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Ionis Pharmaceuticals (IONS) Competitors

Ionis Pharmaceuticals logo
$60.80 +1.18 (+1.98%)
Closing price 08/19/2026 04:00 PM Eastern
Extended Trading
$60.63 -0.17 (-0.29%)
As of 04:29 AM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

IONS vs. BIIB, ALNY, INSM, ROIV, and MRNA

Should you buy Ionis Pharmaceuticals stock or one of its competitors? Ionis Pharmaceuticals's main competitors and comparable companies include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Insmed (INSM), Roivant Sciences (ROIV), and Moderna (MRNA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Ionis Pharmaceuticals compare to Biogen?

Biogen (NASDAQ:BIIB) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their earnings, analyst recommendations, valuation, profitability, dividends, risk, media sentiment and institutional ownership.

Biogen has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$10.03B3.26$1.29B$5.6539.21
Ionis Pharmaceuticals$944M10.70-$381.39M-$3.46N/A

87.9% of Biogen shares are held by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 0.3% of Biogen shares are held by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Biogen has a net margin of 8.32% compared to Ionis Pharmaceuticals' net margin of -64.76%. Biogen's return on equity of 11.18% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

Biogen has a beta of 0.17, meaning that its share price is 83% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.41, meaning that its share price is 59% less volatile than the broader market.

In the previous week, Biogen had 6 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 16 mentions for Biogen and 10 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 1.65 beat Biogen's score of 1.52 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
13 Very Positive mention(s)
2 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Ionis Pharmaceuticals
8 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Biogen presently has a consensus price target of $227.07, indicating a potential upside of 2.49%. Ionis Pharmaceuticals has a consensus price target of $94.15, indicating a potential upside of 54.85%. Given Ionis Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Ionis Pharmaceuticals is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Summary

Biogen beats Ionis Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their risk, dividends, profitability, media sentiment, valuation, institutional ownership, analyst recommendations and earnings.

93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are owned by company insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Alnylam Pharmaceuticals has a beta of 0.3, indicating that its stock price is 70% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.41, indicating that its stock price is 59% less volatile than the broader market.

In the previous week, Alnylam Pharmaceuticals had 8 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 18 mentions for Alnylam Pharmaceuticals and 10 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 1.65 beat Alnylam Pharmaceuticals' score of 0.22 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
5 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
2 Negative mention(s)
0 Very Negative mention(s)
Neutral
Ionis Pharmaceuticals
8 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Ionis Pharmaceuticals' net margin of -64.76%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

Alnylam Pharmaceuticals has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$4.80B6.76$313.75M$5.3845.09
Ionis Pharmaceuticals$944M10.70-$381.39M-$3.46N/A

Alnylam Pharmaceuticals presently has a consensus target price of $386.62, suggesting a potential upside of 59.36%. Ionis Pharmaceuticals has a consensus target price of $94.15, suggesting a potential upside of 54.85%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher possible upside, research analysts plainly believe Alnylam Pharmaceuticals is more favorable than Ionis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
16 Buy rating(s)
3 Strong Buy rating(s)
2.92
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Summary

Alnylam Pharmaceuticals beats Ionis Pharmaceuticals on 11 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Insmed?

Ionis Pharmaceuticals (NASDAQ:IONS) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their risk, valuation, analyst recommendations, profitability, media sentiment, earnings, dividends and institutional ownership.

In the previous week, Ionis Pharmaceuticals and Ionis Pharmaceuticals both had 10 articles in the media. Ionis Pharmaceuticals' average media sentiment score of 1.65 beat Insmed's score of 0.82 indicating that Ionis Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
8 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Insmed
5 Very Positive mention(s)
2 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ionis Pharmaceuticals has higher revenue and earnings than Insmed. Insmed is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M10.70-$381.39M-$3.46N/A
Insmed$606.42M47.05-$1.28B-$4.11N/A

Ionis Pharmaceuticals has a net margin of -64.76% compared to Insmed's net margin of -76.94%. Ionis Pharmaceuticals' return on equity of -111.08% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
Insmed -76.94%-123.94%-44.30%

93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Comparatively, 2.1% of Insmed shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Ionis Pharmaceuticals has a beta of 0.41, indicating that its share price is 59% less volatile than the broader market. Comparatively, Insmed has a beta of 0.81, indicating that its share price is 19% less volatile than the broader market.

Ionis Pharmaceuticals presently has a consensus target price of $94.15, indicating a potential upside of 54.85%. Insmed has a consensus target price of $205.52, indicating a potential upside of 57.30%. Given Insmed's stronger consensus rating and higher possible upside, analysts plainly believe Insmed is more favorable than Ionis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Summary

Ionis Pharmaceuticals beats Insmed on 9 of the 16 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their institutional ownership, media sentiment, dividends, earnings, risk, analyst recommendations, profitability and valuation.

Roivant Sciences presently has a consensus target price of $35.14, indicating a potential downside of 6.05%. Ionis Pharmaceuticals has a consensus target price of $94.15, indicating a potential upside of 54.85%. Given Ionis Pharmaceuticals' higher probable upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.83
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Roivant Sciences has a beta of 1.12, suggesting that its share price is 12% more volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.41, suggesting that its share price is 59% less volatile than the broader market.

In the previous week, Roivant Sciences had 3 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 13 mentions for Roivant Sciences and 10 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 1.65 beat Roivant Sciences' score of 0.52 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
8 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
8 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Roivant Sciences has higher earnings, but lower revenue than Ionis Pharmaceuticals. Roivant Sciences is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,270.55-$299.77M-$0.53N/A
Ionis Pharmaceuticals$944M10.70-$381.39M-$3.46N/A

Ionis Pharmaceuticals has a net margin of -64.76% compared to Roivant Sciences' net margin of -3,534.96%. Roivant Sciences' return on equity of -22.94% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

64.8% of Roivant Sciences shares are held by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 8.8% of Roivant Sciences shares are held by company insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Summary

Roivant Sciences beats Ionis Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Moderna?

Moderna (NASDAQ:MRNA) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, dividends, profitability, earnings, analyst recommendations, institutional ownership, valuation and media sentiment.

Moderna presently has a consensus target price of $56.56, suggesting a potential downside of 67.56%. Ionis Pharmaceuticals has a consensus target price of $94.15, suggesting a potential upside of 54.85%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, analysts clearly believe Ionis Pharmaceuticals is more favorable than Moderna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Moderna
4 Sell rating(s)
10 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.05
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Ionis Pharmaceuticals has a net margin of -64.76% compared to Moderna's net margin of -141.43%. Moderna's return on equity of -28.30% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Moderna-141.43% -28.30% -19.39%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

Ionis Pharmaceuticals has lower revenue, but higher earnings than Moderna. Moderna is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Moderna$1.94B35.81-$2.82B-$7.99N/A
Ionis Pharmaceuticals$944M10.70-$381.39M-$3.46N/A

75.3% of Moderna shares are owned by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 10.8% of Moderna shares are owned by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Moderna has a beta of 0.91, meaning that its stock price is 9% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.41, meaning that its stock price is 59% less volatile than the broader market.

In the previous week, Moderna had 40 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 50 mentions for Moderna and 10 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 1.65 beat Moderna's score of 0.67 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Moderna
28 Very Positive mention(s)
6 Positive mention(s)
3 Neutral mention(s)
4 Negative mention(s)
6 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
8 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Summary

Ionis Pharmaceuticals beats Moderna on 10 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding IONS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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IONS vs. The Competition

MetricIonis PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.91B$3.87B$7.17B$12.86B
Dividend YieldN/A3.66%2.55%10.29%
P/E Ratio-17.5711.71268.9624.23
Price / Sales10.701,339.31620.67101.69
Price / CashN/A102.5678.2352.73
Price / Book22.9417.2513.256.25
Net Income-$381.39M-$12.52M$3.47B$348.04M
7 Day Performance8.82%4.41%2.31%-0.15%
1 Month Performance14.83%7.74%5.39%2.68%
1 Year Performance42.02%63.71%29.20%21.01%

Ionis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
IONS
Ionis Pharmaceuticals
3.4792 of 5 stars
$60.80
+2.0%
$94.15
+54.9%
+43.1%$9.91B$944MN/A1,402
BIIB
Biogen
3.8739 of 5 stars
$209.15
-0.3%
$227.07
+8.6%
+59.6%$31.00B$9.89B37.027,500
ALNY
Alnylam Pharmaceuticals
4.7928 of 5 stars
$224.60
-1.8%
$393.86
+75.4%
-47.1%$30.60B$3.71B41.752,770
INSM
Insmed
3.3132 of 5 stars
$128.32
+3.7%
$205.52
+60.2%
+2.7%$27.02B$606.42MN/A1,664
ROIV
Roivant Sciences
1.5341 of 5 stars
$36.24
+0.1%
$35.14
-3.0%
+218.0%$26.15B$8.26MN/A860

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This page (NASDAQ:IONS) was last updated on 8/20/2026 by MarketBeat.com Staff.
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