Is PHIO or HYPD more profitable?

Phio Pharmaceuticals' return on equity of -77.34% beat Hyperion DeFi's return on equity. Company Net Margins Return on Equity Return on Assets Phio Pharmaceuticals N/A -77.34% -70.87% Hyperion DeFi N/A -91.59% -73.08%

Is IXHL or PHIO more profitable?

Phio Pharmaceuticals' return on equity of -77.34% beat Incannex Healthcare's return on equity. Company Net Margins Return on Equity Return on Assets Incannex Healthcare N/A -81.01% -76.11% Phio Pharmaceuticals N/A -77.34% -70.87%

Do analysts recommend APLM or PHIO?

Phio Pharmaceuticals has a consensus price target of $14.00, suggesting a potential upside of 1,300.00%. Given Phio Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Phio Pharmaceuticals is more favorable than Apollomics. Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Apollomics 1 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 1.00 Phio Pharmaceuticals 1 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 2.00

Which has higher valuation and earnings, APLM or PHIO?

Phio Pharmaceuticals has lower revenue, but higher earnings than Apollomics. Company Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio Apollomics $8.50M 5.06 -$10.94M N/A N/A Phio Pharmaceuticals N/A N/A -$8.70M -$1.38 N/A

Is APLM or PHIO more profitable?

Apollomics' return on equity of 0.00% beat Phio Pharmaceuticals' return on equity. Company Net Margins Return on Equity Return on Assets Apollomics N/A N/A N/A Phio Pharmaceuticals N/A -77.34% -70.87%

Do analysts recommend INMB or PHIO?

Phio Pharmaceuticals has a consensus target price of $14.00, indicating a potential upside of 1,300.00%. Given Phio Pharmaceuticals' higher probable upside, analysts plainly believe Phio Pharmaceuticals is more favorable than INmune Bio. Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score INmune Bio 1 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 1 Strong Buy rating(s) 2.50 Phio Pharmaceuticals 1 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 2.00

Is INMB or PHIO more profitable?

Phio Pharmaceuticals' return on equity of -77.34% beat INmune Bio's return on equity. Company Net Margins Return on Equity Return on Assets INmune Bio N/A -103.03% -77.66% Phio Pharmaceuticals N/A -77.34% -70.87%

Phio Pharmaceuticals (PHIO) Competitors

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Closing price 07/2/2026 04:00 PM Eastern

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$1.01 +0.01 (+0.90%)

As of 07/2/2026 07:21 PM Eastern

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PHIO vs. HYPD, IXHL, MGX, APLM, and INMB

Should you buy Phio Pharmaceuticals stock or one of its competitors? MarketBeat compares Phio Pharmaceuticals with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Phio Pharmaceuticals include Hyperion DeFi (HYPD), Incannex Healthcare (IXHL), Metagenomi (MGX), Apollomics (APLM), and INmune Bio (INMB). These companies are all part of the "pharmaceutical products" industry.

How does Phio Pharmaceuticals compare to Hyperion DeFi?

Phio Pharmaceuticals (NASDAQ:PHIO) and Hyperion DeFi (NASDAQ:HYPD) are both small-cap medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their media sentiment, earnings, analyst recommendations, institutional ownership, dividends, risk, valuation and profitability.

Phio Pharmaceuticals has higher earnings, but lower revenue than Hyperion DeFi. Phio Pharmaceuticals is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Phio Pharmaceuticals	N/A	N/A	-$8.70M	-$1.38	N/A
Hyperion DeFi	$810K	58.21	-$45.31M	-$9.95	N/A

Phio Pharmaceuticals has a beta of 0.81, suggesting that its stock price is 19% less volatile than the broader market. Comparatively, Hyperion DeFi has a beta of 2.49, suggesting that its stock price is 149% more volatile than the broader market.

