NASDAQ:UPB Upstream Bio (UPB) Stock Price, News & Analysis $6.19 +0.18 (+3.00%) Closing price 04:00 PM EasternExtended Trading$6.06 -0.13 (-2.10%) As of 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOwnershipSEC FilingsShort Interest About Upstream Bio Stock (NASDAQ:UPB) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Upstream Bio alerts:Sign Up Key Stats Today's Range$5.77▼$6.2150-Day Range$6.01▼$7.9852-Week Range$5.77▼$33.68Volume949,641 shsAverage Volume571,733 shsMarket Capitalization$339.03 millionP/E RatioN/ADividend YieldN/APrice Target$29.67Consensus RatingHold Company Overview Upstream Bio, Inc. is a clinical-stage biotechnology company focused on the development of next-generation prophylactic vaccines and immuno-oncology therapies. Leveraging a proprietary viral vector platform, the company aims to deliver optimized antigen payloads that stimulate robust and durable immune responses against both infectious diseases and cancer targets. Upstream Bio’s approach emphasizes safety, manufacturability and potential for rapid scale-up to address emerging public health challenges. The company’s research and development pipeline includes multiple viral vector-based candidates in early clinical and preclinical stages. In the immuno-oncology sphere, Upstream Bio is exploring therapeutic vaccine constructs designed to activate tumor-specific T cells, while its infectious disease programs seek to induce protective immunity against viral pathogens. By integrating translational biomarkers and adaptive clinical trial designs, the company strives to accelerate candidate selection and optimize dosing regimens. Upstream Bio operates research facilities in the United States and collaborates with academic and industry partners across several regions to advance its programs globally. The company’s leadership team comprises seasoned executives and scientists with deep expertise in virology, vaccine development and regulatory affairs. Upstream Bio is listed on the Nasdaq Global Market under the symbol UPB and continues to build strategic alliances aimed at expanding its pipeline and commercial capabilities.AI Generated. May Contain Errors. Read More Upstream Bio Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks51st Percentile Overall ScoreUPB MarketRank™: Upstream Bio scored higher than 51% of companies evaluated by MarketBeat, and ranked 537th out of 906 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.0 / 5Analyst RatingHold Consensus RatingUpstream Bio has received a consensus rating of Hold. The company's average rating score is 2.43, and is based on no strong buy ratings, 4 buy ratings, 2 hold ratings, and 1 sell rating.Upside PotentialUpstream Bio has a consensus price target of $29.67, representing about 379.3% upside from its current price of $6.19.Amount of Analyst CoverageUpstream Bio has only been the subject of 4 research reports in the past 90 days.Read more about Upstream Bio's stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthDecreasing Earnings GrowthEarnings for Upstream Bio are expected to decrease in the coming year, from ($2.86) to ($2.93) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Upstream Bio is -2.13, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Upstream Bio is -2.13, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioUpstream Bio has a P/B Ratio of 0.98. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities.Read more about Upstream Bio's valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted8.78% of the float of Upstream Bio has been sold short.Short Interest Ratio / Days to CoverUpstream Bio has a short interest ratio ("days to cover") of 5.64.Change versus previous monthShort interest in Upstream Bio has recently increased by 10.09%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldUpstream Bio does not currently pay a dividend.Dividend GrowthUpstream Bio does not have a long track record of dividend growth. News and Social Media3.3 / 5News Sentiment0.35 News SentimentUpstream Bio has a news sentiment score of 0.35. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.76 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 12 news articles for Upstream Bio this week, compared to 3 articles on an average week.Search Interest4 people have searched for UPB on MarketBeat in the last 30 days. This is an increase of 100% compared to the previous 30 days.MarketBeat Follows1 people have added Upstream Bio to their MarketBeat watchlist in the last 30 days. Company Ownership0.6 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Upstream Bio insiders have not sold or bought any company stock.Percentage Held by Insiders16.46% of the stock of Upstream Bio is held by insiders. A high percentage of insider ownership can be a sign of company health.Percentage Held by InstitutionsUpstream Bio has minimal institutional ownership at this time.Read more about Upstream Bio's insider trading history. 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Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. UPB Stock News HeadlinesUpstream Bio Reports Phase 2 VALIANT Trial Results Showing Verekitug Reduced Severe Asthma Exacerbations by 56% with Quarterly DosingSeptember 8 at 3:51 AM | quiverquant.comQUpstream Bio Presents Results from the Phase 2 VALIANT Trial of Verekitug for the Treatment of Severe Asthma in Oral Presentation at ERS Congress 2026September 8 at 3:30 AM | globenewswire.comMusk just exposed the crack in his empireSpaceX's IPO raised approximately $85.7 billion in gross proceeds. Days later, the company revealed its combined chip demand with Tesla could exceed one terawatt of compute, far beyond current global supply. One small public company has built a dinner-plate-sized AI chip designed to sidestep traditional GPU architecture, potentially positioning it as a target for Musk's expanding compute needs. A January 1, 2027 defense-sourcing restriction on strategic materials adds urgency to the timeline.September 8 at 1:00 AM | The Oxford Club (Ad)HC Wainwright Forecasts Reduced Earnings for Upstream BioSeptember 6 at 1:13 AM | americanbankingnews.comHC Wainwright Reaffirms "Buy" Rating for Upstream Bio (NASDAQ:UPB)September 4, 2026 | americanbankingnews.comAnalysts Are Bullish on These NA Stocks: Upstream Bio, Inc. (UPB), Fervo Energy Company Class A (FRVO)September 2, 2026 | theglobeandmail.comUpstream Bio on Track to Begin Two Phase 3 Verekitug Trials in Q1 2027September 1, 2026 | finance.yahoo.comUpstream Bio Outlines Phase 3 Plans for VerekitugSeptember 1, 2026 | tipranks.comSee More Headlines UPB Stock Analysis - Frequently Asked Questions How have UPB shares performed this year? Upstream Bio's stock was trading at $27.15 at the start of the year. Since then, UPB shares have decreased by 77.2% and is now trading at $6.19. How were Upstream Bio's earnings last quarter? Upstream Bio, Inc. (NASDAQ:UPB) posted its quarterly earnings results on Tuesday, August, 11th. The company reported ($0.73) earnings per share (EPS) for the quarter, topping the consensus estimate of ($0.74) by $0.01. The company earned $0.77 million during the quarter, compared to the consensus estimate of $0.56 million. Upstream Bio had a negative trailing twelve-month return on equity of 48.40% and a negative net margin of 4,955.67%. When did Upstream Bio IPO? Upstream Bio (UPB) raised $200 million in an initial public offering on Friday, October 11th 2024. The company issued 12,500,000 shares at $15.00-$17.00 per share. JPMorgan, TD Cowen, Piper Sandler and William Blair served as the underwriters for the IPO. Who are Upstream Bio's major shareholders? Upstream Bio's top institutional investors include BlackRock Inc. (6.90%), Parkman Healthcare Partners LLC (1.71%), Walleye Capital LLC (0.92%) and Bank of America Corp DE (0.72%). Insiders that own company stock include Erez Chimovits, Ai Upstream Llc and Michael Gray. View institutional ownership trends. How do I buy shares of Upstream Bio? Shares of UPB stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. Company Calendar Last Earnings8/11/2026Today9/08/2026Next Earnings (Estimated)11/04/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (6m+) 1-Year History Sep 25 Dec 25 Mar 26 Jun 26 Sep 26 UPB's financial health is in the Red zone, according to TradeSmith. UPB has been in this zone for over 6 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:UPB Previous SymbolNASDAQ:UPB CIK2022626 Webupstreambio.com Phone(781) 208-2466FaxN/AEmployees38Year Founded2021Price Target and Rating Average Price Target for Upstream Bio$29.67 High Price Target$50.00 Low Price Target$9.00 Potential Upside/Downside+379.3%Consensus RatingHold Rating Score (0-4)2.43 Research Coverage7 Analysts Profitability EPS (Trailing Twelve Months)($2.90) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$143.44 million Net Margins-4,955.67% Pretax Margin-4,955.67% Return on Equity-48.40% Return on Assets-46.57% Debt Debt-to-Equity RatioN/A Current Ratio27.99 Quick Ratio27.99 Sales & Book Value Annual Sales$2.85 million Price / Sales118.96 Cash FlowN/A Price / Cash FlowN/A Book Value$6.29 per share Price / Book0.98Miscellaneous Outstanding Shares54,770,000Free Float45,756,000Market Cap$339.03 million OptionableN/A Beta1.28 Social Links 7 Best Space Stocks to Own in 2026The space race is growing fast, and you don’t have to have gotten in early on SpaceX to profit. This report shows seven space stocks you can buy today that may grow as rockets, satellites, defense, space internet, and new space technology become more important.Get This Free Report This page (NASDAQ:UPB) was last updated on 9/8/2026 by MarketBeat.com Staff. From Our PartnersThis looks like plywood. It's not.AI data centers have a power problem nobody likes to talk about. A single rack of computers can now use more e...Eagle Publishing | SponsoredThis 38 Dollar Fund Holds Every Major AI Stock and Pays WeeklyThe biggest AI stocks like Nvidia, CrowdStrike, and Palantir now trade for hundreds of dollars a share. One fu...Investors Alley | SponsoredMusk just exposed the crack in his empireSpaceX's IPO raised approximately $85.7 billion in gross proceeds. Days later, the company revealed its combin...The Oxford Club | SponsoredBlackRock and Vanguard already own THISInstitutions own roughly 88 percent of an overlooked American oil and natural gas company. 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