Arbutus Biopharma Corporation is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing curative therapies for patients with chronic hepatitis B virus (HBV) infection. Headquartered in Warminster, Pennsylvania, with research and development operations in Vancouver, Canada, Arbutus leverages its proprietary lipid nanoparticle (LNP) delivery platform and RNA interference (RNAi) programs to advance a pipeline of therapies designed to achieve functional cure of HBV.
The company’s lead investigational product, AB-729, is an RNAi therapeutic that targets viral transcripts, aiming to reduce key viral proteins and restore immune control. Arbutus is also developing small-molecule capsid assembly modulators (AB-101 and AB-201) to inhibit viral replication by disrupting the formation of the hepatitis B virus capsid. These programs reflect Arbutus’s integrated approach, combining novel delivery technology with complementary antiviral mechanisms to address multiple stages of the HBV lifecycle.
Since its formation in 2015 through the combination of Tekmira Pharmaceuticals and OnCore Biopharma, Arbutus has built a robust intellectual property portfolio covering LNP formulation and formulation components, RNAi chemistries and HBV-related patents. The company maintains strategic collaborations and licensing agreements to extend its platform capabilities and broaden its reach in antiviral development.
Under the leadership of President and Chief Executive Officer Mark J. F. Myers, Arbutus Biopharma is committed to advancing global efforts against chronic hepatitis B. With a presence in North America and partnerships across Europe and Asia, the company seeks to deliver innovative therapies that could transform the treatment landscape and improve outcomes for millions of patients worldwide.
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