Does the media favor ALT or SPRB?

In the previous week, Altimmune had 2 more articles in the media than Spruce Biosciences. MarketBeat recorded 4 mentions for Altimmune and 2 mentions for Spruce Biosciences. Spruce Biosciences' average media sentiment score of 1.83 beat Altimmune's score of 0.48 indicating that Spruce Biosciences is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Altimmune 1 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Spruce Biosciences 1 Very Positive mention(s) 1 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Very Positive

Do analysts prefer VECT or SPRB?

Spruce Biosciences has a consensus target price of $163.00, indicating a potential upside of 227.31%. Given Spruce Biosciences' stronger consensus rating and higher probable upside, analysts clearly believe Spruce Biosciences is more favorable than VectivBio. Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score VectivBio 0 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 0.00 Spruce Biosciences 1 Sell rating(s) 2 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 2.60

Which has better earnings & valuation, VECT or SPRB?

VectivBio has higher earnings, but lower revenue than Spruce Biosciences. Company Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio VectivBio N/A N/A N/A N/A N/A Spruce Biosciences $4.91M 27.89 -$38.97M -$36.60 N/A

Is VECT or SPRB more profitable?

VectivBio's return on equity of 0.00% beat Spruce Biosciences' return on equity. Company Net Margins Return on Equity Return on Assets VectivBio N/A N/A N/A Spruce Biosciences N/A -155.40% -101.67%

Is SPRB or IMMX more profitable?

Immix Biopharma's return on equity of -73.24% beat Spruce Biosciences' return on equity. Company Net Margins Return on Equity Return on Assets Spruce Biosciences N/A -155.40% -101.67% Immix Biopharma N/A -73.24% -59.20%

Is SPRB or ZURA more profitable?

Zura Bio's return on equity of -55.74% beat Spruce Biosciences' return on equity. Company Net Margins Return on Equity Return on Assets Spruce Biosciences N/A -155.40% -101.67% Zura Bio N/A -55.74% -48.07%

Spruce Biosciences (SPRB) Competitors

$49.80 -0.97 (-1.91%)

Closing price 07/8/2026 04:00 PM Eastern

Extended Trading

$49.90 +0.10 (+0.20%)

As of 07/8/2026 06:37 PM Eastern

Compare

SPRB vs. ALT, VECT, IMMX, ZURA, and STRO

Should you buy Spruce Biosciences stock or one of its competitors? MarketBeat compares Spruce Biosciences with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Spruce Biosciences include Altimmune (ALT), VectivBio (VECT), Immix Biopharma (IMMX), Zura Bio (ZURA), and Sutro Biopharma (STRO). These companies are all part of the "pharmaceutical products" industry.

How does Spruce Biosciences compare to Altimmune?

Altimmune (NASDAQ:ALT) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, dividends, analyst recommendations, profitability, risk, valuation and earnings.

Spruce Biosciences has a net margin of 0.00% compared to Altimmune's net margin of -214,860.98%. Altimmune's return on equity of -42.57% beat Spruce Biosciences' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Altimmune	-214,860.98%	-42.57%	-35.57%
Spruce Biosciences	N/A	-155.40%	-101.67%

Altimmune currently has a consensus price target of $15.71, indicating a potential upside of 405.28%. Spruce Biosciences has a consensus price target of $163.00, indicating a potential upside of 227.31%. Given Altimmune's higher probable upside, equities research analysts plainly believe Altimmune is more favorable than Spruce Biosciences.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Altimmune	2 Sell rating(s)	1 Hold rating(s)	8 Buy rating(s)	0 Strong Buy rating(s)	2.55
Spruce Biosciences	1 Sell rating(s)	2 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.60

78.1% of Altimmune shares are owned by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are owned by institutional investors. 1.6% of Altimmune shares are owned by insiders. Comparatively, 4.3% of Spruce Biosciences shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Spruce Biosciences has higher revenue and earnings than Altimmune. Altimmune is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Altimmune	$40K	15,120.04	-$88.09M	-$0.93	N/A
Spruce Biosciences	$4.91M	27.89	-$38.97M	-$36.60	N/A

In the previous week, Altimmune had 2 more articles in the media than Spruce Biosciences. MarketBeat recorded 4 mentions for Altimmune and 2 mentions for Spruce Biosciences. Spruce Biosciences' average media sentiment score of 1.83 beat Altimmune's score of 0.48 indicating that Spruce Biosciences is being referred to more favorably in the news media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Altimmune	1 Very Positive mention(s)	0 Positive mention(s)	2 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Neutral
Spruce Biosciences	1 Very Positive mention(s)	1 Positive mention(s)	0 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Very Positive

Altimmune has a beta of 0.25, meaning that its stock price is 75% less volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.16, meaning that its stock price is 216% more volatile than the broader market.

Summary

Spruce Biosciences beats Altimmune on 9 of the 16 factors compared between the two stocks.

How does Spruce Biosciences compare to VectivBio?

VectivBio (NASDAQ:VECT) and Spruce Biosciences (NASDAQ:SPRB) are both medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their risk, media sentiment, dividends, profitability, earnings, analyst recommendations, valuation and institutional ownership.

In the previous week, Spruce Biosciences had 2 more articles in the media than VectivBio. MarketBeat recorded 2 mentions for Spruce Biosciences and 0 mentions for VectivBio. Spruce Biosciences' average media sentiment score of 1.83 beat VectivBio's score of 0.00 indicating that Spruce Biosciences is being referred to more favorably in the news media.

Company	Overall Sentiment
VectivBio	Neutral
Spruce Biosciences	Very Positive

91.7% of Spruce Biosciences shares are owned by institutional investors. 9.7% of VectivBio shares are owned by company insiders. Comparatively, 4.3% of Spruce Biosciences shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

VectivBio's return on equity of 0.00% beat Spruce Biosciences' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
VectivBio	N/A	N/A	N/A
Spruce Biosciences	N/A	-155.40%	-101.67%

Spruce Biosciences has a consensus target price of $163.00, indicating a potential upside of 227.31%. Given Spruce Biosciences' stronger consensus rating and higher probable upside, analysts clearly believe Spruce Biosciences is more favorable than VectivBio.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
VectivBio	0 Sell rating(s)	0 Hold rating(s)	0 Buy rating(s)	0 Strong Buy rating(s)	0.00
Spruce Biosciences	1 Sell rating(s)	2 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.60

VectivBio has higher earnings, but lower revenue than Spruce Biosciences.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
VectivBio	N/A	N/A	N/A	N/A	N/A
Spruce Biosciences	$4.91M	27.89	-$38.97M	-$36.60	N/A

Summary

Spruce Biosciences beats VectivBio on 7 of the 10 factors compared between the two stocks.

How does Spruce Biosciences compare to Immix Biopharma?

Spruce Biosciences (NASDAQ:SPRB) and Immix Biopharma (NASDAQ:IMMX) are both small-cap medical companies, but which is the better investment? We will contrast the two companies based on the strength of their profitability, media sentiment, institutional ownership, earnings, risk, analyst recommendations, valuation and dividends.

Immix Biopharma's return on equity of -73.24% beat Spruce Biosciences' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Spruce Biosciences	N/A	-155.40%	-101.67%
Immix Biopharma	N/A	-73.24%	-59.20%

Spruce Biosciences has a beta of 3.16, meaning that its share price is 216% more volatile than the broader market. Comparatively, Immix Biopharma has a beta of 0.09, meaning that its share price is 91% less volatile than the broader market.

Immix Biopharma has lower revenue, but higher earnings than Spruce Biosciences. Immix Biopharma is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Spruce Biosciences	$4.91M	27.89	-$38.97M	-$36.60	N/A
Immix Biopharma	N/A	N/A	-$29.44M	-$0.92	N/A

In the previous week, Spruce Biosciences had 2 more articles in the media than Immix Biopharma. MarketBeat recorded 2 mentions for Spruce Biosciences and 0 mentions for Immix Biopharma. Spruce Biosciences' average media sentiment score of 1.83 beat Immix Biopharma's score of 0.00 indicating that Spruce Biosciences is being referred to more favorably in the media.

Company	Overall Sentiment
Spruce Biosciences	Very Positive
Immix Biopharma	Neutral

91.7% of Spruce Biosciences shares are held by institutional investors. Comparatively, 11.3% of Immix Biopharma shares are held by institutional investors. 4.3% of Spruce Biosciences shares are held by insiders. Comparatively, 30.3% of Immix Biopharma shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Spruce Biosciences currently has a consensus target price of $163.00, indicating a potential upside of 227.31%. Immix Biopharma has a consensus target price of $20.67, indicating a potential upside of 87.88%. Given Spruce Biosciences' higher probable upside, equities research analysts clearly believe Spruce Biosciences is more favorable than Immix Biopharma.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Spruce Biosciences	1 Sell rating(s)	2 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.60
Immix Biopharma	1 Sell rating(s)	1 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.67

Summary

Spruce Biosciences beats Immix Biopharma on 7 of the 13 factors compared between the two stocks.

How does Spruce Biosciences compare to Zura Bio?

Spruce Biosciences (NASDAQ:SPRB) and Zura Bio (NASDAQ:ZURA) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their media sentiment, profitability, valuation, dividends, earnings, analyst recommendations, institutional ownership and risk.

Spruce Biosciences currently has a consensus target price of $163.00, suggesting a potential upside of 227.31%. Zura Bio has a consensus target price of $10.75, suggesting a potential upside of 95.81%. Given Spruce Biosciences' higher possible upside, analysts clearly believe Spruce Biosciences is more favorable than Zura Bio.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Spruce Biosciences	1 Sell rating(s)	2 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.60
Zura Bio	1 Sell rating(s)	1 Hold rating(s)	4 Buy rating(s)	1 Strong Buy rating(s)	2.71

Spruce Biosciences has higher revenue and earnings than Zura Bio. Zura Bio is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Spruce Biosciences	$4.91M	27.89	-$38.97M	-$36.60	N/A
Zura Bio	N/A	N/A	-$99.35M	-$1.09	N/A

In the previous week, Spruce Biosciences had 2 more articles in the media than Zura Bio. MarketBeat recorded 2 mentions for Spruce Biosciences and 0 mentions for Zura Bio. Spruce Biosciences' average media sentiment score of 1.83 beat Zura Bio's score of 0.00 indicating that Spruce Biosciences is being referred to more favorably in the media.

Company	Overall Sentiment
Spruce Biosciences	Very Positive
Zura Bio	Neutral

Spruce Biosciences has a beta of 3.16, indicating that its stock price is 216% more volatile than the broader market. Comparatively, Zura Bio has a beta of -0.03, indicating that its stock price is 103% less volatile than the broader market.

91.7% of Spruce Biosciences shares are owned by institutional investors. Comparatively, 61.1% of Zura Bio shares are owned by institutional investors. 4.3% of Spruce Biosciences shares are owned by insiders. Comparatively, 12.4% of Zura Bio shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Zura Bio's return on equity of -55.74% beat Spruce Biosciences' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Spruce Biosciences	N/A	-155.40%	-101.67%
Zura Bio	N/A	-55.74%	-48.07%

Summary

Spruce Biosciences beats Zura Bio on 9 of the 15 factors compared between the two stocks.

How does Spruce Biosciences compare to Sutro Biopharma?

Spruce Biosciences (NASDAQ:SPRB) and Sutro Biopharma (NASDAQ:STRO) are both small-cap medical companies, but which is the superior investment? We will compare the two companies based on the strength of their profitability, earnings, valuation, media sentiment, analyst recommendations, risk, institutional ownership and dividends.

Spruce Biosciences has a net margin of 0.00% compared to Sutro Biopharma's net margin of -154.21%. Sutro Biopharma's return on equity of 0.00% beat Spruce Biosciences' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Spruce Biosciences	N/A	-155.40%	-101.67%
Sutro Biopharma	-154.21%	N/A	-69.20%

Spruce Biosciences has a beta of 3.16, suggesting that its share price is 216% more volatile than the broader market. Comparatively, Sutro Biopharma has a beta of 1.51, suggesting that its share price is 51% more volatile than the broader market.

91.7% of Spruce Biosciences shares are owned by institutional investors. Comparatively, 97.0% of Sutro Biopharma shares are owned by institutional investors. 4.3% of Spruce Biosciences shares are owned by company insiders. Comparatively, 3.6% of Sutro Biopharma shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Spruce Biosciences has higher earnings, but lower revenue than Sutro Biopharma. Sutro Biopharma is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Spruce Biosciences	$4.91M	27.89	-$38.97M	-$36.60	N/A
Sutro Biopharma	$102.48M	5.15	-$191.09M	-$11.04	N/A

In the previous week, Spruce Biosciences had 2 more articles in the media than Sutro Biopharma. MarketBeat recorded 2 mentions for Spruce Biosciences and 0 mentions for Sutro Biopharma. Spruce Biosciences' average media sentiment score of 1.83 beat Sutro Biopharma's score of 0.00 indicating that Spruce Biosciences is being referred to more favorably in the media.

Company	Overall Sentiment
Spruce Biosciences	Very Positive
Sutro Biopharma	Neutral

Spruce Biosciences presently has a consensus price target of $163.00, suggesting a potential upside of 227.31%. Sutro Biopharma has a consensus price target of $52.44, suggesting a potential upside of 64.71%. Given Spruce Biosciences' higher probable upside, equities analysts plainly believe Spruce Biosciences is more favorable than Sutro Biopharma.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Spruce Biosciences	1 Sell rating(s)	2 Hold rating(s)	7 Buy rating(s)	0 Strong Buy rating(s)	2.60
Sutro Biopharma	1 Sell rating(s)	1 Hold rating(s)	8 Buy rating(s)	2 Strong Buy rating(s)	2.92

Summary

Spruce Biosciences beats Sutro Biopharma on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.

SPRB vs. The Competition

Export

Metric	Spruce Biosciences	Pharmaceutical Industry	Medical Sector	NASDAQ Exchange
Market Cap	$139.73M	$951.54M	$7.00B	$12.46B
Dividend Yield	N/A	4.84%	2.67%	7.39%
P/E Ratio	-1.36	1.54	27.14	24.24
Price / Sales	27.89	113.54	534.05	96.53
Price / Cash	N/A	20.06	49.24	56.96
Price / Book	1.25	8.34	10.83	6.38
Net Income	-$38.97M	-$4.99M	$3.56B	$331.19M
7 Day Performance	-5.16%	-1.18%	-0.02%	-1.32%
1 Month Performance	1.57%	4.03%	5.28%	1.27%
1 Year Performance	813.34%	48.50%	30.31%	20.73%

Spruce Biosciences Competitors List

Export

Company	MarketRank	Share Price	Analysts' Price Target	1Y Price Performance	Market Cap	Revenue	P/E Ratio	Employee Count	Indicator(s)
SPRB Spruce Biosciences	3.2745 of 5 stars	$49.80 -1.9%	$163.00 +227.3%	+848.6%	$139.73M	$4.91M	N/A	20	News Coverage Positive News
ALT Altimmune	2.0868 of 5 stars	$3.03 +2.9%	$15.71 +419.5%	-32.1%	$588.27M	$40K	N/A	50	Options Volume
VECT VectivBio	N/A	$16.85 flat	N/A	N/A	$573.24M	$27.34M	N/A	30	High Trading Volume
IMMX Immix Biopharma	2.9703 of 5 stars	$10.31 -1.7%	$20.67 +100.5%	+313.5%	$560.98M	N/A	N/A	9	High Trading Volume
ZURA Zura Bio	2.7015 of 5 stars	$5.90 +4.8%	$10.75 +82.2%	+357.5%	$559.79M	N/A	N/A	3	Analyst Forecast High Trading Volume

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This page (NASDAQ:SPRB) was last updated on 7/9/2026 by MarketBeat.com Staff.

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Spruce Biosciences (SPRB) Competitors

SPRB vs. ALT, VECT, IMMX, ZURA, and STRO

How does Spruce Biosciences compare to Altimmune?

Summary

How does Spruce Biosciences compare to VectivBio?

Summary

How does Spruce Biosciences compare to Immix Biopharma?

Summary

How does Spruce Biosciences compare to Zura Bio?

Summary

How does Spruce Biosciences compare to Sutro Biopharma?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

SPRB vs. The Competition

Spruce Biosciences Competitors List

Related Companies and Tools

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Stock Ideas and Recommendations

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About MarketBeat

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Spruce Biosciences (SPRB) Competitors

SPRB vs. ALT, VECT, IMMX, ZURA, and STRO

How does Spruce Biosciences compare to Altimmune?

Is ALT or SPRB more profitable?

Do analysts rate ALT or SPRB?

Do institutionals and insiders believe in ALT or SPRB?

Which has stronger valuation and earnings, ALT or SPRB?

Does the media favor ALT or SPRB?

Which has more risk & volatility, ALT or SPRB?

Summary

How does Spruce Biosciences compare to VectivBio?

Does the media refer more to VECT or SPRB?

Do insiders & institutionals have more ownership in VECT or SPRB?

Is VECT or SPRB more profitable?

Do analysts prefer VECT or SPRB?

Which has better earnings & valuation, VECT or SPRB?

Summary

How does Spruce Biosciences compare to Immix Biopharma?

Is SPRB or IMMX more profitable?

Which has more risk and volatility, SPRB or IMMX?

Which has stronger earnings & valuation, SPRB or IMMX?

Does the media refer more to SPRB or IMMX?

Do insiders and institutionals believe in SPRB or IMMX?

Do analysts prefer SPRB or IMMX?

Summary

How does Spruce Biosciences compare to Zura Bio?

Do analysts prefer SPRB or ZURA?

Which has preferable earnings and valuation, SPRB or ZURA?

Does the media favor SPRB or ZURA?

Which has more volatility and risk, SPRB or ZURA?

Do institutionals & insiders have more ownership in SPRB or ZURA?

Is SPRB or ZURA more profitable?

Summary

How does Spruce Biosciences compare to Sutro Biopharma?

Is SPRB or STRO more profitable?

Which has more volatility & risk, SPRB or STRO?

Do institutionals and insiders have more ownership in SPRB or STRO?

Which has stronger valuation and earnings, SPRB or STRO?

Does the media favor SPRB or STRO?

Do analysts rate SPRB or STRO?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

SPRB vs. The Competition

Spruce Biosciences Competitors List

Related Companies and Tools

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools