Jazz Pharmaceuticals Q2 2026 Earnings Call Transcript

Quartr
Provided by Quartr
August 3, 2026

Key Takeaways

  • Positive Sentiment: Record revenue of $1.21 billion rose 16% year over year, prompting Jazz to raise 2026 revenue guidance to $4.60 billion–$4.75 billion. Adjusted EPS was $5.71, while first-half operating cash flow reached $824 million.
  • Positive Sentiment: XYWAV sales increased 13% to $471 million, with approximately 525 net patient additions and limited uptake of high-sodium generics. Jazz now expects double-digit XYWAV growth in 2026 and raised rare-sleep revenue guidance to $2.025 billion–$2.125 billion.
  • Positive Sentiment: Epidiolex sales grew 16% to $292 million on strong underlying demand, particularly among adult and long-term-care patients. Jazz is pursuing a capsule formulation and several clinical trials to expand usage across additional treatment-resistant seizure populations.
  • Positive Sentiment: Jazz expressed high confidence in zanidatamab’s approval for first-line HER2-positive metastatic GEA by the August 25 PDUFA date and said it is prepared for launch. The company highlighted median overall survival of 26.4 months in the combination arm and expects additional doublet overall-survival data in the third quarter.
  • Negative Sentiment: Zepzelca sales rose 42% to $106 million, driven by first-line maintenance adoption, but Jazz plans to submit a labeling supplement removing the second-line indication after the LAGOON results. Management expects the historical second-line business to continue eroding, with a possible acceleration following the label change.
AI Generated. May Contain Errors.
Earnings Conference Call
Jazz Pharmaceuticals Q2 2026
00:00 / 00:00

Transcript Sections

Skip to Participants
Operator

Good day, and thank you for standing by. Welcome to Jazz Pharmaceuticals' second quarter 2026 earnings conference call. At this time, all participants are on a listen only mode. After the speaker's presentation, there will be a question and answer session. To ask a question during the session, you will need to press star one one on your telephone. You will hear an automated message advising your hand is raised. Please note that today's conference is being recorded. I will now hand the conference over to your first speaker today, John Bluth, VP and Head of Investor Relations. Please go ahead.

John Bluth
John Bluth
VP and Head of Investor Relations at Jazz Pharmaceuticals

Thank you, and good afternoon, everyone. Today, Jazz Pharmaceuticals reported its second quarter 2026 financial results. The slide presentation accompanying this webcast is available on the Investors section of our website, along with the press release and quarterly report on Form 10-Q for the second quarter ended June 30, 2026. On the call today are Renée Galá, President and Chief Executive Officer; Sam Pearce, Chief Commercial Officer; Rob Iannone, Global Head of R&D and Chief Medical Officer; and Phil Johnson, Chief Financial Officer. On slide two, I'd like to remind you that today's webcast includes forward-looking statements such as those related to our future financial and operating results, growth, potential, and anticipated development, regulatory and commercial milestones, which involve risks and uncertainties that could cause actual events, performance, and results to differ materially from those contained in these forward-looking statements.

John Bluth
John Bluth
VP and Head of Investor Relations at Jazz Pharmaceuticals

We encourage you to review these risks and uncertainties described in today's press release and under the caption Risk Factors in our annual report on Form 10-K for the fiscal year ended December 31st, 2025. We undertake no duty or obligation to update our forward-looking statements. As noted on slide three, we will discuss non-GAAP financial measures on this webcast. Descriptions of these non-GAAP financial measures and reconciliations of GAAP to non-GAAP financial measures are included in today's press release and the slide presentation available on the Investors section of our website. I'd like to turn the call over to Renée.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Thanks, John. Good afternoon, everyone, and thank you for joining today's conference call. We delivered another outstanding quarter, generating record revenue of $1.2 billion, representing 16% year-over-year growth. The momentum we've built in the first half of the year provides us with confidence to raise our full-year revenue guidance. Our results reflect an intense focus on aligned execution across our diversified portfolio, sustained demand of our commercial products, and progress in advancing our long-term priorities for value creation. As we approach a significant milestone with the August 25th PDUFA date for zanidatamab in first-line HER2-positive metastatic GEA, our commercial, medical, and market access teams are fully prepared to successfully launch zanidatamab. We're entering a new phase of growth created by the opportunity to deliver clinically meaningful outcomes for patients facing this highly aggressive, difficult to treat disease.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Our consistent execution reflects the focus strategy we outlined at the beginning of the year. Expand our leadership in key therapeutic areas, advance differentiated innovation, and create durable long-term value. Across the business, our teams are delivering key therapies to patients, advancing zanidatamab, and leveraging our financial strength to invest in both internal R&D and external innovation. An example of this approach is our preclinical research collaboration with AbCellera, which leverages their T-cell engager platform to discover novel multi-specific antibodies. This agreement directly complements our oncology expertise and supports our refined rare disease strategy. These exceptional results from the quarter position us to sustain our momentum while delivering meaningful benefits for patients and driving robust returns for our shareholders. With that, I'll turn the call over to Sam to share more details on our commercial performance.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Thank you, Renée. Our commercial teams delivered another impressive quarter of revenue, with 16% growth across the portfolio and double-digit growth from each of our key promoted brands. This performance is a result of focused investment and targeted, impactful execution, which is driving sustained momentum across our increasingly diversified portfolio. I'll begin on slide seven with rare sleep. XYWAV's profile as the only low-sodium oxybate on the market continues to resonate with physicians and patients. XYWAV net product sales increased 13% to $471 million in the second quarter of 2026 compared to the second quarter of 2025. Supported by targeted healthcare provider and patient-focused digital campaigns, our field execution continues to expand the narcolepsy and idiopathic hypersomnia markets and deliver sustained new patient adds.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

These efforts emphasize XYWAV's differentiated low-sodium profile and the efficacy it provides by treating underlying disrupted nighttime sleep and addressing daytime symptoms for patients living with narcolepsy and idiopathic hypersomnia. Demand for XYWAV remains robust, with approximately 525 net patient additions in the quarter. This brings our total active patients to approximately 17,125, representing more than 12% year-over-year growth. This momentum is supported by our targeted investments in high-touch patient support services such as our field nurse educator program, which deliver differentiated support to help patients achieve optimal dosing and sustained treatment.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

This first-half performance underscores the durability of our sleep franchise, with limited impact from high-sodium generics. Whilst we will closely monitor second-half market dynamics, including generic availability and potential new product launches, our confidence in XYWAV's foundational role is unwavering. Its clinical profile remains differentiated as the only low-sodium oxybate and the only FDA-approved option for IH patients.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Moving to slide eight and Epidiolex. Epidiolex delivered another outstanding quarter, with net product sales growing 16% year-over-year to $292 million, driven primarily by robust underlying demand. This momentum is fueled by our field team's ongoing success in educating HCPs and caregivers on Epidiolex's broad-spectrum efficacy and its meaningful beyond-seizure benefits for new and existing patients. Concurrently, we are actively expanding the Epidiolex franchise. While Rob will cover our clinical expansion into new treatment-resistant seizures, I want to highlight a critical lifecycle initiative, our novel capsule formulation.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Designed to unlock additional utilization within our approved indications, the capsule targets deeper penetration in certain segments of the adult patient population. By offering this convenient alternative alongside our oral solution formulation, we aim to improve accessibility and compliance for adult patients while firmly reinforcing our long-term leadership in the anti-seizure market. Turning to our oncology portfolio.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

We are extremely pleased with the ongoing launch of Ziihera in BTC, as shown on slide nine. In the second quarter of 2026, Ziihera generated $15 million in net product sales. Since launching in second-line BTC, we have rapidly established clinical leadership, achieving more than 50% of the addressable market share in the U.S. This clinical momentum is driven by deepening utilization in academic centers and expanding adoption across community settings, supported by highly consistent, positive real-world prescriber experiences. Critically, our success in BTC serves as a powerful commercial foundation for our next major growth phase in GEA. Because there is significant direct overlap between existing BTC and GEA treating accounts, our commercial infrastructure is fully primed. On slide 10, you can see how our launch readiness framework is designed to drive rapid uptake.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Our commercial footprint is highly optimized, with over 90% target physician overlap, allowing our team to rapidly generate clinician excitement and demand. This enthusiasm is rooted in zanidatamab's exceptional clinical data, specifically an unprecedented median overall survival exceeding two years, establishing it as the potential preferred backbone in HER2-positive GEA. To support immediate clinical adoption at launch, we've submitted this data to key oncology pathways and will leverage our already established permanent J-code to minimize reimbursement barriers. Backed by our robust JazzCares patient support program, we are fully prepared to deliver seamless access to patients upon approval. Turning to slide 11 and Modeyso. Modeyso generated $48 million in net product sales in the second quarter of 2026, representing remarkable progress since our launch in August of last year.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Driven by highly coordinated, disciplined execution, more than 600 patients have now been treated with Modeyso through the end of the second quarter. To sustain this upward trajectory, we initiated additional non-personal promotion and peer-to-peer speaker programs in the second quarter. These initiatives are designed to educate community-based physicians and expand our reach to ensure timely referral of patients to academic centers of excellence. On the diagnostic front, while biomarker testing is already high in high-grade gliomas, we are actively working to establish reflexive testing across all gliomas. This systematic approach is critical to ensure every H3K27M patient is identified early and referred to targeted care. To support this, updated NCCN guidelines now endorse liquid biopsy for the H3K27M biomarker. This represents a major milestone that broadens diagnostic pathways, reduces patient risk, and accelerates time to treatment. Finally, Modeyso continues to benefit from robust, highly favorable payer coverage.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Combined with our dedicated patient support services, we are exceptionally well-positioned to maintain this strong commercial momentum. Moving to slide 12 and Zepzelca. We are very pleased with Zepzelca's performance this quarter, achieving $106 million in net product sales, a 42% year-over-year increase. This robust growth was driven by highly positive prescriber feedback and rapid adoption in the first-line maintenance setting, which more than offset the anticipated tapering of our historical second-line business. The strength of our IMforte trial data clearly demonstrates that Zepzelca's greatest clinical value is in early intervention in combination with a PD-L1 inhibitor in the first-line maintenance setting, a consensus recently reinforced by its elevation to a Category 1 listing in the NCCN guidelines. Because metastatic small cell lung cancer progresses so rapidly, reaching patients earlier in their journey is critical. Later, Rob will provide an update on the second-line indication.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Overall, we are very pleased with the commercial performance across our portfolio in the second quarter, and we remain focused on sustaining this momentum throughout the remainder of the year. With that, I'll now turn the call over to Rob to provide an update on our pipeline. Rob?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Thanks, Sam. I'll start on slide 14. This is a very exciting time at Jazz, driven in part by the August 25th zanidatamab data map. The phase III HERIZON-GEA-01 trial results were recently published in The New England Journal of Medicine, further characterizing the efficacy and safety profile of zanidatamab in combination with chemotherapy, with and without the PD-L1 inhibitor tislelizumab. Publication in The New England Journal of Medicine underscores the clinical significance of these results and we believe will support awareness and adoption of zanidatamab among oncologists treating GEA patients. We also presented subgroup data at ASCO confirming that the zani and tisle combination delivers a consistent survival benefit irrespective of PD-L1 tumor expression. A 26.4-month median overall survival was observed with the zanidatamab plus tislelizumab arm, which was more than seven months longer than the control arm with trastuzumab.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

The benefit was seen for all HER2-positive patients, irrespective of tumor PD-L1 status, and represents a remarkable advance for this patient population. zanidatamab plus chemotherapy showed a clinically meaningful survival benefit with a median OS of more than two years and a strong trend towards statistical significance at the time of the first interim OS analysis. We look forward to the upcoming top-line results from the second interim OS analysis of this double arm, which are expected in 3Q 2026. In addition, we have submitted The New England Journal of Medicine manuscript for potential inclusion in the NCCN guidelines. Our belief in zanidatamab increases as it was recently granted Breakthrough Therapy Designation for adults with previously treated locally advanced, unresectable, or metastatic HER2-positive colorectal cancer. We look forward to sharing more on our development plans for colorectal cancer in the near term. Turning to slide 15.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Our R&D programs remain focused on building the next generation of growth drivers through internal innovation and external partnerships. We are leveraging our deep expertise in rare epilepsies to broaden our pipeline and extend the potential benefits of Epidiolex, also known as cannabidiol, to more patients with treatment-resistant seizures. We are initiating three new clinical trials, including a phase IV trial in adults with LGS, a phase III trial assessing the anti-seizure efficacy in a broad group of developmental and epileptic encephalopathies, and a seamless phase II-III trial that will explore the capsule formulation in juvenile myoclonic epilepsy. These new trials build on the phase I-B trial in focal onset seizures that was initiated at the end of last year, and the phase I trial of JZP047, a novel molecular entity discovered by Jazz being developed in absence epilepsy.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

In addition, we submitted an NDA to the FDA for a novel capsule formulation to broaden utilization of Epidiolex in currently approved indications of LGS, DS, and TSC to improve flexibility and provide a new administration option for patients. Moving to oncology and Zepzelca. Based on the results of the LAGOON trial and in alignment with FDA, in 3Q 2026, we will submit for FDA's review and subsequent action a labeling supplement to remove the second-line indication. The first-line maintenance indication will not be affected. Lastly, on Modeyso, our phase III ACTION trial is progressing. Based on the latest estimate of event accrual, we now anticipate that the overall survival interim analysis will be in the first half of 2027. This trial is designed to confirm the benefit of Modeyso and support regulatory approval as a frontline therapy directly following radiation.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

We are making meaningful progress across our pipeline and in-house R&D efforts, and we look forward to sharing more updates as our programs advance. Now I will turn the call over to Phil for a financial update. Phil?

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Thanks, Rob. Before diving into the financials for the quarter, I'd like to underscore our consistent progress delivering on our rare disease strategy. Our commercial organization is firing on all cylinders, and we're making targeted investments to continue our momentum. Our R&D organization is working with urgency to generate practice-changing clinical data Highlighted by the NEJM publication of the zanidatamab first-line GEA results, and speed new medicines to market while also expanding indications for our existing medicines to benefit even more patients. And we're deploying capital in a disciplined manner to enhance our growth prospects, most recently with the AbCellera deal. Turning to the financial results for the quarter, I'll start with high-level comments on our non-GAAP adjusted P&L, as shown on slide 17. Please note that our full financial results are available in today's press release and 10-Q.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

The outstanding execution of our field-based teams was reflected in record quarterly revenue of $1.21 billion, an increase of 16% over the second quarter of 2025, driven by 32% growth in our oncology portfolio, 13% growth in XYWAV, and 16% growth in Epidiolex. Moving down the P&L, our non-GAAP adjusted gross margin declined slightly year-on-year due to higher sales of Zepzelca and Modeyso, which carry third-party royalties. Non-GAAP adjusted SG&A and R&D expenses both grew 11%, with the increase in SG&A driven by higher expenses for Modeyso and Ziihera first-line GEA, and to a lesser extent, by investments in key commercial capabilities in digital and AI. While the increase in R&D was driven by higher expenses related to clinical trial costs, primarily related to zanidatamab.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Our non-GAAP adjusted effective tax rate this quarter was moderately higher than our full-year 2026 guidance due to shifts in the expected geographic mix of income and expenses. Our shares outstanding for the quarter reflect the accounting effect of our higher share price on our convertible notes and employee stock plans. At the bottom line, we posted very robust non-GAAP adjusted EPS of $5.71, which included IPR&D charges totaling $0.94. Beyond the income statement, I'd highlight that we generated operating cash flow of $824 million in the first half of the year. During the second quarter, we paid off our 2026 convertible notes. With our strong financial position, we're able to continue to invest in our currently marketed products and our existing pipeline, as well as in corporate development.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Turning to slide 18 and our 2026 financial guidance, I'll focus my comments on those guidance elements that have changed since our last earnings call. We now expect total revenues in the range of $4.60 billion-$4.75 billion. This significant upward revision is largely driven by the outstanding execution of our XYWAV field teams, driving home the unique benefits that XYWAV offers as the only low-sodium oxybate. To date, uptake of high-sodium generics has been quite limited. We continue to post strong net patient adds. We now anticipate double-digit growth for XYWAV in 2026 and rare sleep revenue of between $2.025 billion-$2.125 billion. Strong first half results of our rare oncology and epilepsy portfolio further support our revised total revenue guidance range. On the expense side, we've modestly increased our SG&A expense guidance.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

This reflects deliberate strategic investments to build upon momentum in XYWAV and Epidiolex, as well as to drive implementation of our rare disease strategy and our corporate development efforts. Finally, our updated share count guidance is 69 million-70 million shares, reflecting the increase in our stock price since our last earnings call and its accounting effect on our convertible notes and employee stock compensation plans. I'll now turn the call back to Renée for closing remarks.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Thank you, Phil. I'll conclude our prepared remarks on slide 20. Our second quarter results demonstrated the strength and continued diversification of our product portfolio, delivering record quarterly revenue, including a 32% increase from our oncology products compared to 2Q 2025. Consistent execution across our commercial and R&D pipeline. Importantly, we enter the second half of the year with significant momentum, highlighted by the anticipated zanidatamab approval and launch in GEA.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Multiple upcoming clinical readouts. Building on our proven scientific capabilities and strong financial position, we are making a meaningful impact for patients. Over the past 12 months, we have embarked on a period of rapid and deliberate transformation. I am incredibly proud of the execution by the entire Jazz team during this time and deeply grateful for the trust you have placed in our shared vision. That concludes our prepared remarks. I would now like to turn the call over to the operator to open the line for Q&A.

Operator

Thank you. Ladies and gentlemen, to ask a question at this time, you will need to press star one one on your telephone and wait for your name to be announced. To withdraw your question, simply press star one one again. As a reminder, in the consideration of time, please limit yourself to only one question per person. One moment for our first question in queue. First question in the queue coming from the line of Marc Goodman with Leerink. Your line is now open.

Marc Goodman
Marc Goodman
Analyst at Leerink

Yes. Could you guys give us a little more color on Epidiolex? Just give us a sense of, was there any inventory in the U.S. or anything strange in the quarter? What was really just driving it? Were there new indications? Just give us a sense of what's happening here, because the quarter was much better than expected. Thanks.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Hi there, Marc. This is Sam. Yes, thanks for the question. Yeah, very pleased with the continued momentum that we've seen for Epidiolex. 16% revenue growth, taking us to $292 million for the quarter. This was 12% volume growth, which again, just reflects really good, strong demand in both the pediatric and the adult settings, reinforcing our position as the number one branded anti-seizure medication in refractory epilepsy. I think some of this growth continues to come from our focus on the long-term care setting. As you know, we've generated some good data there. Beyond seizure benefits really resonate with adults. We continue to see good headroom for growth, actually, in that segment as well. There were no really significant unusual inventory movements, but I'll hand over to Phil if he wants to comment further on that topic.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Yeah. Thanks, Sam. Just to note, Marc, ex-U.S., you may recall that in the second quarter last year, we had talked about some one-time pricing adjustments that were made in a couple of the ex-U.S. markets that did depress second quarter 2025 revenue. That led to some of the favorability on the compare in the second quarter of this year for ex-U.S. revenue. We also did have a decent effect in this first half of the year coming from FX that was most pronounced in the first quarter and came down pretty significantly here in the second quarter, but did also help drive a little bit of the ex-U.S. revenue growth.

Operator

Thank you. Our next question coming from the line of Jessica Fye with JPMorgan. Your line is now open.

Jessica Fye
Jessica Fye
Analyst at JPMorgan

Hey, guys. Good afternoon. Thanks for taking my question. Wanted to ask about zani and just hoping you could speak to your confidence in approval heading into the upcoming PDUFA. There had been some talk about the possibility of maybe approval before the PDUFA date. We're getting pretty close now. Just wanted to hear your confidence there. Maybe related to zani, can you speak to your confidence in the zani doublet hitting on OS with the upcoming interim? Thank you.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Questions, yes. We've been productively engaged with the FDA. That does feel like we're in the home stretch. We're highly confident in the approval. I would still say on or before the PDUFA date, and we are certainly ready to launch. On your second question around the second interim for the doublet. Certainly we had a great result at the very first interim, and certainly we have more power at this next turn. Looking forward to those results in 3Q of this year.

Operator

Thank you. Our next question coming from the lineup. Jason Gerberry with Bank of America. Your line is now open.

Jason Gerberry
Jason Gerberry
Analyst at Bank of America

Hey, guys. Thanks for taking my question. Maybe one for Phil. Just when you look at the strength of XYWAV in the first half, how do you see that carrying over into next year? Should investors look at the outperformance as more or less just the delayed generics, and more of a headwind in 2027? Or do you think that the strength offers a rebasing of numbers going into 2027 for XYWAV? Thanks.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Yep. Appreciate the question. Definitely extremely pleased with the performance of our field teams driving XYWAV. It really is a pretty astounding and amazing story, and really based in the unique benefits that XYWAV offers as the only low sodium oxybate. We've been seeing this resonate with physicians as well as patients. I think we've continued to see that during this year, probably leading to even slower uptake of generics than we might have originally anticipated, which is leading to some of the raise we have for the guidance this year. I would say that continues to put us in a really strong position as we think about the go-forward discussions that we might have with payers as well, given that the market continues to highly value the unique position that only XYWAV occupies. I'm not ready to give specific guidance on 2027 yet.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

We'll do that when we get to the fourth quarter 2026 call early next year. The momentum we've got gives us increasing confidence in the position that XYWAV will have in this market on a go-forward basis.

Operator

Thank you. Our next question coming from the line of Ash Verma with UBS. Your line is now open.

Ash Verma
Ash Verma
Analyst at UBS

Hi. Thanks for taking our questions and congrats on the progress here. Maybe just on the GEA market dynamic. Can you talk about, in terms of how many patients are in the major academic centers versus the large community practice network, and if you think that the adoption is going to look different one way or the other in either of these channels? Thanks.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Yes. Thanks for the question, Ash. Yes. We do believe that for the GEA launch, obviously having a strong foundation of support from those academic centers is key. Of course, the data really has been well received by those physicians following the publication in the New England Journal of Medicine. They're eagerly anticipating the launch. What will be very important with this launch, and something we really appreciate, is how important it will be for the community physicians to really understand the data and to quickly adopt Ziihera as the new standard of care in GEA.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

This is something that we're quite well prepared for because it pretty much mirrors the situation with Zepzelca. We have a team already out there who are very well positioned. There's very strong overlap, as you know, between Zepzelca and Ziihera. They're well-positioned to communicate the benefits of Ziihera to community physicians. We anticipate good, strong uptake there for all the reasons that we've talked about previously. The overlap, the fact that we have the permanent J-code already established, and we have those relationships already in place.

Operator

Thank you. Our next question coming from the line of Joe Thome with TD Cowen. Your line is now open.

Joe Thome
Joe Thome
Analyst at TD Cowen

Hi there. Good afternoon, and thank you for taking my question. Can you talk a little bit about the breakdown between front-line and second-line Zepzelca patients that are presenting at this point? Just trying to understand a little bit how much the second-line label update will impact sort of your thoughts on the long-term value of Zepzelca and kind of your peak sales estimates there. Thank you.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Yes, thanks for the question. I'll take that one. We're very pleased, obviously, since we launched Zepzelca in the first-line maintenance segment in October last year. We've seen really strong adoption of Zepzelca with those patients. That's really what's driven the growth that we've seen over the last few quarters. 42% growth this quarter, taking us to $106 million. That growth is really all being down to our success in that first-line segment. We estimate now that between 30%-40% of our overall U.S. sales are coming from that first-line maintenance segment. Of course, that's growing. That is reinforced by the recent NCCN category listing elevated to Category 1 as a preferred regimen in first-line maintenance in combination with Tecentriq.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Whilst we have been seeing a gradual decline in that second-line business as a result of competition, also as patients get initiated onto Zepzelca in the front-line segment, they're not going to get retreated in that second-line segment. We can expect the second-line business to erode. That's what we were anticipating. Of course, with the announcement today, we may expect that to accelerate. Of course, all of that is factored into the guidance that we've provided for this year. Rob, would you like to add anything from your perspective on that?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

I mean, I would just say that we designed the IMforte trial because we really felt that it was important to preempt progression in this pretty aggressive disease. Had a strong hypothesis that Zepzelca would synergize with a PD-L1 inhibitor like atezolizumab, and that is what we observed in IMforte. We think front-line maintenance is the best place to use Zepzelca for patients to get the best benefit and the longest treatment duration. We think there is a synergy with PD-L1 antagonists, and there was important data published at ASCO showing just that. Looking at the impact of tumor-associated macrophages of Zepzelca and explaining the potential synergy with a PD-L1 agent. We do think front line is the best place to use Zepzelca.

Operator

Thank you. Our next question in queue coming from the line of Sean Laaman with Morgan Stanley. Your line is now open.

Sean Laaman
Sean Laaman
Analyst at Morgan Stanley

Good afternoon, Renée and team. Congratulations on the numbers, and hope everyone's well. My question is on the durability of XYWAV. It seems that most of the net patient adds came in IH. I guess just given the biology of the disease with normal levels of orexin, and then you do have a pretty competitive bar there on perusal in the medical literature in terms of MWT. How do you think that evolves, the mix of XYWAV for patients on IH and how defendable or otherwise do you think it may be as orexins to agonists advance? Thanks.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Hi. Yes. Thanks for the question. Yes, of course, we're very pleased with the durability that we've seen for XYWAV. We did, as you mentioned, we had really good solid patient adds this quarter. 200 for narcolepsy, 325 for idiopathic hypersomnia. In total, 525 net patient adds. Actually, the highest number of adds that we've had for a year. Very happy to see that continued momentum.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Obviously, the brand is proving itself to be very durable in the face of multi-source generics. That's perhaps not surprising given the differentiation factors for XYWAV haven't changed with the availability of multi-source generics. We're still the only low sodium oxybate on the market, the only product approved for IH. Obviously, as we look ahead, we are anticipating the launch of the orexins. I'll maybe get Rob to comment a little bit on how he's seeing the potential combinability of orexins with XYWAV. Rob?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Yeah. Thanks, Sam. Across the hypersomnias NT1, NT2, IH, the root cause really is disrupted nighttime sleep. XYWAV is the only approach to address the disrupted nighttime sleep. We think it's a cornerstone of therapy there. It's been the case that patients will also use daytime stimulating agents, and we think that orexin offers another opportunity to complement the potential benefit of oxybate and specifically XYWAV.

Operator

Thank you. Our next question in queue, coming from the line of Mohit Bansal with Wells Fargo. Your line is now open.

Will Zhang
Will Zhang
Analyst at Wells Fargo

Hi, this is Will Zhang on for Mohit. Thanks for taking our question. I guess looking at zani's phase III trial in breast cancer, just want to understand, given that you guys are developing in this post-T-DXd, post-Enhertu setting, what is the patient pool? What is the size of the patient population that you're looking to address here? Since Enhertu is still beginning in the early phases of its launch into the first-line breast cancer setting. Thanks.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Do you want to jump in a bit on the trial?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Yeah. The trial is positioned in patients who have been treated with Enhertu. In the current treatment paradigm, that's typically third-line plus patients. I'll remind you that we have data showing that zanidatamab, given its unique mechanism of action, is active even in patients who've progressed on Enhertu. That comes from monotherapy data. It comes from combination data with standard of care, say, in the HER2-positive, ER-positive population that we published, also with novel agents like the ALX agent. We think this is roughly 150,000 patients annually.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

We also feel that it's a significant unmet need as Enhertu progressively moves to the front line, that zanidatamab would be, I think, unique in having data demonstrating its activity versus standard of care in patients who've progressed on Enhertu, regardless of the line of therapy. We're eager to see those results. We've said in the past that we expect to see the trial complete enrollment mid-2027, we could see results, depending on how the events progress, late 2027 or early 2028.

Operator

Thank you. Our next question coming from the line of Leonid Timashev with RBC Capital. Your line is now open.

Leonid Timashev
Leonid Timashev
Analyst at RBC Capital

Hey, guys. Thanks for taking my question. I wanted to ask on the Epidiolex strategy from here, and maybe how the pieces there fit together. You guys are running a number of additional studies, LGS in adults, DE, JME. I guess what I'm trying to understand is, to what extent is this growing the opportunity versus defending it from future branded entrants as the DE space sort of heats up competitively? Is this new capsule formulation something that's going to extend the IP runway as well? Thanks.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Yeah, thanks. I'll start and then also welcome comments from Sam and Rob in terms of both the broader commercial opportunity and some of what we are investing in on the clinical side. But if you step back and think about Epidiolex as a growth driver for the company with the visibility of long durability into the very late 2030s now with this franchise, we believe we have multiple opportunities to invest. We talked today about multiple clinical programs underway, and we also believe having the capsule formulation allows us greater potential penetration into the adult market for certain patients who are more suitable for the capsule formulation. And if we step back and think about the impact that this business development transaction of bringing Epidiolex into the company has had for us, it's created now a major growth driver.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

We paid a little over $7 billion for what is a franchise that is growing nicely, over $1 billion a year, with the opportunity to grow in multiple formulations through clinical data and also internationally. It's a really nice business for us to be in and also continue to build around when we think about future business development transactions. Sam, do you want to comment further on the capsule?

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Yes, happy to. We're very excited about the potential for Epidiolex to continue its strong momentum into the future. We have seen, we continue to execute on our strategy to grow Epidiolex in the adult segment. We continue to see growth in keeping patients on treatment for longer, and that persistency is really very material in terms of the long-term outlook. We also identify an opportunity for patients to restart Epidiolex who maybe have previously discontinued treatment. When you look at the capsule formulation, the capsule formulation is going to enable us to do all of those things even better, particularly for those adolescent and adult patients, where the oral liquid solution is a less convenient option for them.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

We believe the capsule will enable us to capture naive patients, improve persistency in existing patients, and encourage restarts for patients that maybe started on the oral solid dose on the liquid, and it wasn't the best treatment for them. We do believe when you take all of those together, this is a material incremental opportunity that will drive more patients benefiting from Epidiolex.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Maybe just to hit your IP question right before Rob jumps in. The capsule launch does not have any impact on IP. It does not have any impact on our ANDA agreements that extend the durability, as I'd mentioned, out to the 2030s, the very late 2030s. Our patent estate contains method of use patents that are relevant to all approved indications, and that's relevant to both the existing oral solution as well as the new capsule formulation. Rob, do you want to cover now the clinical programs?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Yeah. We're excited to be initiating a number of new clinical trials with Epidiolex. We're convinced of its broad activity across different seizure types based on prior data we have for the current indications and the EAP. As you know, about a year ago, we initiated a phase II trial in focal onset seizure. We just announced a trial we initiated in juvenile myoclonic epilepsy. That will be with the capsule formulation, and that's a phase II-III seamless design, so potentially pivotal. We also are initiating a trial in a broad set of DEs that could lead to a broader label there. That would be pivotal. Doing some more work in adult LGS patients to really try to better characterize its efficacy there and support its use from adult prescribers.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Confident in the activity that Epidiolex has, its ability to combine, and as has already been said, because of the longevity that we're initiating new trials in the space. Since I have the mic, I just want to make sure my comments earlier on breast cancer for Ziihera were understood. 150,000 really represents the pool of metastatic patients globally. Obviously it's a subset of that who would have progressed and still are eligible for treatment after an HER2.

Operator

Thank you. Our next question in queue coming from the line of David Amsellem with Piper Sandler. Your line is now open.

David Amsellem
David Amsellem
Analyst at Piper Sandler

Thanks. I have a long-term question on the oxybate franchise, namely XYWAV in IH. Obviously we have the data in hand for Lumryz, and just wondering how you're thinking about the trajectory of IH. It's obviously growing nicely. There's good headroom here. That's definitely not lost on me. The question is, once you do have that competition emerging in 2028, how do you think about your growth trajectory longer term and then even beyond that with potential availability of orexin? If you could just comment on how you're thinking about the next several years for your IH part of your sleep business, that would be helpful. Thanks.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

I can certainly start and then maybe hand over to Rob. Yeah, the differentiation for XYWAV is twofold. Perhaps one of the most kind of important things about XYWAV is the low sodium. Of course, that's going to be a component of its differentiation that will go beyond just another product having an IH indication. This is a message that really does resonate with prescribers. We know that patients who are diagnosed with IH or narcolepsy, the majority of them do have a cardiometabolic or cardiovascular comorbidity. Increasingly, I think physicians and patients recognize the importance of having a low sodium option. That differentiation is obviously pretty durable. In relation to the orexin question, maybe I'll hand that over to Rob.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Thanks, Sam. I was just going to add, again, that XYWAV is differentiated on the basis of low sodium. While it's well understood that not only narcolepsy, but IH patients have a significant risk of negative cardiometabolic outcomes. We also demonstrated that in the XYWAV study that after initiation of high sodium oxybate, you see a change in blood pressure, which is clinically meaningful. Patients benefiting from XYWAV now, I think that will be pretty sticky. Did I miss another aspect of the question on narcolepsy that you wanted me to address, Sam?

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

I think there was a question just around the competition versus the longer-term availability of orexin.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Yeah. Again, I think I answered this earlier. Whether it be IH or narcolepsy, the root cause of the daytime sleepiness and symptoms such as cataplexy have to do with disrupted nighttime sleep and only oxybate and XYWAV being really the safest oxybate, can address that root cause. We continue to think that that will have an important role in treating patients, even if they would additionally benefit from daytime wake-promoting agents.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Just to build one last point here. With respect to the IH market, we are still very early in our overall penetration. We think there's probably 37,000+ patients diagnosed and seeking treatment for IH. While we've made significant progress and headway, we do believe there's a lot of room still to grow here. We believe that XYWAV, as we've seen with narcolepsy, including the patient support services, supporting the overall journey that patients go through with a new diagnosis of idiopathic hypersomnia. We do believe that XYWAV will continue to compete well in this market.

Operator

Thank you. Our next question coming from the line of Ami Fadia with Needham & Company. Your line is now open.

Ami Fadia
Ami Fadia
Analyst at Needham & Company

Hi. Good afternoon. Thanks for taking my question. I had a question on zani. As we think about potential for indications beyond breast cancer, can you talk about what type of updates we could expect with regards to CRC or non-small cell lung cancer and how you might go about pursuing those indications?

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

Sure. We have the ongoing basket trial, which is the 206 study. In that trial, we continue to enroll patients with second-line colorectal cancer and non-small cell lung cancer. We had previously published on colorectal cancer, and those were some of the data that we brought to FDA, including, in addition, data from the emerging 206 trial that led to the breakthrough designation for colorectal cancer. We'll continue to generate data in both of those indications through that study. We'll work with FDA now that we have BTD to identify the path forward ultimately for approval in colorectal cancer. More broadly, we're very excited about the potential of zanidatamab. We have the ongoing frontline BTC trial that we're optimistic about. You know, we're about to launch in GEA.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

We're contemplating other areas in gastric cancer, such as early gastric cancer, where there's no approved HER2 therapy. Of course, we have the ongoing late-stage metastatic breast cancer trial, as well as other phase II trials looking to determine how else we might use zani in combinations, sometimes novel combinations in the breast cancer setting, as well as the new indications such as CRC and non-small cell lung cancer, as you mentioned. Overall, we do think this is a pipeline and a product, and we're pursuing every opportunity to its fullest.

Operator

Thank you. Our next question coming from the line of Gary Nachman with Canaccord. Your line is now open.

Gary Nachman
Gary Nachman
Analyst at Canaccord

Hey, thanks. Good afternoon. For Ziihera and GEA, just back to that, if approved, how long before you think the NCCN guidelines will be updated since you already submitted the data for that? How much would that impact the uptake? I'm also curious, has there been any real off-label use in first-line GEA since the data came out late last year? Maybe just generally, a bit more on how you're thinking about the pace of the uptake in GEA, including with reimbursement, because you obviously can leverage the BTC indication and have a lot in place already. Thank you.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

I can start on NCCN. We've been providing NCCN all the data we have as soon as we have it. We shared the data that went into the abstract, and then we immediately shared the New England Journal publication. Obviously, we don't control their timelines, we do think they have everything they need to adopt that into the guidelines, potentially even before approval. Obviously, that's up to them.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Yeah. Just I'll follow up with your question in relation to our kind of readiness to launch. We are ready to launch in GEA. We sized our team specifically with a GEA launch in mind, and made some investments to ensure that we can cover all of the customer groups that we want to cover very rapidly at launch. BTC will serve as a powerful foundation for the next major growth phase in GEA. There's a number of features around our presence in BTC that make us very confident that we will be able to launch successfully and rapidly. We have more than 90% physician overlap between GEA treating centers. We obviously have access already established with the permanent J-code already active from the BTC approval.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

We've submitted the data to Oncology Pathways, we have onboarded a team of clinical nurse educators who are ready to support smooth, efficient access and patient onboarding, really leveraging our JazzCares program. We are ready, we think our readiness combined with the data, the compelling nature of the data which you're all familiar with by now, means that we should see really very rapid uptake. We're committed to ensuring that patients who need this product can get it as soon as possible.

Operator

Thank you. Our next question coming from the line of Akash Tewari with Jefferies. Your line is now open.

Anastasia Parafetas
Anastasia Parafetas
Analyst at Jefferies

Hey, this is Anastasia on for Akash. Thanks for taking the question, and congrats on the quarter. On the post-Enhertu trial, I know you compared our arm as the trastuzumab plus physician's choice chemo, I believe, but it looks like the NCCN guidelines list tucatinib plus trastuzumab and capecitabine as the preferred second, third-line regimen. Can you talk us through how you chose the comparator arm and what you consider the bar for success in the trial, as well as what is considered clinically meaningful? Also, just verifying you're still on track to complete enrollment in the first half of 2027? Thanks.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

On the second part of the question, yes. We're on track to complete enrollment by mid-year 2027. When we have results will depend on the events, but we haven't changed our guidance on that for end of 2027, 2028. In terms of the design of the trial, most of the data with other HER2 agents were generated before the availability of Enhertu. That's really the motivation for this trial is, it's unclear what to use once patients have progressed on Enhertu. The trial is set up to be a third-line plus trial. It's a global trial, in some places that will mean that patients may have gotten tucatinib previously. In some parts of the world, such as South Korea, tucatinib is not commonly used. It'll be a trial where you'd expect third-line, fourth-line, or even possibly fifth-line patients.

Rob Iannone
Rob Iannone
Global Head of R&D and Chief Medical Officer at Jazz Pharmaceuticals

While that's a poor prognosis group, we have prior data suggesting that zanidatamab can be active in that setting. Again, this is a head-to-head against trastuzumab, so we continue to be confident in zani's ability to beat what would be the standard of care in certain settings.