Phio Pharmaceuticals' return on equity of -77.34% beat Hyperion DeFi's return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Phio Pharmaceuticals	N/A	-77.34%	-70.87%
Hyperion DeFi	N/A	-91.59%	-73.08%

In the previous week, Hyperion DeFi had 1 more articles in the media than Phio Pharmaceuticals. MarketBeat recorded 2 mentions for Hyperion DeFi and 1 mentions for Phio Pharmaceuticals. Phio Pharmaceuticals' average media sentiment score of 1.00 beat Hyperion DeFi's score of 0.88 indicating that Phio Pharmaceuticals is being referred to more favorably in the media.

Company	Overall Sentiment
Phio Pharmaceuticals	Positive
Hyperion DeFi	Positive

Phio Pharmaceuticals presently has a consensus target price of $14.00, indicating a potential upside of 1,300.00%. Hyperion DeFi has a consensus target price of $6.95, indicating a potential upside of 123.47%. Given Phio Pharmaceuticals' higher possible upside, research analysts plainly believe Phio Pharmaceuticals is more favorable than Hyperion DeFi.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Phio Pharmaceuticals	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00
Hyperion DeFi	2 Sell rating(s)	0 Hold rating(s)	2 Buy rating(s)	0 Strong Buy rating(s)	2.00

57.3% of Phio Pharmaceuticals shares are owned by institutional investors. Comparatively, 25.8% of Hyperion DeFi shares are owned by institutional investors. 0.9% of Phio Pharmaceuticals shares are owned by insiders. Comparatively, 7.5% of Hyperion DeFi shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Summary

Phio Pharmaceuticals beats Hyperion DeFi on 7 of the 13 factors compared between the two stocks.

How does Phio Pharmaceuticals compare to Incannex Healthcare?

Incannex Healthcare (NASDAQ:IXHL) and Phio Pharmaceuticals (NASDAQ:PHIO) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, profitability, earnings, media sentiment, risk, analyst recommendations, institutional ownership and dividends.

Phio Pharmaceuticals has lower revenue, but higher earnings than Incannex Healthcare. Incannex Healthcare is trading at a lower price-to-earnings ratio than Phio Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Incannex Healthcare	$90K	528.01	-$46.88M	-$1.55	N/A
Phio Pharmaceuticals	N/A	N/A	-$8.70M	-$1.38	N/A

Incannex Healthcare currently has a consensus price target of $18.00, suggesting a potential upside of 353.40%. Phio Pharmaceuticals has a consensus price target of $14.00, suggesting a potential upside of 1,300.00%. Given Phio Pharmaceuticals' higher possible upside, analysts clearly believe Phio Pharmaceuticals is more favorable than Incannex Healthcare.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Incannex Healthcare	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00
Phio Pharmaceuticals	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00

Incannex Healthcare has a beta of 6.95, meaning that its stock price is 595% more volatile than the broader market. Comparatively, Phio Pharmaceuticals has a beta of 0.81, meaning that its stock price is 19% less volatile than the broader market.

0.4% of Incannex Healthcare shares are held by institutional investors. Comparatively, 57.3% of Phio Pharmaceuticals shares are held by institutional investors. 1.3% of Incannex Healthcare shares are held by insiders. Comparatively, 0.9% of Phio Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Phio Pharmaceuticals' return on equity of -77.34% beat Incannex Healthcare's return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Incannex Healthcare	N/A	-81.01%	-76.11%
Phio Pharmaceuticals	N/A	-77.34%	-70.87%

In the previous week, Phio Pharmaceuticals had 1 more articles in the media than Incannex Healthcare. MarketBeat recorded 1 mentions for Phio Pharmaceuticals and 0 mentions for Incannex Healthcare. Phio Pharmaceuticals' average media sentiment score of 1.00 beat Incannex Healthcare's score of 0.00 indicating that Phio Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
Incannex Healthcare	Neutral
Phio Pharmaceuticals	Positive

Summary

Phio Pharmaceuticals beats Incannex Healthcare on 9 of the 12 factors compared between the two stocks.

How does Phio Pharmaceuticals compare to Metagenomi?

Metagenomi (NASDAQ:MGX) and Phio Pharmaceuticals (NASDAQ:PHIO) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, earnings, valuation, risk, dividends, analyst recommendations, institutional ownership and media sentiment.

Metagenomi has a beta of 0.69, meaning that its share price is 31% less volatile than the broader market. Comparatively, Phio Pharmaceuticals has a beta of 0.81, meaning that its share price is 19% less volatile than the broader market.

Phio Pharmaceuticals has a net margin of 0.00% compared to Metagenomi's net margin of -384.61%. Metagenomi's return on equity of -51.23% beat Phio Pharmaceuticals' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Metagenomi	-384.61%	-51.23%	-36.62%
Phio Pharmaceuticals	N/A	-77.34%	-70.87%

57.3% of Phio Pharmaceuticals shares are held by institutional investors. 12.5% of Metagenomi shares are held by company insiders. Comparatively, 0.9% of Phio Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Phio Pharmaceuticals had 1 more articles in the media than Metagenomi. MarketBeat recorded 1 mentions for Phio Pharmaceuticals and 0 mentions for Metagenomi. Phio Pharmaceuticals' average media sentiment score of 1.00 beat Metagenomi's score of 0.00 indicating that Phio Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
Metagenomi	Neutral
Phio Pharmaceuticals	Positive

Phio Pharmaceuticals has lower revenue, but higher earnings than Metagenomi. Phio Pharmaceuticals is trading at a lower price-to-earnings ratio than Metagenomi, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Metagenomi	$25.21M	1.88	-$87.87M	-$2.30	N/A
Phio Pharmaceuticals	N/A	N/A	-$8.70M	-$1.38	N/A

Metagenomi presently has a consensus target price of $9.00, suggesting a potential upside of 614.29%. Phio Pharmaceuticals has a consensus target price of $14.00, suggesting a potential upside of 1,300.00%. Given Phio Pharmaceuticals' higher probable upside, analysts clearly believe Phio Pharmaceuticals is more favorable than Metagenomi.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Metagenomi	1 Sell rating(s)	0 Hold rating(s)	3 Buy rating(s)	1 Strong Buy rating(s)	2.80
Phio Pharmaceuticals	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00

Summary

Metagenomi and Phio Pharmaceuticals tied by winning 8 of the 16 factors compared between the two stocks.

How does Phio Pharmaceuticals compare to Apollomics?

Apollomics (NASDAQ:APLM) and Phio Pharmaceuticals (NASDAQ:PHIO) are both small-cap medical companies, but which is the superior investment? We will compare the two companies based on the strength of their valuation, profitability, dividends, media sentiment, risk, analyst recommendations, earnings and institutional ownership.

In the previous week, Apollomics and Apollomics both had 1 articles in the media. Phio Pharmaceuticals' average media sentiment score of 1.00 beat Apollomics' score of 0.59 indicating that Phio Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
Apollomics	Positive
Phio Pharmaceuticals	Positive

Apollomics' return on equity of 0.00% beat Phio Pharmaceuticals' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Apollomics	N/A	N/A	N/A
Phio Pharmaceuticals	N/A	-77.34%	-70.87%

Phio Pharmaceuticals has lower revenue, but higher earnings than Apollomics.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Apollomics	$8.50M	5.06	-$10.94M	N/A	N/A
Phio Pharmaceuticals	N/A	N/A	-$8.70M	-$1.38	N/A

19.1% of Apollomics shares are held by institutional investors. Comparatively, 57.3% of Phio Pharmaceuticals shares are held by institutional investors. 0.9% of Phio Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Phio Pharmaceuticals has a consensus price target of $14.00, suggesting a potential upside of 1,300.00%. Given Phio Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Phio Pharmaceuticals is more favorable than Apollomics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Apollomics	1 Sell rating(s)	0 Hold rating(s)	0 Buy rating(s)	0 Strong Buy rating(s)	1.00
Phio Pharmaceuticals	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00

Apollomics has a beta of 1.44, indicating that its stock price is 44% more volatile than the broader market. Comparatively, Phio Pharmaceuticals has a beta of 0.81, indicating that its stock price is 19% less volatile than the broader market.

Summary

Phio Pharmaceuticals beats Apollomics on 7 of the 11 factors compared between the two stocks.

How does Phio Pharmaceuticals compare to INmune Bio?

INmune Bio (NASDAQ:INMB) and Phio Pharmaceuticals (NASDAQ:PHIO) are both small-cap medical companies, but which is the better stock? We will compare the two businesses based on the strength of their analyst recommendations, valuation, institutional ownership, risk, profitability, dividends, earnings and media sentiment.

Phio Pharmaceuticals has a consensus target price of $14.00, indicating a potential upside of 1,300.00%. Given Phio Pharmaceuticals' higher probable upside, analysts plainly believe Phio Pharmaceuticals is more favorable than INmune Bio.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
INmune Bio	1 Sell rating(s)	0 Hold rating(s)	0 Buy rating(s)	1 Strong Buy rating(s)	2.50
Phio Pharmaceuticals	1 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	2.00

Phio Pharmaceuticals has lower revenue, but higher earnings than INmune Bio. INmune Bio is trading at a lower price-to-earnings ratio than Phio Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
INmune Bio	$50K	903.72	-$45.93M	-$1.67	N/A
Phio Pharmaceuticals	N/A	N/A	-$8.70M	-$1.38	N/A

In the previous week, INmune Bio had 1 more articles in the media than Phio Pharmaceuticals. MarketBeat recorded 2 mentions for INmune Bio and 1 mentions for Phio Pharmaceuticals. Phio Pharmaceuticals' average media sentiment score of 1.00 beat INmune Bio's score of 0.00 indicating that Phio Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
INmune Bio	Neutral
Phio Pharmaceuticals	Positive

Phio Pharmaceuticals' return on equity of -77.34% beat INmune Bio's return on equity.

Company	Net Margins	Return on Equity	Return on Assets
INmune Bio	N/A	-103.03%	-77.66%
Phio Pharmaceuticals	N/A	-77.34%	-70.87%

INmune Bio has a beta of 0.97, indicating that its share price is 3% less volatile than the broader market. Comparatively, Phio Pharmaceuticals has a beta of 0.81, indicating that its share price is 19% less volatile than the broader market.

12.7% of INmune Bio shares are owned by institutional investors. Comparatively, 57.3% of Phio Pharmaceuticals shares are owned by institutional investors. 21.4% of INmune Bio shares are owned by company insiders. Comparatively, 0.9% of Phio Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Summary

Phio Pharmaceuticals beats INmune Bio on 9 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PHIO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.

PHIO vs. The Competition

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Metric	Phio Pharmaceuticals	MED Industry	Medical Sector	NASDAQ Exchange
Market Cap	$11.62M	$3.10B	$7.16B	$12.48B
Dividend Yield	N/A	2.05%	2.66%	6.52%
P/E Ratio	-0.72	20.06	28.02	24.70
Price / Sales	N/A	360.34	540.55	99.42
Price / Cash	N/A	57.49	49.26	57.09
Price / Book	0.53	4.32	10.96	6.46
Net Income	-$8.70M	$64.45M	$3.57B	$337.01M
7 Day Performance	3.09%	2.97%	2.12%	1.69%
1 Month Performance	-5.66%	6.83%	5.25%	3.81%
1 Year Performance	-58.92%	29.07%	33.29%	23.90%

