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Agios Pharmaceuticals (AGIO) Competitors

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$34.19 -0.78 (-2.23%)
Closing price 09/23/2026 04:00 PM Eastern
Extended Trading
$34.35 +0.16 (+0.46%)
As of 08:09 AM Eastern
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AGIO vs. SYRE, IMVT, ALKS, RYTM, and SRRK

Should you buy Agios Pharmaceuticals stock or one of its competitors? Agios Pharmaceuticals's main competitors and comparable companies include Spyre Therapeutics (SYRE), Immunovant (IMVT), Alkermes (ALKS), Rhythm Pharmaceuticals (RYTM), and Scholar Rock (SRRK). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Agios Pharmaceuticals compare to Spyre Therapeutics?

Spyre Therapeutics (NASDAQ:SYRE) and Agios Pharmaceuticals (NASDAQ:AGIO) are both mid-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their risk, analyst recommendations, earnings, valuation, institutional ownership, dividends, media sentiment and profitability.

Spyre Therapeutics has a net margin of 0.00% compared to Agios Pharmaceuticals' net margin of -418.24%. Spyre Therapeutics' return on equity of -30.74% beat Agios Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Spyre TherapeuticsN/A -30.74% -22.23%
Agios Pharmaceuticals -418.24%-35.67%-33.06%

Spyre Therapeutics has a beta of 2.99, indicating that its share price is 199% more volatile than the broader market. Comparatively, Agios Pharmaceuticals has a beta of 0.6, indicating that its share price is 40% less volatile than the broader market.

80.4% of Spyre Therapeutics shares are held by institutional investors. 15.7% of Spyre Therapeutics shares are held by insiders. Comparatively, 5.4% of Agios Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

In the previous week, Agios Pharmaceuticals had 14 more articles in the media than Spyre Therapeutics. MarketBeat recorded 17 mentions for Agios Pharmaceuticals and 3 mentions for Spyre Therapeutics. Agios Pharmaceuticals' average media sentiment score of 0.83 beat Spyre Therapeutics' score of 0.05 indicating that Agios Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spyre Therapeutics
0 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Agios Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Spyre Therapeutics has higher earnings, but lower revenue than Agios Pharmaceuticals. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Agios Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spyre TherapeuticsN/AN/A-$155.20M-$1.95N/A
Agios Pharmaceuticals$54.03M37.78-$412.78M-$7.01N/A

Spyre Therapeutics presently has a consensus price target of $109.69, indicating a potential upside of 24.41%. Agios Pharmaceuticals has a consensus price target of $41.75, indicating a potential upside of 22.11%. Given Spyre Therapeutics' stronger consensus rating and higher possible upside, equities research analysts clearly believe Spyre Therapeutics is more favorable than Agios Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87
Agios Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.55

Summary

Spyre Therapeutics beats Agios Pharmaceuticals on 11 of the 15 factors compared between the two stocks.

How does Agios Pharmaceuticals compare to Immunovant?

Immunovant (NASDAQ:IMVT) and Agios Pharmaceuticals (NASDAQ:AGIO) are both mid-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their earnings, risk, valuation, profitability, dividends, analyst recommendations, media sentiment and institutional ownership.

Immunovant currently has a consensus target price of $44.00, suggesting a potential upside of 27.39%. Agios Pharmaceuticals has a consensus target price of $41.75, suggesting a potential upside of 22.11%. Given Immunovant's stronger consensus rating and higher possible upside, research analysts clearly believe Immunovant is more favorable than Agios Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Immunovant
1 Sell rating(s)
3 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.58
Agios Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.55

Immunovant has a beta of 0.81, suggesting that its share price is 19% less volatile than the broader market. Comparatively, Agios Pharmaceuticals has a beta of 0.6, suggesting that its share price is 40% less volatile than the broader market.

Immunovant has a net margin of 0.00% compared to Agios Pharmaceuticals' net margin of -418.24%. Agios Pharmaceuticals' return on equity of -35.67% beat Immunovant's return on equity.

Company Net Margins Return on Equity Return on Assets
ImmunovantN/A -69.59% -62.49%
Agios Pharmaceuticals -418.24%-35.67%-33.06%

Agios Pharmaceuticals has higher revenue and earnings than Immunovant. Immunovant is trading at a lower price-to-earnings ratio than Agios Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ImmunovantN/AN/A-$505.61M-$2.82N/A
Agios Pharmaceuticals$54.03M37.78-$412.78M-$7.01N/A

In the previous week, Agios Pharmaceuticals had 6 more articles in the media than Immunovant. MarketBeat recorded 17 mentions for Agios Pharmaceuticals and 11 mentions for Immunovant. Agios Pharmaceuticals' average media sentiment score of 0.83 beat Immunovant's score of 0.01 indicating that Agios Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Immunovant
1 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
4 Negative mention(s)
0 Very Negative mention(s)
Neutral
Agios Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

47.1% of Immunovant shares are owned by institutional investors. 1.9% of Immunovant shares are owned by company insiders. Comparatively, 5.4% of Agios Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Summary

Agios Pharmaceuticals beats Immunovant on 9 of the 16 factors compared between the two stocks.

How does Agios Pharmaceuticals compare to Alkermes?

Alkermes (NASDAQ:ALKS) and Agios Pharmaceuticals (NASDAQ:AGIO) are both mid-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, profitability, earnings, media sentiment, risk, analyst recommendations, institutional ownership and dividends.

Alkermes has higher revenue and earnings than Agios Pharmaceuticals. Agios Pharmaceuticals is trading at a lower price-to-earnings ratio than Alkermes, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alkermes$1.48B4.79$241.66M$0.38110.87
Agios Pharmaceuticals$54.03M37.78-$412.78M-$7.01N/A

Alkermes has a net margin of 3.96% compared to Agios Pharmaceuticals' net margin of -418.24%. Alkermes' return on equity of 4.15% beat Agios Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alkermes3.96% 4.15% 2.19%
Agios Pharmaceuticals -418.24%-35.67%-33.06%

In the previous week, Alkermes had 9 more articles in the media than Agios Pharmaceuticals. MarketBeat recorded 26 mentions for Alkermes and 17 mentions for Agios Pharmaceuticals. Agios Pharmaceuticals' average media sentiment score of 0.83 beat Alkermes' score of 0.67 indicating that Agios Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alkermes
9 Very Positive mention(s)
6 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agios Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Alkermes currently has a consensus price target of $54.47, suggesting a potential upside of 29.29%. Agios Pharmaceuticals has a consensus price target of $41.75, suggesting a potential upside of 22.11%. Given Alkermes' stronger consensus rating and higher possible upside, equities analysts clearly believe Alkermes is more favorable than Agios Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alkermes
1 Sell rating(s)
4 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
2.78
Agios Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.55

Alkermes has a beta of 0.31, meaning that its stock price is 69% less volatile than the broader market. Comparatively, Agios Pharmaceuticals has a beta of 0.6, meaning that its stock price is 40% less volatile than the broader market.

95.2% of Alkermes shares are held by institutional investors. 4.6% of Alkermes shares are held by insiders. Comparatively, 5.4% of Agios Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Summary

Alkermes beats Agios Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

How does Agios Pharmaceuticals compare to Rhythm Pharmaceuticals?

Agios Pharmaceuticals (NASDAQ:AGIO) and Rhythm Pharmaceuticals (NASDAQ:RYTM) are both mid-cap healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their valuation, risk, profitability, institutional ownership, media sentiment, earnings, dividends and analyst recommendations.

In the previous week, Agios Pharmaceuticals had 6 more articles in the media than Rhythm Pharmaceuticals. MarketBeat recorded 17 mentions for Agios Pharmaceuticals and 11 mentions for Rhythm Pharmaceuticals. Agios Pharmaceuticals' average media sentiment score of 0.83 beat Rhythm Pharmaceuticals' score of 0.44 indicating that Agios Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Agios Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Rhythm Pharmaceuticals
1 Very Positive mention(s)
2 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Rhythm Pharmaceuticals has a net margin of -85.59% compared to Agios Pharmaceuticals' net margin of -418.24%. Agios Pharmaceuticals' return on equity of -35.67% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Agios Pharmaceuticals-418.24% -35.67% -33.06%
Rhythm Pharmaceuticals -85.59%-159.87%-44.00%

Rhythm Pharmaceuticals has higher revenue and earnings than Agios Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Agios Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Agios Pharmaceuticals$54.03M37.78-$412.78M-$7.01N/A
Rhythm Pharmaceuticals$189.76M35.48-$196.54M-$3.11N/A

Agios Pharmaceuticals presently has a consensus price target of $41.75, indicating a potential upside of 22.11%. Rhythm Pharmaceuticals has a consensus price target of $140.67, indicating a potential upside of 43.19%. Given Rhythm Pharmaceuticals' stronger consensus rating and higher probable upside, analysts clearly believe Rhythm Pharmaceuticals is more favorable than Agios Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Agios Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.55
Rhythm Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.76

Agios Pharmaceuticals has a beta of 0.6, meaning that its stock price is 40% less volatile than the broader market. Comparatively, Rhythm Pharmaceuticals has a beta of 1.97, meaning that its stock price is 97% more volatile than the broader market.

Summary

Rhythm Pharmaceuticals beats Agios Pharmaceuticals on 8 of the 15 factors compared between the two stocks.

How does Agios Pharmaceuticals compare to Scholar Rock?

Scholar Rock (NASDAQ:SRRK) and Agios Pharmaceuticals (NASDAQ:AGIO) are both mid-cap healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their analyst recommendations, risk, earnings, dividends, media sentiment, institutional ownership, valuation and profitability.

91.1% of Scholar Rock shares are held by institutional investors. 10.3% of Scholar Rock shares are held by company insiders. Comparatively, 5.4% of Agios Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Scholar Rock has higher earnings, but lower revenue than Agios Pharmaceuticals. Scholar Rock is trading at a lower price-to-earnings ratio than Agios Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Scholar RockN/AN/A-$377.94M-$3.45N/A
Agios Pharmaceuticals$54.03M37.78-$412.78M-$7.01N/A

In the previous week, Agios Pharmaceuticals had 9 more articles in the media than Scholar Rock. MarketBeat recorded 17 mentions for Agios Pharmaceuticals and 8 mentions for Scholar Rock. Agios Pharmaceuticals' average media sentiment score of 0.83 beat Scholar Rock's score of 0.76 indicating that Agios Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Scholar Rock
3 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Agios Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Scholar Rock has a beta of 0.67, suggesting that its stock price is 33% less volatile than the broader market. Comparatively, Agios Pharmaceuticals has a beta of 0.6, suggesting that its stock price is 40% less volatile than the broader market.

Scholar Rock presently has a consensus target price of $66.69, indicating a potential upside of 33.78%. Agios Pharmaceuticals has a consensus target price of $41.75, indicating a potential upside of 22.11%. Given Scholar Rock's stronger consensus rating and higher possible upside, equities analysts clearly believe Scholar Rock is more favorable than Agios Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Scholar Rock
2 Sell rating(s)
1 Hold rating(s)
11 Buy rating(s)
4 Strong Buy rating(s)
2.94
Agios Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.55

Scholar Rock has a net margin of 0.00% compared to Agios Pharmaceuticals' net margin of -418.24%. Agios Pharmaceuticals' return on equity of -35.67% beat Scholar Rock's return on equity.

Company Net Margins Return on Equity Return on Assets
Scholar RockN/A -160.19% -87.18%
Agios Pharmaceuticals -418.24%-35.67%-33.06%

Summary

Scholar Rock beats Agios Pharmaceuticals on 10 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding AGIO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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AGIO vs. The Competition

MetricAgios PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$2.09B$3.98B$7.31B$13.28B
Dividend YieldN/A3.63%2.52%12.57%
P/E Ratio-4.8813.88274.1025.70
Price / Sales37.781,437.48672.6190.85
Price / CashN/A113.2977.8052.76
Price / Book1.6715.4510.486.32
Net Income-$412.78M-$22.82M$3.49B$359.73M
7 Day Performance1.73%-1.68%-0.68%0.17%
1 Month Performance4.75%-6.15%-3.18%-3.27%
1 Year Performance-8.39%30.67%15.13%5.58%

Agios Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
AGIO
Agios Pharmaceuticals
3.33 of 5 stars
$34.19
-2.2%
$41.75
+22.1%
-9.7%$2.09B$54.03MN/A540
SYRE
Spyre Therapeutics
2.432 of 5 stars
$90.80
+0.2%
$109.69
+20.8%
+450.4%$7.97BN/AN/A112
IMVT
Immunovant
2.8163 of 5 stars
$37.66
+0.8%
$44.00
+16.8%
+131.8%$7.72BN/AN/A315
ALKS
Alkermes
3.525 of 5 stars
$45.83
-0.3%
$54.56
+19.1%
+51.8%$7.71B$1.48B120.612,050
RYTM
Rhythm Pharmaceuticals
2.8168 of 5 stars
$102.44
-2.2%
$140.67
+37.3%
-0.5%$7.18B$189.76MN/A414

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This page (NASDAQ:AGIO) was last updated on 9/24/2026 by MarketBeat.com Staff.
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