NASDAQ:APLT Applied Therapeutics (APLT) Stock Price, News & Analysis $0.60 -0.01 (-1.14%) Closing price 04:00 PM EasternExtended Trading$0.60 -0.01 (-1.64%) As of 06:26 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock About Applied Therapeutics Stock (NASDAQ:APLT) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Applied Therapeutics alerts:Sign Up Key Stats Today's Range$0.56▼$0.6250-Day Range$0.41▼$1.2452-Week Range$0.30▼$10.62Volume5.04 million shsAverage Volume3.21 million shsMarket Capitalization$87.11 millionP/E RatioN/ADividend YieldN/APrice Target$4.13Consensus RatingHold Company Overview Applied Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery and development of novel small-molecule therapies for genetically defined diseases. Its research strategy centers on structure-based drug design and proprietary screening technologies aimed at correcting underlying metabolic dysfunction in disorders characterized by enzyme deficiencies and toxic metabolite accumulation. The company’s lead investigational candidate, AT-007, is an aldose reductase inhibitor engineered to cross the blood–brain barrier and is currently in clinical development for classic galactosemia. In addition to AT-007, Applied Therapeutics is advancing multiple programs targeting rare neurological and endocrine disorders, leveraging its platform to identify and optimize compounds that address high unmet medical needs in orphan and genetically defined patient populations. Founded and headquartered in New York City, Applied Therapeutics has established collaborative partnerships with academic research institutions and contract research organizations throughout North America and Europe to support its preclinical and clinical operations. The company is guided by a leadership team with extensive experience in drug discovery, clinical development and regulatory affairs, positioning Applied Therapeutics to advance its pipeline toward key clinical milestones and potential regulatory approval.AI Generated. May Contain Errors. Read More Applied Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks72nd Percentile Overall ScoreAPLT MarketRank™: Applied Therapeutics scored higher than 72% of companies evaluated by MarketBeat, and ranked 269th out of 950 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion3.2 / 5Analyst RatingHold Consensus RatingApplied Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.40, and is based on 2 buy ratings, 3 hold ratings, and no sell ratings.Upside PotentialApplied Therapeutics has a consensus price target of $4.13, representing about 575.1% upside from its current price of $0.61.Amount of Analyst CoverageApplied Therapeutics has received no research coverage in the past 90 days.Read more about Applied Therapeutics' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Applied Therapeutics are expected to grow in the coming year, from ($0.65) to ($0.62) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Applied Therapeutics is -1.34, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Applied Therapeutics is -1.34, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioApplied Therapeutics has a P/B Ratio of 1.25. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.Read more about Applied Therapeutics' valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted6.34% of the outstanding shares of Applied Therapeutics have been sold short.Short Interest Ratio / Days to CoverApplied Therapeutics has a short interest ratio ("days to cover") of 6.4.Change versus previous monthShort interest in Applied Therapeutics has recently increased by 5.06%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldApplied Therapeutics does not currently pay a dividend.Dividend GrowthApplied Therapeutics does not have a long track record of dividend growth. Sustainability and ESG4.7 / 5Environmental Score-0.88 Percentage of Shares Shorted6.34% of the outstanding shares of Applied Therapeutics have been sold short.Short Interest Ratio / Days to CoverApplied Therapeutics has a short interest ratio ("days to cover") of 6.4.Change versus previous monthShort interest in Applied Therapeutics has recently increased by 5.06%, indicating that investor sentiment is decreasing significantly. News and Social Media2.6 / 5News Sentiment0.71 News SentimentApplied Therapeutics has a news sentiment score of 0.71. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.91 average news sentiment score of Medical companies.News Coverage This WeekMarketBeat has tracked 6 news articles for Applied Therapeutics this week, compared to 6 articles on an average week.Search Interest13 people have searched for APLT on MarketBeat in the last 30 days. This is an increase of 1,200% compared to the previous 30 days.MarketBeat Follows8 people have added Applied Therapeutics to their MarketBeat watchlist in the last 30 days. This is an increase of 100% compared to the previous 30 days. Company Ownership1.7 / 5Insider TradingN/A Insider Buying vs. Insider SellingIn the past three months, Applied Therapeutics insiders have not sold or bought any company stock.Percentage Held by InsidersOnly 1.60% of the stock of Applied Therapeutics is held by insiders.Percentage Held by Institutions98.31% of the stock of Applied Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Applied Therapeutics' insider trading history. Receive APLT Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Applied Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. APLT Stock News HeadlinesApplied Therapeutics stock plunges after FDA meeting on CMT-SORD drugSeptember 29 at 11:37 PM | investing.comApplied Therapeutics Shares Plunge Following FDA Meeting on CMT-SORD TreatmentSeptember 29 at 11:37 PM | msn.comBuy this stock tomorrowFamed futurist Eric Fry just unveiled his “Sell This, Buy That” strategy — including 7 free trade ideas like a small robotics firm he calls an “upgrade to Tesla,” already sitting on a $23 billion backlog.September 30 at 2:00 AM | InvestorPlace (Ad)Applied Therapeutics Provides Update Following Meeting with FDASeptember 29 at 7:00 AM | globenewswire.comApplied Therapeutics up after details posted for confirmatory govorestat studySeptember 26, 2025 | msn.comApplied Therapeutics Inc. (NASDAQ:APLT) Receives Average Recommendation of "Hold" from AnalystsSeptember 21, 2025 | americanbankingnews.comApplied Therapeutics Reports Q2 LossAugust 15, 2025 | theglobeandmail.comApplied Therapeutics reports Q2 EPS (15c), consensus (16c)August 14, 2025 | msn.comSee More Headlines APLT Stock Analysis - Frequently Asked Questions How have APLT shares performed this year? Applied Therapeutics' stock was trading at $0.8562 on January 1st, 2025. Since then, APLT shares have decreased by 28.6% and is now trading at $0.6110. How were Applied Therapeutics' earnings last quarter? Applied Therapeutics Inc. (NASDAQ:APLT) released its quarterly earnings results on Wednesday, August, 13th. The company reported ($0.15) EPS for the quarter, beating analysts' consensus estimates of ($0.17) by $0.02. When did Applied Therapeutics IPO? Applied Therapeutics (APLT) raised $60 million in an initial public offering on the week of May 13th 2019. The company issued 4,000,000 shares at a price of $14.00-$16.00 per share. Citigroup, Cowen and UBS Investment Bank acted as the underwriters for the IPO and Baird was co-manager. How do I buy shares of Applied Therapeutics? Shares of APLT stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Applied Therapeutics own? Based on aggregate information from My MarketBeat watchlists, some other companies that Applied Therapeutics investors own include NVIDIA (NVDA), Broadcom (AVGO), Meta Platforms (META), Adobe (ADBE), Arista Networks (ANET), Advanced Micro Devices (AMD) and ServiceNow (NOW). Company Calendar Last Earnings8/13/2025Today9/30/2025Next Earnings (Estimated)11/06/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:APLT CIK1697532 Webwww.appliedtherapeutics.com Phone(212) 220-9226FaxN/AEmployees30Year Founded2017Price Target and Rating Average Price Target for Applied Therapeutics$4.13 High Price Target$8.00 Low Price Target$1.50 Potential Upside/Downside+574.1%Consensus RatingHold Rating Score (0-4)2.40 Research Coverage5 Analysts Profitability EPS (Trailing Twelve Months)($0.45) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$105.62 million Net MarginsN/A Pretax Margin-55,523.77% Return on Equity-354.24% Return on Assets-144.16% Debt Debt-to-Equity RatioN/A Current Ratio1.94 Quick Ratio1.94 Sales & Book Value Annual Sales$460 thousand Price / Sales191.56 Cash FlowN/A Price / Cash FlowN/A Book Value$0.49 per share Price / Book1.25Miscellaneous Outstanding Shares144,010,000Free Float141,708,000Market Cap$88.12 million OptionableOptionable Beta2.05 Social Links 7 Stocks to Buy And Hold ForeverEnter your email address and we'll send you MarketBeat's list of seven stocks and why their long-term outlooks are very promising. Get This Free Report This page (NASDAQ:APLT) was last updated on 9/30/2025 by MarketBeat.com Staff From Our PartnersMarket Panic: Trump Just Dropped a Bomb on Your Stockstock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tarif...American Alternative | SponsoredBuy this stock tomorrowFamed futurist Eric Fry just unveiled his “Sell This, Buy That” strategy — including 7 free trade ideas like a...InvestorPlace | SponsoredAn $8 trillion-dollar discovery 17,000 ft underwater A strange rock pulled from the ocean floor may hold the key to a $16 trillion resource boom. Inside it: materi...Porter & Company | SponsoredTrump's Law S.1582: $21T Dollar Revolution ComingDo you have money in any of these banks? Chase. Bank of America. Citigroup. Wells Fargo. U.S. Bancorp. 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