Phio Pharmaceuticals Competitors List

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Company	MarketRank	Share Price	Analysts' Price Target	1Y Price Performance	Market Cap	Revenue	P/E Ratio	Employee Count	Indicator(s)
PHIO Phio Pharmaceuticals	4.1636 of 5 stars	$1.00 flat	$14.00 +1,300.0%	-58.9%	$11.62M	N/A	N/A	10	Positive News
HYPD Hyperion DeFi	3.4216 of 5 stars	$3.10 -2.5%	$5.65 +82.3%	-80.5%	$46.99M	$1.04M	N/A	40	Positive News Analyst Forecast
IXHL Incannex Healthcare	2.1917 of 5 stars	$3.75 +3.6%	$18.00 +380.0%	-36.7%	$45.01M	$90K	N/A	3	Gap Down
MGX Metagenomi	2.3722 of 5 stars	$1.18 -2.1%	$9.00 +666.0%	-23.8%	$44.24M	$22.33M	N/A	236
APLM Apollomics	0.7489 of 5 stars	$19.95 -6.1%	N/A	+200.7%	$43.80M	$8.50M	N/A	45

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This page (NASDAQ:PHIO) was last updated on 7/5/2026 by MarketBeat.com Staff.

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Phio Pharmaceuticals (PHIO) Competitors

PHIO vs. HYPD, IXHL, MGX, APLM, and INMB

How does Phio Pharmaceuticals compare to Hyperion DeFi?

Summary

How does Phio Pharmaceuticals compare to Incannex Healthcare?

Summary

How does Phio Pharmaceuticals compare to Metagenomi?

Summary

How does Phio Pharmaceuticals compare to Apollomics?

Summary

How does Phio Pharmaceuticals compare to INmune Bio?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

PHIO vs. The Competition

Phio Pharmaceuticals Competitors List

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Stock Ideas and Recommendations

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Phio Pharmaceuticals (PHIO) Competitors

PHIO vs. HYPD, IXHL, MGX, APLM, and INMB

How does Phio Pharmaceuticals compare to Hyperion DeFi?

Which has preferable valuation and earnings, PHIO or HYPD?

Which has more risk & volatility, PHIO or HYPD?

Is PHIO or HYPD more profitable?

Does the media prefer PHIO or HYPD?

Do analysts prefer PHIO or HYPD?

Do institutionals and insiders have more ownership in PHIO or HYPD?

Summary

How does Phio Pharmaceuticals compare to Incannex Healthcare?

Which has better valuation and earnings, IXHL or PHIO?

Do analysts prefer IXHL or PHIO?

Which has more risk and volatility, IXHL or PHIO?

Do institutionals & insiders hold more shares of IXHL or PHIO?

Is IXHL or PHIO more profitable?

Does the media prefer IXHL or PHIO?

Summary

How does Phio Pharmaceuticals compare to Metagenomi?

Which has more volatility and risk, MGX or PHIO?

Is MGX or PHIO more profitable?

Do institutionals and insiders hold more shares of MGX or PHIO?

Does the media prefer MGX or PHIO?

Which has higher earnings & valuation, MGX or PHIO?

Do analysts prefer MGX or PHIO?

Summary

How does Phio Pharmaceuticals compare to Apollomics?

Does the media prefer APLM or PHIO?

Is APLM or PHIO more profitable?

Which has higher valuation and earnings, APLM or PHIO?

Do institutionals & insiders hold more shares of APLM or PHIO?

Do analysts recommend APLM or PHIO?

Which has more volatility and risk, APLM or PHIO?

Summary

How does Phio Pharmaceuticals compare to INmune Bio?

Do analysts recommend INMB or PHIO?

Which has preferable earnings and valuation, INMB or PHIO?

Does the media favor INMB or PHIO?

Is INMB or PHIO more profitable?

Which has more volatility & risk, INMB or PHIO?

Do institutionals and insiders have more ownership in INMB or PHIO?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

PHIO vs. The Competition

Phio Pharmaceuticals Competitors List

Related Companies and Tools

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools