Applied Therapeutics (APLT) Stock Price, News & Analysis

Company Overview

Applied Therapeutics is a clinical‐stage biopharmaceutical company dedicated to discovering and developing novel therapeutics that address the underlying causes of serious diseases. The company’s research focuses on metabolic and renal indications, aiming to bring differentiated treatments to patients with high unmet medical needs. Applied Therapeutics leverages a deep understanding of human biology and a precision medicine approach to identify targets that can modulate disease pathways and deliver meaningful clinical benefits.

The company’s most advanced program targets mitochondrial dysfunction and impaired energy metabolism with its investigational small molecule, beraprost sodium. Initially developed as a prostacyclin analogue, beraprost is being repositioned by Applied Therapeutics to explore new indications in rare metabolic disorders and chronic kidney disease. In addition to beraprost, the company’s pipeline includes small molecules designed to restore cellular homeostasis by enhancing nicotinamide adenine dinucleotide (NAD+) levels. These programs are supported by preclinical and early‐stage clinical studies that aim to validate mechanisms of action and demonstrate safety and efficacy in targeted patient populations.

Applied Therapeutics was founded in 2018 and is headquartered in New York City. Since its inception, the company has built a specialized team of drug discovery scientists, clinical development experts, and regulatory professionals. Applied Therapeutics collaborates with academic institutions and biotech partners to accelerate the translation of its research into clinical milestones. The company’s strategic alliances and in-licensing agreements have expanded its capabilities in medicinal chemistry, preclinical toxicology, and clinical trial execution.

Under the leadership of President and Chief Executive Officer James (“Jim”) McArthur, Applied Therapeutics has advanced from an early research outfit to a publicly traded biotech firm listed on the Nasdaq exchange. The management team includes seasoned executives with prior experience at leading pharmaceutical and biotechnology companies, providing strong governance and operational expertise. As Applied Therapeutics progresses its clinical programs, the company remains committed to delivering innovative therapies that improve patient outcomes in metabolic and renal diseases worldwide.

Key Stats

• Today's Range: $0.36 to $0.40
• 50-Day Range: $0.30 to $0.60
• 52-Week Range: $0.30 to $10.62
• Volume: 2.36 million shs
• Average Volume: 3.44 million shs
• Market Capitalization: $55.92 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $6.10
• Consensus Rating: Moderate Buy

Applied Therapeutics Stock Analysis - MarketRank™

Applied Therapeutics scored higher than 76% of companies evaluated by MarketBeat, and ranked 239th out of 921 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.3 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Applied Therapeutics has received a consensus rating of Moderate Buy. The company's average rating score is 2.50, and is based on 3 buy ratings, 3 hold ratings, and no sell ratings.

Amount of Analyst Coverage

Applied Therapeutics has only been the subject of 1 research reports in the past 90 days.

Earnings and Valuation

• Score: 1.3 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Applied Therapeutics are expected to grow in the coming year, from ($0.65) to ($0.62) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Applied Therapeutics is -0.92, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Applied Therapeutics is -0.92, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Applied Therapeutics has a P/B Ratio of 0.81. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

15.31% of the float of Applied Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Applied Therapeutics has a short interest ratio ("days to cover") of 9.9.

Change versus previous month

Short interest in Applied Therapeutics has recently increased by 18.43%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Applied Therapeutics does not currently pay a dividend.

Dividend Growth

Applied Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 4.7 / 5
• Environmental Score: -0.88

Percentage of Shares Shorted

15.31% of the float of Applied Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Applied Therapeutics has a short interest ratio ("days to cover") of 9.9.

Change versus previous month

Short interest in Applied Therapeutics has recently increased by 18.43%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 0.6 / 5
• News Sentiment: N/A

News Coverage This Week

MarketBeat has tracked 1 news article for Applied Therapeutics this week, compared to 8 articles on an average week.

Search Interest

Only 2 people have searched for APLT on MarketBeat in the last 30 days. This is a decrease of -60% compared to the previous 30 days.

MarketBeat Follows

5 people have added Applied Therapeutics to their MarketBeat watchlist in the last 30 days. This is an increase of 150% compared to the previous 30 days.

Company Ownership

• Score: 1.7 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Applied Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

Only 1.60% of the stock of Applied Therapeutics is held by insiders.

Percentage Held by Institutions

98.31% of the stock of Applied Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

APLT Stock Analysis - Frequently Asked Questions

How have APLT shares performed this year?

Applied Therapeutics' stock was trading at $0.8562 at the beginning of 2025. Since then, APLT shares have decreased by 53.9% and is now trading at $0.3950.

How were Applied Therapeutics' earnings last quarter?

Applied Therapeutics Inc. (NASDAQ:APLT) issued its quarterly earnings data on Monday, April, 14th. The company reported ($0.24) EPS for the quarter, missing the consensus estimate of ($0.18) by $0.06. The firm earned $0 million during the quarter, compared to analyst estimates of $0.61 million.

When did Applied Therapeutics IPO?

Applied Therapeutics (APLT) raised $60 million in an initial public offering on the week of May 13th 2019. The company issued 4,000,000 shares at a price of $14.00-$16.00 per share. Citigroup, Cowen and UBS Investment Bank served as the underwriters for the IPO and Baird was co-manager.

How do I buy shares of Applied Therapeutics?

Shares of APLT stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Applied Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Applied Therapeutics investors own include NVIDIA (NVDA), Broadcom (AVGO), Meta Platforms (META), Adobe (ADBE), Arista Networks (ANET), Advanced Micro Devices (AMD) and ServiceNow (NOW).

Company Calendar

• Last Earnings: 4/14/2025
• Today: 7/09/2025
• Next Earnings (Estimated): 8/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:APLT
• CIK: 1697532
• Web: www.appliedtherapeutics.com
• Phone: (212) 220-9226
• Fax: N/A
• Employees: 30
• Year Founded: 2017

Price Target and Rating

• Average Price Target for Applied Therapeutics: $6.10
• High Price Target: $14.00
• Low Price Target: $1.50
• Potential Upside/Downside: +1,444.3%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.50
• Research Coverage: 6 Analysts

Profitability

• EPS (Trailing Twelve Months): ($0.43)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$105.62 million
• Net Margins: N/A
• Pretax Margin: -16,357.52%
• Return on Equity: -184.67%
• Return on Assets: -84.02%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 3.00
• Quick Ratio: 3.00

Sales & Book Value

• Annual Sales: $460 thousand
• Price / Sales: 121.57
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $0.49 per share
• Price / Book: 0.81

Miscellaneous

• Outstanding Shares: 141,580,000
• Free Float: 139,311,000
• Market Cap: $55.92 million
• Optionable: Optionable
• Beta: 1.82