NASDAQ:SPRB Spruce Biosciences Q4 2025 Earnings Results & Report $46.20 -0.47 (-1.01%) Closing price 04:00 PM EasternExtended Trading$46.33 +0.13 (+0.28%) As of 07:56 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Spruce Biosciences missed analyst earnings expectations in its Q4 2025 results, released March 12, 2026. The company reported EPS of -$9.58 versus the -$9.1575 consensus estimate. Research:ProfileEarnings HistoryForecast Earnings Announcement Details QuarterQ4 2025Report DateMarch 12, 2026TimeBefore Market OpensConference Call DateMarch 9, 2026Conference Call7:00 AM ET Spruce Biosciences EPS ResultsActual EPS-$9.58Consensus EPS -$9.1575Beat/MissMissed by -$0.4225One Year Ago EPSN/AEPS Beat Rate3 of last 8 quartersSpruce Biosciences Revenue ResultsActual RevenueN/AExpected RevenueN/ABeat/MissN/AYoY Revenue GrowthN/AConference Call ResourcesPress Release (8-K)Annual Report (10-K)Earnings HistoryCompany ProfilePowered by Earnings DocumentsPress Release(8-K)Annual report(10-K) Spruce Biosciences Q4 2025 Earnings FAQ Did Spruce Biosciences beat earnings estimates for Q4 2025? Spruce Biosciences (NASDAQ:SPRB) reported earnings of -$9.58 per share for Q4 2025, missing the consensus estimate of -$9.1575. The report was announced on Thursday, March 12, 2026. Spruce Biosciences Earnings HeadlinesSpruce Biosciences, Inc. Reports Earnings Results for the Third Quarter and Nine Months Ended September 30, 2026November 10 at 11:00 PM | marketscreener.comMSpruce Biosciences Faces Funding Risk as Uncertainty Looms Over TA-ERT FDA Priority Review Voucher and Sale ProspectsNovember 10 at 1:11 AM | tipranks.comA letter from Shannon StansberryPorter Stansberry nearly canceled the entire project. When he first saw the claimed returns - only one down year in nearly two decades and total gains of almost 2,000% - his immediate reaction was disbelief. It took a trusted friend's personal vouching for Emmet Savage and a face-to-face trip to Ireland to change his mind. The full documentary, Investigating Project Prophet, is now live.November 11 at 1:00 AM | Porter & Company (Ad)Spruce Biosciences Separates CAH Program Into New Company Adrenyx BiosciencesNovember 9 at 3:04 PM | rttnews.comSpruce Biosciences establishes Adrenyx subsidiary to develop CAH treatment CRHX-101November 9 at 3:04 PM | msn.comComparing Spruce Biosciences (SPRB) and Its RivalsNovember 5, 2026 | americanbankingnews.comSee More Spruce Biosciences Headlines Get Earnings Announcements in your inboxWant to stay updated on the latest earnings announcements and upcoming reports for companies like Spruce Biosciences? Sign up for Earnings360's daily newsletter to receive timely earnings updates on Spruce Biosciences and other key companies, straight to your email. Email Address About Spruce BiosciencesSpruce Biosciences (NASDAQ:SPRB) is a clinical-stage biopharmaceutical company focused on developing medicines for rare endocrine disorders. The company’s research is centered on conditions in which abnormal hormone production or regulation creates significant health risks and limited treatment options. Its lead investigational product is tildacerfont, an oral, selective corticotropin-releasing factor type 1 receptor antagonist. Spruce has studied tildacerfont as a potential treatment for congenital adrenal hyperplasia, a rare genetic disorder affecting the adrenal glands, and has evaluated its ability to reduce hormone imbalances associated with the disease. Tildacerfont is investigational and has not been approved for commercial use. Spruce Biosciences was founded in 2014 and is headquartered in San Francisco, California. The company’s development activities have included clinical research conducted in the United States and other regions. As a development-stage biotechnology company, Spruce has focused primarily on advancing its endocrine-disease pipeline rather than marketing an established portfolio of commercial products.View Spruce Biosciences ProfileRead more More Earnings Resources from MarketBeat Earnings Tools Today's Earnings Tomorrow's Earnings Next Week's Earnings Upcoming Earnings Calls Earnings Newsletter Earnings Call Transcripts Earnings Beats & Misses Corporate Guidance Earnings Screener Latest Articles Keeping AI Cool: AAON Rides the AI Heatwave to Record GrowthCan Constellation Energy's Contracts Power a Stock Rebound?IonQ Raised the Bar, But 3 Quantum Rivals Face Tough QuestionsAmazon's Rally Is Outpacing Big Tech, But Can AWS Justify the AI Spending?Aehr Test Systems Notches Another Post-Earnings Win as Sales Triple on AI DemandAST SpaceMobile Has a New Rocket Plan, But Its Cash-Burn Problem Isn't Going AwayPowering Up the Moon: Redwire’s $40 Million NASA Award Upcoming Earnings Brookfield (11/12/2026)NU (11/12/2026)Applied Materials (11/12/2026)Cisco Systems (11/12/2026)Mizuho Financial Group (11/13/2026)Mitsubishi UFJ Financial Group (11/13/2026)Sumitomo Mitsui Financial Group (11/13/2026)Home Depot (11/17/2026)Walt Disney (11/17/2026)NVIDIA (11/17/2026) Unlock superior investment research and tools. 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