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Ionis Pharmaceuticals (IONS) Competitors

Ionis Pharmaceuticals logo
$56.71 -1.38 (-2.38%)
Closing price 09/8/2026 04:00 PM Eastern
Extended Trading
$56.40 -0.31 (-0.54%)
As of 05:41 AM Eastern
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IONS vs. BIIB, ALNY, INSM, BNTX, and INCY

Should you buy Ionis Pharmaceuticals stock or one of its competitors? Ionis Pharmaceuticals's main competitors and comparable companies include Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), Insmed (INSM), BioNTech (BNTX), and Incyte (INCY). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Ionis Pharmaceuticals compare to Biogen?

Ionis Pharmaceuticals (NASDAQ:IONS) and Biogen (NASDAQ:BIIB) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, institutional ownership, media sentiment, earnings, risk, analyst recommendations, dividends and valuation.

Ionis Pharmaceuticals currently has a consensus target price of $91.50, indicating a potential upside of 61.35%. Biogen has a consensus target price of $228.50, indicating a potential upside of 7.53%. Given Ionis Pharmaceuticals' stronger consensus rating and higher possible upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than Biogen.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58

Biogen has a net margin of 8.32% compared to Ionis Pharmaceuticals' net margin of -64.76%. Biogen's return on equity of 11.18% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
Biogen 8.32%11.18%6.88%

Biogen has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M9.98-$381.39M-$3.46N/A
Biogen$9.89B3.17$1.29B$5.6537.61

Ionis Pharmaceuticals has a beta of 0.42, suggesting that its stock price is 58% less volatile than the broader market. Comparatively, Biogen has a beta of 0.17, suggesting that its stock price is 83% less volatile than the broader market.

In the previous week, Ionis Pharmaceuticals had 6 more articles in the media than Biogen. MarketBeat recorded 29 mentions for Ionis Pharmaceuticals and 23 mentions for Biogen. Biogen's average media sentiment score of 1.02 beat Ionis Pharmaceuticals' score of 0.25 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
9 Very Positive mention(s)
6 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral
Biogen
15 Very Positive mention(s)
3 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. Comparatively, 87.9% of Biogen shares are held by institutional investors. 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Comparatively, 0.3% of Biogen shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Summary

Biogen beats Ionis Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better business? We will compare the two companies based on the strength of their dividends, media sentiment, institutional ownership, profitability, earnings, analyst recommendations, valuation and risk.

Alnylam Pharmaceuticals has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$3.71B9.37$313.75M$5.3848.35
Ionis Pharmaceuticals$944M9.98-$381.39M-$3.46N/A

Alnylam Pharmaceuticals has a net margin of 15.26% compared to Ionis Pharmaceuticals' net margin of -64.76%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

In the previous week, Ionis Pharmaceuticals had 13 more articles in the media than Alnylam Pharmaceuticals. MarketBeat recorded 29 mentions for Ionis Pharmaceuticals and 16 mentions for Alnylam Pharmaceuticals. Alnylam Pharmaceuticals' average media sentiment score of 0.87 beat Ionis Pharmaceuticals' score of 0.25 indicating that Alnylam Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
8 Very Positive mention(s)
3 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
9 Very Positive mention(s)
6 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral

93.0% of Alnylam Pharmaceuticals shares are owned by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are owned by insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Alnylam Pharmaceuticals has a beta of 0.31, indicating that its stock price is 69% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.42, indicating that its stock price is 58% less volatile than the broader market.

Alnylam Pharmaceuticals currently has a consensus target price of $382.96, suggesting a potential upside of 47.23%. Ionis Pharmaceuticals has a consensus target price of $91.50, suggesting a potential upside of 61.35%. Given Ionis Pharmaceuticals' higher possible upside, analysts clearly believe Ionis Pharmaceuticals is more favorable than Alnylam Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
18 Buy rating(s)
2 Strong Buy rating(s)
2.88
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Summary

Alnylam Pharmaceuticals beats Ionis Pharmaceuticals on 11 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Insmed?

Ionis Pharmaceuticals (NASDAQ:IONS) and Insmed (NASDAQ:INSM) are both healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their valuation, analyst recommendations, media sentiment, profitability, dividends, earnings, risk and institutional ownership.

Ionis Pharmaceuticals currently has a consensus price target of $91.50, suggesting a potential upside of 61.35%. Insmed has a consensus price target of $205.52, suggesting a potential upside of 64.56%. Given Insmed's stronger consensus rating and higher probable upside, analysts plainly believe Insmed is more favorable than Ionis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
Insmed
1 Sell rating(s)
0 Hold rating(s)
22 Buy rating(s)
2 Strong Buy rating(s)
3.00

Ionis Pharmaceuticals has a beta of 0.42, indicating that its share price is 58% less volatile than the broader market. Comparatively, Insmed has a beta of 0.82, indicating that its share price is 18% less volatile than the broader market.

Ionis Pharmaceuticals has higher revenue and earnings than Insmed. Insmed is trading at a lower price-to-earnings ratio than Ionis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M9.98-$381.39M-$3.46N/A
Insmed$606.42M44.97-$1.28B-$4.11N/A

Ionis Pharmaceuticals has a net margin of -64.76% compared to Insmed's net margin of -76.94%. Ionis Pharmaceuticals' return on equity of -111.08% beat Insmed's return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
Insmed -76.94%-123.94%-44.30%

In the previous week, Ionis Pharmaceuticals had 18 more articles in the media than Insmed. MarketBeat recorded 29 mentions for Ionis Pharmaceuticals and 11 mentions for Insmed. Insmed's average media sentiment score of 1.00 beat Ionis Pharmaceuticals' score of 0.25 indicating that Insmed is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
9 Very Positive mention(s)
6 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral
Insmed
7 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. 1.8% of Ionis Pharmaceuticals shares are held by company insiders. Comparatively, 2.1% of Insmed shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Summary

Ionis Pharmaceuticals beats Insmed on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to BioNTech?

Ionis Pharmaceuticals (NASDAQ:IONS) and BioNTech (NASDAQ:BNTX) are both healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their institutional ownership, earnings, media sentiment, dividends, analyst recommendations, valuation, risk and profitability.

Ionis Pharmaceuticals has a beta of 0.42, indicating that its stock price is 58% less volatile than the broader market. Comparatively, BioNTech has a beta of 1.29, indicating that its stock price is 29% more volatile than the broader market.

Ionis Pharmaceuticals has higher earnings, but lower revenue than BioNTech. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than BioNTech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$944M9.98-$381.39M-$3.46N/A
BioNTech$2.65B9.41-$1.29B-$7.83N/A

BioNTech has a net margin of -63.54% compared to Ionis Pharmaceuticals' net margin of -64.76%. BioNTech's return on equity of -6.86% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-64.76% -111.08% -17.41%
BioNTech -63.54%-6.86%-6.00%

In the previous week, Ionis Pharmaceuticals had 19 more articles in the media than BioNTech. MarketBeat recorded 29 mentions for Ionis Pharmaceuticals and 10 mentions for BioNTech. Ionis Pharmaceuticals' average media sentiment score of 0.25 beat BioNTech's score of 0.23 indicating that Ionis Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
9 Very Positive mention(s)
6 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral
BioNTech
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. Comparatively, 15.5% of BioNTech shares are owned by institutional investors. 1.8% of Ionis Pharmaceuticals shares are owned by insiders. Comparatively, 19.2% of BioNTech shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Ionis Pharmaceuticals currently has a consensus target price of $91.50, suggesting a potential upside of 61.35%. BioNTech has a consensus target price of $126.00, suggesting a potential upside of 27.71%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than BioNTech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73
BioNTech
1 Sell rating(s)
5 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.68

Summary

Ionis Pharmaceuticals beats BioNTech on 9 of the 17 factors compared between the two stocks.

How does Ionis Pharmaceuticals compare to Incyte?

Incyte (NASDAQ:INCY) and Ionis Pharmaceuticals (NASDAQ:IONS) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, risk, earnings, analyst recommendations, institutional ownership, profitability, valuation and dividends.

Incyte has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Incyte, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Incyte$5.82B4.33$1.29B$7.8515.85
Ionis Pharmaceuticals$944M9.98-$381.39M-$3.46N/A

97.0% of Incyte shares are owned by institutional investors. Comparatively, 93.9% of Ionis Pharmaceuticals shares are owned by institutional investors. 16.2% of Incyte shares are owned by company insiders. Comparatively, 1.8% of Ionis Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Incyte has a net margin of 27.71% compared to Ionis Pharmaceuticals' net margin of -64.76%. Incyte's return on equity of 29.93% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Incyte27.71% 29.93% 22.88%
Ionis Pharmaceuticals -64.76%-111.08%-17.41%

In the previous week, Ionis Pharmaceuticals had 17 more articles in the media than Incyte. MarketBeat recorded 29 mentions for Ionis Pharmaceuticals and 12 mentions for Incyte. Incyte's average media sentiment score of 1.25 beat Ionis Pharmaceuticals' score of 0.25 indicating that Incyte is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Incyte
10 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Ionis Pharmaceuticals
9 Very Positive mention(s)
6 Positive mention(s)
5 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral

Incyte presently has a consensus target price of $124.05, suggesting a potential downside of 0.28%. Ionis Pharmaceuticals has a consensus target price of $91.50, suggesting a potential upside of 61.35%. Given Ionis Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Ionis Pharmaceuticals is more favorable than Incyte.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Incyte
0 Sell rating(s)
12 Hold rating(s)
11 Buy rating(s)
1 Strong Buy rating(s)
2.54
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.73

Incyte has a beta of 0.77, meaning that its stock price is 23% less volatile than the broader market. Comparatively, Ionis Pharmaceuticals has a beta of 0.42, meaning that its stock price is 58% less volatile than the broader market.

Summary

Incyte beats Ionis Pharmaceuticals on 12 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding IONS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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IONS vs. The Competition

MetricIonis PharmaceuticalsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$9.65B$4.01B$7.39B$12.89B
Dividend YieldN/A3.60%2.54%9.14%
P/E Ratio-16.3912.50270.7525.39
Price / Sales9.981,428.33646.2296.55
Price / CashN/A108.6077.0752.39
Price / Book18.7816.1110.926.40
Net Income-$381.39M-$22.81M$3.48B$358.18M
7 Day Performance-7.53%-0.67%-0.85%0.07%
1 Month Performance0.27%4.99%3.03%-0.78%
1 Year Performance-11.94%47.28%22.29%12.49%

Ionis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
IONS
Ionis Pharmaceuticals
3.4108 of 5 stars
$56.71
-2.4%
$91.50
+61.3%
-7.0%$9.65B$944MN/A1,402
BIIB
Biogen
3.7239 of 5 stars
$216.65
-0.8%
$227.79
+5.1%
+50.3%$32.28B$10.03B38.357,500
ALNY
Alnylam Pharmaceuticals
4.6013 of 5 stars
$240.69
+1.5%
$386.14
+60.4%
-42.8%$31.73B$4.80B44.742,770
INSM
Insmed
3.8552 of 5 stars
$121.82
+2.8%
$205.52
+68.7%
-14.9%$25.89B$606.42MN/A1,664
BNTX
BioNTech
3.6592 of 5 stars
$101.61
-0.5%
$127.44
+25.4%
-3.9%$25.81B$3.25BN/A7,807

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This page (NASDAQ:IONS) was last updated on 9/9/2026 by MarketBeat.com Staff.
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