Spruce Biosciences (SPRB) Competitors $0.10 -0.01 (-5.66%) As of 07/17/2025 03:51 PM Eastern Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SPRB vs. DRRX, LPCN, PMN, GELS, ASBP, ALLR, MTEX, ATHA, FLGC, and EDSAShould you be buying Spruce Biosciences stock or one of its competitors? The main competitors of Spruce Biosciences include DURECT (DRRX), Lipocine (LPCN), Promis Neurosciences (PMN), Gelteq (GELS), Aspire Biopharma (ASBP), Allarity Therapeutics (ALLR), Mannatech (MTEX), Athira Pharma (ATHA), Flora Growth (FLGC), and Edesa Biotech (EDSA). These companies are all part of the "pharmaceutical products" industry. Spruce Biosciences vs. Its Competitors DURECT Lipocine Promis Neurosciences Gelteq Aspire Biopharma Allarity Therapeutics Mannatech Athira Pharma Flora Growth Edesa Biotech Spruce Biosciences (NASDAQ:SPRB) and DURECT (NASDAQ:DRRX) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, risk, dividends, institutional ownership, analyst recommendations, profitability, earnings and media sentiment. Do institutionals & insiders hold more shares of SPRB or DRRX? 91.7% of Spruce Biosciences shares are owned by institutional investors. Comparatively, 28.0% of DURECT shares are owned by institutional investors. 6.9% of Spruce Biosciences shares are owned by company insiders. Comparatively, 3.2% of DURECT shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Is SPRB or DRRX more profitable? DURECT has a net margin of -91.54% compared to Spruce Biosciences' net margin of -555.23%. Spruce Biosciences' return on equity of -62.10% beat DURECT's return on equity.Company Net Margins Return on Equity Return on Assets Spruce Biosciences-555.23% -62.10% -47.49% DURECT -91.54%-267.36%-64.00% Which has more volatility & risk, SPRB or DRRX? Spruce Biosciences has a beta of 2.4, indicating that its stock price is 140% more volatile than the S&P 500. Comparatively, DURECT has a beta of 0.64, indicating that its stock price is 36% less volatile than the S&P 500. Do analysts rate SPRB or DRRX? Spruce Biosciences currently has a consensus target price of $1.75, suggesting a potential upside of 1,742.11%. Given Spruce Biosciences' higher probable upside, equities research analysts clearly believe Spruce Biosciences is more favorable than DURECT.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Spruce Biosciences 0 Sell rating(s) 6 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 2.00DURECT 0 Sell rating(s) 1 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 2.00 Does the media favor SPRB or DRRX? In the previous week, DURECT's average media sentiment score of 1.87 beat Spruce Biosciences' score of 0.00 indicating that DURECT is being referred to more favorably in the news media. Company Overall Sentiment Spruce Biosciences Neutral DURECT Very Positive Which has preferable valuation & earnings, SPRB or DRRX? DURECT has lower revenue, but higher earnings than Spruce Biosciences. DURECT is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSpruce Biosciences$4.91M0.82-$47.92M-$1.32-0.07DURECT$2.03M8.01-$8.32M-$0.15-3.49 SummarySpruce Biosciences beats DURECT on 8 of the 13 factors compared between the two stocks. Get Spruce Biosciences News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRB and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRB vs. The Competition Export to ExcelMetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$4.01M$761.07M$5.57B$9.34BDividend YieldN/A4.84%3.80%4.06%P/E Ratio-0.101.3928.1019.86Price / Sales0.8225.51441.4199.92Price / CashN/A19.5635.8457.94Price / Book0.056.728.265.67Net Income-$47.92M-$4.32M$3.24B$257.80M7 Day PerformanceN/A-0.31%1.48%1.87%1 Month PerformanceN/A1.39%8.07%10.92%1 Year PerformanceN/A1.51%30.29%18.51% Spruce Biosciences Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPRBSpruce Biosciences2.064 of 5 stars$0.10-5.7%$1.75+1,742.1%-83.1%$4.01M$4.91M-0.1020Gap UpDRRXDURECT1.0789 of 5 stars$0.56-10.5%N/A-63.6%$17.39M$1.86M-3.7380Positive NewsGap DownLPCNLipocine3.0569 of 5 stars$3.20-2.1%$9.00+181.3%-50.3%$17.12M$3.67M-3.1410PMNPromis Neurosciences3.1626 of 5 stars$0.52+33.2%$4.33+733.3%-78.1%$17.00MN/A-10.405News CoverageAnalyst RevisionGap DownHigh Trading VolumeGELSGelteqN/A$1.76-2.8%N/AN/A$16.61M$100K0.00N/ANews CoverageGap DownASBPAspire BiopharmaN/A$0.33+0.3%N/AN/A$16.39MN/A0.00N/APositive NewsALLRAllarity Therapeutics0.6499 of 5 stars$1.05+4.0%N/A-83.7%$15.83MN/A0.0010Positive NewsMTEXMannatech1.2354 of 5 stars$8.31-2.2%N/A+12.3%$15.80M$117.87M-83.14250ATHAAthira Pharma3.7738 of 5 stars$0.40-7.5%$11.25+2,696.4%-88.4%$15.71MN/A-0.1940Positive NewsFLGCFlora Growth2.5086 of 5 stars$0.69+0.6%$4.00+480.6%-42.6%$15.55M$53.26M-0.70280Positive NewsGap UpEDSAEdesa Biotech2.214 of 5 stars$2.20+5.3%$5.00+127.3%-49.5%$15.44MN/A-1.3820Positive NewsGap Up Related Companies and Tools Related Companies DURECT Competitors Lipocine Competitors Promis Neurosciences Competitors Gelteq Competitors Aspire Biopharma Competitors Allarity Therapeutics Competitors Mannatech Competitors Athira Pharma Competitors Flora Growth Competitors Edesa Biotech Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRB) was last updated on 7/18/2025 by MarketBeat.com Staff From Our PartnersElon Just Fired the IRS Agents Targeting Your SavingsElon Musk just fired 6,700 IRS agents — and exposed a war on your retirement. 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