Agios Pharmaceuticals (AGIO) Short Interest Ratio & Short Volume $40.61 -1.82 (-4.29%) Closing price 10/10/2025 04:00 PM EasternExtended Trading$40.50 -0.11 (-0.27%) As of 10/10/2025 06:24 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Agios Pharmaceuticals Short Interest DataAgios Pharmaceuticals (AGIO) has a short interest of 4.74 million shares, representing 8.63% of the float (the number of shares available for trading by the public). This marks a -0.42% decrease in short interest from the previous month. The short interest ratio (days to cover) is 6.0, indicating that it would take 6.0 days of the average trading volume of 581,490 shares to cover all short positions.Current Short Interest4,740,000 sharesPrevious Short Interest4,760,000 sharesChange Vs. Previous Month-0.42%Dollar Volume Sold Short$172.06 millionShort Interest Ratio6.0 Days to CoverLast Record DateSeptember 15, 2025Outstanding Shares58,102,000 sharesFloat Size54,910,000 sharesShort Percent of Float8.63%Today's Trading Volume657,660 sharesAverage Trading Volume581,490 sharesToday's Volume Vs. Average113% Short Selling Agios Pharmaceuticals? Sign up to receive the latest short interest report for Agios Pharmaceuticals and its competitors with MarketBeat's FREE newsletter. 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Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartAGIO Short Interest Over TimeAGIO Days to Cover Over TimeAGIO Percentage of Float Shorted Over Time Agios Pharmaceuticals Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 9/15/20254,740,000 shares $172.06 million -0.4%8.6%6 $36.30 8/31/20254,760,000 shares $179.50 million -1.2%8.8%6 $37.71 8/15/20254,820,000 shares $178.39 million +17.6%8.9%6.5 $37.01 7/31/20254,100,000 shares $152.60 million -1.9%7.4%5.5 $37.22 7/15/20254,180,000 shares $163.81 million +10.6%7.6%7 $39.19 6/30/20253,780,000 shares $125.72 million -12.5%6.8%6.3 $33.26 6/15/20254,320,000 shares $148.18 million +1.7%7.8%7.2 $34.30 5/31/20254,250,000 shares $137.66 million +2.2%7.7%6.8 $32.39 5/15/20254,160,000 shares $117.56 million +5.9%7.5%6.5 $28.26 4/30/20253,930,000 shares $116.68 million +12.9%7.1%5.9 $29.69 Get the Latest News and Ratings for AGIO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Agios Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. 4/15/20253,480,000 shares $96.81 million -2.0%6.3%5.2 $27.82 3/31/20253,550,000 shares $104.02 million +4.4%6.4%4.8 $29.30 3/15/20253,400,000 shares $105.16 million -13.7%6.2%4.3 $30.93 2/28/20253,940,000 shares $140.03 million -14.9%7.1%4.4 $35.54 2/15/20254,630,000 shares $153.81 million -8.0%8.4%5.4 $33.22 1/31/20255,030,000 shares $172.98 million -6.0%9.1%5.7 $34.39 1/15/20255,350,000 shares $178.05 million -3.3%9.7%6.2 $33.28 12/31/20245,530,000 shares $181.72 million +8.0%10.0%6.6 $32.86 12/15/20245,120,000 shares $199.50 million +12.0%9.3%6.4 $38.97 11/30/20244,570,000 shares $271.41 million +0.4%8.3%6.9 $59.39 11/15/20244,550,000 shares $244.70 million +4.8%8.3%8 $53.78 10/31/20244,340,000 shares $192.83 million +5.6%7.9%8.3 $44.43 10/15/20244,110,000 shares $172.78 million +25.3%7.5%8.8 $42.04 9/30/20243,280,000 shares $145.73 million +10.1%6.0%6.5 $44.43 9/15/20242,980,000 shares $139.14 million +2.8%5.4%6.5 $46.69 8/31/20242,900,000 shares $133.14 million -16.2%5.3%5.4 $45.91 8/15/20243,460,000 shares $155.39 million -2.5%6.3%4.9 $44.91 7/31/20243,550,000 shares $164.72 million +11.3%6.4%4.7 $46.40 7/15/20243,190,000 shares $149.80 million +1.9%5.8%4 $46.96 6/30/20243,130,000 shares $134.97 million -25.8%5.7%3.9 $43.12 6/15/20244,220,000 shares $186.14 million -5.6%7.6%5.3 $44.11 5/31/20244,470,000 shares $162.44 million -26.5%8.1%6 $36.34 5/15/20246,080,000 shares $213.89 million -6.6%11.0%8.5 $35.18 4/30/20246,510,000 shares $211.58 million -2.1%11.8%8.5 $32.50 4/15/20246,650,000 shares $194.58 million +0.8%12.2%8.9 $29.26 3/31/20246,600,000 shares $192.98 million -3.7%12.1%8.3 $29.24 3/15/20246,850,000 shares $205.09 million -6.6%12.5%8.3 $29.94 2/29/20247,330,000 shares $236.91 million -4.2%13.4%8.8 $32.32 2/15/20247,650,000 shares $205.02 million +4.2%14.0%10 $26.80 1/31/20247,340,000 shares $166.03 million -8.6%13.4%11.3 $22.62 1/15/20248,030,000 shares $182.60 million +13.1%14.7%11.5 $22.74 12/31/20237,100,000 shares $158.12 million +3.4%13.0%10.9 $22.27 12/15/20236,870,000 shares $159.66 million +7.2%12.5%11.6 $23.24 11/30/20236,410,000 shares $142.49 million +6.5%11.7%11.7 $22.23 11/15/20236,020,000 shares $135.27 million +6.4%11.0%11.3 $22.47 10/31/20235,660,000 shares $118.92 million +2.5%10.6%11.2 $21.01 10/15/20235,520,000 shares $127.62 million -5.5%10.3%13.3 $23.12 9/30/20235,840,000 shares $144.54 million -3.5%10.9%15.3 $24.75 9/15/20236,050,000 shares $157.84 million +2.5%11.3%16.6 $26.09 8/31/20235,900,000 shares $161.84 million -1.0%11.0%15.2 $27.43 8/15/20235,960,000 shares $165.39 million -1.5%11.2%14.4 $27.75 7/31/20236,050,000 shares $160.45 million -2.9%11.3%14.1 $26.52 7/15/20236,230,000 shares $169.58 million +5.4%11.7%13.4 $27.22 6/30/20235,910,000 shares $167.37 million +2.4%11.1%12.7 $28.32 6/15/20235,770,000 shares $148.92 million +0.5%10.8%12.2 $25.81 5/31/20235,740,000 shares $145.11 million -0.9%10.8%12.1 $25.28 5/15/20235,790,000 shares $151.70 million +1.6%10.9%11.3 $26.20 4/30/20235,700,000 shares $130.36 million +6.3%10.7%10.8 $22.87 4/15/20235,360,000 shares $117.60 million -6.9%10.1%10 $21.94 3/31/20235,760,000 shares $132.31 million -3.2%10.9%10.8 $22.97 3/15/20235,950,000 shares $140.60 million +1.2%11.2%11.4 $23.63 2/28/20235,880,000 shares $148.82 million +1.7%11.1%11.4 $25.31 2/15/20235,780,000 shares $160.16 million +0.2%11.0%11.9 $27.71 1/31/20235,770,000 shares $170.10 million -13.8%10.9%12.1 $29.48 1/15/20236,690,000 shares $199.16 million -1.2%12.7%13.5 $29.77 12/30/20226,770,000 shares $190.10 million +2.1%12.8%14.3 $28.08 12/15/20226,630,000 shares $196.98 million +4.1%12.6%13 $29.71 11/30/20226,370,000 shares $191.99 million +1.0%12.1%11.2 $30.14 11/15/20226,310,000 shares $179.27 million -1.1%12.0%9.4 $28.41 10/31/20226,380,000 shares $175.71 million +7.4%12.1%9.2 $27.54 10/15/20225,940,000 shares $160.20 million +6.6%11.3%8.1 $26.97 9/30/20225,570,000 shares $157.52 million -1.9%10.6%7.6 $28.28 9/15/20225,680,000 shares $193.57 million +3.3%10.5%7.5 $34.08 8/31/20225,500,000 shares $140.25 million -11.0%10.2%6.9 $25.50 8/15/20226,180,000 shares $174.96 million -4.2%11.4%8.8 $28.31 7/31/20226,450,000 shares $139.13 million +3.4%12.7%8.8 $21.57 7/15/20226,240,000 shares $139.21 million +1.5%12.3%8.7 $22.31 6/30/20226,150,000 shares $136.35 million -4.2%12.1%8.4 $22.17 6/15/20226,420,000 shares $117.68 million -1.7%12.6%9.4 $18.33 5/31/20226,530,000 shares $127.14 million +9.0%12.1%11 $19.47 5/15/20225,990,000 shares $132.50 million +1.5%11.1%10 $22.12 4/30/20225,900,000 shares $129.62 million -6.9%10.9%10.1 $21.97 4/15/20226,340,000 shares $176.89 million +3.3%11.8%11.1 $27.90 3/31/20226,140,000 shares $178.74 million -2.9%11.4%11.2 $29.11 3/15/20226,320,000 shares $171.78 million +2.3%11.7%11.2 $27.18 2/28/20226,180,000 shares $192.38 million -0.3%11.5%9.7 $31.13 2/15/20226,200,000 shares $193.63 million +2.3%11.6%9.4 $31.23 1/31/20226,060,000 shares $187.19 million +4.3%11.3%9.9 $30.89 1/15/20225,810,000 shares $192.54 million +4.3%10.8%10 $33.14 12/31/20215,570,000 shares $183.09 million -14.6%10.4%10 $32.87 12/15/20216,520,000 shares $213.60 million -12.0%12.2%11.8 $32.76 11/30/20217,410,000 shares $263.94 million -2.1%13.8%16.1 $35.62 11/15/20217,570,000 shares $307.19 million +7.5%14.1%18.6 $40.58 10/29/20217,040,000 shares $330.88 million +5.6%13.2%16.4 $47.00 10/15/20216,670,000 shares $308.69 million +7.4%11.5%13.4 $46.28 9/30/20216,210,000 shares $286.59 million +8.6%10.7%10.9 $46.15 9/15/20215,720,000 shares $263.75 million +1.4%9.8%7.9 $46.11 8/31/20215,640,000 shares $252.00 million +1.3%9.7%7.5 $44.68 8/13/20215,570,000 shares $244.80 million +15.8%9.5%7.4 $43.95 7/30/20214,810,000 shares $231.31 million -4.4%8.2%6.3 $48.09 7/15/20215,030,000 shares $282.18 million +10.3%8.3%7 $56.10 6/30/20214,560,000 shares $251.30 million +2.5%7.5%6.5 $55.11 6/15/20214,450,000 shares $258.90 million -4.7%7.3%7.2 $58.18 5/28/20214,670,000 shares $260.49 million -8.6%7.7%7.4 $55.78 5/14/20215,110,000 shares $280.79 million -4.7%N/A7.1 $54.95 4/30/20215,360,000 shares $298.98 million -3.1%N/A7.1 $55.78 4/15/20215,530,000 shares $295.08 million +4.5%N/A7.4 $53.36 3/31/20215,290,000 shares $260.53 million -15.5%N/A6.8 $49.25 3/15/20216,260,000 shares $322.95 million +7.6%N/A7.3 $51.59 2/26/20215,820,000 shares $292.69 million +2.5%N/A6.5 $50.29 2/12/20215,680,000 shares $326.60 million +3.1%N/A6.7 $57.50 1/29/20215,510,000 shares $250.37 million -0.2%N/A6.8 $45.44 1/15/20215,520,000 shares $253.64 million -5.5%N/A6.7 $45.95 12/31/20205,840,000 shares $260.00 million +7.6%N/A7 $44.52 12/15/20205,430,000 shares $185.43 million +9.5%N/A6.3 $34.15 11/30/20204,960,000 shares $221.56 million -11.1%N/A6.8 $44.67 11/15/20205,580,000 shares $231.74 million -8.1%N/A8.1 $41.53 10/30/20206,070,000 shares $238.19 million -16.6%N/A8.8 $39.24 10/15/20207,280,000 shares $264.99 million +5.1%N/A10.5 $36.40 AGIO Short Interest - Frequently Asked Questions What is Agios Pharmaceuticals' current short interest? Short interest is the volume of Agios Pharmaceuticals shares that have been sold short but have not yet been closed out or covered. As of September 15th, investors have sold 4,740,000 shares of AGIO short. 8.63% of Agios Pharmaceuticals' shares are currently sold short. Learn More on Agios Pharmaceuticals' current short interest. What is a good short interest ratio for Agios Pharmaceuticals? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. AGIO shares currently have a short interest ratio of 6.0. Learn More on Agios Pharmaceuticals's short interest ratio. Which institutional investors are shorting Agios Pharmaceuticals? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Agios Pharmaceuticals: Group One Trading LLC, Caption Management LLC, and JPMorgan Chase & Co.. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. What is a good short interest percentage for Agios Pharmaceuticals? Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 8.63% of Agios Pharmaceuticals' floating shares are currently sold short. Is Agios Pharmaceuticals' short interest increasing or decreasing? Agios Pharmaceuticals saw a decline in short interest during the month of September. As of September 15th, there was short interest totaling 4,740,000 shares, a decline of 0.4% from the previous total of 4,760,000 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. What is Agios Pharmaceuticals' float size? Agios Pharmaceuticals currently has issued a total of 58,100,000 shares. Some of Agios Pharmaceuticals' outstanding shares are available for trading, while others are subject to various restrictions. The public float, also referred to as floating shares or "the float", are shares that publicly owned, unrestricted and available to trade on the open market. Agios Pharmaceuticals currently has a public float of 54,910,000 shares. How does Agios Pharmaceuticals' short interest compare to its competitors? 8.63% of Agios Pharmaceuticals' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Agios Pharmaceuticals: Revolution Medicines, Inc. (9.66%), Grifols, S.A. (2.08%), Rhythm Pharmaceuticals, Inc. (7.86%), Avidity Biosciences, Inc. (15.24%), Abivax SA Sponsored ADR (2.73%), Legend Biotech Corporation Sponsored ADR (5.25%), Cytokinetics, Incorporated (12.19%), Nuvalent, Inc. (11.93%), Axsome Therapeutics, Inc. (6.91%), TG Therapeutics, Inc. (15.50%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: AppLovin Corporation ($8.81 billion), Canadian Natural Resources Limited ($5.82 billion), Reddit Inc. ($5.19 billion), Coinbase Global, Inc. ($4.52 billion), Robinhood Markets, Inc. ($4.30 billion), Charter Communications, Inc. ($3.75 billion), CoreWeave Inc. ($3.66 billion), Seagate Technology Holdings PLC ($3.57 billion), Live Nation Entertainment, Inc. ($3.33 billion), and Rocket Lab Corporation ($3.26 billion). View all of the most shorted stocks. What does it mean to sell short Agios Pharmaceuticals stock? Short selling AGIO is an investing strategy that aims to generate trading profit from Agios Pharmaceuticals as its price is falling. AGIO shares are trading down $1.82 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Agios Pharmaceuticals? A short squeeze for Agios Pharmaceuticals occurs when it has a large amount of short interest and its stock appreciates in price. This forces short sellers to cover their short interest positions by buying actual shares of AGIO, which in turn drives the price of the stock up even further. How often is Agios Pharmaceuticals' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including AGIO, twice per month. The most recent reporting period available is September, 15 2025. More Short Interest Resources from MarketBeat Related Companies RVMD Short Interest Data GRFS Short Interest Data RYTM Short Interest Data RNA Short Interest Data ABVX Short Interest Data LEGN Short Interest Data CYTK Short Interest Data NUVL Short Interest Data AXSM Short Interest Data TGTX Short Interest Data Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:AGIO) was last updated on 10/12/2025 by MarketBeat.com Staff From Our PartnersURGENT: The Market's 3 Red Flags Are FlashingHere’s the uncomfortable truth: The smartest investors in the world are already preparing for a crash befor...StockEarnings | SponsoredMiss This IRS Strategy Now, Regret It LaterWith Donald Trump back in the White House, many believe an economic revival could be underway — but it also br...American Alternative | SponsoredTrump’s “Smart Dollar” just went mainstream"I Made Millions in the Tech Boom. 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