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Spruce Biosciences (SPRB) Competitors

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$52.92 +0.28 (+0.53%)
Closing price 08/17/2026 04:00 PM Eastern
Extended Trading
$52.00 -0.92 (-1.74%)
As of 04:00 AM Eastern
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SPRB vs. PRME, ARTV, RGNX, ZURA, and EVMN

Should you buy Spruce Biosciences stock or one of its competitors? Spruce Biosciences's main competitors and comparable companies include Prime Medicine (PRME), Artiva Biotherapeutics (ARTV), REGENXBIO (RGNX), Zura Bio (ZURA), and Evommune (EVMN). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Spruce Biosciences compare to Prime Medicine?

Prime Medicine (NASDAQ:PRME) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their institutional ownership, media sentiment, risk, earnings, dividends, valuation, profitability and analyst recommendations.

Spruce Biosciences has higher revenue and earnings than Prime Medicine. Prime Medicine is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prime Medicine$4.63M124.18-$201.14M-$1.06N/A
Spruce Biosciences$4.91M30.93-$38.97M-$39.78N/A

In the previous week, Prime Medicine had 6 more articles in the media than Spruce Biosciences. MarketBeat recorded 16 mentions for Prime Medicine and 10 mentions for Spruce Biosciences. Prime Medicine's average media sentiment score of 0.28 beat Spruce Biosciences' score of 0.05 indicating that Prime Medicine is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prime Medicine
3 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spruce Biosciences
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Spruce Biosciences has a net margin of 0.00% compared to Prime Medicine's net margin of -4,613.11%. Spruce Biosciences' return on equity of -123.53% beat Prime Medicine's return on equity.

Company Net Margins Return on Equity Return on Assets
Prime Medicine-4,613.11% -188.27% -59.11%
Spruce Biosciences N/A -123.53%-90.35%

Prime Medicine has a beta of 2.31, meaning that its stock price is 131% more volatile than the broader market. Comparatively, Spruce Biosciences has a beta of 3.23, meaning that its stock price is 223% more volatile than the broader market.

Prime Medicine presently has a consensus target price of $7.53, indicating a potential upside of 137.58%. Spruce Biosciences has a consensus target price of $159.50, indicating a potential upside of 201.40%. Given Spruce Biosciences' higher possible upside, analysts clearly believe Spruce Biosciences is more favorable than Prime Medicine.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prime Medicine
1 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.88
Spruce Biosciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

70.4% of Prime Medicine shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 16.0% of Prime Medicine shares are held by company insiders. Comparatively, 4.3% of Spruce Biosciences shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Summary

Spruce Biosciences beats Prime Medicine on 9 of the 17 factors compared between the two stocks.

How does Spruce Biosciences compare to Artiva Biotherapeutics?

Spruce Biosciences (NASDAQ:SPRB) and Artiva Biotherapeutics (NASDAQ:ARTV) are both small-cap healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their risk, profitability, earnings, analyst recommendations, media sentiment, institutional ownership, dividends and valuation.

Spruce Biosciences currently has a consensus price target of $159.50, suggesting a potential upside of 201.40%. Artiva Biotherapeutics has a consensus price target of $39.00, suggesting a potential upside of 232.20%. Given Artiva Biotherapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Artiva Biotherapeutics is more favorable than Spruce Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Artiva Biotherapeutics
1 Sell rating(s)
0 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.83

Spruce Biosciences has higher revenue and earnings than Artiva Biotherapeutics. Artiva Biotherapeutics is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M30.93-$38.97M-$39.78N/A
Artiva BiotherapeuticsN/AN/A-$83.86M-$3.30N/A

In the previous week, Spruce Biosciences and Spruce Biosciences both had 10 articles in the media. Artiva Biotherapeutics' average media sentiment score of 0.64 beat Spruce Biosciences' score of 0.05 indicating that Artiva Biotherapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spruce Biosciences
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Artiva Biotherapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

91.7% of Spruce Biosciences shares are owned by institutional investors. 4.3% of Spruce Biosciences shares are owned by company insiders. Comparatively, 1.8% of Artiva Biotherapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Artiva Biotherapeutics' return on equity of -53.86% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce BiosciencesN/A -123.53% -90.35%
Artiva Biotherapeutics N/A -53.86%-48.16%

Spruce Biosciences has a beta of 3.23, meaning that its share price is 223% more volatile than the broader market. Comparatively, Artiva Biotherapeutics has a beta of 2.16, meaning that its share price is 116% more volatile than the broader market.

Summary

Spruce Biosciences and Artiva Biotherapeutics tied by winning 7 of the 14 factors compared between the two stocks.

How does Spruce Biosciences compare to REGENXBIO?

Spruce Biosciences (NASDAQ:SPRB) and REGENXBIO (NASDAQ:RGNX) are both small-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their institutional ownership, risk, media sentiment, analyst recommendations, profitability, dividends, valuation and earnings.

Spruce Biosciences has a net margin of 0.00% compared to REGENXBIO's net margin of -112.58%. Spruce Biosciences' return on equity of -123.53% beat REGENXBIO's return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce BiosciencesN/A -123.53% -90.35%
REGENXBIO -112.58%-220.07%-46.04%

Spruce Biosciences has higher earnings, but lower revenue than REGENXBIO. REGENXBIO is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M30.93-$38.97M-$39.78N/A
REGENXBIO$170.44M4.39-$193.88M-$3.79N/A

Spruce Biosciences has a beta of 3.23, indicating that its stock price is 223% more volatile than the broader market. Comparatively, REGENXBIO has a beta of 0.94, indicating that its stock price is 6% less volatile than the broader market.

Spruce Biosciences currently has a consensus price target of $159.50, indicating a potential upside of 201.40%. REGENXBIO has a consensus price target of $23.73, indicating a potential upside of 109.42%. Given Spruce Biosciences' stronger consensus rating and higher possible upside, research analysts plainly believe Spruce Biosciences is more favorable than REGENXBIO.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
REGENXBIO
1 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.62

91.7% of Spruce Biosciences shares are held by institutional investors. Comparatively, 88.1% of REGENXBIO shares are held by institutional investors. 4.3% of Spruce Biosciences shares are held by company insiders. Comparatively, 14.2% of REGENXBIO shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

In the previous week, REGENXBIO had 5 more articles in the media than Spruce Biosciences. MarketBeat recorded 15 mentions for REGENXBIO and 10 mentions for Spruce Biosciences. REGENXBIO's average media sentiment score of 0.83 beat Spruce Biosciences' score of 0.05 indicating that REGENXBIO is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spruce Biosciences
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
REGENXBIO
3 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Spruce Biosciences beats REGENXBIO on 10 of the 16 factors compared between the two stocks.

How does Spruce Biosciences compare to Zura Bio?

Spruce Biosciences (NASDAQ:SPRB) and Zura Bio (NASDAQ:ZURA) are both small-cap healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their profitability, institutional ownership, earnings, media sentiment, analyst recommendations, risk, dividends and valuation.

Zura Bio's return on equity of -56.13% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce BiosciencesN/A -123.53% -90.35%
Zura Bio N/A -56.13%-50.15%

Spruce Biosciences has a beta of 3.23, suggesting that its share price is 223% more volatile than the broader market. Comparatively, Zura Bio has a beta of -0.02, suggesting that its share price is 102% less volatile than the broader market.

Spruce Biosciences presently has a consensus target price of $159.50, indicating a potential upside of 201.40%. Zura Bio has a consensus target price of $14.00, indicating a potential upside of 146.48%. Given Spruce Biosciences' higher probable upside, research analysts plainly believe Spruce Biosciences is more favorable than Zura Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Zura Bio
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

91.7% of Spruce Biosciences shares are owned by institutional investors. Comparatively, 61.1% of Zura Bio shares are owned by institutional investors. 4.3% of Spruce Biosciences shares are owned by insiders. Comparatively, 12.4% of Zura Bio shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Spruce Biosciences has higher revenue and earnings than Zura Bio. Zura Bio is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M30.93-$38.97M-$39.78N/A
Zura BioN/AN/A-$99.35M-$1.13N/A

In the previous week, Spruce Biosciences had 5 more articles in the media than Zura Bio. MarketBeat recorded 10 mentions for Spruce Biosciences and 5 mentions for Zura Bio. Zura Bio's average media sentiment score of 0.44 beat Spruce Biosciences' score of 0.05 indicating that Zura Bio is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spruce Biosciences
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Zura Bio
2 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Spruce Biosciences beats Zura Bio on 8 of the 14 factors compared between the two stocks.

How does Spruce Biosciences compare to Evommune?

Spruce Biosciences (NASDAQ:SPRB) and Evommune (NYSE:EVMN) are both small-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, profitability, institutional ownership, valuation, earnings, dividends, analyst recommendations and risk.

Spruce Biosciences has higher earnings, but lower revenue than Evommune. Spruce Biosciences is trading at a lower price-to-earnings ratio than Evommune, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spruce Biosciences$4.91M30.93-$38.97M-$39.78N/A
Evommune$13M39.86-$68.87M-$11.03N/A

Spruce Biosciences currently has a consensus price target of $159.50, indicating a potential upside of 201.40%. Evommune has a consensus price target of $43.25, indicating a potential upside of 202.87%. Given Evommune's stronger consensus rating and higher possible upside, analysts clearly believe Evommune is more favorable than Spruce Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spruce Biosciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75
Evommune
1 Sell rating(s)
3 Hold rating(s)
8 Buy rating(s)
2 Strong Buy rating(s)
2.79

Evommune's return on equity of -62.63% beat Spruce Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Spruce BiosciencesN/A -123.53% -90.35%
Evommune N/A -62.63%-40.55%

91.7% of Spruce Biosciences shares are held by institutional investors. 4.3% of Spruce Biosciences shares are held by company insiders. Comparatively, 31.1% of Evommune shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

In the previous week, Evommune had 2 more articles in the media than Spruce Biosciences. MarketBeat recorded 12 mentions for Evommune and 10 mentions for Spruce Biosciences. Spruce Biosciences' average media sentiment score of 0.05 beat Evommune's score of -0.53 indicating that Spruce Biosciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spruce Biosciences
1 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Evommune
1 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Negative

Summary

Evommune beats Spruce Biosciences on 11 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SPRB vs. The Competition

MetricSpruce BiosciencesBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$151.29M$3.73B$7.03B$13.06B
Dividend YieldN/A3.69%2.56%10.63%
P/E Ratio-1.3311.49270.8125.39
Price / Sales30.931,162.45560.8371.27
Price / CashN/A45.1128.8738.47
Price / Book1.3317.4111.166.51
Net Income-$38.97M-$13.19M$3.45B$347.22M
7 Day Performance14.03%0.91%0.62%1.27%
1 Month Performance21.54%2.63%2.09%2.72%
1 Year Performance487.35%54.05%61.61%21.85%

Spruce Biosciences Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SPRB
Spruce Biosciences
2.7658 of 5 stars
$52.92
+0.5%
$159.50
+201.4%
+487.3%$151.29M$4.91MN/A20
PRME
Prime Medicine
2.5081 of 5 stars
$3.09
-2.7%
$7.53
+144.1%
N/A$558.65M$4.63MN/AN/A
ARTV
Artiva Biotherapeutics
2.8031 of 5 stars
$11.40
+0.9%
$39.00
+242.1%
+326.9%$557.35M$250KN/A81
RGNX
REGENXBIO
4.0116 of 5 stars
$10.65
-0.1%
$23.73
+122.8%
+28.5%$549.83M$170.44MN/A370
ZURA
Zura Bio
2.6363 of 5 stars
$5.64
+0.1%
$14.00
+148.4%
+242.2%$534.65MN/AN/A3

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This page (NASDAQ:SPRB) was last updated on 8/18/2026 by MarketBeat.com Staff.
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