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Exelixis (EXEL) Competitors

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$55.26 -0.84 (-1.50%)
Closing price 08/27/2026 04:00 PM Eastern
Extended Trading
$53.60 -1.66 (-3.00%)
As of 08/27/2026 07:59 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

EXEL vs. NTRA, RVMD, BIIB, ALNY, and BNTX

Should you buy Exelixis stock or one of its competitors? Exelixis's main competitors and comparable companies include Natera (NTRA), Revolution Medicines (RVMD), Biogen (BIIB), Alnylam Pharmaceuticals (ALNY), and BioNTech (BNTX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Exelixis compare to Natera?

Exelixis (NASDAQ:EXEL) and Natera (NASDAQ:NTRA) are both large-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their profitability, valuation, analyst recommendations, earnings, media sentiment, institutional ownership, risk and dividends.

Exelixis currently has a consensus price target of $50.07, suggesting a potential downside of 9.40%. Natera has a consensus price target of $319.38, suggesting a potential downside of 5.71%. Given Natera's stronger consensus rating and higher probable upside, analysts clearly believe Natera is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30
Natera
1 Sell rating(s)
4 Hold rating(s)
15 Buy rating(s)
2 Strong Buy rating(s)
2.82

Exelixis has higher revenue and earnings than Natera. Natera is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Exelixis$2.32B5.90$782.57M$3.1817.38
Natera$2.31B21.17-$208.16M-$1.36N/A

In the previous week, Natera had 22 more articles in the media than Exelixis. MarketBeat recorded 47 mentions for Natera and 25 mentions for Exelixis. Exelixis' average media sentiment score of 1.34 beat Natera's score of 1.28 indicating that Exelixis is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Exelixis
20 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Natera
36 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
2 Negative mention(s)
2 Very Negative mention(s)
Positive

Exelixis has a beta of 0.44, meaning that its stock price is 56% less volatile than the broader market. Comparatively, Natera has a beta of 1.51, meaning that its stock price is 51% more volatile than the broader market.

85.3% of Exelixis shares are owned by institutional investors. Comparatively, 99.9% of Natera shares are owned by institutional investors. 2.6% of Exelixis shares are owned by company insiders. Comparatively, 5.1% of Natera shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Exelixis has a net margin of 35.33% compared to Natera's net margin of -7.11%. Exelixis' return on equity of 42.17% beat Natera's return on equity.

Company Net Margins Return on Equity Return on Assets
Exelixis35.33% 42.17% 31.76%
Natera -7.11%-11.38%-7.87%

Summary

Natera beats Exelixis on 9 of the 17 factors compared between the two stocks.

How does Exelixis compare to Revolution Medicines?

Exelixis (NASDAQ:EXEL) and Revolution Medicines (NASDAQ:RVMD) are both large-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their analyst recommendations, valuation, risk, profitability, institutional ownership, media sentiment, earnings and dividends.

Exelixis has a net margin of 35.33% compared to Revolution Medicines' net margin of 0.00%. Exelixis' return on equity of 42.17% beat Revolution Medicines' return on equity.

Company Net Margins Return on Equity Return on Assets
Exelixis35.33% 42.17% 31.76%
Revolution Medicines N/A -88.20%-57.85%

Exelixis currently has a consensus price target of $50.07, suggesting a potential downside of 9.40%. Revolution Medicines has a consensus price target of $193.28, suggesting a potential downside of 12.60%. Given Exelixis' higher possible upside, equities analysts clearly believe Exelixis is more favorable than Revolution Medicines.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30
Revolution Medicines
1 Sell rating(s)
1 Hold rating(s)
18 Buy rating(s)
2 Strong Buy rating(s)
2.95

Exelixis has a beta of 0.44, indicating that its share price is 56% less volatile than the broader market. Comparatively, Revolution Medicines has a beta of 1.39, indicating that its share price is 39% more volatile than the broader market.