Operator

Thank you. Our next question in queue coming from the line of Etzer Darout with Barclays. Your line is now open.

Etzer Darout
Etzer Darout
Analyst at Barclays

Great. Thanks for taking the question. Just a follow-up on comments around XYWAV and guidance from Phil earlier. Just wondering how much of that change in the sleep franchise revenue guidance is revised expectations on generics in 2026? Maybe related to that, if you could provide any additional color on the additional investments for XYWAV and Epidiolex reflected in the SG&A guidance that would be helpful. Thank you.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

Yeah. This is Phil. Thanks for the question. Maybe I'll take the first part, then turn it over to Sam for color behind some of the additional investments to drive even further momentum and revenue growth for XYWAV and Epidiolex. The revised guidance really comes down to extremely strong execution in the field that's led to this unique benefit that XYWAV has resonating with physicians and patients, which we believe is what's likely leading to the very slow uptake that we're seeing of generic high sodium oxybates. We had said all along that we didn't expect really much of any impact in the first half of the year, that impact has played out as we had expected. However, based on the pace of introduction of the high sodium generics, we're now expecting a much more muted impact in the back half of the year as well.

Phil Johnson
Phil Johnson
CFO at Jazz Pharmaceuticals

That is behind the guidance raise for XYWAV, where before we had expected the product to be flat to up mid-single digits this year, and now we're expecting double-digit growth for the full year. Really pleased with the momentum that we have and look for that to continue. Sam?

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Yeah. In terms of the investments that we're making, obviously given the strong resilience of XYWAV and momentum, we are continuing to invest in some of the media spend that has been particularly effective in ensuring that diagnosed patients get treated with XYWAV, as well as some continued investment in the patient support program. For Epidiolex, we have continued to invest and upgraded our investment in ensuring that we can fully penetrate the LTC adult segment where we've started to see some good inroads.

Sam Pearce
Sam Pearce
Chief Commercial Officer at Jazz Pharmaceuticals

Also, we do see an opportunity to drive persistence, and we have invested to expand our JazzCares program so that more patients can get enrolled onto the JazzCares program. We know those patients generally do better on treatment. In addition, of course, we're starting to prepare for the oral solid dose launch as well. That's the nature of some of the additional investments that are outlined in the guidance.

Operator

Thank you. Our next question in queue coming from the line of Brian Skorney with Baird. Your line is now open.

Luke Herrmann
Luke Herrmann
Analyst at Baird

Hi, this is Luke on for Brian. Thanks for the question. Just one quick one on business development strategy. Can you provide any color on particular areas of interest within rare disease or with regard to development stage you'd be looking for? Or would you say you're fairly agnostic? Thank you.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Yeah. This is Renée. Thanks for the question. We won't comment on specific deals for obvious reasons, but I would say we do remain highly engaged on the BD front. I'll remind you that we hired a new CBO earlier this year to drive those efforts, and we do continue to expect to announce one or more deals still in 2026. In terms of the areas that we're interested in, we really do focus on where we believe there's a significant unmet need and where we believe we can have a meaningful impact with our unique, either expertise, global footprint, or current other operations that we have underway. We generally will look for an efficiency of commercial call point, one where the support services that we do offer to our patients can also be relevant and valued.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

We are focused on strengthening our current areas of rare epilepsy, rare sleep, rare oncology. We think there's a lot of substrate there, but we are also looking into other areas of rare disease, and we'll delay on actually providing much commentary there because there are so many different areas that we could go into that I wouldn't want to be too specific there in terms of inadvertently commenting on specific deals we might be interested in. In terms of the stage, we were really excited to announce the AbCellera deal this last quarter. That is a preclinical collaboration looking at next-gen T-cell engagers, very early in our pipeline, but it directly aligns with our overall rare disease strategy, really expanding our focus on GI cancers. We are also, though, looking at later pipeline deals as well as commercial and near commercial transactions.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

It really depends on the specific asset and the type of deal that we are interested in. Importantly, we have a strong track record of doing deals that have generated meaningful value. I mentioned Epidiolex with GW earlier last year. We did the Modeyso Chimerix transaction that was near commercial, obviously. We talked about quite a bit on this call about zani that also came into our business via business development, which we're incredibly pleased by.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

I'll just close with a reminder that we're in an incredibly strong financial position to be able to execute on BD. We generated $824 million in cash flow in the first half of this year. $2.2 billion of cash on the balance sheet supports our ability to execute in BD, in addition to the investments that we've talked about throughout the call today behind our commercial brands as well as our pipeline.

Operator

Thank you. Ladies and gentlemen, that's all the time we have for our Q&A session. I will now turn the call back over to Renée for any closing comments.

Renée Galá
Renée Galá
President and CEO at Jazz Pharmaceuticals

Great. Thank you, operator. I'd like to close today's call by thanking all of our employees as well as our partners and stakeholders for their continued confidence and support. We look forward to sharing additional updates on the potential approval of zanidatamab and GEA, as well as other progress in our business. Looking forward to sharing those updates with you over the remainder of the year. Thank you for joining us today, we can close the call.

Operator

Ladies and gentlemen, this concludes today's conference call. Thank you for your participation, you may now disconnect.

Executives
    • John Bluth
      John Bluth
      VP and Head of Investor Relations
    • Renée Galá
      Renée Galá
      President and CEO
    • Sam Pearce
      Sam Pearce
      Chief Commercial Officer
    • Rob Iannone
      Rob Iannone
      Global Head of R&D and Chief Medical Officer
    • Phil Johnson
      Phil Johnson
      CFO
Analysts
Powered by Quartr