Janux Therapeutics (JANX) Stock Price, News & Analysis

Company Overview

Janux Therapeutics is a clinical-stage biotechnology company focused on developing next-generation intratumoral immuno-oncology therapies that harness the body’s innate and adaptive immune systems. The company designs and synthesizes proprietary Toll-like receptor (TLR) agonists to reprogram the tumor microenvironment. Janux is publicly traded on the Nasdaq under the symbol JANX.

Its lead programs include JTX-8064, a fully synthetic TLR4 agonist engineered for optimal stability and potency, and JTX-4014, a TLR1/2 agonist formulated for direct intratumoral administration. By activating key pathways of the innate immune response, these candidates aim to recruit and amplify antitumor T-cell activity while minimizing systemic exposure. Janux’s pipeline is advancing through early-stage clinical trials to evaluate safety, tolerability and preliminary signals of efficacy in a variety of solid tumors.

Based in San Diego, Janux leverages collaborations with contract research organizations and academic centers to support manufacturing and clinical development. The company’s leadership team comprises experienced immuno-oncology researchers and drug developers with backgrounds in biologics, formulation science and regulatory strategy. Janux continues to build its infrastructure and partnerships to accelerate the translation of its TLR agonists from preclinical research into potential new treatment options for cancer patients.

Key Stats

• Today's Range: $23.38 to $24.79
• 50-Day Range: $22.58 to $27.75
• 52-Week Range: $21.97 to $71.71
• Volume: 538,344 shs
• Average Volume: 907,081 shs
• Market Capitalization: $1.41 billion
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $78.31
• Consensus Rating: Buy

Janux Therapeutics Stock Analysis - MarketRank™

Janux Therapeutics scored higher than 61% of companies evaluated by MarketBeat, and ranked 424th out of 958 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.5 / 5
• Analyst Rating: Buy

Consensus Rating

Janux Therapeutics has received a consensus rating of Buy. The company's average rating score is 3.06, and is based on 13 buy ratings, 1 hold rating, and no sell ratings.

Upside Potential

Janux Therapeutics has a consensus price target of $78.31, representing about 233.8% upside from its current price of $23.46.

Amount of Analyst Coverage

Janux Therapeutics has been the subject of 6 research reports in the past 90 days, demonstrating strong analyst interest in this stock.

Earnings and Valuation

• Score: 0.0 / 5
• Proj. Earnings Growth: Decreasing

Earnings Growth

Earnings for Janux Therapeutics are expected to decrease in the coming year, from ($1.38) to ($2.35) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Janux Therapeutics is -13.03, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Janux Therapeutics is -13.03, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Janux Therapeutics has a P/B Ratio of 1.20. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 1.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

14.89% of the float of Janux Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Janux Therapeutics has a short interest ratio ("days to cover") of 10.5, which indicates bearish sentiment.

Change versus previous month

Short interest in Janux Therapeutics has recently decreased by 0.37%, indicating that investor sentiment is improving.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Janux Therapeutics does not currently pay a dividend.

Dividend Growth

Janux Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

14.89% of the float of Janux Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Janux Therapeutics has a short interest ratio ("days to cover") of 10.5, which indicates bearish sentiment.

Change versus previous month

Short interest in Janux Therapeutics has recently decreased by 0.37%, indicating that investor sentiment is improving.

News and Social Media

• Score: 3.1 / 5
• News Sentiment: 0.51

News Sentiment

Janux Therapeutics has a news sentiment score of 0.51. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.92 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 14 news articles for Janux Therapeutics this week, compared to 6 articles on an average week.

Search Interest

14 people have searched for JANX on MarketBeat in the last 30 days. This is an increase of 367% compared to the previous 30 days.

MarketBeat Follows

5 people have added Janux Therapeutics to their MarketBeat watchlist in the last 30 days. This is an increase of 400% compared to the previous 30 days.

Company Ownership

• Score: 3.3 / 5
• Insider Trading: N/A

Insider Buying vs. Insider Selling

In the past three months, Janux Therapeutics insiders have not sold or bought any company stock.

Percentage Held by Insiders

29.40% of the stock of Janux Therapeutics is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

75.39% of the stock of Janux Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

JANX Stock Analysis - Frequently Asked Questions

How have JANX shares performed this year?

Janux Therapeutics' stock was trading at $53.54 at the beginning of 2025. Since then, JANX shares have decreased by 56.2% and is now trading at $23.46.

How were Janux Therapeutics' earnings last quarter?

Janux Therapeutics, Inc. (NASDAQ:JANX) issued its quarterly earnings data on Thursday, August, 7th. The company reported ($0.55) EPS for the quarter, missing the consensus estimate of ($0.48) by $0.07.

When did Janux Therapeutics IPO?

Janux Therapeutics (JANX) raised $152 million in an initial public offering on Friday, June 11th 2021. The company issued 9,500,000 shares at $15.00-$17.00 per share. BofA Securities, Cowen and Evercore ISI served as the underwriters for the IPO and H.C. Wainwright & Co. LLC was co-manager.

Who are Janux Therapeutics' major shareholders?

Janux Therapeutics' top institutional investors include Adage Capital Partners GP L.L.C. (4.20%), Orbimed Advisors LLC (2.01%), Franklin Resources Inc. (1.78%) and Geode Capital Management LLC (1.52%). Insiders that own company stock include Ra Capital Management, LP, Tighe Reardon, David Alan Campbell, Andrew Hollman Meyer and Ventures Xi LP Avalon.
View institutional ownership trends.

How do I buy shares of Janux Therapeutics?

Shares of JANX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Janux Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Janux Therapeutics investors own include American Water Works (AWK), The RMR Group (RMR), DiamondRock Hospitality (DRH), iShares Micro-Cap ETF (IWC), Voyager Therapeutics (VYGR), Waste Connections (WCN) and AU Optronics (AUOTY).

Company Calendar

• Last Earnings: 8/07/2025
• Today: 9/17/2025
• Next Earnings (Estimated): 11/05/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:JANX
• CIK: 1817713
• Web: www.januxrx.com
• Phone: 858-751-4493
• Fax: N/A
• Employees: 30
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Janux Therapeutics: $80.92
• High Price Target: $200.00
• Low Price Target: $41.00
• Potential Upside/Downside: +245.7%
• Consensus Rating: Buy
• Rating Score (0-4): 3.07
• Research Coverage: 15 Analysts

Profitability

• EPS (Trailing Twelve Months): ($1.80)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$68.99 million
• Net Margins: N/A
• Pretax Margin: -24,064.01%
• Return on Equity: -11.48%
• Return on Assets: -11.01%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 47.03
• Quick Ratio: 47.03

Sales & Book Value

• Annual Sales: $10.59 million
• Price / Sales: 132.83
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $19.49 per share
• Price / Book: 1.20

Miscellaneous

• Outstanding Shares: 60,090,000
• Free Float: 42,426,000
• Market Cap: $1.41 billion
• Optionable: Optionable
• Beta: 2.84