| 07/17/2026 4:12 PM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/17/2026 4:12 PM | HERMAN JOAN E (1248398) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/17/2026 4:13 PM | HANTSON LUDWIG (1491435) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/17/2026 4:13 PM | Ionis Pharmaceuticals (874015) Issuer Reikes Peter N (1753652) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/09/2026 8:03 PM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 07/09/2026 6:26 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/09/2026 5:07 PM | Ionis Pharmaceuticals (874015) Issuer Kordasiewicz Holly B. (2102721) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/09/2026 5:07 PM | Diaz Allene M. (1773314) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/09/2026 1:55 PM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 07/07/2026 3:28 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 07/07/2026 3:30 PM | Ionis Pharmaceuticals (874015) Subject Kordasiewicz Holly B. (2102721) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
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| 07/07/2026 3:33 PM | Diaz Allene M. (1773314) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 07/06/2026 5:44 PM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:44 PM | Diaz Allene M. (1773314) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:45 PM | Hayden Michael R (1352908) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:49 PM | Ionis Pharmaceuticals (874015) Issuer KLEIN JOSEPH III (1206369) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:49 PM | HERMAN JOAN E (1248398) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:50 PM | Ionis Pharmaceuticals (874015) Issuer LOSCALZO JOSEPH (1276128) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/06/2026 5:50 PM | Ionis Pharmaceuticals (874015) Issuer YANG MICHAEL J. (1702283) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/01/2026 4:29 PM | Ionis Pharmaceuticals (874015) Subject KLEIN JOSEPH III (1206369) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/30/2026 4:48 PM | Ionis Pharmaceuticals (874015) Issuer Schneider Eugene (1838539) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 4:48 PM | Ionis Pharmaceuticals (874015) Issuer O'NEIL PATRICK R. (1564926) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 4:48 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/26/2026 6:09 PM | Ionis Pharmaceuticals (874015) Issuer Swayze Eric (1791058) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/26/2026 6:09 PM | Ionis Pharmaceuticals (874015) Issuer Monia Brett P (1537529) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/26/2026 4:43 PM | Ionis Pharmaceuticals (874015) Subject Schneider Eugene (1838539) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/26/2026 4:47 PM | Ionis Pharmaceuticals (874015) Subject O'NEIL PATRICK R. (1564926) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/26/2026 4:48 PM | Baroldi Mariana (1961885) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/25/2026 5:53 PM | Ionis Pharmaceuticals (874015) Subject Swayze Eric (1791058) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/24/2026 2:48 PM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 06/16/2026 4:26 PM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/16/2026 4:26 PM | Ionis Pharmaceuticals (874015) Issuer Kordasiewicz Holly B. (2102721) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/15/2026 9:17 AM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/12/2026 1:20 PM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 06/08/2026 3:58 PM | HANTSON LUDWIG (1491435) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 06/08/2026 3:59 PM | Ionis Pharmaceuticals (874015) Issuer Reikes Peter N (1753652) Reporting | Form 3 Initial statement of beneficial ownership of securities | |
| 06/08/2026 3:59 PM | HANTSON LUDWIG (1491435) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/08/2026 3:59 PM | Ionis Pharmaceuticals (874015) Issuer Reikes Peter N (1753652) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/08/2026 11:49 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 06/03/2026 4:34 PM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/01/2026 9:47 AM | BERTHELSEN SPENCER R (1181548) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
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| 05/28/2026 11:41 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 05/15/2026 5:15 PM | Ionis Pharmaceuticals (874015) Issuer Monia Brett P (1537529) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/15/2026 9:06 AM | Ionis Pharmaceuticals (874015) Subject T. Rowe Price Investment Management, Inc. (1897612) Filed by | Form SCHEDULE 13G/A | |
| 05/14/2026 12:55 PM | Capital World Investors (1422849) Filed by Ionis Pharmaceuticals (874015) Subject | Form SCHEDULE 13G/A | |
| 05/13/2026 4:20 PM | Ionis Pharmaceuticals (874015) Subject Monia Brett P (1537529) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 05/06/2026 4:27 PM | Ionis Pharmaceuticals (874015) Issuer LOSCALZO JOSEPH (1276128) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/04/2026 5:05 PM | Ionis Pharmaceuticals (874015) Subject LOSCALZO JOSEPH (1276128) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 04/30/2026 3:21 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/30/2026 10:07 AM | Ionis Pharmaceuticals (874015) Subject VANGUARD CAPITAL MANAGEMENT LLC (2100119) Filed by | Form SCHEDULE 13G | |
