Spruce Biosciences, Inc. is a clinical‐stage biopharmaceutical company focused on developing and commercializing therapies for patients with endocrine and rare diseases. Headquartered in Redwood City, California, Spruce was established in 2022 as a strategic spin‐out from Sage Therapeutics and holds global rights, including the United States, Canada, Australia, New Zealand and Israel, to its lead investigational candidate.
The company’s flagship asset is zuranolone, an investigational, oral neuroactive steroid designed as a positive allosteric modulator of GABAA receptors. Zuranolone is being evaluated for the treatment of major depressive disorder and postpartum depression. Spruce has completed multiple pivotal Phase 3 trials and regulatory reviews supporting applications for marketing authorization in its licensed territories. In addition to zuranolone, Spruce Biosciences is advancing next‐generation pipeline programs aimed at addressing other central nervous system and endocrine disorders with significant unmet medical needs.
Since its inception, Spruce has entered into strategic collaborations and licensing agreements to accelerate development and commercialization. The company leverages a lean organizational structure and a seasoned team of drug development professionals to efficiently manage clinical operations, regulatory interactions and commercial planning. Spruce’s research and development operations are complemented by partnerships with contract research organizations and clinical sites across North America and Oceania.
Under the leadership of Chief Executive Officer Jack Lief, who has extensive experience in neuroscience and regulatory strategy, Spruce Biosciences aims to build a sustainable portfolio of therapies for patients with serious neuroendocrine and mood disorders. The company’s management team brings together expertise in clinical development, regulatory affairs and commercial execution to advance its mission of transforming patient care in underserved therapeutic areas.
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