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Ionis Pharmaceuticals (IONS) Competitors

Ionis Pharmaceuticals logo
$27.86 +0.55 (+2.02%)
As of 11:11 AM Eastern
This is a fair market value price provided by Massive. Learn more.

IONS vs. UTHR, INCY, INSM, BNTX, and ALNY

Should you buy Ionis Pharmaceuticals stock or one of its competitors? Ionis Pharmaceuticals's main competitors and comparable companies include United Therapeutics (UTHR), Incyte (INCY), Insmed (INSM), BioNTech (BNTX), and Alnylam Pharmaceuticals (ALNY). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Ionis Pharmaceuticals compare to United Therapeutics?

Ionis Pharmaceuticals (NASDAQ:IONS) and United Therapeutics (NASDAQ:UTHR) are both healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their valuation, dividends, profitability, earnings, risk, analyst recommendations, media sentiment and institutional ownership.

United Therapeutics has a net margin of 38.61% compared to Ionis Pharmaceuticals' net margin of -56.98%. United Therapeutics' return on equity of 19.18% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-56.98% -120.62% -16.99%
United Therapeutics 38.61%19.18%17.07%

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. Comparatively, 94.1% of United Therapeutics shares are held by institutional investors. 1.8% of Ionis Pharmaceuticals shares are held by insiders. Comparatively, 8.6% of United Therapeutics shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

United Therapeutics has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than United Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M4.82-$381.39M-$3.32N/A
United Therapeutics$3.18B7.94$1.33B$26.5022.39

In the previous week, Ionis Pharmaceuticals had 18 more articles in the media than United Therapeutics. MarketBeat recorded 52 mentions for Ionis Pharmaceuticals and 34 mentions for United Therapeutics. United Therapeutics' average media sentiment score of 0.76 beat Ionis Pharmaceuticals' score of -0.01 indicating that United Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
4 Very Positive mention(s)
5 Positive mention(s)
21 Neutral mention(s)
12 Negative mention(s)
2 Very Negative mention(s)
Neutral
United Therapeutics
14 Very Positive mention(s)
4 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ionis Pharmaceuticals currently has a consensus target price of $78.00, suggesting a potential upside of 185.61%. United Therapeutics has a consensus target price of $676.40, suggesting a potential upside of 14.00%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, equities research analysts clearly believe Ionis Pharmaceuticals is more favorable than United Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.78
United Therapeutics
1 Sell rating(s)
3 Hold rating(s)
12 Buy rating(s)
0 Strong Buy rating(s)
2.69

Ionis Pharmaceuticals has a beta of 0.43, meaning that its share price is 57% less volatile than the broader market. Comparatively, United Therapeutics has a beta of 0.49, meaning that its share price is 51% less volatile than the broader market.

Summary

United Therapeutics beats Ionis Pharmaceuticals on 12 of the 16 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Incyte?

Ionis Pharmaceuticals (NASDAQ:IONS) and Incyte (NASDAQ:INCY) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their profitability, valuation, media sentiment, risk, earnings, analyst recommendations, dividends and institutional ownership.

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. Comparatively, 97.0% of Incyte shares are held by institutional investors. 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Comparatively, 16.2% of Incyte shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Ionis Pharmaceuticals had 35 more articles in the media than Incyte. MarketBeat recorded 52 mentions for Ionis Pharmaceuticals and 17 mentions for Incyte. Incyte's average media sentiment score of 0.50 beat Ionis Pharmaceuticals' score of -0.01 indicating that Incyte is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
4 Very Positive mention(s)
5 Positive mention(s)
21 Neutral mention(s)
12 Negative mention(s)
2 Very Negative mention(s)
Neutral
Incyte
7 Very Positive mention(s)
0 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
2 Very Negative mention(s)
Positive

Incyte has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Incyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M4.82-$381.39M-$3.32N/A
Incyte$5.14B4.82$1.29B$1.8864.73

Ionis Pharmaceuticals presently has a consensus price target of $78.00, indicating a potential upside of 185.61%. Incyte has a consensus price target of $132.86, indicating a potential upside of 9.17%. Given Ionis Pharmaceuticals' stronger consensus rating and higher possible upside, research analysts clearly believe Ionis Pharmaceuticals is more favorable than Incyte.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.78
Incyte
1 Sell rating(s)
13 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.40

Ionis Pharmaceuticals has a beta of 0.43, meaning that its stock price is 57% less volatile than the broader market. Comparatively, Incyte has a beta of 0.78, meaning that its stock price is 22% less volatile than the broader market.

Incyte has a net margin of 6.71% compared to Ionis Pharmaceuticals' net margin of -56.98%. Incyte's return on equity of 7.92% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-56.98% -120.62% -16.99%
Incyte 6.71%7.92%6.12%

Summary

Incyte beats Ionis Pharmaceuticals on 12 of the 16 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Insmed?

Insmed (NASDAQ:INSM) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their profitability, risk, media sentiment, analyst recommendations, earnings, valuation, dividends and institutional ownership.

Insmed has a net margin of -39.85% compared to Ionis Pharmaceuticals' net margin of -56.98%. Insmed's return on equity of -96.38% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Insmed-39.85% -96.38% -32.55%
Ionis Pharmaceuticals -56.98%-120.62%-16.99%

Ionis Pharmaceuticals has higher revenue and earnings than Insmed. Insmed is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Insmed$606.42M42.71-$1.28B-$2.82N/A
Ionis Pharmaceuticals$944M4.82-$381.39M-$3.32N/A

Insmed has a beta of 0.83, indicating that its share price is 17% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.43, indicating that its share price is 57% less volatile than the broader market.

Insmed presently has a consensus target price of $196.52, indicating a potential upside of 66.45%. Ionis Pharmaceuticals has a consensus target price of $78.00, indicating a potential upside of 185.61%. Given Ionis Pharmaceuticals' higher probable upside, analysts clearly believe Ionis Pharmaceuticals is more favorable than Insmed.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Insmed
1 Sell rating(s)
1 Hold rating(s)
23 Buy rating(s)
1 Strong Buy rating(s)
2.92
Ionis Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.78

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 2.1% of Insmed shares are held by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

In the previous week, Ionis Pharmaceuticals had 43 more articles in the media than Insmed. MarketBeat recorded 52 mentions for Ionis Pharmaceuticals and 9 mentions for Insmed. Insmed's average media sentiment score of 1.45 beat Ionis Pharmaceuticals' score of -0.01 indicating that Insmed is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Insmed
7 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
4 Very Positive mention(s)
5 Positive mention(s)
21 Neutral mention(s)
12 Negative mention(s)
2 Very Negative mention(s)
Neutral

Summary

Insmed beats Ionis Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, valuation, risk, analyst recommendations, profitability, institutional ownership, dividends and earnings.

In the previous week, Ionis Pharmaceuticals had 38 more articles in the media than BioNTech. MarketBeat recorded 52 mentions for Ionis Pharmaceuticals and 14 mentions for BioNTech. BioNTech's average media sentiment score of 0.36 beat Ionis Pharmaceuticals' score of -0.01 indicating that BioNTech is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
5 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Neutral
Ionis Pharmaceuticals
4 Very Positive mention(s)
5 Positive mention(s)
21 Neutral mention(s)
12 Negative mention(s)
2 Very Negative mention(s)
Neutral

BioNTech presently has a consensus target price of $122.27, indicating a potential upside of 43.78%. Ionis Pharmaceuticals has a consensus target price of $78.00, indicating a potential upside of 185.61%. Given Ionis Pharmaceuticals' stronger consensus rating and higher possible upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than BioNTech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68
Ionis Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.78

BioNTech has a beta of 1.28, meaning that its share price is 28% more volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.43, meaning that its share price is 57% less volatile than the broader market.

Ionis Pharmaceuticals has a net margin of -56.98% compared to BioNTech's net margin of -61.39%. BioNTech's return on equity of -4.51% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-61.39% -4.51% -3.96%
Ionis Pharmaceuticals -56.98%-120.62%-16.99%

Ionis Pharmaceuticals has lower revenue, but higher earnings than BioNTech. BioNTech is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$3.25B6.62-$1.29B-$6.85N/A
Ionis Pharmaceuticals$944M4.82-$381.39M-$3.32N/A

15.5% of BioNTech shares are owned by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 19.2% of BioNTech shares are owned by company insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Summary

Ionis Pharmaceuticals beats BioNTech on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Alnylam Pharmaceuticals?

Ionis Pharmaceuticals (NASDAQ:IONS) and Alnylam Pharmaceuticals (NASDAQ:ALNY) are both healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their risk, media sentiment, dividends, profitability, analyst recommendations, valuation, institutional ownership and earnings.

Alnylam Pharmaceuticals has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M4.82-$381.39M-$3.32N/A
Alnylam Pharmaceuticals$5.01B4.19$313.75M$19.268.13

93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. Comparatively, 93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Comparatively, 0.9% of Alnylam Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Alnylam Pharmaceuticals has a net margin of 52.85% compared to Ionis Pharmaceuticals' net margin of -56.98%. Alnylam Pharmaceuticals' return on equity of 155.33% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-56.98% -120.62% -16.99%
Alnylam Pharmaceuticals 52.85%155.33%44.81%

Ionis Pharmaceuticals presently has a consensus price target of $78.00, indicating a potential upside of 185.61%. Alnylam Pharmaceuticals has a consensus price target of $305.86, indicating a potential upside of 95.25%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, research analysts plainly believe Ionis Pharmaceuticals is more favorable than Alnylam Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
19 Buy rating(s)
0 Strong Buy rating(s)
2.78
Alnylam Pharmaceuticals
0 Sell rating(s)
10 Hold rating(s)
15 Buy rating(s)
1 Strong Buy rating(s)
2.65

Ionis Pharmaceuticals has a beta of 0.43, meaning that its stock price is 57% less volatile than the broader market. Comparatively, Alnylam Pharmaceuticals has a beta of 0.42, meaning that its stock price is 58% less volatile than the broader market.

In the previous week, Ionis Pharmaceuticals had 33 more articles in the media than Alnylam Pharmaceuticals. MarketBeat recorded 52 mentions for Ionis Pharmaceuticals and 19 mentions for Alnylam Pharmaceuticals. Alnylam Pharmaceuticals' average media sentiment score of 0.39 beat Ionis Pharmaceuticals' score of -0.01 indicating that Alnylam Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
4 Very Positive mention(s)
5 Positive mention(s)
21 Neutral mention(s)
12 Negative mention(s)
2 Very Negative mention(s)
Neutral
Alnylam Pharmaceuticals
4 Very Positive mention(s)
3 Positive mention(s)
9 Neutral mention(s)
0 Negative mention(s)
2 Very Negative mention(s)
Neutral

Summary

Alnylam Pharmaceuticals beats Ionis Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding IONS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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IONS vs. The Competition

MetricIonis PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$4.62B$4.08B$7.85B$12.00B
Dividend YieldN/A3.62%2.46%4.50%
P/E Ratio-8.3624.5134.4330.31
Price / Sales4.9216.788.845.84
Price / CashN/A26.8922.2322.80
Price / Book11.814.114.383.77
Net Income-$381.39M-$22.78M$3.51B$390.69M
7 Day Performance-29.32%-3.18%-1.80%-0.60%
1 Month Performance-34.25%-6.16%-4.19%-6.88%
1 Year Performance-60.10%-0.85%0.57%-6.20%

Ionis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
IONS
Ionis Pharmaceuticals
2.9932 of 5 stars
$27.86
+2.0%
$78.00
+179.9%
-62.4%$4.62B$944MN/A1,402
UTHR
United Therapeutics
4.6178 of 5 stars
$582.46
+3.6%
$676.40
+16.1%
+28.6%$26.10B$3.18B21.981,400
INCY
Incyte
2.8744 of 5 stars
$121.89
+1.9%
$132.86
+9.0%
+12.4%$25.04B$5.14B57.952,844
INSM
Insmed
3.4205 of 5 stars
$116.10
+1.5%
$196.52
+69.3%
-39.3%$24.13B$606.42MN/A1,664
BNTX
BioNTech
3.8871 of 5 stars
$87.51
flat
$122.27
+39.7%
-23.8%$22.94B$3.25BN/A7,807

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This page (NASDAQ:IONS) was last updated on 11/13/2026 by MarketBeat.com Staff.
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