| 05/26/2026 3:30 PM | Spruce Biosciences (1683553) Issuer Walbert Keli (2051489) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/26/2026 3:30 PM | Barretto-Ko Percival (1978654) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/26/2026 3:30 PM | GREY MICHAEL G (1240122) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/26/2026 3:30 PM | SIMPSON CAMILLA V (1822557) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/26/2026 3:30 PM | SPIEGELMAN DANIEL K (1238403) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/26/2026 3:02 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 05/15/2026 3:47 PM | Alyeska Investment Group, L.P. (1453072) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G/A | |
| 05/15/2026 11:02 AM | Spruce Biosciences (1683553) Subject Squadron Capital Management LLC (2050709) Filed by | Form SCHEDULE 13G/A | |
| 05/15/2026 6:24 AM | Spruce Biosciences (1683553) Subject WELLINGTON MANAGEMENT GROUP LLP (902219) Filed by | Form SCHEDULE 13G/A | |
| 05/13/2026 3:06 PM | Spruce Biosciences (1683553) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 05/13/2026 7:05 AM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
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| 05/07/2026 4:13 PM | Ikarian Capital, LLC (1778253) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G/A | |
| 04/21/2026 4:23 PM | Spruce Biosciences (1683553) Filer | Form 424B5 | |
| 04/20/2026 3:02 PM | Spruce Biosciences (1683553) Filer | Form 424B5 | |
| 04/09/2026 4:06 PM | Spruce Biosciences (1683553) Filer | Form ARS | |
| 04/09/2026 4:02 PM | Spruce Biosciences (1683553) Filer | Form DEF 14A | |
| 04/09/2026 4:04 PM | Spruce Biosciences (1683553) Filer | Form DEFA14A | |
| 03/20/2026 4:04 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/09/2026 3:07 PM | Hooks Corwin Dale (1665347) Reporting Spruce Biosciences (1683553) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 03/09/2026 3:08 PM | Hooks Corwin Dale (1665347) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/09/2026 6:29 AM | Spruce Biosciences (1683553) Filer | Form S-8 Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans | |
| 03/09/2026 6:31 AM | Spruce Biosciences (1683553) Filer | Form 424B5 | |
| 03/09/2026 6:21 AM | Spruce Biosciences (1683553) Filer | Form 10-K Annual report pursuant to Section 13 or 15(d) | |
| 03/09/2026 6:23 AM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 02/24/2026 3:47 PM | INTEGRATED CORE STRATEGIES (0) US Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G | |
| 02/17/2026 7:16 PM | ADAR1 Capital Management, LLC (1940272) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G | |
| 02/17/2026 11:27 AM | Spruce Biosciences (1683553) Subject Squadron Capital Management LLC (2050709) Filed by | Form SCHEDULE 13G/A | |
| 02/10/2026 10:19 AM | Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G | |
| 02/05/2026 3:11 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 01/08/2026 7:05 AM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 01/05/2026 3:43 PM | Spruce Biosciences (1683553) Issuer Szwarcberg Javier B. (1903669) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/17/2025 3:56 PM | Spruce Biosciences (1683553) Issuer Szwarcberg Javier B. (1903669) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/17/2025 3:58 PM | Gharib Samir M. (1533302) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:52 PM | Spruce Biosciences (1683553) Issuer Szwarcberg Javier B. (1903669) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:54 PM | Gharib Samir M. (1533302) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:58 PM | GREY MICHAEL G (1240122) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 6:00 PM | SPIEGELMAN DANIEL K (1238403) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:50 PM | SIMPSON CAMILLA V (1822557) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:44 PM | Spruce Biosciences (1683553) Issuer Walbert Keli (2051489) Reporting | Form 3 Initial statement of beneficial ownership of securities | |
| 12/15/2025 5:46 PM | Spruce Biosciences (1683553) Issuer Walbert Keli (2051489) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/15/2025 5:47 PM | Barretto-Ko Percival (1978654) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
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| 12/15/2025 7:05 AM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 12/12/2025 6:03 PM | Spruce Biosciences (1683553) Issuer Szwarcberg Javier B. (1903669) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/12/2025 6:05 PM | Gharib Samir M. (1533302) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 12/12/2025 3:03 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 12/12/2025 3:08 PM | Spruce Biosciences (1683553) Filer | Form 424B3 | |
| 11/27/2025 11:15 PM | Spruce Biosciences (1683553) Filer | Form EFFECT | |
| 11/27/2025 11:15 PM | Spruce Biosciences (1683553) Filer | Form EFFECT | |
| 11/07/2025 3:30 PM | Ikarian Capital, LLC (1778253) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G/A | |
| 10/29/2025 4:15 PM | Spruce Biosciences (1683553) Filer | Form S-3 Registration statement under Securities Act of 1933 | |
| 10/29/2025 4:17 PM | Spruce Biosciences (1683553) Filer | Form S-3 Registration statement under Securities Act of 1933 | |
| 10/22/2025 3:15 PM | Spruce Biosciences (1683553) Issuer Szwarcberg Javier B. (1903669) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 10/22/2025 3:15 PM | Gharib Samir M. (1533302) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 10/16/2025 5:34 PM | Spruce Biosciences (1683553) Filer | Form D Notice of Exempt Offering of Securities | |
| 10/16/2025 4:10 PM | CITADEL ADVISORS LLC (1423053) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G | |
| 10/15/2025 3:30 PM | Martinez Gregory (2091748) Reporting Parkman Healthcare Partners LLC (1777015) Reporting Spruce Biosciences (1683553) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 10/15/2025 3:32 PM | Martinez Gregory (2091748) Reporting Parkman Healthcare Partners LLC (1777015) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 10/15/2025 2:11 PM | Spruce Biosciences (1683553) Subject Squadron Capital Management LLC (2050709) Filed by | Form SCHEDULE 13G | |
| 10/09/2025 4:33 PM | HealthCap VIII, L.P. (1783281) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13D/A | |
| 10/08/2025 7:53 PM | Parkman Healthcare Partners LLC (1777015) Reporting Spruce Biosciences (1683553) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 10/08/2025 7:55 PM | Parkman Healthcare Partners LLC (1777015) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 10/08/2025 3:07 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 10/08/2025 10:04 AM | Ikarian Capital, LLC (1778253) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G | |
| 08/14/2025 3:10 PM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 08/13/2025 3:26 PM | Radoff Bradley Louis (1380585) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G/A | |
| 08/13/2025 3:31 PM | Rock Springs Capital Management LP (1595725) Filed by Spruce Biosciences (1683553) Subject | Form SCHEDULE 13G/A | |
| 07/24/2025 6:30 PM | Muralidhar Bali (1784138) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:34 PM | Spruce Biosciences (1683553) Issuer Ways Kirk (1869391) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:35 PM | Aynechi Tiba (1669220) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:36 PM | Barretto-Ko Percival (1978654) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:36 PM | GREY MICHAEL G (1240122) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:38 PM | SIMPSON CAMILLA V (1822557) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/24/2025 6:38 PM | SPIEGELMAN DANIEL K (1238403) Reporting Spruce Biosciences (1683553) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/12/2025 7:05 AM | Spruce Biosciences (1683553) Filer | Form DEFA14A | |
| 06/12/2025 7:10 AM | Spruce Biosciences (1683553) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |