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Prelude Therapeutics (PRLD) Competitors

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$3.67 -0.12 (-3.17%)
Closing price 10/2/2026 04:00 PM Eastern
Extended Trading
$3.66 0.00 (-0.14%)
As of 10/2/2026 07:30 PM Eastern
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PRLD vs. KARD, TYRA, MAZE, AVBP, and OMER

Should you buy Prelude Therapeutics stock or one of its competitors? Prelude Therapeutics's main competitors and comparable companies include Kardigan (KARD), Tyra Biosciences (TYRA), Maze Therapeutics (MAZE), ArriVent BioPharma (AVBP), and Omeros (OMER). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Prelude Therapeutics compare to Kardigan?

Kardigan (NASDAQ:KARD) and Prelude Therapeutics (NASDAQ:PRLD) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their profitability, valuation, risk, dividends, institutional ownership, media sentiment, analyst recommendations and earnings.

In the previous week, Kardigan had 2 more articles in the media than Prelude Therapeutics. MarketBeat recorded 5 mentions for Kardigan and 3 mentions for Prelude Therapeutics. Kardigan's average media sentiment score of 0.22 beat Prelude Therapeutics' score of 0.21 indicating that Kardigan is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Kardigan
1 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Prelude Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Kardigan has higher earnings, but lower revenue than Prelude Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
KardiganN/AN/AN/AN/AN/A
Prelude Therapeutics$12.14M24.12-$99.50M-$0.73N/A

Kardigan's return on equity of 0.00% beat Prelude Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
KardiganN/A N/A N/A
Prelude Therapeutics N/A -75.35%-44.39%

79.7% of Prelude Therapeutics shares are held by institutional investors. 49.2% of Prelude Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Kardigan presently has a consensus target price of $42.25, indicating a potential upside of 185.67%. Prelude Therapeutics has a consensus target price of $8.75, indicating a potential upside of 138.42%. Given Kardigan's higher possible upside, research analysts clearly believe Kardigan is more favorable than Prelude Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Kardigan
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Prelude Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50

Summary

Kardigan beats Prelude Therapeutics on 5 of the 8 factors compared between the two stocks.

How does Prelude Therapeutics compare to Tyra Biosciences?

Prelude Therapeutics (NASDAQ:PRLD) and Tyra Biosciences (NASDAQ:TYRA) are both small-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their institutional ownership, risk, analyst recommendations, valuation, profitability, earnings, dividends and media sentiment.

Prelude Therapeutics currently has a consensus price target of $8.75, suggesting a potential upside of 138.42%. Tyra Biosciences has a consensus price target of $46.89, suggesting a potential upside of 129.51%. Given Prelude Therapeutics' higher possible upside, analysts clearly believe Prelude Therapeutics is more favorable than Tyra Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prelude Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Tyra Biosciences
1 Sell rating(s)
1 Hold rating(s)
11 Buy rating(s)
1 Strong Buy rating(s)
2.86

79.7% of Prelude Therapeutics shares are owned by institutional investors. Comparatively, 84.1% of Tyra Biosciences shares are owned by institutional investors. 49.2% of Prelude Therapeutics shares are owned by insiders. Comparatively, 12.5% of Tyra Biosciences shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

In the previous week, Prelude Therapeutics and Prelude Therapeutics both had 3 articles in the media. Tyra Biosciences' average media sentiment score of 0.67 beat Prelude Therapeutics' score of 0.21 indicating that Tyra Biosciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prelude Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Tyra Biosciences
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Prelude Therapeutics has a beta of 0.97, indicating that its share price is 3% less volatile than the broader market. Comparatively, Tyra Biosciences has a beta of 0.75, indicating that its share price is 25% less volatile than the broader market.

Prelude Therapeutics has higher revenue and earnings than Tyra Biosciences. Tyra Biosciences is trading at a lower price-to-earnings ratio than Prelude Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prelude Therapeutics$12.14M24.12-$99.50M-$0.73N/A
Tyra BiosciencesN/AN/A-$119.95M-$2.40N/A

Tyra Biosciences' return on equity of -46.39% beat Prelude Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Prelude TherapeuticsN/A -75.35% -44.39%
Tyra Biosciences N/A -46.39%-43.07%

Summary

Prelude Therapeutics and Tyra Biosciences tied by winning 7 of the 14 factors compared between the two stocks.

How does Prelude Therapeutics compare to Maze Therapeutics?

Prelude Therapeutics (NASDAQ:PRLD) and Maze Therapeutics (NASDAQ:MAZE) are both small-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their valuation, risk, earnings, institutional ownership, media sentiment, profitability, dividends and analyst recommendations.

Maze Therapeutics' return on equity of -34.94% beat Prelude Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Prelude TherapeuticsN/A -75.35% -44.39%
Maze Therapeutics N/A -34.94%-30.18%

79.7% of Prelude Therapeutics shares are owned by institutional investors. 49.2% of Prelude Therapeutics shares are owned by company insiders. Comparatively, 5.3% of Maze Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Prelude Therapeutics has higher earnings, but lower revenue than Maze Therapeutics. Maze Therapeutics is trading at a lower price-to-earnings ratio than Prelude Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prelude Therapeutics$12.14M24.12-$99.50M-$0.73N/A
Maze Therapeutics$167.50M8.77-$131.12M-$2.52N/A

Prelude Therapeutics has a beta of 0.97, meaning that its share price is 3% less volatile than the broader market. Comparatively, Maze Therapeutics has a beta of 2.16, meaning that its share price is 116% more volatile than the broader market.

In the previous week, Maze Therapeutics had 9 more articles in the media than Prelude Therapeutics. MarketBeat recorded 12 mentions for Maze Therapeutics and 3 mentions for Prelude Therapeutics. Maze Therapeutics' average media sentiment score of 0.57 beat Prelude Therapeutics' score of 0.21 indicating that Maze Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prelude Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Maze Therapeutics
6 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Prelude Therapeutics presently has a consensus price target of $8.75, indicating a potential upside of 138.42%. Maze Therapeutics has a consensus price target of $63.40, indicating a potential upside of 139.88%. Given Maze Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Maze Therapeutics is more favorable than Prelude Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prelude Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Maze Therapeutics
1 Sell rating(s)
0 Hold rating(s)
9 Buy rating(s)
3 Strong Buy rating(s)
3.08

Summary

Maze Therapeutics beats Prelude Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Prelude Therapeutics compare to ArriVent BioPharma?

ArriVent BioPharma (NASDAQ:AVBP) and Prelude Therapeutics (NASDAQ:PRLD) are both small-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their media sentiment, risk, valuation, earnings, dividends, institutional ownership, profitability and analyst recommendations.

ArriVent BioPharma currently has a consensus target price of $44.86, suggesting a potential upside of 58.67%. Prelude Therapeutics has a consensus target price of $8.75, suggesting a potential upside of 138.42%. Given Prelude Therapeutics' higher probable upside, analysts clearly believe Prelude Therapeutics is more favorable than ArriVent BioPharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ArriVent BioPharma
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.70
Prelude Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50

Prelude Therapeutics has higher revenue and earnings than ArriVent BioPharma. ArriVent BioPharma is trading at a lower price-to-earnings ratio than Prelude Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ArriVent BioPharmaN/AN/A-$166.31M-$3.62N/A
Prelude Therapeutics$12.14M24.12-$99.50M-$0.73N/A

In the previous week, Prelude Therapeutics had 2 more articles in the media than ArriVent BioPharma. MarketBeat recorded 3 mentions for Prelude Therapeutics and 1 mentions for ArriVent BioPharma. ArriVent BioPharma's average media sentiment score of 0.90 beat Prelude Therapeutics' score of 0.21 indicating that ArriVent BioPharma is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
ArriVent BioPharma
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Prelude Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

9.5% of ArriVent BioPharma shares are owned by institutional investors. Comparatively, 79.7% of Prelude Therapeutics shares are owned by institutional investors. 8.6% of ArriVent BioPharma shares are owned by insiders. Comparatively, 49.2% of Prelude Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

ArriVent BioPharma has a beta of 1.34, meaning that its stock price is 34% more volatile than the broader market. Comparatively, Prelude Therapeutics has a beta of 0.97, meaning that its stock price is 3% less volatile than the broader market.

ArriVent BioPharma's return on equity of -50.26% beat Prelude Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
ArriVent BioPharmaN/A -50.26% -46.66%
Prelude Therapeutics N/A -75.35%-44.39%

Summary

Prelude Therapeutics beats ArriVent BioPharma on 9 of the 14 factors compared between the two stocks.

How does Prelude Therapeutics compare to Omeros?

Omeros (NASDAQ:OMER) and Prelude Therapeutics (NASDAQ:PRLD) are both small-cap healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their valuation, dividends, institutional ownership, profitability, earnings, media sentiment, analyst recommendations and risk.

Prelude Therapeutics' return on equity of -75.35% beat Omeros' return on equity.

Company Net Margins Return on Equity Return on Assets
OmerosN/A -164.92% 69.41%
Prelude Therapeutics N/A -75.35%-44.39%

Omeros has a beta of 2.57, indicating that its stock price is 157% more volatile than the broader market. Comparatively, Prelude Therapeutics has a beta of 0.97, indicating that its stock price is 3% less volatile than the broader market.

48.8% of Omeros shares are owned by institutional investors. Comparatively, 79.7% of Prelude Therapeutics shares are owned by institutional investors. 10.5% of Omeros shares are owned by company insiders. Comparatively, 49.2% of Prelude Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Omeros currently has a consensus price target of $34.00, suggesting a potential upside of 82.70%. Prelude Therapeutics has a consensus price target of $8.75, suggesting a potential upside of 138.42%. Given Prelude Therapeutics' higher probable upside, analysts clearly believe Prelude Therapeutics is more favorable than Omeros.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Omeros
0 Sell rating(s)
3 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.71
Prelude Therapeutics
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50

Omeros has higher earnings, but lower revenue than Prelude Therapeutics. Prelude Therapeutics is trading at a lower price-to-earnings ratio than Omeros, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
OmerosN/AN/A-$3.35M$1.2814.54
Prelude Therapeutics$12.14M24.12-$99.50M-$0.73N/A

In the previous week, Omeros and Omeros both had 3 articles in the media. Omeros' average media sentiment score of 0.67 beat Prelude Therapeutics' score of 0.21 indicating that Omeros is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Omeros
3 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Prelude Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Omeros beats Prelude Therapeutics on 8 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PRLD and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PRLD vs. The Competition

MetricPrelude TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$292.88M$3.87B$7.14B$13.22B
Dividend YieldN/A3.64%2.53%16.78%
P/E RatioN/A13.13275.9726.04
Price / Sales24.121,430.61672.86109.50
Price / CashN/A122.6077.6051.75
Price / Book3.3716.6310.936.31
Net Income-$99.50M-$22.71M$3.51B$362.16M
7 Day Performance-5.41%-2.99%-2.00%-1.66%
1 Month Performance-30.10%-10.60%-6.15%-4.50%
1 Year Performance149.66%19.44%7.44%2.06%

Prelude Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PRLD
Prelude Therapeutics
2.1571 of 5 stars
$3.67
-3.2%
$8.75
+138.4%
+154.9%$292.88M$12.14MN/A79
KARD
Kardigan
3.1968 of 5 stars
$16.28
-0.1%
$42.25
+159.5%
N/A$1.52BN/AN/A241
TYRA
Tyra Biosciences
3.3501 of 5 stars
$25.27
-1.5%
$46.89
+85.5%
+52.6%$1.51BN/AN/A87
MAZE
Maze Therapeutics
2.6883 of 5 stars
$27.02
+20.7%
$66.00
+144.2%
-0.3%$1.50B$167.50MN/A141
AVBP
ArriVent BioPharma
2.6803 of 5 stars
$30.36
+2.1%
$44.86
+47.8%
+50.1%$1.50BN/AN/A77

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This page (NASDAQ:PRLD) was last updated on 10/3/2026 by MarketBeat.com Staff.
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