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Spruce Biosciences (SPRB) Competitors

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$51.27 +2.08 (+4.23%)
Closing price 04:00 PM Eastern
Extended Trading
$51.44 +0.17 (+0.33%)
As of 05:39 PM Eastern
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SPRB vs. ALT, DNA, TECX, PRME, and EIKN

Should you buy Spruce Biosciences stock or one of its competitors? MarketBeat compares Spruce Biosciences with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Spruce Biosciences include Altimmune (ALT), Ginkgo Bioworks (DNA), Tectonic Therapeutic (TECX), Prime Medicine (PRME), and EIKN (EIKN). These companies are all part of the "pharmaceutical products" industry.

How does Spruce Biosciences compare to Altimmune?

Altimmune (NASDAQ:ALT) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their dividends, analyst recommendations, profitability, earnings, risk, media sentiment, institutional ownership and valuation.

Altimmune currently has a consensus target price of $16.67, indicating a potential upside of 446.45%. Spruce Biosciences has a consensus target price of $186.60, indicating a potential upside of 263.96%. Given Altimmune's higher possible upside, equities research analysts plainly believe Altimmune is more favorable than Spruce Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Altimmune
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.50
Spruce Biosciences
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50

78.1% of Altimmune shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 1.6% of Altimmune shares are held by company insiders. Comparatively, 4.3% of Spruce Biosciences shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Altimmune has a beta of 0.18, suggesting that its stock price is 82% less volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.26, suggesting that its stock price is 226% more volatile than the broader market.

Spruce Biosciences has higher revenue and earnings than Altimmune. Altimmune is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Altimmune$40K14,828.34-$88.09M-$0.93N/A
Spruce Biosciences$4.91M28.72-$38.97M-$36.60N/A

In the previous week, Altimmune had 2 more articles in the media than Spruce Biosciences. MarketBeat recorded 6 mentions for Altimmune and 4 mentions for Spruce Biosciences. Altimmune's average media sentiment score of 0.73 beat Spruce Biosciences' score of 0.66 indicating that Altimmune is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Altimmune
1 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spruce Biosciences
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Spruce Biosciences has a net margin of 0.00% compared to Altimmune's net margin of -214,860.98%. Altimmune's return on equity of -42.57% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Altimmune-214,860.98% -42.57% -35.57%
Spruce Biosciences N/A -155.40%-101.67%

Summary

Altimmune beats Spruce Biosciences on 8 of the 15 factors compared between the two stocks.

How does Spruce Biosciences compare to Ginkgo Bioworks?

Ginkgo Bioworks (NYSE:DNA) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap medical companies, but which is the better stock? We will compare the two businesses based on the strength of their media sentiment, analyst recommendations, profitability, earnings, risk, institutional ownership, dividends and valuation.

78.6% of Ginkgo Bioworks shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 12.7% of Ginkgo Bioworks shares are held by insiders. Comparatively, 4.3% of Spruce Biosciences shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Spruce Biosciences has lower revenue, but higher earnings than Ginkgo Bioworks. Ginkgo Bioworks is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ginkgo Bioworks$170.15M3.60-$312.76M-$5.36N/A
Spruce Biosciences$4.91M28.72-$38.97M-$36.60N/A

Ginkgo Bioworks currently has a consensus price target of $8.50, indicating a potential downside of 9.33%. Spruce Biosciences has a consensus price target of $186.60, indicating a potential upside of 263.96%. Given Spruce Biosciences' stronger consensus rating and higher possible upside, analysts clearly believe Spruce Biosciences is more favorable than Ginkgo Bioworks.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ginkgo Bioworks
2 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.67
Spruce Biosciences
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50

In the previous week, Ginkgo Bioworks and Ginkgo Bioworks both had 4 articles in the media. Spruce Biosciences' average media sentiment score of 0.66 beat Ginkgo Bioworks' score of 0.16 indicating that Spruce Biosciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ginkgo Bioworks
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spruce Biosciences
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Spruce Biosciences has a net margin of 0.00% compared to Ginkgo Bioworks' net margin of -215.41%. Ginkgo Bioworks' return on equity of -56.08% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Ginkgo Bioworks-215.41% -56.08% -26.06%
Spruce Biosciences N/A -155.40%-101.67%

Ginkgo Bioworks has a beta of 1.77, suggesting that its share price is 77% more volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.26, suggesting that its share price is 226% more volatile than the broader market.

Summary

Spruce Biosciences beats Ginkgo Bioworks on 10 of the 15 factors compared between the two stocks.

How does Spruce Biosciences compare to Tectonic Therapeutic?

Tectonic Therapeutic (NASDAQ:TECX) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap medical companies, but which is the better business? We will compare the two businesses based on the strength of their analyst recommendations, profitability, dividends, valuation, risk, earnings, media sentiment and institutional ownership.

In the previous week, Spruce Biosciences had 1 more articles in the media than Tectonic Therapeutic. MarketBeat recorded 4 mentions for Spruce Biosciences and 3 mentions for Tectonic Therapeutic. Spruce Biosciences' average media sentiment score of 0.66 beat Tectonic Therapeutic's score of 0.62 indicating that Spruce Biosciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Tectonic Therapeutic
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spruce Biosciences
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Tectonic Therapeutic's return on equity of -32.33% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Tectonic TherapeuticN/A -32.33% -30.92%
Spruce Biosciences N/A -155.40%-101.67%

Spruce Biosciences has higher revenue and earnings than Tectonic Therapeutic. Tectonic Therapeutic is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Tectonic TherapeuticN/AN/A-$74.15M-$4.46N/A
Spruce Biosciences$4.91M28.72-$38.97M-$36.60N/A

Tectonic Therapeutic presently has a consensus target price of $80.67, indicating a potential upside of 158.80%. Spruce Biosciences has a consensus target price of $186.60, indicating a potential upside of 263.96%. Given Spruce Biosciences' higher probable upside, analysts plainly believe Spruce Biosciences is more favorable than Tectonic Therapeutic.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Tectonic Therapeutic
1 Sell rating(s)
0 Hold rating(s)
4 Buy rating(s)
2 Strong Buy rating(s)
3.00
Spruce Biosciences
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50

62.6% of Tectonic Therapeutic shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 39.8% of Tectonic Therapeutic shares are held by company insiders. Comparatively, 4.3% of Spruce Biosciences shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Tectonic Therapeutic has a beta of 3.27, suggesting that its share price is 227% more volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.26, suggesting that its share price is 226% more volatile than the broader market.

Summary

Spruce Biosciences beats Tectonic Therapeutic on 8 of the 15 factors compared between the two stocks.

How does Spruce Biosciences compare to Prime Medicine?

Prime Medicine (NASDAQ:PRME) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap pharmaceutical products companies, but which is the superior investment? We will contrast the two companies based on the strength of their profitability, analyst recommendations, media sentiment, risk, earnings, valuation, institutional ownership and dividends.

Spruce Biosciences has higher revenue and earnings than Prime Medicine. Prime Medicine is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prime Medicine$4.63M138.49-$201.14M-$1.23N/A
Spruce Biosciences$4.91M28.72-$38.97M-$36.60N/A

70.4% of Prime Medicine shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 22.7% of Prime Medicine shares are held by insiders. Comparatively, 4.3% of Spruce Biosciences shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

In the previous week, Spruce Biosciences had 2 more articles in the media than Prime Medicine. MarketBeat recorded 4 mentions for Spruce Biosciences and 2 mentions for Prime Medicine. Prime Medicine's average media sentiment score of 0.94 beat Spruce Biosciences' score of 0.66 indicating that Prime Medicine is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prime Medicine
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spruce Biosciences
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Prime Medicine currently has a consensus price target of $7.65, indicating a potential upside of 115.49%. Spruce Biosciences has a consensus price target of $186.60, indicating a potential upside of 263.96%. Given Spruce Biosciences' higher possible upside, analysts plainly believe Spruce Biosciences is more favorable than Prime Medicine.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prime Medicine
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.67
Spruce Biosciences
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50

Prime Medicine has a beta of 2.35, suggesting that its stock price is 135% more volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.26, suggesting that its stock price is 226% more volatile than the broader market.

Spruce Biosciences has a net margin of 0.00% compared to Prime Medicine's net margin of -4,917.55%. Spruce Biosciences' return on equity of -155.40% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
Prime Medicine-4,917.55% -188.82% -60.97%
Spruce Biosciences N/A -155.40%-101.67%

Summary

Spruce Biosciences beats Prime Medicine on 10 of the 17 factors compared between the two stocks.

How does Spruce Biosciences compare to EIKN?

Spruce Biosciences (NASDAQ:SPRB) and EIKN (NASDAQ:EIKN) are both small-cap pharmaceutical products companies, but which is the superior business? We will contrast the two businesses based on the strength of their valuation, media sentiment, profitability, analyst recommendations, institutional ownership, earnings, dividends and risk.

In the previous week, Spruce Biosciences had 3 more articles in the media than EIKN. MarketBeat recorded 4 mentions for Spruce Biosciences and 1 mentions for EIKN. EIKN's average media sentiment score of 0.96 beat Spruce Biosciences' score of 0.66 indicating that EIKN is being referred to more favorably in the news media.

Company Overall Sentiment
Spruce Biosciences Positive
EIKN Positive

EIKN's return on equity of 0.00% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce BiosciencesN/A -155.40% -101.67%
EIKN N/A N/A N/A

EIKN has lower revenue, but higher earnings than Spruce Biosciences.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M28.72-$38.97M-$36.60N/A
EIKNN/AN/AN/AN/AN/A

Spruce Biosciences currently has a consensus target price of $186.60, suggesting a potential upside of 263.96%. EIKN has a consensus target price of $25.20, suggesting a potential upside of 132.47%. Given Spruce Biosciences' higher probable upside, research analysts plainly believe Spruce Biosciences is more favorable than EIKN.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50
EIKN
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57

91.7% of Spruce Biosciences shares are held by institutional investors. 4.3% of Spruce Biosciences shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Summary

Spruce Biosciences beats EIKN on 5 of the 9 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SPRB vs. The Competition

MetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ Exchange
Market Cap$140.99M$934.65M$6.41B$12.58B
Dividend YieldN/A4.84%2.75%5.26%
P/E Ratio-1.401.4621.2526.28
Price / Sales28.72120.60561.59114.77
Price / CashN/A20.0643.4956.90
Price / Book4.077.6910.607.33
Net Income-$38.97M-$3.80M$3.56B$337.06M
7 Day Performance0.37%2.50%2.84%3.43%
1 Month Performance-7.65%75.56%6.16%7.24%
1 Year Performance883.60%120.46%36.73%37.98%

Spruce Biosciences Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SPRB
Spruce Biosciences
2.4778 of 5 stars
$51.27
+4.2%
$186.60
+264.0%
+924.8%$140.99M$4.91MN/A20
ALT
Altimmune
3.0413 of 5 stars
$2.93
+1.0%
$16.67
+468.8%
-44.1%$569.80M$40KN/A50
DNA
Ginkgo Bioworks
1.2041 of 5 stars
$8.71
+3.6%
$8.50
-2.4%
+27.7%$568.94M$170.15MN/A640
TECX
Tectonic Therapeutic
2.4019 of 5 stars
$29.99
+3.0%
$80.67
+169.0%
+38.2%$565.91MN/AN/A120
PRME
Prime Medicine
2.1614 of 5 stars
$2.97
flat
$7.65
+157.6%
N/A$536.44M$4.63MN/AN/A

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This page (NASDAQ:SPRB) was last updated on 5/29/2026 by MarketBeat.com Staff.
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