In the previous week, Revolution Medicines had 20 more articles in the media than Exelixis. MarketBeat recorded 45 mentions for Revolution Medicines and 25 mentions for Exelixis. Exelixis' average media sentiment score of 1.34 beat Revolution Medicines' score of 0.91 indicating that Exelixis is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Exelixis
20 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Revolution Medicines
27 Very Positive mention(s)
5 Positive mention(s)
4 Neutral mention(s)
1 Negative mention(s)
3 Very Negative mention(s)
Positive

Exelixis has higher revenue and earnings than Revolution Medicines. Revolution Medicines is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Exelixis$2.32B5.90$782.57M$3.1817.38
Revolution Medicines$11.58M4,093.38-$1.13B-$8.82N/A

85.3% of Exelixis shares are owned by institutional investors. Comparatively, 94.3% of Revolution Medicines shares are owned by institutional investors. 2.6% of Exelixis shares are owned by insiders. Comparatively, 7.6% of Revolution Medicines shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Summary

Exelixis beats Revolution Medicines on 9 of the 17 factors compared between the two stocks.

How does Exelixis compare to Biogen?

Biogen (NASDAQ:BIIB) and Exelixis (NASDAQ:EXEL) are both large-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their valuation, profitability, dividends, media sentiment, risk, institutional ownership, earnings and analyst recommendations.

87.9% of Biogen shares are owned by institutional investors. Comparatively, 85.3% of Exelixis shares are owned by institutional investors. 0.3% of Biogen shares are owned by company insiders. Comparatively, 2.6% of Exelixis shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Biogen had 13 more articles in the media than Exelixis. MarketBeat recorded 38 mentions for Biogen and 25 mentions for Exelixis. Exelixis' average media sentiment score of 1.34 beat Biogen's score of 1.23 indicating that Exelixis is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biogen
29 Very Positive mention(s)
2 Positive mention(s)
5 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Exelixis
20 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Biogen has a beta of 0.17, meaning that its share price is 83% less volatile than the broader market. Comparatively, Exelixis has a beta of 0.44, meaning that its share price is 56% less volatile than the broader market.

Biogen currently has a consensus target price of $227.79, suggesting a potential upside of 2.84%. Exelixis has a consensus target price of $50.07, suggesting a potential downside of 9.40%. Given Biogen's stronger consensus rating and higher possible upside, analysts clearly believe Biogen is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biogen
1 Sell rating(s)
13 Hold rating(s)
18 Buy rating(s)
1 Strong Buy rating(s)
2.58
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30

Exelixis has a net margin of 35.33% compared to Biogen's net margin of 8.32%. Exelixis' return on equity of 42.17% beat Biogen's return on equity.

Company Net Margins Return on Equity Return on Assets
Biogen8.32% 11.18% 6.88%
Exelixis 35.33%42.17%31.76%

Biogen has higher revenue and earnings than Exelixis. Exelixis is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biogen$9.89B3.31$1.29B$5.6539.20
Exelixis$2.32B5.90$782.57M$3.1817.38

Summary

Biogen beats Exelixis on 9 of the 16 factors compared between the two stocks.

How does Exelixis compare to Alnylam Pharmaceuticals?

Alnylam Pharmaceuticals (NASDAQ:ALNY) and Exelixis (NASDAQ:EXEL) are both large-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, profitability, valuation, risk, institutional ownership, earnings, analyst recommendations and media sentiment.

Exelixis has lower revenue, but higher earnings than Alnylam Pharmaceuticals. Exelixis is trading at a lower price-to-earnings ratio than Alnylam Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Alnylam Pharmaceuticals$3.71B8.52$313.75M$5.3843.97
Exelixis$2.32B5.90$782.57M$3.1817.38

Alnylam Pharmaceuticals presently has a consensus price target of $386.14, suggesting a potential upside of 63.23%. Exelixis has a consensus price target of $50.07, suggesting a potential downside of 9.40%. Given Alnylam Pharmaceuticals' stronger consensus rating and higher probable upside, equities analysts clearly believe Alnylam Pharmaceuticals is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alnylam Pharmaceuticals
0 Sell rating(s)
5 Hold rating(s)
16 Buy rating(s)
3 Strong Buy rating(s)
2.92
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30

In the previous week, Alnylam Pharmaceuticals had 2 more articles in the media than Exelixis. MarketBeat recorded 27 mentions for Alnylam Pharmaceuticals and 25 mentions for Exelixis. Exelixis' average media sentiment score of 1.34 beat Alnylam Pharmaceuticals' score of 1.18 indicating that Exelixis is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Alnylam Pharmaceuticals
21 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Exelixis
20 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Alnylam Pharmaceuticals has a beta of 0.3, meaning that its share price is 70% less volatile than the broader market. Comparatively, Exelixis has a beta of 0.44, meaning that its share price is 56% less volatile than the broader market.

Exelixis has a net margin of 35.33% compared to Alnylam Pharmaceuticals' net margin of 15.26%. Alnylam Pharmaceuticals' return on equity of 84.93% beat Exelixis' return on equity.

Company Net Margins Return on Equity Return on Assets
Alnylam Pharmaceuticals15.26% 84.93% 14.30%
Exelixis 35.33%42.17%31.76%

93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. Comparatively, 85.3% of Exelixis shares are held by institutional investors. 0.9% of Alnylam Pharmaceuticals shares are held by insiders. Comparatively, 2.6% of Exelixis shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Summary

Alnylam Pharmaceuticals beats Exelixis on 11 of the 17 factors compared between the two stocks.

How does Exelixis compare to BioNTech?

BioNTech (NASDAQ:BNTX) and Exelixis (NASDAQ:EXEL) are both large-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their profitability, media sentiment, dividends, valuation, risk, institutional ownership, analyst recommendations and earnings.

Exelixis has a net margin of 35.33% compared to BioNTech's net margin of -63.54%. Exelixis' return on equity of 42.17% beat BioNTech's return on equity.

Company Net Margins Return on Equity Return on Assets
BioNTech-63.54% -6.86% -6.00%
Exelixis 35.33%42.17%31.76%

BioNTech currently has a consensus target price of $127.81, suggesting a potential upside of 14.73%. Exelixis has a consensus target price of $50.07, suggesting a potential downside of 9.40%. Given BioNTech's stronger consensus rating and higher probable upside, equities research analysts plainly believe BioNTech is more favorable than Exelixis.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
BioNTech
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74
Exelixis
2 Sell rating(s)
11 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.30

15.5% of BioNTech shares are held by institutional investors. Comparatively, 85.3% of Exelixis shares are held by institutional investors. 19.2% of BioNTech shares are held by company insiders. Comparatively, 2.6% of Exelixis shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Exelixis has lower revenue, but higher earnings than BioNTech. BioNTech is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
BioNTech$3.25B8.68-$1.29B-$7.83N/A
Exelixis$2.32B5.90$782.57M$3.1817.38

In the previous week, Exelixis had 11 more articles in the media than BioNTech. MarketBeat recorded 25 mentions for Exelixis and 14 mentions for BioNTech. Exelixis' average media sentiment score of 1.34 beat BioNTech's score of 0.05 indicating that Exelixis is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
BioNTech
3 Very Positive mention(s)
1 Positive mention(s)
5 Neutral mention(s)
3 Negative mention(s)
1 Very Negative mention(s)
Neutral
Exelixis
20 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

BioNTech has a beta of 1.27, meaning that its stock price is 27% more volatile than the broader market. Comparatively, Exelixis has a beta of 0.44, meaning that its stock price is 56% less volatile than the broader market.

Summary

Exelixis beats BioNTech on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding EXEL and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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EXEL vs. The Competition

MetricExelixisBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$13.90B$4.04B$7.32B$12.78B
Dividend YieldN/A3.62%2.53%11.03%
P/E Ratio17.3811.26271.2925.71
Price / Sales5.901,425.95643.60106.82
Price / Cash18.53108.4679.1753.57
Price / Book7.4316.4713.016.26
Net Income$782.57M-$22.76M$3.46B$348.07M
7 Day Performance2.18%1.99%0.98%0.47%
1 Month Performance-2.21%13.04%8.59%5.19%
1 Year Performance45.80%59.10%26.54%16.68%

Exelixis Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
EXEL
Exelixis
3.3485 of 5 stars
$55.26
-1.5%
$50.07
-9.4%
+43.5%$13.90B$2.32B17.381,077
NTRA
Natera
2.708 of 5 stars
$336.71
+2.7%
$319.38
-5.1%
+107.7%$48.53B$2.71BN/A6,140
RVMD
Revolution Medicines
2.5335 of 5 stars
$211.40
-0.1%
$167.89
-20.6%
+481.4%$45.31B$11.58MN/A250
BIIB
Biogen
3.5183 of 5 stars
$220.77
+1.2%
$227.79
+3.2%
+62.4%$32.62B$9.89B39.077,500
ALNY
Alnylam Pharmaceuticals
4.7882 of 5 stars
$240.08
+1.7%
$386.14
+60.8%
-47.9%$32.13B$3.71B44.622,770

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This page (NASDAQ:EXEL) was last updated on 8/28/2026 by MarketBeat.com Staff.
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