| 04/29/2026 1:33 PM | Ionis Pharmaceuticals (874015) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 04/29/2026 6:00 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/23/2026 3:22 PM | Ionis Pharmaceuticals (874015) Filer | Form DEFA14A | |
| 04/23/2026 3:24 PM | Ionis Pharmaceuticals (874015) Filer | Form ARS | |
| 04/23/2026 3:21 PM | Ionis Pharmaceuticals (874015) Filer | Form DEF 14A | |
| 04/21/2026 6:00 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/17/2026 6:19 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/17/2026 6:19 PM | Birchler Brian (1970151) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/17/2026 6:19 PM | Ionis Pharmaceuticals (874015) Issuer Jenne Kyle (1791857) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/17/2026 6:19 PM | Ionis Pharmaceuticals (874015) Issuer PARSHALL B LYNNE (1073385) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/16/2026 5:45 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 04/16/2026 5:47 PM | Birchler Brian (1970151) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 04/16/2026 5:49 PM | Ionis Pharmaceuticals (874015) Subject Jenne Kyle (1791857) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 04/02/2026 6:43 PM | Devers Shannon L. (2037721) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/02/2026 6:43 PM | Ionis Pharmaceuticals (874015) Issuer KLEIN JOSEPH III (1206369) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/31/2026 4:28 PM | Diaz Allene M. (1773314) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/27/2026 8:52 AM | Ionis Pharmaceuticals (874015) Subject VANGUARD GROUP INC (102909) Filed by | Form SCHEDULE 13G/A | |
| 03/24/2026 3:43 PM | Ionis Pharmaceuticals (874015) Subject Schneider Eugene (1838539) Reporting | Form 144/A | |
| 03/23/2026 6:36 PM | Ionis Pharmaceuticals (874015) Issuer Schneider Eugene (1838539) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/19/2026 3:01 PM | Ionis Pharmaceuticals (874015) Subject Schneider Eugene (1838539) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/09/2026 3:16 PM | Ionis Pharmaceuticals (874015) Subject O'NEIL PATRICK R. (1564926) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/09/2026 6:00 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/05/2026 5:13 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/05/2026 5:13 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/05/2026 5:14 PM | Devers Shannon L. (2037721) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/05/2026 5:14 PM | Diaz Allene M. (1773314) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/05/2026 5:14 PM | Ionis Pharmaceuticals (874015) Issuer KLEIN JOSEPH III (1206369) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/05/2026 5:14 PM | Ionis Pharmaceuticals (874015) Issuer LOSCALZO JOSEPH (1276128) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/03/2026 4:34 PM | Devers Shannon L. (2037721) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/03/2026 4:35 PM | Ionis Pharmaceuticals (874015) Subject KLEIN JOSEPH III (1206369) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/03/2026 4:42 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 03/03/2026 4:43 PM | Baroldi Mariana (1961885) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 02/25/2026 6:00 AM | Ionis Pharmaceuticals (874015) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 02/17/2026 9:28 AM | Ionis Pharmaceuticals (874015) Subject T. Rowe Price Investment Management, Inc. (1897612) Filed by | Form SCHEDULE 13G/A | |
| 02/13/2026 6:40 PM | Ionis Pharmaceuticals (874015) Issuer PARSHALL B LYNNE (1073385) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/13/2026 6:40 PM | Ionis Pharmaceuticals (874015) Issuer Swayze Eric (1791058) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/13/2026 6:40 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4/A | |
| 02/04/2026 3:06 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:51 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:51 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:51 PM | Birchler Brian (1970151) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
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| 02/02/2026 7:51 PM | HOUGEN ELIZABETH L (1074773) Reporting Ionis Pharmaceuticals (874015) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:51 PM | Ionis Pharmaceuticals (874015) Issuer Monia Brett P (1537529) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:51 PM | Ionis Pharmaceuticals (874015) Issuer O'NEIL PATRICK R. (1564926) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:52 PM | Ionis Pharmaceuticals (874015) Issuer Schneider Eugene (1838539) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/02/2026 7:52 PM | Ionis Pharmaceuticals (874015) Issuer Swayze Eric (1791058) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/30/2026 7:47 PM | Birchler Brian (1970151) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 01/30/2026 7:50 PM | Baroldi Joseph (1813775) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 01/30/2026 7:34 PM | HOUGEN ELIZABETH L (1074773) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 01/30/2026 7:40 PM | BENNETT C FRANK (1073387) Reporting Ionis Pharmaceuticals (874015) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |