| 06/10/2026 3:44 PM | 667, L.P. (1551139) Reporting Baker Bros. Advisors (0) GP BAKER BROS. ADVISORS LP (1263508) Reporting Baker Brothers Life Sciences LP (1363364) Reporting BAKER FELIX (1087940) Reporting BAKER JULIAN (1087939) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/10/2026 3:11 PM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 06/10/2026 3:12 PM | FRIEDMAN PAUL A (1236927) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/10/2026 3:13 PM | Prelude Therapeutics (1678660) Issuer Sandor Victor (1620368) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/10/2026 3:13 PM | Bonita David P (1572451) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/10/2026 3:15 PM | Babler Martin (1435618) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/10/2026 3:15 PM | Dorton Katina (1617541) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/12/2026 6:11 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 05/12/2026 6:19 AM | Prelude Therapeutics (1678660) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 04/28/2026 4:13 PM | Kolchinsky Peter (1384859) Reporting Prelude Therapeutics (1678660) Issuer RA Capital Healthcare Fund LP (1315082) Reporting RA CAPITAL MANAGEMENT, L.P. (1346824) Reporting Shah Rajeev M. (1619841) Reporting | Form 3 Initial statement of beneficial ownership of securities | |
| 04/28/2026 4:14 PM | Kolchinsky Peter (1384859) Reporting Prelude Therapeutics (1678660) Issuer RA Capital Healthcare Fund LP (1315082) Reporting RA CAPITAL MANAGEMENT, L.P. (1346824) Reporting Shah Rajeev M. (1619841) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
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| 04/28/2026 4:16 PM | Prelude Therapeutics (1678660) Subject RA CAPITAL MANAGEMENT, L.P. (1346824) Filed by | Form SCHEDULE 13G | |
| 04/23/2026 7:42 PM | ORBIMED ADVISORS LLC (1055951) Filed by Prelude Therapeutics (1678660) Subject | Form SCHEDULE 13D/A | |
| 04/23/2026 5:48 PM | ORBIMED ADVISORS LLC (1055951) Reporting OrbiMed Capital GP VI LLC (1682115) Reporting ORBIMED CAPITAL LLC (1157524) Reporting OrbiMed Genesis GP LLC (1808744) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/23/2026 5:50 PM | Bonita David P (1572451) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/22/2026 3:15 PM | 667, L.P. (1551139) Reporting Baker Bros. Advisors (0) GP BAKER BROS. ADVISORS LP (1263508) Reporting Baker Brothers Life Sciences LP (1363364) Reporting BAKER FELIX (1087940) Reporting BAKER JULIAN (1087939) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/22/2026 3:22 PM | BAKER BROS. ADVISORS LP (1263508) Filed by Prelude Therapeutics (1678660) Subject | Form SCHEDULE 13D/A | |
| 04/20/2026 5:16 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/15/2026 3:19 PM | Morris Charles Q (1489966) Reporting Prelude Therapeutics (1678660) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 04/15/2026 6:41 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/19/2026 6:39 PM | Brusky Sean P. (1884733) Reporting Prelude Therapeutics (1678660) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 03/12/2026 3:16 PM | Prelude Therapeutics (1678660) Filer | Form 424B5 | |
| 03/12/2026 3:18 PM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/10/2026 7:40 AM | Prelude Therapeutics (1678660) Filer | Form S-8 Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans | |
| 03/10/2026 7:17 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/10/2026 7:24 AM | Prelude Therapeutics (1678660) Filer | Form 10-K Annual report pursuant to Section 13 or 15(d) | |
| 02/13/2026 3:02 PM | Prelude Therapeutics (1678660) Subject Vaddi Krishna (1824633) Filed by | Form SCHEDULE 13G/A | |
| 02/05/2026 3:10 PM | Prelude Therapeutics (1678660) Issuer Vaddi Krishna (1824633) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 3:11 PM | Lim Bryant David (1752888) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 3:12 PM | Prelude Therapeutics (1678660) Issuer Scherle Peggy (1824632) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/05/2026 3:14 PM | Combs Andrew (1825005) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/03/2026 8:11 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 01/09/2026 6:30 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 12/16/2025 11:15 PM | Prelude Therapeutics (1678660) Filer | Form EFFECT | |
| 11/12/2025 6:07 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 11/12/2025 6:15 AM | Prelude Therapeutics (1678660) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 11/07/2025 3:28 PM | Prelude Therapeutics (1678660) Issuer Sandor Victor (1620368) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 11/04/2025 7:53 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 10/17/2025 6:40 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 10/07/2025 6:05 AM | Huang Jane (1683913) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 09/19/2025 6:41 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
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| 08/14/2025 6:23 AM | Prelude Therapeutics (1678660) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 08/14/2025 6:07 AM | Prelude Therapeutics (1678660) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 07/08/2025 3:06 PM | Huang Jane (1683913) Reporting Prelude Therapeutics (1678660) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |