Sionna Therapeutics (SION) Competitors

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$42.77 +1.68 (+4.09%)
Closing price 04:00 PM Eastern
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$42.86 +0.09 (+0.22%)
As of 04:10 PM Eastern
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SION vs. RYTM, PTCT, LEGN, MIRM, and CNTA

Should you buy Sionna Therapeutics stock or one of its competitors? MarketBeat compares Sionna Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Sionna Therapeutics include Rhythm Pharmaceuticals (RYTM), PTC Therapeutics (PTCT), Legend Biotech (LEGN), Mirum Pharmaceuticals (MIRM), and Centessa Pharmaceuticals (CNTA). These companies are all part of the "pharmaceutical products" industry.

How does Sionna Therapeutics compare to Rhythm Pharmaceuticals?

Sionna Therapeutics (NASDAQ:SION) and Rhythm Pharmaceuticals (NASDAQ:RYTM) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their earnings, risk, dividends, media sentiment, valuation, institutional ownership, profitability and analyst recommendations.

Sionna Therapeutics has higher earnings, but lower revenue than Rhythm Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Sionna Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Sionna TherapeuticsN/AN/A-$75.27M-$1.93N/A
Rhythm Pharmaceuticals$189.76M39.10-$196.54M-$3.13N/A

Sionna Therapeutics has a beta of 1.3, suggesting that its stock price is 30% more volatile than the broader market. Comparatively, Rhythm Pharmaceuticals has a beta of 1.91, suggesting that its stock price is 91% more volatile than the broader market.

Sionna Therapeutics currently has a consensus target price of $53.22, suggesting a potential upside of 24.44%. Rhythm Pharmaceuticals has a consensus target price of $133.13, suggesting a potential upside of 22.97%. Given Sionna Therapeutics' stronger consensus rating and higher probable upside, equities analysts clearly believe Sionna Therapeutics is more favorable than Rhythm Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Sionna Therapeutics
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
2.85
Rhythm Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
14 Buy rating(s)
1 Strong Buy rating(s)
2.83

Sionna Therapeutics has a net margin of 0.00% compared to Rhythm Pharmaceuticals' net margin of -93.33%. Sionna Therapeutics' return on equity of -27.31% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Sionna TherapeuticsN/A -27.31% -25.88%
Rhythm Pharmaceuticals -93.33%-203.25%-44.99%

In the previous week, Rhythm Pharmaceuticals had 3 more articles in the media than Sionna Therapeutics. MarketBeat recorded 4 mentions for Rhythm Pharmaceuticals and 1 mentions for Sionna Therapeutics. Sionna Therapeutics' average media sentiment score of 0.00 beat Rhythm Pharmaceuticals' score of -0.09 indicating that Sionna Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Sionna Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Rhythm Pharmaceuticals
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Sionna Therapeutics beats Rhythm Pharmaceuticals on 10 of the 14 factors compared between the two stocks.

How does Sionna Therapeutics compare to PTC Therapeutics?

PTC Therapeutics (NASDAQ:PTCT) and Sionna Therapeutics (NASDAQ:SION) are both medical companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, media sentiment, valuation, profitability, risk, analyst recommendations, dividends and institutional ownership.

PTC Therapeutics currently has a consensus price target of $91.36, indicating a potential upside of 8.10%. Sionna Therapeutics has a consensus price target of $53.22, indicating a potential upside of 24.44%. Given Sionna Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Sionna Therapeutics is more favorable than PTC Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
PTC Therapeutics
2 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.71
Sionna Therapeutics
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
2.85

Sionna Therapeutics has a net margin of 0.00% compared to PTC Therapeutics' net margin of -22.58%. Sionna Therapeutics' return on equity of -27.31% beat PTC Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
PTC Therapeutics-22.58% -362.45% -6.76%
Sionna Therapeutics N/A -27.31%-25.88%

PTC Therapeutics has a beta of 0.56, meaning that its stock price is 44% less volatile than the broader market. Comparatively, Sionna Therapeutics has a beta of 1.3, meaning that its stock price is 30% more volatile than the broader market.

In the previous week, PTC Therapeutics had 10 more articles in the media than Sionna Therapeutics. MarketBeat recorded 11 mentions for PTC Therapeutics and 1 mentions for Sionna Therapeutics. PTC Therapeutics' average media sentiment score of 0.53 beat Sionna Therapeutics' score of 0.00 indicating that PTC Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
PTC Therapeutics
6 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Sionna Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

PTC Therapeutics has higher revenue and earnings than Sionna Therapeutics. PTC Therapeutics is trading at a lower price-to-earnings ratio than Sionna Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
PTC Therapeutics$827.11M8.48$682.64M-$2.33N/A
Sionna TherapeuticsN/AN/A-$75.27M-$1.93N/A

Summary

Sionna Therapeutics beats PTC Therapeutics on 8 of the 14 factors compared between the two stocks.

How does Sionna Therapeutics compare to Legend Biotech?

Legend Biotech (NASDAQ:LEGN) and Sionna Therapeutics (NASDAQ:SION) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their profitability, media sentiment, risk, institutional ownership, valuation, dividends, earnings and analyst recommendations.

70.9% of Legend Biotech shares are held by institutional investors. 0.0% of Legend Biotech shares are held by insiders. Comparatively, 5.1% of Sionna Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Legend Biotech has a beta of 0.35, suggesting that its stock price is 65% less volatile than the broader market. Comparatively, Sionna Therapeutics has a beta of 1.3, suggesting that its stock price is 30% more volatile than the broader market.

Sionna Therapeutics has a net margin of 0.00% compared to Legend Biotech's net margin of -21.98%. Legend Biotech's return on equity of -24.92% beat Sionna Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Legend Biotech-21.98% -24.92% -14.87%
Sionna Therapeutics N/A -27.31%-25.88%

In the previous week, Legend Biotech and Legend Biotech both had 1 articles in the media. Legend Biotech's average media sentiment score of 0.32 beat Sionna Therapeutics' score of 0.00 indicating that Legend Biotech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Legend Biotech
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Sionna Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Legend Biotech currently has a consensus price target of $60.23, suggesting a potential upside of 111.86%. Sionna Therapeutics has a consensus price target of $53.22, suggesting a potential upside of 24.44%. Given Legend Biotech's higher probable upside, analysts plainly believe Legend Biotech is more favorable than Sionna Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Legend Biotech
1 Sell rating(s)
3 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.67
Sionna Therapeutics
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
2.85

Sionna Therapeutics has lower revenue, but higher earnings than Legend Biotech. Legend Biotech is trading at a lower price-to-earnings ratio than Sionna Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Legend Biotech$1.03B5.13-$296.80M-$0.68N/A
Sionna TherapeuticsN/AN/A-$75.27M-$1.93N/A

Summary

Legend Biotech beats Sionna Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Sionna Therapeutics compare to Mirum Pharmaceuticals?

Sionna Therapeutics (NASDAQ:SION) and Mirum Pharmaceuticals (NASDAQ:MIRM) are both medical companies, but which is the better investment? We will compare the two companies based on the strength of their earnings, media sentiment, profitability, valuation, institutional ownership, dividends, risk and analyst recommendations.

Sionna Therapeutics has a beta of 1.3, indicating that its stock price is 30% more volatile than the broader market. Comparatively, Mirum Pharmaceuticals has a beta of 0.5, indicating that its stock price is 50% less volatile than the broader market.

In the previous week, Mirum Pharmaceuticals had 5 more articles in the media than Sionna Therapeutics. MarketBeat recorded 6 mentions for Mirum Pharmaceuticals and 1 mentions for Sionna Therapeutics. Mirum Pharmaceuticals' average media sentiment score of 0.53 beat Sionna Therapeutics' score of 0.00 indicating that Mirum Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Sionna Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Mirum Pharmaceuticals
2 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Sionna Therapeutics currently has a consensus target price of $53.22, suggesting a potential upside of 24.44%. Mirum Pharmaceuticals has a consensus target price of $139.80, suggesting a potential upside of 19.20%. Given Sionna Therapeutics' higher probable upside, analysts plainly believe Sionna Therapeutics is more favorable than Mirum Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Sionna Therapeutics
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
2.85
Mirum Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.93

Sionna Therapeutics has a net margin of 0.00% compared to Mirum Pharmaceuticals' net margin of -140.24%. Mirum Pharmaceuticals' return on equity of -11.28% beat Sionna Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Sionna TherapeuticsN/A -27.31% -25.88%
Mirum Pharmaceuticals -140.24%-11.28%-3.84%

Mirum Pharmaceuticals has higher revenue and earnings than Sionna Therapeutics. Sionna Therapeutics is trading at a lower price-to-earnings ratio than Mirum Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Sionna TherapeuticsN/AN/A-$75.27M-$1.93N/A
Mirum Pharmaceuticals$521.31M13.72-$23.36M-$13.61N/A

Summary

Mirum Pharmaceuticals beats Sionna Therapeutics on 9 of the 14 factors compared between the two stocks.

How does Sionna Therapeutics compare to Centessa Pharmaceuticals?

Sionna Therapeutics (NASDAQ:SION) and Centessa Pharmaceuticals (NASDAQ:CNTA) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, media sentiment, risk, analyst recommendations, institutional ownership, profitability, valuation and earnings.

In the previous week, Centessa Pharmaceuticals had 3 more articles in the media than Sionna Therapeutics. MarketBeat recorded 4 mentions for Centessa Pharmaceuticals and 1 mentions for Sionna Therapeutics. Centessa Pharmaceuticals' average media sentiment score of 0.54 beat Sionna Therapeutics' score of 0.00 indicating that Centessa Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Sionna Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Centessa Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Sionna Therapeutics presently has a consensus price target of $53.22, indicating a potential upside of 24.44%. Centessa Pharmaceuticals has a consensus price target of $41.33, indicating a potential upside of 2.06%. Given Sionna Therapeutics' stronger consensus rating and higher probable upside, research analysts plainly believe Sionna Therapeutics is more favorable than Centessa Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Sionna Therapeutics
2 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
3 Strong Buy rating(s)
2.85
Centessa Pharmaceuticals
1 Sell rating(s)
9 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.21

Sionna Therapeutics has higher earnings, but lower revenue than Centessa Pharmaceuticals. Centessa Pharmaceuticals is trading at a lower price-to-earnings ratio than Sionna Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Sionna TherapeuticsN/AN/A-$75.27M-$1.93N/A
Centessa Pharmaceuticals$15M417.77-$197.53M-$1.79N/A

Sionna Therapeutics' return on equity of -27.31% beat Centessa Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Sionna TherapeuticsN/A -27.31% -25.88%
Centessa Pharmaceuticals N/A -60.37%-44.17%

Sionna Therapeutics has a beta of 1.3, indicating that its share price is 30% more volatile than the broader market. Comparatively, Centessa Pharmaceuticals has a beta of 1.11, indicating that its share price is 11% more volatile than the broader market.

82.0% of Centessa Pharmaceuticals shares are held by institutional investors. 5.1% of Sionna Therapeutics shares are held by insiders. Comparatively, 4.1% of Centessa Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Summary

Sionna Therapeutics beats Centessa Pharmaceuticals on 10 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SION and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SION vs. The Competition

MetricSionna TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$1.93B$3.55B$6.67B$12.21B
Dividend YieldN/A2.28%2.68%5.89%
P/E Ratio-22.1621.3125.7824.03
Price / SalesN/A329.03589.32117.77
Price / CashN/A130.9645.2953.76
Price / Book6.228.0310.516.32
Net Income-$75.27M$23.91M$3.57B$337.22M
7 Day Performance14.66%1.34%0.81%-1.20%
1 Month Performance3.99%1.71%0.68%0.40%
1 Year Performance185.70%56.85%30.98%29.26%

Sionna Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SION
Sionna Therapeutics
2.4405 of 5 stars
$42.77
+4.1%
$53.22
+24.4%
+156.2%$1.93BN/AN/A35
RYTM
Rhythm Pharmaceuticals
3.023 of 5 stars
$96.79
+1.0%
$133.13
+37.5%
+68.9%$6.57B$189.76MN/A140
PTCT
PTC Therapeutics
2.3015 of 5 stars
$78.98
+0.6%
$91.36
+15.7%
+70.1%$6.51B$1.73BN/A1,410
LEGN
Legend Biotech
4.335 of 5 stars
$27.93
-16.7%
$60.23
+115.6%
-14.3%$6.23B$1.03BN/A2,965
MIRM
Mirum Pharmaceuticals
3.6901 of 5 stars
$107.13
+5.0%
$139.80
+30.5%
+124.5%$6.22B$521.31MN/A140

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This page (NASDAQ:SION) was last updated on 6/25/2026 by MarketBeat.com Staff.
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