Positive News SentimentPositive NewsNASDAQ:GYRE Gyre Therapeutics (GYRE) Stock Price, News & Analysis $6.19 +0.50 (+8.79%) Closing price 04:00 PM EasternExtended Trading$6.19 0.00 (0.00%) As of 06:38 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock About Gyre Therapeutics Stock (NASDAQ:GYRE) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Gyre Therapeutics alerts:Sign Up Key Stats Today's Range$5.71▼$6.2950-Day Range$5.56▼$8.1052-Week Range$5.44▼$9.42Volume133,446 shsAverage Volume91,614 shsMarket Capitalization$600.62 millionP/E RatioN/ADividend YieldN/APrice Target$17.00Consensus RatingHold Company Overview Gyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering and developing small-molecule therapies that target lipid biology to treat a range of metabolic, inflammatory and neurodegenerative diseases. The company’s proprietary platform combines lipidomic profiling with drug discovery tools to identify compounds that selectively modulate membrane lipid composition and restore normal protein function in disease-relevant cells. Gyre’s preclinical pipeline includes programs in nonalcoholic steatohepatitis (NASH), Alzheimer’s disease and autoimmune conditions, reflecting its strategy of applying a unified lipid-targeted approach across multiple therapeutic areas. By leveraging its platform to validate novel targets and generate lead candidates, the company aims to address unmet medical needs where dysregulated lipid environments drive disease progression. Headquartered in South San Francisco, California, Gyre Therapeutics was founded in 2021 and completed its initial public offering on the Nasdaq Global Market under the ticker symbol GYRE in mid-2023. Operating primarily in the United States, the company collaborates with academic researchers and industry partners to advance its discovery efforts. Through its innovative focus on membrane biochemistry, Gyre seeks to build a diversified portfolio of first-in-class small-molecule therapies.AI Generated. May Contain Errors. Read More Gyre Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks49th Percentile Overall ScoreGYRE MarketRank™: Gyre Therapeutics scored higher than 49% of companies evaluated by MarketBeat, and ranked 694th out of 865 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion3.4 / 5Analyst RatingHold Consensus RatingGyre Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no strong buy ratings, 2 buy ratings, no hold ratings, and 2 sell ratings.Upside PotentialGyre Therapeutics has a consensus price target of $17.00, representing about 174.6% upside from its current price of $6.19.Amount of Analyst CoverageGyre Therapeutics has only been the subject of 2 research reports in the past 90 days.Read more about Gyre Therapeutics' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Gyre Therapeutics are expected to grow in the coming year, from ($0.30) to ($0.20) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Gyre Therapeutics is -68.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Gyre Therapeutics is -68.77, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioGyre Therapeutics has a P/B Ratio of 4.18. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Gyre Therapeutics' valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted1.92% of the float of Gyre Therapeutics has been sold short.Short Interest Ratio / Days to CoverGyre Therapeutics has a short interest ratio ("days to cover") of 18.17, which indicates bearish sentiment.Change versus previous monthShort interest in Gyre Therapeutics has recently increased by 6.03%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldGyre Therapeutics does not currently pay a dividend.Dividend GrowthGyre Therapeutics does not have a long track record of dividend growth. News and Social Media3.7 / 5News SentimentN/A News SentimentGyre Therapeutics has a news sentiment score of 1.87. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.81 average news sentiment score of Medical companies.MarketBeat Follows1 people have added Gyre Therapeutics to their MarketBeat watchlist in the last 30 days. Company Ownership1.3 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Gyre Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $219,580.00 in company stock.Percentage Held by Insiders9.50% of the stock of Gyre Therapeutics is held by insiders.Percentage Held by Institutions23.99% of the stock of Gyre Therapeutics is held by institutions.Read more about Gyre Therapeutics' insider trading history. Receive GYRE Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Gyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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GYRE Stock News HeadlinesGyre Therapeutics (NASDAQ:GYRE) COO Sells $57,810.00 in StockMay 25, 2026 | americanbankingnews.comGyre Therapeutics (NASDAQ:GYRE) COO Sells $78,843.00 in StockMay 25, 2026 | americanbankingnews.comSkip the Line Opportunity: The SpaceX IPOFormer tech executive and angel investor Jeff Brown - who identified Bitcoin, Tesla, and Nvidia before their historic runs - says the SpaceX IPO is set for June 12 and could be the most anticipated market debut ever. Brown is showing investors how to legally claim a stake before the company goes public, ahead of what chief market strategist Shay Boloor called 'the craziest IPO in the history of the stock market.'June 4 at 1:00 AM | Brownstone Research (Ad)Gyre Therapeutics (NASDAQ:GYRE) COO Weiguo Ye Sells 9,400 SharesMay 23, 2026 | insidertrades.comGyre Therapeutics Announces NMPA Acceptance of New Drug Application for F351 (hydronidone) for CHB-Induced Liver Fibrosis TreatmentMay 12, 2026 | globenewswire.comGyre Therapeutics Reports First Quarter 2026 Results and Provides Business UpdateMay 7, 2026 | globenewswire.comGyre Therapeutics Completes Acquisition of Cullgen to Create U.S.- and China-based Fully Integrated Biopharmaceutical CompanyMay 4, 2026 | globenewswire.comGyre Therapeutics Announces China’s NMPA Grants Priority Review to the NDA for Hydronidone (F351) for CHB-Induced Liver Fibrosis TreatmentMarch 17, 2026 | markets.businessinsider.comSee More Headlines GYRE Stock Analysis - Frequently Asked Questions How have GYRE shares performed this year? Gyre Therapeutics' stock was trading at $7.06 at the beginning of the year. Since then, GYRE shares have decreased by 12.3% and is now trading at $6.19. How were Gyre Therapeutics' earnings last quarter? Gyre Therapeutics, Inc. (NASDAQ:GYRE) released its earnings results on Thursday, March, 12th. The company reported $0.04 EPS for the quarter, missing analysts' consensus estimates of $0.08 by $0.04. The business earned $37.20 million during the quarter, compared to the consensus estimate of $36.30 million. Gyre Therapeutics had a negative net margin of 5.44% and a positive trailing twelve-month return on equity of 3.13%. Who are Gyre Therapeutics' major shareholders? Top institutional investors of Gyre Therapeutics include Bank of New York Mellon Corp (0.04%), Dimensional Fund Advisors LP (0.03%) and Royal Bank of Canada (0.01%). Insiders that own company stock include Songjiang Ma, Ying Luo, Weiguo Ye and Nassim Usman. View institutional ownership trends. How do I buy shares of Gyre Therapeutics? Shares of GYRE stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Gyre Therapeutics own? Based on aggregate information from My MarketBeat watchlists, some other companies that Gyre Therapeutics investors own include NVIDIA (NVDA), Meta Platforms (META), Advanced Micro Devices (AMD), Netflix (NFLX), Broadcom (AVGO), Palo Alto Networks (PANW) and Invesco QQQ (QQQ). Company Calendar Last Earnings3/12/2026Today6/04/2026Next Earnings (Estimated)8/10/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Red Zone (14m+) 1-Year History Jun 25 Sep 25 Dec 25 Mar 26 Jun 26 GYRE's financial health is in the Red zone, according to TradeSmith. GYRE has been in this zone for over 14 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:GYRE Previous SymbolNASDAQ:GYRE CIK1124105 Webwww.catalystbiosciences.com Phone(619) 949-3681Fax336-480-2107Employees40Year FoundedN/APrice Target and Rating Average Price Target for Gyre Therapeutics$17.00 High Price Target$18.00 Low Price Target$16.00 Potential Upside/Downside+174.6%Consensus RatingHold Rating Score (0-4)2.00 Research Coverage4 Analysts Profitability EPS (Trailing Twelve Months)($0.09) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income$5.03 million Net Margins-5.44% Pretax Margin0.48% Return on Equity3.13% Return on Assets2.67% Debt Debt-to-Equity RatioN/A Current Ratio4.64 Quick Ratio4.06 Sales & Book Value Annual Sales$116.59 million Price / Sales5.15 Cash Flow$0.25 per share Price / Cash Flow25.02 Book Value$1.48 per share Price / Book4.18Miscellaneous Outstanding Shares97,030,000Free Float87,810,000Market Cap$600.62 million OptionableNo Data Beta1.90 5G Stocks: The Path Forward is ProfitableClick the link to see MarketBeat's guide to investing in 5G and which 5G stocks show the most promise. Get This Free Report This page (NASDAQ:GYRE) was last updated on 6/4/2026 by MarketBeat.com Staff. From Our PartnersDo NOT Buy SpaceX – Do This InsteadSpaceX is set to go public as soon as June 11, with OpenAI and Anthropic likely to follow. Whitney Tilson - Ha...Stansberry Research | SponsoredBOXABL Expected to Trade as $BXBLBOXABL, known for its factory-built, foldable Casita homes that unfold on-site in under an hour, has announced...BOXABL | SponsoredTrump's gold order: the announcement they won't put on the front pageOn August 15, 1971, Nixon interrupted prime-time television and ended the gold standard in 15 minutes - no deb...Reagan Gold Group | SponsoredTrump’s secret China dealTrump just returned from Beijing with the most powerful business delegation in American history - Elon Musk, J...Porter & Company | SponsoredGiving “2022 pre-ChatGPT” vibes (but 10x bigger)When ChatGPT launched in 2022, Nvidia surged 1,800% over three years. 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