of cancer.

[Eric Lefkofsky, CEO at Tempus AI]

We're not making nearly enough progress as it relates to eradicating that. I think you're seeing a movement among institutions that are saying. We need to help stop the waste, make sure these patients get better drugs and get them in market faster. We see that as a constant movement and a benefit of the kind of data we collect, and then on a de-identified basis, take to market.

[Operator]

Our next question comes on the line of Dan Brennan with TD Cowen. Please go ahead.

[Dan Brennan, Managing Director at TD Cowen]

Great, thank you. Thanks, Dan.

[Eric Lefkofsky, CEO at Tempus AI]

Can't hear you.

[Dan Brennan, Managing Director at TD Cowen]

Oh, sorry about that, Eric. Just maybe one on MRD and on Insights. Just on MRD, any update on the first-gen CRC assay? I know it's sitting at MolDX. Just any color there. On the next-gen tumor-naive assay, have you guys discussed kind of what type of performance advantage you would expect to get out of that? Obviously, you're filing for 2, you know, tumor types this year, and then you have another 2 that you mentioned in the letter. Just wondering what kind of performance enhancements you think that could offer versus the existing tumor-naive landscape.

[Eric Lefkofsky, CEO at Tempus AI]

We're in a back and forth with MolDX now. You know, we didn't call out when that gets resolved, I mean, 'cause I don't control MolDX. I mean, it's possible that we have reimbursement in a month, and it's possible that it takes longer. I don't, I don't have any idea. We also didn't call it out because it's just not that relevant to our current MRD offering, which is, I don't know, like 95% tumor-informed. Because we're largely in market with a tumor-informed product in partnership with Personalis, it just represents the vast majority of our current market penetration. This particular product, which I do expect will be reimbursed by MolDX, is just not gonna be a needle mover because the goalposts keep moving.

[Eric Lefkofsky, CEO at Tempus AI]

What's happening is tumor-naive products have to keep getting better and better to really compete. In CRC, I think it's gonna be quite some time before you have a significant amount of the volume moving away from tumor-informed to tumor-naive. I think the naive market is either episodic or it's for those patients where, for whatever reason, they can't get tissue. Tissue is pretty pervasive in colorectal cancer, I think tumor-informed wins the day in that subtype for a while. There are other subtypes, like, for example, lung, where tissue is more sparse, where I think tumor-naive products can do quite well. We realized that we just weren't getting the performance off the first version of our assay. Instead of like, you know, we're running a ton of studies to collect samples.

[Eric Lefkofsky, CEO at Tempus AI]

I mean, a ton. We decided to kind of pivot and begin working on the 2nd generation of the assay. Instead of, like, burning those very precious study samples on an old version, we wanted to move to the new version, we kind of pivoted, and we were fortunate. Everything we do takes into consideration this notion of like a comprehensive portfolio, we were fortunate that we had a tumor-naive product that was just, you know, kind of doing super well in the market, more than giving us more volume than we candidly want or need. We didn't have to kind of overly push on the accelerator for tumor-naive. The 2nd version is coming along well, and I suspect at some point we'll have a really nice assay in market.

[Operator]

The next question comes from the line of Mark Schappel with Loop Capital Markets. Please go ahead.

[Mark Schappel, Managing Director at Loop Capital Markets]

Eric, you know, the start of the year is typically when companies adjust their sales organizations and their go-to-market strategies. First, if you could just give us an idea of whether you've implemented any meaningful changes to the sales org this year. Then as a follow-up, maybe you could just sketch out what you believe are the firm's kind of key investment priorities for the coming year.

[Eric Lefkofsky, CEO at Tempus AI]

In terms of the sale, in terms of the sales force, we've made no big moves to reorg the sales force. We did that obviously early 2025, and we announced the impact of that. The good news is we've We're long lapping that. In terms of our priorities, they remain the same: to bring the benefits of technology and AI broadly to diagnostics and make sure that every decision, whether that's a decision in clinic or a decision for research, is data-driven. I would expect us, given that we're growing so rapidly and our business accelerating, I would expect us to stay the course.

[Operator]

Our final question comes from the line of Bradley Bowers with Mizuho. Please go ahead.

[Bradley Bowers, Director and Senior Research Analyst at Mizuho Securities USA LLC]

Hey there. Thanks for taking the question. Just wanted to get into some of the ASP outlook and maybe the gross margin implication. You know, obviously a lot of upside here with the $2,200 a test outlook. Just wanted to kind of hear about what the expectations should be for gross margin. You know, it assumes a big lift. I mean, if you assume that the costs hold and do some math, it kind of gets towards, you know, gross margin in the genomic side of, you know, 70%+. You know, what can you say about that progression, and is that one to one with ASP, or are there some offsets we should be considering? Thank you.

[Eric Lefkofsky, CEO at Tempus AI]

Yeah, I think when we, you know, obviously, anytime ASP increases, that would lead to an increase in gross margin. I think we've long kind of taken the approach that as ASPs kind of increase or as costs of sequencing come down, to reassess kind of how much you kind of increase the size of panels to generate more data. Obviously, that's great for patients and great for doctors and all that. That's something that we do on kind of an annual basis. You know, we're not, you know, given the fact that we have kind of these two businesses, diagnostics and data, we're less reliant on maximizing gross profit within the diagnostics kind of product line as some of our peers may be.

[Eric Lefkofsky, CEO at Tempus AI]

That said, as ASPs increase, we would anticipate seeing some increases in gross profit, but always balancing to make sure that we're, you know, bringing to the market the broadest panels possible because it obviously has a bunch of downstream implications.

[Operator]

With no further questions in queue, I will now hand the call back over to Liz Krutoholow for closing remarks.

[Elizabeth Krutoholow, VP of Investor Relations at Tempus AI]

Thank you all for joining us today. We look forward to updating you again next quarter. Have a great day.

[Operator]

Thank you again for joining us today. This does conclude today's conference call. You may now disconnect.

Participants

Executives

• Elizabeth Krutoholow, VP of Investor Relations
• Eric Lefkofsky, CEO
• James William Rogers, CFO

Analysts

• Andrew Brackmann, Equity Research Analyst at William Blair & Company
• Bradley Bowers, Director and Senior Research Analyst at Mizuho Securities USA LLC
• Callum Titchmarsh, VP and Equity Research Analyst at Morgan Stanley
• Casey Woodring, VP of Equity Research at JPMorgan Securities
• Colleen Kusy, Research Analyst at Wolfe Research
• Dan Brennan, Managing Director at TD Cowen
• Jesse Case, Managing Director at Canaccord Genuity
• Mark Massaro, Director at BTIG
• Mark Schappel, Managing Director at Loop Capital Markets
• Ryan MacDonald, Senior Analyst at Needham & Company
• Subbu Nambi, Senior Managing Director at Guggenheim Securities