Lowest-Rated StocksLowest-RatedNASDAQ:SION Sionna Therapeutics (SION) Stock Price, News & Analysis $4.85 -0.06 (-1.22%) Closing price 04:00 PM EasternExtended Trading$4.86 +0.01 (+0.19%) As of 06:17 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsInsider TradesNews and TrendsOwnershipSEC FilingsShort Interest About Sionna Therapeutics Stock (NASDAQ:SION) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Sionna Therapeutics alerts:Sign Up Key Stats Today's Range$4.63▼$4.9650-Day Range$4.50▼$51.0452-Week Range$4.01▼$54.97Volume1.10 million shsAverage Volume972,943 shsMarket Capitalization$219.27 millionP/E RatioN/ADividend YieldN/APrice Target$42.33Consensus RatingHold Company Overview Sionna Therapeutics, Inc. (NASDAQ:SION) is a clinical-stage biopharmaceutical company focused on developing treatments for cystic fibrosis (CF), a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The company is developing small-molecule therapies intended to address the underlying cause of CF by improving the production, processing, stability and function of defective CFTR proteins. Sionna’s research platform is centered on CFTR modulators, including compounds designed to stabilize the CFTR protein’s nucleotide-binding domain 1 (NBD1). Its pipeline has included SION-638, an investigational NBD1 stabilizer intended for use as part of combination treatment regimens. The company’s approach is designed to potentially benefit people with a broad range of CFTR mutations, including patients who may not be adequately served by existing therapies. Sionna conducts drug discovery and clinical development activities for the CF community. As a development-stage company, its investigational products remain subject to clinical testing and regulatory review, and there is no assurance that they will receive approval or become commercially available.AI Generated. May Contain Errors. Read More Sionna Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks61st Percentile Overall ScoreSION MarketRank™: Sionna Therapeutics scored higher than 61% of companies evaluated by MarketBeat, and ranked 330th out of 888 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.0 / 5Analyst RatingHold Consensus RatingSionna Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no strong buy ratings, 1 buy rating, 11 hold ratings, and 1 sell rating.Upside PotentialSionna Therapeutics has a consensus price target of $42.33, representing about 772.9% upside from its current price of $4.85.Amount of Analyst CoverageSionna Therapeutics has been the subject of 11 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Sionna Therapeutics' stock forecast and price target. Earnings and Valuation1.3 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Sionna Therapeutics are expected to grow in the coming year, from ($2.54) to ($2.44) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Sionna Therapeutics is -2.22, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Sionna Therapeutics is -2.22, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioSionna Therapeutics has a P/B Ratio of 0.70. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities. Short Interest4.0 / 5Short Interest LevelHealthy Percentage of Shares Shorted9.24% of the float of Sionna Therapeutics has been sold short.Short Interest Ratio / Days to CoverSionna Therapeutics has a short interest ratio ("days to cover") of 3.1, which is generally considered an acceptable ratio of short interest to trading volume.Change versus previous monthShort interest in Sionna Therapeutics has recently decreased by 7.74%, indicating that investor sentiment is improving significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldSionna Therapeutics does not currently pay a dividend.Dividend GrowthSionna Therapeutics does not have a long track record of dividend growth. News and Social Media0.0 / 5News Sentiment0.00 News Coverage This WeekMarketBeat has tracked 2 news articles for Sionna Therapeutics this week, compared to 5 articles on an average week.Search InterestOnly 10 people have searched for SION on MarketBeat in the last 30 days. This is a decrease of -29% compared to the previous 30 days. Company Ownership0.9 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Sionna Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $29,539,537.00 in company stock.Percentage Held by Insiders5.10% of the stock of Sionna Therapeutics is held by insiders.Percentage Held by InstitutionsSionna Therapeutics has minimal institutional ownership at this time.Read more about Sionna Therapeutics' insider trading history. Receive SION Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Sionna Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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SION Stock News HeadlinesINVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONOctober 1, 2026 | prnewswire.comINVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONSeptember 29, 2026 | globenewswire.comDo NOT Buy SpaceX – Do This InsteadSpaceX just went public - and Whitney Tilson, Harvard MBA and 30-year Wall Street veteran, says buying in could be a costly mistake. He calls it among the most overhyped, overvalued large-cap offerings ever pushed onto everyday investors. Tilson believes a rare economic event is approaching - one with serious consequences for your portfolio this summer. He has prepared a free analysis outlining what he sees and the specific steps he recommends taking now.October 5 at 1:00 AM | Stansberry Research (Ad)INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONSeptember 24, 2026 | prnewswire.comINVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONSeptember 22, 2026 | globenewswire.comSionna Therapeutics (NASDAQ:SION) Director Sells 3,448,811 Shares of StockSeptember 22, 2026 | insidertrades.comSionna Therapeutics, Inc.(NasdaqGM:SION) dropped from S&P Biotechnology Select Industry IndexSeptember 20, 2026 | marketscreener.comMLifeSci Capital Sticks to Its Hold Rating for Sionna Therapeutics, Inc. (SION)September 20, 2026 | theglobeandmail.comSee More Headlines SION Stock Analysis - Frequently Asked Questions How have SION shares performed this year? Sionna Therapeutics' stock was trading at $41.14 on January 1st, 2026. Since then, SION stock has decreased by 88.2% and is now trading at $4.85. How were Sionna Therapeutics' earnings last quarter? Sionna Therapeutics, Inc. (NASDAQ:SION) posted its quarterly earnings data on Thursday, August, 6th. The company reported ($0.66) earnings per share for the quarter, missing analysts' consensus estimates of ($0.64) by $0.02. When did Sionna Therapeutics IPO? Sionna Therapeutics (SION) raised $180 million in an IPO on Friday, February 7th 2025. The company issued 10,588,233 shares at a price of $16.00-$18.00 per share. How do I buy shares of Sionna Therapeutics? Shares of SION stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. Company Calendar Last Earnings8/06/2026Today10/05/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (3w+) 1-Year History Oct 25 Jan 26 Apr 26 Jul 26 Oct 26 For the last 3 weeks, SION's financial health has been in the Green zone, according to TradeSmith. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:SION Previous SymbolNASDAQ:SION CIK2036042 Webwww.sionnatx.com Phone(617) 819-2020FaxN/AEmployees59Year FoundedN/APrice Target and Rating Average Price Target for Sionna Therapeutics$42.33 High Price Target$63.00 Low Price Target$5.00 Potential Upside/Downside+772.9%Consensus RatingHold Rating Score (0-4)2.00 Research Coverage13 Analysts Profitability EPS (Trailing Twelve Months)($2.18) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$75.27 million Net MarginsN/A Pretax MarginN/A Return on Equity-32.94% Return on Assets-31.08% Debt Debt-to-Equity RatioN/A Current Ratio20.05 Quick Ratio20.05 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$6.88 per share Price / Book0.70Miscellaneous Outstanding Shares45,210,000Free Float42,906,000Market Cap$219.27 million OptionableN/A Beta1.00 Options Trading Made Easy - Download NowLearn the basics of options trading and how to use them to boost returns and manage risk with this free report from MarketBeat. 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