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Ionis Pharmaceuticals (IONS) Competitors

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$45.57 +1.07 (+2.40%)
Closing price 09/28/2026 04:00 PM Eastern
Extended Trading
$45.86 +0.29 (+0.63%)
As of 09:04 AM Eastern
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IONS vs. ROIV, INSM, INCY, BNTX, and GMAB

Should you buy Ionis Pharmaceuticals stock or one of its competitors? Ionis Pharmaceuticals's main competitors and comparable companies include Roivant Sciences (ROIV), Insmed (INSM), Incyte (INCY), BioNTech (BNTX), and Genmab A/S (GMAB). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Ionis Pharmaceuticals compare to Roivant Sciences?

Roivant Sciences (NASDAQ:ROIV) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their profitability, dividends, analyst recommendations, risk, institutional ownership, earnings, media sentiment and valuation.

Roivant Sciences has higher earnings, but lower revenue than Ionis Pharmaceuticals. Roivant Sciences is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Roivant Sciences$8.26M3,233.82-$299.77M-$0.53N/A
Ionis Pharmaceuticals$944M8.02-$381.39M-$3.46N/A

In the previous week, Ionis Pharmaceuticals had 4 more articles in the media than Roivant Sciences. MarketBeat recorded 14 mentions for Ionis Pharmaceuticals and 10 mentions for Roivant Sciences. Ionis Pharmaceuticals' average media sentiment score of 0.48 beat Roivant Sciences' score of 0.09 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Roivant Sciences
0 Very Positive mention(s)
1 Positive mention(s)
5 Neutral mention(s)
3 Negative mention(s)
0 Very Negative mention(s)
Neutral
Ionis Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Ionis Pharmaceuticals has a net margin of -64.76% compared to Roivant Sciences' net margin of -3,534.96%. Roivant Sciences' return on equity of -22.94% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Roivant Sciences-3,534.96% -22.94% -21.53%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

Roivant Sciences presently has a consensus price target of $45.64, suggesting a potential upside of 23.41%. Ionis Pharmaceuticals has a consensus price target of $89.20, suggesting a potential upside of 95.74%. Given Ionis Pharmaceuticals' higher probable upside, analysts clearly believe Ionis Pharmaceuticals is more favorable than Roivant Sciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Roivant Sciences
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.85
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

64.8% of Roivant Sciences shares are held by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 8.8% of Roivant Sciences shares are held by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Roivant Sciences has a beta of 1.12, indicating that its share price is 12% more volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.42, indicating that its share price is 58% less volatile than the broader market.

Summary

Ionis Pharmaceuticals beats Roivant Sciences on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Insmed?

Ionis Pharmaceuticals (NASDAQ:IONS) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their media sentiment, dividends, earnings, institutional ownership, risk, profitability, valuation and analyst recommendations.

93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 1.8% of Ionis Pharmaceuticals shares are owned by company insiders. Comparatively, 2.1% of Insmed shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Ionis Pharmaceuticals has higher revenue and earnings than Insmed. Insmed is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M8.02-$381.39M-$3.46N/A
Insmed$606.42M42.37-$1.28B-$4.11N/A

In the previous week, Ionis Pharmaceuticals had 2 more articles in the media than Insmed. MarketBeat recorded 14 mentions for Ionis Pharmaceuticals and 12 mentions for Insmed. Insmed's average media sentiment score of 0.99 beat Ionis Pharmaceuticals' score of 0.48 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Insmed
4 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ionis Pharmaceuticals has a net margin of -64.76% compared to Insmed's net margin of -76.94%. Ionis Pharmaceuticals' return on equity of -111.08% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
Insmed -76.94%-123.94%-44.30%

Ionis Pharmaceuticals currently has a consensus target price of $89.20, indicating a potential upside of 95.74%. Insmed has a consensus target price of $201.87, indicating a potential upside of 71.56%. Given Ionis Pharmaceuticals' higher possible upside, equities analysts clearly believe Ionis Pharmaceuticals is more favorable than Insmed.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Ionis Pharmaceuticals has a beta of 0.42, meaning that its share price is 58% less volatile than the broader market. Comparatively, Insmed has a beta of 0.82, meaning that its share price is 18% less volatile than the broader market.

Summary

Ionis Pharmaceuticals beats Insmed on 10 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Incyte?

Ionis Pharmaceuticals (NASDAQ:IONS) and Incyte (NASDAQ:INCY) are both healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their dividends, profitability, media sentiment, earnings, analyst recommendations, institutional ownership, risk and valuation.

In the previous week, Incyte had 13 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 27 mentions for Incyte and 14 mentions for Ionis Pharmaceuticals. Incyte's average media sentiment score of 0.54 beat Ionis Pharmaceuticals' score of 0.48 indicating that Incyte is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Incyte
8 Very Positive mention(s)
6 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive

Ionis Pharmaceuticals has a beta of 0.42, suggesting that its share price is 58% less volatile than the broader market. Comparatively, Incyte has a beta of 0.77, suggesting that its share price is 23% less volatile than the broader market.

Ionis Pharmaceuticals presently has a consensus target price of $89.20, indicating a potential upside of 95.74%. Incyte has a consensus target price of $124.80, indicating a potential downside of 0.02%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, equities analysts clearly believe Ionis Pharmaceuticals is more favorable than Incyte.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
Incyte
0 Sell rating(s)
12 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.56

Incyte has a net margin of 27.71% compared to Ionis Pharmaceuticals' net margin of -64.76%. Incyte's return on equity of 29.93% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
Incyte 27.71%29.93%22.88%

Incyte has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Incyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M8.02-$381.39M-$3.46N/A
Incyte$5.14B4.92$1.29B$7.8515.90

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. Comparatively, 97.0% of Incyte shares are held by institutional investors. 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Comparatively, 16.2% of Incyte shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Summary

Incyte beats Ionis Pharmaceuticals on 13 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to BioNTech?

Ionis Pharmaceuticals (NASDAQ:IONS) and BioNTech (NASDAQ:BNTX) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their media sentiment, analyst recommendations, institutional ownership, dividends, earnings, risk, valuation and profitability.

93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. Comparatively, 15.5% of BioNTech shares are owned by institutional investors. 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Comparatively, 19.2% of BioNTech shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Ionis Pharmaceuticals has higher earnings, but lower revenue than BioNTech. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M8.02-$381.39M-$3.46N/A
BioNTech$3.25B7.72-$1.29B-$7.83N/A

In the previous week, BioNTech had 14 more articles in the media than Ionis Pharmaceuticals. MarketBeat recorded 28 mentions for BioNTech and 14 mentions for Ionis Pharmaceuticals. Ionis Pharmaceuticals' average media sentiment score of 0.48 beat BioNTech's score of 0.07 indicating that Ionis Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
BioNTech
9 Very Positive mention(s)
2 Positive mention(s)
7 Neutral mention(s)
2 Negative mention(s)
1 Very Negative mention(s)
Neutral

Ionis Pharmaceuticals has a beta of 0.42, suggesting that its stock price is 58% less volatile than the broader market. Comparatively, BioNTech has a beta of 1.29, suggesting that its stock price is 29% more volatile than the broader market.

Ionis Pharmaceuticals presently has a consensus price target of $89.20, suggesting a potential upside of 95.74%. BioNTech has a consensus price target of $126.00, suggesting a potential upside of 27.17%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, research analysts plainly believe Ionis Pharmaceuticals is more favorable than BioNTech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68

BioNTech has a net margin of -63.54% compared to Ionis Pharmaceuticals' net margin of -64.76%. BioNTech's return on equity of -6.86% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
BioNTech -63.54%-6.86%-6.00%

Summary

BioNTech beats Ionis Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Genmab A/S?

Genmab A/S (NASDAQ:GMAB) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their dividends, earnings, profitability, analyst recommendations, risk, media sentiment, institutional ownership and valuation.

7.1% of Genmab A/S shares are held by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 1.5% of Genmab A/S shares are held by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Genmab A/S has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Genmab A/S, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Genmab A/S$3.72B5.93$963M$1.2727.84
Ionis Pharmaceuticals$944M8.02-$381.39M-$3.46N/A

In the previous week, Ionis Pharmaceuticals had 7 more articles in the media than Genmab A/S. MarketBeat recorded 14 mentions for Ionis Pharmaceuticals and 7 mentions for Genmab A/S. Ionis Pharmaceuticals' average media sentiment score of 0.48 beat Genmab A/S's score of 0.25 indicating that Ionis Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Genmab A/S
0 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral
Ionis Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Genmab A/S has a beta of 0.84, indicating that its share price is 16% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.42, indicating that its share price is 58% less volatile than the broader market.

Genmab A/S has a net margin of 19.08% compared to Ionis Pharmaceuticals' net margin of -64.76%. Genmab A/S's return on equity of 14.89% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Genmab A/S19.08% 14.89% 7.73%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

Genmab A/S presently has a consensus target price of $39.50, indicating a potential upside of 11.71%. Ionis Pharmaceuticals has a consensus target price of $89.20, indicating a potential upside of 95.74%. Given Ionis Pharmaceuticals' higher possible upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than Genmab A/S.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Genmab A/S
0 Sell rating(s)
3 Hold rating(s)
9 Buy rating(s)
1 Strong Buy rating(s)
2.85
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Summary

Genmab A/S beats Ionis Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding IONS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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IONS vs. The Competition

MetricIonis PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$7.40B$3.94B$7.33B$13.18B
Dividend YieldN/A3.63%2.52%14.03%
P/E Ratio-13.1713.88274.7025.59
Price / Sales8.021,317.27615.7583.42
Price / CashN/A40.8828.0235.00
Price / Book15.0915.3810.526.44
Net Income-$381.39M-$22.71M$3.50B$360.47M
7 Day Performance-0.39%-4.24%-2.65%-1.46%
1 Month Performance-25.36%-7.81%-3.76%-3.75%
1 Year Performance-28.96%27.27%13.56%3.91%

Ionis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
IONS
Ionis Pharmaceuticals
3.3963 of 5 stars
$45.57
+2.4%
$89.20
+95.7%
-28.9%$7.40B$944MN/A1,402
ROIV
Roivant Sciences
2.8027 of 5 stars
$38.99
-2.0%
$45.64
+17.0%
+143.8%$28.73B$8.26MN/A721
INSM
Insmed
3.8255 of 5 stars
$121.00
+0.8%
$204.91
+69.3%
-14.1%$26.21B$606.42MN/A1,664
INCY
Incyte
3.0568 of 5 stars
$124.65
-0.5%
$124.05
-0.5%
+50.9%$25.40B$5.14B15.882,844
BNTX
BioNTech
3.4165 of 5 stars
$98.00
+2.0%
$126.00
+28.6%
+1.0%$24.29B$3.25BN/A7,807

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This page (NASDAQ:IONS) was last updated on 9/29/2026 by MarketBeat.com Staff.
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