CryoPort Q4 2025 Earnings Report

CryoPort EPS Results

• Actual EPS: -$0.21
• Consensus EPS: -$0.19
• Beat/Miss: Missed by -$0.02
• One Year Ago EPS: N/A

CryoPort Revenue Results

• Actual Revenue: $45.45 million
• Expected Revenue: $42.92 million
• Beat/Miss: Beat by +$2.53 million
• YoY Revenue Growth: N/A

CryoPort Announcement Details

• Quarter: Q4 2025
• Date: 3/3/2026
• Time: After Market Closes
• Conference Call Date: Tuesday, March 3, 2026
• Conference Call Time: 5:00PM ET

CryoPort (NASDAQ:CYRX) (NASDAQ: CYRX) is a global provider of temperature-controlled logistics solutions for the life sciences industry. The company specializes in cryogenic shipping for critical biological materials, supporting the development, clinical testing and commercialization of cell and gene therapies, biologics, vaccines and reproductive medicine. By offering end-to-end supply chain management, CryoPort helps ensure the integrity and viability of temperature-sensitive products from point of origin to destination.

CryoPort’s product portfolio includes proprietary cryogenic dry shippers, advanced active and passive thermal packaging, and real-time data monitoring platforms. These solutions enable uninterrupted maintenance of ultra-low temperatures during transit, while providing customers with transparency and compliance documentation. In addition to specialized containers for liquid nitrogen-based shipments, CryoPort offers on-demand logistics services, temperature excursion management and supply chain optimization tools via its cloud-based CryoPortal platform.

Leveraging a global network of logistics partners, CryoPort delivers services across North America, Europe, Asia-Pacific and Latin America. The company’s 24/7 operations and qualified service centers help streamline regulatory requirements and minimize risk for research institutions, pharmaceutical and biotechnology companies, contract research organizations and cell therapy manufacturers. CryoPort continues to expand its infrastructure and technology offerings to support the growing demand for advanced therapy supply chains worldwide.

CryoPort Q4 2025 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: Full-year revenue from continuing operations was $176.2M, above the prior guidance range, with Q4 double-digit growth; management guided 2026 revenue of $190M–$194M and expects positive adjusted EBITDA in H2 2026.
• Positive Sentiment: Commercial cell & gene therapy momentum accelerated—commercial revenue rose 29% and now represents ~20% of revenue, while Cryoport supports a record 760 clinical trials and 20 commercial therapies, with 86 phase‑3 and 361 phase‑2 trials described as a "spring‑loaded" pipeline for future commercial revenue.
• Positive Sentiment: Operational discipline and product innovation showed progress: gross margin improved to 47% with a $12M YoY adjusted EBITDA improvement, plus investments in global supply‑chain centers and new MVE product offerings (Fusion 800, CryoVerse, integrated monitoring) and enterprise AI adoption.
• Neutral Sentiment: The sale of CRYOPDP to DHL delivered a meaningful capital infusion and a strategic partnership expected to expand APAC/EMEA reach, but management noted integration and full benefit realization will take time.
• Negative Sentiment: Guidance and upside remain sensitive to regulatory approvals, macro volatility and timing of commercial therapy ramps; product (MVE) sales are lumpy and management modeled only mid‑single‑digit product growth, leaving downside risk if approvals or commercial rollouts slow.

Presentation

[Operator]

Good afternoon. Welcome to Cryoport's fourth quarter and full year 2025 earnings conference call. All participants will start in a listen-only mode. Following the presentation, we will conduct a question-and-answer session.

[Operator]

If at any time during this call you require needed assistance, please press star zero for the operator. As a reminder, this call is being recorded. I will now turn the call over to your host, Todd Fromer from KCSA Strategic Communications. Please go ahead.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

Thank you, operator. Before we begin today, I would like to remind everyone that this conference call contains certain forward-looking statements. All statements that address our operating performance, events or developments that we expect or anticipate occurring in the future are forward-looking statements.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

These forward-looking statements are based on management's beliefs and assumptions and are information currently available to our management team. Our management team believes that these forward-looking statements are reasonable as and when made.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

However, you should not place undue reliance on any such forward-looking statements because such statements speak only as of the date when made. We do not undertake any obligation to publicly update or revise any forward-looking statements, whether as a result of new information or future events or otherwise, except as required by law.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

In addition, forward-looking statements are subject to certain risks and uncertainties that could cause actual results, events and developments to differ materially from our historical experience and our present expectations or projections.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

These risks and uncertainties include, but are not limited to, those described in Item 1A, Risk Factors, and elsewhere in our annual report on Form 10-K we filed with the Securities and Exchange Commission, and those described from time to time in the other reports which we file with the Securities and Exchange Commission.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

As a reminder, Cryoport has uploaded their fourth quarter and full year 2025 in review document to the main page of the Cryoport, Inc. website. This document provides a review of Cryoport's financial and operational performance and the general business outlook.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

Before I turn the call over to Jerry, please note that because of the strategic partnership that has been established with DHL and the related sale of CRYOPDP to DHL, CRYOPDP's financials, which were previously a part of Cryoport's Life Science and Services Reportable Segment, are now presented as discontinued operations.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

Cryoport previously provided 1/4ly historical information on this basis for fiscal year 2024 in our first 1/4 2025 in review document, which remains available on the Cryoport Inc. website. This information is intended to support the financial model modeling efforts of those needing this type of information.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

Please note that unless otherwise indicated, all revenue figures discussed today will refer to continuing operations. This includes Cryoport's fiscal year 2025 revenue guidance. It's now my pleasure to turn the call over to Mr.

[Todd Fromer, Managing Partner at KCSA Strategic Communications]

Jerrell Shelton, Chief Executive Officer of Cryoport. Jerry, the floor is yours.

[Jerrell Shelton, CEO at Cryoport]

Thank you, Todd. We have a great report for you today, ladies and gentlemen. Before we begin, with us this afternoon is our Chief Financial Officer, Robert Stefanovich, our Chief Scientific Officer, Mark Sawicki, and our Vice President of Corporate Development and Investor Relations, Thomas Heinzen.

[Jerrell Shelton, CEO at Cryoport]

Today, we reported our full year results for 2025, which was a year of strong progress for Cryoport. We delivered full year revenue from continuing operations of $176.2 million, exceeding the high end of our prior guidance and reflecting continued momentum across our core markets.

[Jerrell Shelton, CEO at Cryoport]

In the fourth quarter, we again achieved double-digit revenue growth driven by expanding commercial cell and gene therapy activity and revenue from the support of commercial cell and gene therapy, increasing 29% year-over-year to a record $33.4 million for the year.

[Jerrell Shelton, CEO at Cryoport]

Commercial cell and gene therapy revenue in the fourth quarter represented 20% of our overall revenue, while clinical trial revenue remains solid, growing 14% year-over-year to $47.1 million. We concluded 2025 supporting a record 760 clinical trials and 20 commercial therapies worldwide.

[Jerrell Shelton, CEO at Cryoport]

Our clinical trial support showed a net increase of 59 over the previous year and represented approximately 70% of total trials for the cell and gene therapy industry. Looking ahead to 2026, based on the information that we have, we anticipate another 13 BLA or MAA application filings, including 2 of which have already been filed, 9 new therapy approvals and an additional 2 approvals for label or geographic expansion. In the near term, Cryoport has 3 customers that are anticipating new therapy approval decisions in March and April of this year.

[Jerrell Shelton, CEO at Cryoport]

We believe our clinical trial pipeline is spring-loaded with 86 clinical trials in phase III and 361 clinical trials in phase II. Remember, most of the cell therapies that were approved today were from phase II. In our opinion, this market leading base will drive the growth of our commercial revenue in the near and the long term.

[Jerrell Shelton, CEO at Cryoport]

We continue to execute on our mission of expanding services to the life sciences by broadening our revenue streams and capturing more revenue per client. For 2025, revenue from our life sciences services segment increased 18% year-over-year, including 22% growth in biostorage, bioservices revenue.

[Jerrell Shelton, CEO at Cryoport]

Our performance reflects the expanding scale and scope of the clinical and commercial programs we support and the trust our customers place in our comprehensive end-to-end supply chain solutions.

[Jerrell Shelton, CEO at Cryoport]

While our primary focus remains on accelerating revenue growth and strengthening our market position, we continue to enhance our operational discipline across the organization as we advance on our pathway to profitability. In 2025, our cost reduction initiatives contributed to our gross margin of 47%, accompanied by a $12 million year-over-year improvement in adjusted EBITDA.

[Jerrell Shelton, CEO at Cryoport]

With our progress to date, we anticipate achieving positive adjusted EBITDA in the second half of 2026. Turning to our life sciences product segment, revenue grew 7% year-over-year in 2025. MVE Biological Solutions focused on execution and innovation and continues to further enhance its position as the global leader in the production of high-quality cryogenic systems. Recently, MVE launched its integrated condition monitoring solutions for its dry vapor shippers.

[Jerrell Shelton, CEO at Cryoport]

These novel condition monitoring solutions are integrated with each dewar, combining MVE's trusted cryogenic systems with advanced real-time conditioning monitoring technology supplied by Tec4med, another Cryoport company.

[Jerrell Shelton, CEO at Cryoport]

This system communicates with MVE's new CryoVerse, a cloud-based data capture and shipment management system. More recently, MVE launched its Fusion 800 Series, a revolutionary self-sustaining cryogenic freezer that can fit through a single door, which opens up substantial market opportunities.

[Jerrell Shelton, CEO at Cryoport]

These revolutionary cryogenic freezers eliminate the need for continuous liquid nitrogen supply, delivering exceptional reliability, safety, and sustainability in a compact footprint that is designed for settings where there is limited space and no readily available sources of liquid nitrogen. At Cryoport Systems, we increased our internal investments to support the traction that we are seeing across our broad portfolio of cell and gene therapy clients.

[Jerrell Shelton, CEO at Cryoport]

These strategic investments include the completion of our global supply chain center in Paris, France, the expansion of our Belgian operations to accommodate a key commercial client, and continuing the build-out of a global supply chain center in Santa Ana, California, which consolidates 3 existing facilities into a single expanded campus and enhances our service capabilities.

[Jerrell Shelton, CEO at Cryoport]

Of course, 1 topic of the day is AI, and it is certainly a tool we are embracing. As a part of our overall digital strategy, we are actively leveraging generative AI to enhance internal workflows and day-to-day operations.

[Jerrell Shelton, CEO at Cryoport]

Our focus is on enabling employees to use secure enterprise-approved generative AI tools to reduce manual tasks, accelerate execution, and improve accuracy and consistency of outcomes. These focused efforts emphasize practical adoption through education, hands-on support, and real production use cases tied directly to current business needs.

[Jerrell Shelton, CEO at Cryoport]

There's no doubt that AI is reshaping our business and will play a significant role in our future. In 2025, we reported a strategic partnership with DHL Group, which included DHL's acquisition of CRYOPDP. This action was completed in the second 1/4 of 2025 and provided Cryoport with a substantial capital infusion.

[Jerrell Shelton, CEO at Cryoport]

Over time, we expect this relationship to enhance our position in APAC and EMEIA regions and strengthen our competitive industry profile by leveraging the global scale and capabilities of this key strategic partner.

[Jerrell Shelton, CEO at Cryoport]

As a part of our continuing strategic initiatives to embed our market-leading solutions in the cell and gene therapy ecosystem and improve our growth trajectory, we expanded our global partnerships by entering into strategic collaborations with Cardinal Health and Parexel. Both companies are leveraging Cryoport Systems supply chain solutions in support of their complementary offerings in the cell and gene therapy space.

[Jerrell Shelton, CEO at Cryoport]

These partnerships reinforce our position as a market leader in this space and the industry's drive to standardize. As we enter 2026 and consider global macro puts and takes, we believe that our full year revenue guidance of $190 million-$194 million is an appropriate starting point for the year. On a second point, we anticipate achieving positive adjusted EBITDA in the second half of 2026. There's a lot coming into focus for us.

[Jerrell Shelton, CEO at Cryoport]

We're very excited about our prospects for 2026 and intend to capitalize on our current momentum, leadership position as the only pure-play temperature control supply chain integrated platform supporting the life sciences industry's largest portfolio of clinical and commercial cell and gene therapies.

[Jerrell Shelton, CEO at Cryoport]

This concludes my remarks, and I now will turn the call over to the operator to open the lines for your questions and our discussion.

[Operator]

Ladies and gentlemen, we will now begin the question and answer session. If you have a question, please press star followed by 1 on your touch-tone phone. You will hear a prompt that your hand has been raised.

[Operator]

If you'd like to withdraw from the polling process, please press star, then 2. If you're using a speakerphone, please make sure to list your handset before pressing any keys. Your first question comes from the line of Puneet Souda from Leerink Partners. Please go ahead.

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Yeah. Hi, guys. Thanks for taking my questions here. First one, Jerry, or maybe for Robert, you know, the guide that you have, high single digit, nearly 9% at midpoint for the year, could you elaborate a bit more on that? In terms of the segments, how should we think about the growth in biologics and the services and the MVE? Given the commercial momentum, commercial therapy momentum that you're seeing, how should we think about that growth in, you know, for the full year? I have a follow-up.

[Jerrell Shelton, CEO at Cryoport]

Okay. There are several questions, in that request, Puneet. I'd like to start to kind of parse those questions. Your question, the first 1 is how we feel about the... It was your last point about how we feel about the growth of cell and gene therapy for 2026. Is that correct?

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Yeah. More on the commercial side. I mean, what's your growth expectation for commercial therapies? Also if you can provide more color on the segments, each of the segments, the biologistics, the biostorage, and the MVE.

[Jerrell Shelton, CEO at Cryoport]

Okay. I'm gonna start with the last question first, and I'm gonna turn it over to Mark, okay? Because he has a view on this. We do expect continued progress with our existing customers, and we do expect to be bringing on other commercial therapies during the year. It does take time for them to ramp up, but they will have some impact.

[Jerrell Shelton, CEO at Cryoport]

Some of those that we've already brought on will have a continuing impact. Mark can name some of those names, perhaps, but, you know, we do try to avoid commenting directly on customers' business. In general, let me turn it over to Mark and let him answer the rest of that.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah. Puneet Souda, you know, obviously, we typically don't furnish guidance on composition by type. We did increase our commercial revenue by 29% in 2025, it's now eclipsing 20% of our overall revenue. You know, looking at 2026, you know, we do expect to have another good year in 2026, although we haven't disclosed the percentages associated with the commercial revenue at this point.

[Jerrell Shelton, CEO at Cryoport]

Puneet, there's no doubt about it that commercial therapy will be the driver of our future. I mean, it is the fastest-growing market. As I mentioned, you know, earlier, we're forecasting 9 new therapies in 2026, furthermore, we're forecasting 11 BLA/MAA filings to take place.

[Jerrell Shelton, CEO at Cryoport]

As I mentioned in my comments, we think we're spring-loaded. We have 86 trials in phase III, and then we have that, I think it was 391 in phase II. We're spring-loaded for a brilliant future. You know, even if half of those in phase III are approved, it's a fantastic for us.

[Robert Stefanovich, CFO at Cryoport]

Maybe just to add to it, you know, we've grown in all of our service lines, and we've grown on our product side as well. We expect, you know, to continue to see growth really in all of our product lines and service lines. We always talk about services growing double digit. Obviously, commercial therapy being the strong grower within that. And then on the product side, you know, single-digit growth, mid single digit growth, potentially high single digit growth, depending on how the demand is coming back.

[Jerrell Shelton, CEO at Cryoport]

On your second part of your question, Puneet, and if I've missed anything or we've missed anything, you can come back. Second part of your question on biostorage, bioservices. Biostorage, bioservices grew by 22% for this past year.

[Jerrell Shelton, CEO at Cryoport]

We're very pleased with that. It will continue to grow. In fact, we think it will pick up growth. I'm certain about that. It, of course, it is driven by cell therapy approval. It's a bright future for biostorage, bioservices. The third part of your question-

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Got it. Mm-hmm. Please go ahead.

[Jerrell Shelton, CEO at Cryoport]

Go ahead, Puneet.

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Yeah. Just on the MVE segment too, I mean, you had 2% growth, I believe, in the 1/4, and correct me if I'm wrong, how should we think about that?

[Jerrell Shelton, CEO at Cryoport]

Yeah, we were up 7% for the year. MVE is doing well. I mean, it's got... You know, we try to create these fountains of innovation throughout the company to make sure that we're moving ahead. MVE has introduced its, you know, the integrated monitoring systems that I mentioned during my comments.

[Jerrell Shelton, CEO at Cryoport]

Equally important are the things that will be introduced in this next 1/4 or in this 1/4, as a matter of fact. We've introduced the CryoVerse. You're gonna see MVE also adding some services to the product that it's producing. Remember that Fusion 800 opens up a vast new market for us.

[Jerrell Shelton, CEO at Cryoport]

I mean, vast, because there are many facilities on second floors in countries around the world.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

That can't get a large freezer on that second floor that need a large cryogenic freezer. Hospital pharmacies will like this product as we move forward and as allogeneic therapies are developed.

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Got it. Super. Just a quick clarification on Q1? Any color you can provide there would be helpful. I wanted to know if there are any flight cancellations, disruptions from any of the geopolitical flight cancellations that you're expecting in Q1. Thank you.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

There's nothing that we're expecting in terms of cancellations, and today there's been, minimal, impact on us. Nothing to report there at this time.

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Got it. Color on Q1?

[Robert Stefanovich, CFO at Cryoport]

Yeah, we've had a solid start to Q1, Puneet. We're not expecting a light 1 like some other life science companies are.

[Puneet Souda, Senior Research Analyst at Leerink Partners]

Right. Got it. All right, guys. Thank you.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Thanks, Puneet.

[Operator]

Your next question comes from the line of Anna Snopkowski from KeyBank Capital Markets. Please go ahead.

[Anna Kopkowski, Analyst at KeyBank Capital Markets]

Hi. Thanks for taking my question, and congrats on a great 1/4, and a nice guide for 26. Maybe to start, you mentioned in your prepared remarks that total biopharma funding, and CGT funding in particular, saw the strongest funding month in December in the past 4 years, I believe. I was wondering what the usual lag is between the funding environment and maybe your customer conversations or orders. A quick follow-up. Thank you.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah. Obviously funding is dependent on the client, but on average, you'll typically see that kick in after about half a year time frame. Some may be a little bit quicker, some may be a little bit slower, but it's a good average for you to consider.

[Anna Kopkowski, Analyst at KeyBank Capital Markets]

Okay, perfect. Maybe just touching on the margin side of things, you mentioned that you expect positive adjusted EBITDA, I think, in the second half of 2026. Could you just outline how you expect to get there, and what operational or cost reduction milestones need to happen in order to achieve this? Thank you.

[Robert Stefanovich, CFO at Cryoport]

Yeah. It's really less about cost reduction milestones. You may recall in 2024, early 2025, we did take some initiatives and operational initiatives to drive improvements, and that was, you know, quite successful. We improved adjusted EBITDA about $12 million year-over-year.

[Robert Stefanovich, CFO at Cryoport]

We are starting to invest in specific growth initiatives and completing some of the initiatives that we commenced in 2025 in setting up our global supply chain center in Paris and setting up our global supply chain center in California, which is going to consolidate 3 locations and expand our footprint there to include bioservices and IntegriCell. We also have a lot of insight with our client base. If you kind of step back and look at how we're positioned, it's really an unmatched positioning.

[Robert Stefanovich, CFO at Cryoport]

We, you know, serve about 70% of clinical trials, have a record 670 clinical trials, and we support 20 commercially approved, therapies, for which a majority are cell therapies. We have a lot of insight as to what's to come. We've been very successful in expanding our service offerings into bioservices, where we've seen strong growth. That expected growth, together with some of the efficiencies that we've identified, will really drive, you know, the further margin improvement.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

I just want to comment on the push out of the adjusted EBITDA, you know, positive numbers out of the end of Q 25. You know, 1 of the key elements here is that we've seen specific client requests to accelerate certain business opportunities.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Our site in Belgium is a very good example of that, where we had to build out in a very rapid timeframe, GMP compliant sterile kitting services for 1 of the very large volume commercial accounts. That is actually up and running. We were able to do this in record time, commission the site in December, and it is now contributing revenue, which will ramp significantly over the next few years.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

you know, we do still have to remain a little bit opportunistic on these types of opportunities, because they'll benefit the organization in the long term.

[Anna Kopkowski, Analyst at KeyBank Capital Markets]

Got it. Thank you, and congrats again.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Thank you.

[Robert Stefanovich, CFO at Cryoport]

Thanks, Anna.

[Operator]

Your next question comes from the line of Subbu Nambi from Guggenheim Securities. Please go ahead.

[Subbu Nambi, Analyst at Guggenheim Securities]

Hey, guys. Thank you for taking my question. Within the 2026 guidance, can you speak to what you expect from the macro environment or at the low end and the high end of your revenue guidance range?

[Robert Stefanovich, CFO at Cryoport]

In terms of I mean, obviously, if you look at the macro environment, it's quite volatile. If you look at specifically, you know, the markets that we're addressing, those have been progressing very nicely in spite of, you know, some of the challenges within the regulatory agencies and the macro environment.

[Robert Stefanovich, CFO at Cryoport]

You know, if you look at clinical trials, we had a record increase year-over-year in clinical trials, and we see, you know, a lot of interest for the services that we're providing. I think, you know, there's certainly an opportunity to beat the guidance that we're giving if we see some of the acceleration happening sooner. I think the downside risk is, you know, really the same thing as for all other companies.

[Robert Stefanovich, CFO at Cryoport]

You know, there's it's more of the unknown of what may happen. We don't really have specific risks identified, at this point in time. We feel quite comfortable with the guidance that we're providing.

[Subbu Nambi, Analyst at Guggenheim Securities]

Thank you for that. As a follow-up, you discussed the outlook for FDA approvals, but what is assumed in the guidance for animal health and reproductive health growth contributions?

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah, we don't typically disclose our segmentation by product segment. So I'm not sure. That's not something we typically outline.

[Jerrell Shelton, CEO at Cryoport]

Yeah. It's moderate growth. I think the real growth drivers, you know, for us as a business is clearly the cell and gene therapy space on the services side. And then within that, in terms of, you know, growth drivers, it's really further advancing the commercial you know, cell therapies.

[Jerrell Shelton, CEO at Cryoport]

You know, there's a number of activities, some happen in 2025. You know, the removal of the REMS requirement, which really started to... You know, we started to see our clients accelerating their therapies into the outpatient setting. And that's a significant move which portends to, you know, higher number of patients being treated, and that, again, translates into additional revenue to us.

[Subbu Nambi, Analyst at Guggenheim Securities]

Thank you for the additional color. Thank you, guys.

[Operator]

Your next question comes from the line of David Saxon from Needham & Company. Please go ahead.

[David Saxon, Analyst at Needham & Company]

Great. good afternoon, guys. Thanks for taking my questions. Just 2 for me. wanted to follow up on some of the comments earlier about product growth. I think last 1/4, you were kind of feeling good about high single digits for 2026. Sounds like you might be thinking more around mid-single digit growth for the year. Can you just give an update on, you know, NVE, the pipeline, the outlook there? Like, was there any incremental softening since last 1/4, or is that just kind of conservatism baked in?

[Jerrell Shelton, CEO at Cryoport]

David, I, I think that, you know, we pretty much addressed that. We think our guidance is a good starting point for the year. There are a lot of macro risk out there, we did assess those. Our starting point for our guidance is that $190-$194, and we think it's a good starting point. NVE continues to work on a stabilized basis. It's got a great forecast, a budget for, you know, 2026, and it has innovation coming out of it on a constant basis now.

[Jerrell Shelton, CEO at Cryoport]

We think NVE is in good condition, but we're not forecasting growth, more than the, you know, higher single digits, 7%-8%.

[David Saxon, Analyst at Needham & Company]

Okay. That's super helpful. Thanks, Jerry. Wanted to follow up on some of the partnerships. Obviously DHL. I guess can you give an update there? Like, is everything fully integrated and at a point where you can start to really see the benefits come through? You also mentioned Cardinal and Parexel. Can you just double-click there? Like, you know, frame those.

[Jerrell Shelton, CEO at Cryoport]

Yeah. Let me talk about DHL first.

[David Saxon, Analyst at Needham & Company]

Yeah. Great.

[Jerrell Shelton, CEO at Cryoport]

Look, DHL is a lumbering, big lumbering organization. I've got I wanna go back to 1 of your points, your question a little bit earlier, a comment, but after I talk about this. DHL is a large, very large organization, 600,000 employees spread all over the world. It takes time for them to mobilize and to.

[Jerrell Shelton, CEO at Cryoport]

They can't operate as agilely as we do. It's gonna take time for that relationship. That's why I said the promise of in terms of EMEA and Asia Pac and that impact. We are doing some things with them already, we do have some cooperative endeavors underway. For the full effect, it's gonna take a while for that to roll out.

[Jerrell Shelton, CEO at Cryoport]

I'm gonna let Mark comment on Cardinal and Parexel. Before we do that, you were talking about NVE and the 7% growth and all that kind of stuff. I just want you to remember, the driver for this company is a commercialized cell and gene therapies.

[Jerrell Shelton, CEO at Cryoport]

When that happens, that will dwarf NVE. NVE is a crucial part of our business. It's a foundational business. It's an important, it's an important company, and it's healthy, and it has great cash flow. It has innovation. It's 70% of the market. It's the world leader. You know, it will not be as significant in terms of revenue, proportionality in the future as it is today because cell and gene therapy will outgrow it.

[David Saxon, Analyst at Needham & Company]

just-

[Jerrell Shelton, CEO at Cryoport]

Now Mark can comment on those partnerships we have with the other 2, Parexel and Cardinal.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah. Yeah. You know, obviously, what we're doing is focused on building out an ecosystem that supports a cell and gene therapy global environment. 1 of the key elements of that strategy is to really define very strong partnerships with leading entities in the space that are complementary to what we do, but don't conflict with what we do.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Parexel and Cardinal Health are 2 very good examples of that. You know, so Parexel is a large CRO that really focuses on clinical trial design, FDA advisory services and, you know, clinical engagement. Cardinal Health is obviously order to cash management, reimbursement, regulatory support, and then patient and provider support. Us working closely with them really allows our mutual client base to have a best-in-class product offering.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

You know, folks like Cardinal and Parexel have come to us because we are best in class from a supply chain services standpoint. These help drive the industry. We're focused on long-term partnerships that help drive standardization and efficiency of the industry over time.

[David Saxon, Analyst at Needham & Company]

Great. Thanks so much.

[Operator]

Ladies and gentlemen, as a reminder, if you would like to ask a question, please press star followed by 1 on your touchtone phone. If you are using a speakerphone, please make sure to lift your handset before pressing any keys. Your next question comes from the line of Jacob Johnson from Stephens. Please go ahead.

[Jacob Johnson, Analyst at Stephens]

Hey, good afternoon, and thank you for taking my questions. Maybe just 1 for me. I think you highlighted on your prepared remarks that a large portion of these therapies are getting approved out of phase 2 already. With the FDA officially moving towards, like a default 1 pivotal trial, how do you anticipate this change impacting approvals and investments over the near term? Thanks.

[Jerrell Shelton, CEO at Cryoport]

Tom, why don't you take that question?

[Thomas Heinzen, VP of Corporate Development and Investor Relations at Cryoport]

I was gonna let Mark do it.

[Jerrell Shelton, CEO at Cryoport]

Yeah.

[Thomas Heinzen, VP of Corporate Development and Investor Relations at Cryoport]

All right. Anything that's gonna streamline the process, Mac, is a good thing. In our view, it's about more patients getting treated on the commercial side. Commercial revenue is higher than clinical revenue 'cause there's typically more addressable patients for a commercial therapy than a clinical trial. I'll let Mark comment.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah. Obviously, yeah, I mean, if they follow through with a single pivotal and don't require follow-up, that's beneficial to us. If they come back and require additional follow-up, then obviously that may slow things down. If you combine it with some of the other elements, in particular, the REMS requirement changes, that's gonna be a huge driver for us 'cause that really allows us to push into the community care setting and our client base.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

If you recall, the vast majority of the addressable patient population is still in the community care setting, and so it provides a significant opportunity for upside on the already existing commercial products as well as the new ones that are coming to market.

[Jacob Johnson, Analyst at Stephens]

I appreciate it. I'll leave it there.

[Robert Stefanovich, CFO at Cryoport]

Thanks.

[Operator]

The last question comes from the line of David Larsen from BTIG. Please go ahead.

[David Larsen, Analyst at BTIG]

Hi. Congratulations on a good 1/4. Can you talk about the MVE or product revenue growth in the fourth quarter? It looks like it was up 2% year-over-year. For the year, it was up 7% year-over-year. It looks like it maybe slowed a little bit in the fourth quarter. Why was that, and what will sort of drive the re-acceleration in growth in 2026?

[Jerrell Shelton, CEO at Cryoport]

David, you can't look at MVE systems on a 1/4ly basis and make too many judgments. I mean, the decisions for purchase of capital equipment that MVE manufactures as cryogenic systems is planned over a period of time.

[Jerrell Shelton, CEO at Cryoport]

Many times it's highly engineered in terms of the setting that it's going into the installation and its purpose. It's difficult to look at it. You're better off to look at an annual growth rate or a moving 12 months if you wanna look at it as moving 12 months. MVE is solid. It's a solid company, and the markets seem to be. We certainly are trying to help stabilize, you know, those markets.

[Jerrell Shelton, CEO at Cryoport]

You know, there's nothing more to add there, you know, other than if you have some comments, Robert, but I think that's the summary.

[Robert Stefanovich, CFO at Cryoport]

Yeah. just to give you maybe a little bit more granular picture of 2025, you know, when we looked at kind of the market growth and the MVE starting to come back and demand starting to come back, we've seen that on both sides of the product portfolio, the cryogenic freezers as well as the cryogenic transportation and cryogenic dewar portfolio.

[Robert Stefanovich, CFO at Cryoport]

From a regional perspective, as well, you know, in the various 1/4s, we've seen really all 3 regions at certain times, you know, starting to see a pickup in demand. Certainly it's a departure from what we've experienced in 2022, 2023. With that, you know, our guidance does, you know, assume some moderate, you know, mid-single digit type of growth rates for 2026.

[Jerrell Shelton, CEO at Cryoport]

David, I wanna remind you of 1 other thing, and this is just a matter of explanation so that you're aware of it. I mean, MVE furnishes both Cryoport Systems and CRYOGENE with products, with cryogenic freezers as well as dewars. The number you're seeing, the 7% for the year, for example, is a net number. It's it doesn't include its sales internally. I just wanted you. You know, just wanted to point that out.

[David Larsen, Analyst at BTIG]

Okay. Then 5 years from now, what % of total revenue do you think could be coming from commercial?

[Jerrell Shelton, CEO at Cryoport]

We'll come back and talk with you about that. I can't tell you right offhand right now. You know, I don't have a forecast for that. There's too many uncertainties right now for 5 years out. Five years is a long time in this business.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah. We do model everything out, right? You know, but as the timeframe goes out, there's more uncertainties that creep into the modeling, in particular, around the timing of new product launches and their adoption to the market.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

There's been products where, you know, the consensus from a market standpoint was, you know, this would be a very high growth, high traction product, and it disappointed or vice versa. There've been a couple of sleeper surprises where folks didn't anticipate much out of the product, it came in a lot stronger than anticipated. The key here to think about is again, the portfolio effect, right?

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Our focus is around, you know, capturing the plurality of the clinical market and then holding it through commercial activity and a commercial launch. You know, so we're currently supporting 20 commercial products.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

You know, you've seen the positive benefit over the last 12 months of that commercial portfolio, you know, where our commercial revenue has been extremely strong from a growth standpoint. We have a very strong prognosis on portfolio clients. You know, we've already talked about, you know, the potential of another 9 approvals this year, as well as additional geographic and market expansions. You know, as you look out further, that continues to expand out.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

If you're looking at the support mechanism of those, you know, of our phase II and phase III programs, a significant percentage of those will have a decision from a regulatory standpoint over the next 3 to 4 years, which will really impact those numbers fairly dramatically, assuming that we get a reasonable return on commercial approvals. Then you have to also look at, obviously, the impact of the REMS and the community care engagement, which is gonna be a huge factor as it relates to what that growth rate looks like.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

If our partners are successful in driving into the community care setting, and, you know, and the leader on that is really Janssen CARVYKTI product, where, you know, they've published data that shows that they're, you know, they're in the mid-30s now on a community care engagement standpoint. You know, if they push that up to 50%, 60%, 70% and you have others that are doing the same, that's gonna have a significant material impact, not only in the existing commercial products but the new ones coming to market.

[Jerrell Shelton, CEO at Cryoport]

David, you know, just a couple of other comments. I mean, while, you know, to, you know, add to what Mark is saying. I think you can undoubtedly say that in the future that we that cell and gene therapy, commercial cell and gene therapy revenues will be the dominant factor. It'll be the dominant factor in our revenue. It'll be by far, and because it drives not only the biologistics, it drives the bio storage, bioservices. You saw in this last 1/4, I think it was a 1/4, we grew about 23%.

[Jerrell Shelton, CEO at Cryoport]

What you're gonna see over time is you're gonna see as cell and gene therapy picks up, that is the commercial therapy approvals happen, you're gonna see our growth rate, you know, come more in line with the growth of the industry. Because we, you know, the lower growth segments, which are foundational to what we do, you know, will be of a less proportion. It's an interesting question. I just don't we don't have a specific answer, but we directionally, we know where we're going. You had something else to add, Mark?

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Yeah, I just wanna, you know, I just wanna point out, if you go to slide 6 in our presentation deck, that'll give you some market data that should give you a reasonable understanding of the opportunity associated with the, our commercial portfolio at this point.

[David Larsen, Analyst at BTIG]

Thanks very much.

[Mark Sawicki, Chief Scientific Officer at Cryoport]

Thank you.

[Operator]

There are no further questions at this time. I'm going to turn the call back to the management team for closing comments. Please go ahead.

[Jerrell Shelton, CEO at Cryoport]

Okay, 1 second. I wasn't prepared for that. Okay. Well, thank you know, for your questions. Very good questions and good discussion, and we appreciate those questions. In summary, we made some significant strides in 2025 with solid results showing full year revenue performance above guidance.

[Jerrell Shelton, CEO at Cryoport]

Our life science services business segment grew 18% year-over-year, including 22% increase in biostorage, bioservices revenue, a 29% increase in revenue from commercial cell and gene therapy we support. We concluded 2025 supporting a record 760 clinical trials and 20 commercially approved cell and gene therapies worldwide.

[Jerrell Shelton, CEO at Cryoport]

Of the 760 clinical trials we support, 86 are in phase III and 361 in phase II, creating what we believe is a spring-loaded position to future commercial cell and gene therapy revenue streams. In addition to our financial performance, we continue to advance targeted strategic initiatives which are designed to strengthen our growth trajectory in 2026 and beyond.

[Jerrell Shelton, CEO at Cryoport]

Based on our market position and industry insights, we are encouraged by the opportunities ahead, and we will continue to keep you updated on our progress. Thank you for joining us on today's call. We appreciate your continued interest and support and look forward to speaking with you again when we report our first 1/4 financial results for 2026. We wish you all a good evening. Operator?

[Operator]

Ladies and gentlemen, this concludes today's conference call. Thank you very much for your participation. You may now disconnect.

Participants

Executives

• Jerrell Shelton, CEO
• Mark Sawicki, Chief Scientific Officer
• Robert Stefanovich, CFO

Analysts

• Anna Kopkowski, Analyst at KeyBank Capital Markets
• David Larsen, Analyst at BTIG
• David Saxon, Analyst at Needham & Company
• Jacob Johnson, Analyst at Stephens
• Puneet Souda, Senior Research Analyst at Leerink Partners
• Subbu Nambi, Analyst at Guggenheim Securities
• Thomas Heinzen, VP of Corporate Development and Investor Relations at Cryoport
• Todd Fromer, Managing Partner at KCSA Strategic Communications