Karyopharm Therapeutics (KPTI) Stock Price, News & Analysis

Company Overview

Karyopharm Therapeutics (NASDAQ: KPTI) is a clinical-stage biopharmaceutical company focused on discovering and developing novel first-in-class drugs that target the nuclear export protein XPO1. The company’s lead product, selinexor (marketed as XPOVIO), is an oral selective inhibitor of nuclear export (SINE) compound approved for treatment of multiple myeloma and diffuse large B-cell lymphoma. In addition to selinexor, Karyopharm’s pipeline includes second-generation SINE compounds and combination studies in solid tumors and hematologic malignancies.

Founded in 2008 and headquartered in Newton, Massachusetts, Karyopharm has built a research platform around modulation of nuclear export pathways. The company conducts clinical trials both domestically and internationally, working with regulatory agencies in the United States and Europe. Through strategic collaborations, Karyopharm seeks to expand the therapeutic reach of its SINE technology into other areas of oncology and potentially neurodegenerative diseases.

Karyopharm is led by Michael Kauffman, M.D., President and Chief Executive Officer, who co-founded the company and has guided its transition from preclinical research to commercial-stage operations. Under his leadership, Karyopharm has forged partnerships with global pharmaceutical firms to advance pipeline candidates and ensure broader patient access. The company maintains a scientific advisory board composed of experts in cancer biology, translational medicine and drug development.

Key Stats

• Today's Range: $6.31 to $6.78
• 50-Day Range: $3.77 to $7.81
• 52-Week Range: $3.51 to $16.95
• Volume: 24,596 shs
• Average Volume: 124,260 shs
• Market Capitalization: $54.11 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $34.00
• Consensus Rating: Moderate Buy

Karyopharm Therapeutics Stock Analysis - MarketRank™

Karyopharm Therapeutics scored higher than 78% of companies evaluated by MarketBeat, and ranked 257th out of 954 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 3.8 / 5
• Analyst Rating: Moderate Buy

Consensus Rating

Karyopharm Therapeutics has received a consensus rating of Moderate Buy. The company's average rating score is 2.80, and is based on 4 buy ratings, 1 hold rating, and no sell ratings.

Upside Potential

Karyopharm Therapeutics has a consensus price target of $34.00, representing about 427.1% upside from its current price of $6.45.

Amount of Analyst Coverage

Karyopharm Therapeutics has only been the subject of 2 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Karyopharm Therapeutics are expected to grow in the coming year, from ($0.71) to ($0.43) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Karyopharm Therapeutics is -0.44, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Karyopharm Therapeutics is -0.44, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Short Interest

• Score: 0.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

27.39% of the float of Karyopharm Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Karyopharm Therapeutics has a short interest ratio ("days to cover") of 13.6, which indicates bearish sentiment.

Change versus previous month

Short interest in Karyopharm Therapeutics has recently increased by 1.87%, indicating that investor sentiment is decreasing.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Karyopharm Therapeutics does not currently pay a dividend.

Dividend Growth

Karyopharm Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: 4.6 / 5
• Environmental Score: -1.11

Percentage of Shares Shorted

27.39% of the float of Karyopharm Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Karyopharm Therapeutics has a short interest ratio ("days to cover") of 13.6, which indicates bearish sentiment.

Change versus previous month

Short interest in Karyopharm Therapeutics has recently increased by 1.87%, indicating that investor sentiment is decreasing.

News and Social Media

• Score: 2.6 / 5
• News Sentiment: 0.72

News Sentiment

Karyopharm Therapeutics has a news sentiment score of 0.72. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.94 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 5 news articles for Karyopharm Therapeutics this week, compared to 3 articles on an average week.

Search Interest

9 people have searched for KPTI on MarketBeat in the last 30 days. This is an increase of 80% compared to the previous 30 days.

Company Ownership

• Score: 2.5 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Karyopharm Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $1,868.00 in company stock.

Percentage Held by Insiders

Only 2.75% of the stock of Karyopharm Therapeutics is held by insiders.

Percentage Held by Institutions

66.44% of the stock of Karyopharm Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

KPTI Stock Analysis - Frequently Asked Questions

How have KPTI shares performed this year?

Karyopharm Therapeutics' stock was trading at $10.1445 at the beginning of 2025. Since then, KPTI stock has decreased by 36.4% and is now trading at $6.45.

How were Karyopharm Therapeutics' earnings last quarter?

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) released its quarterly earnings data on Monday, August, 11th. The company reported ($4.32) earnings per share for the quarter, missing the consensus estimate of ($3.80) by $0.52. The business earned $37.93 million during the quarter, compared to analysts' expectations of $37.92 million.
Read the conference call transcript.

When did Karyopharm Therapeutics' stock split?

Karyopharm Therapeutics's stock reverse split before market open on Wednesday, February 26th 2025.The 1-15 reverse split was announced on Monday, February 24th 2025. The number of shares owned by shareholders was adjusted after the market closes on Tuesday, February 25th 2025. An investor that had 100 shares of stock prior to the reverse split would have 7 shares after the split.

Who are Karyopharm Therapeutics' major shareholders?

Top institutional shareholders of Karyopharm Therapeutics include Bank of America Corp DE (1.94%), Geode Capital Management LLC (1.06%), Silverback Asset Management LLC (0.81%) and Bridgeway Capital Management LLC (0.44%). Insiders that own company stock include Richard A Paulson, Reshma Rangwala, Stuart Poulton, Michael Mason, Michael Mano, Sohanya Roshan Cheng, Kristin Abate, Stephen Mitchener and Garen G Bohlin.
View institutional ownership trends.

How do I buy shares of Karyopharm Therapeutics?

Shares of KPTI stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Karyopharm Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Karyopharm Therapeutics investors own include NVIDIA (NVDA), Meta Platforms (META), Enovix (ENVX), Tesla (TSLA), Globant (GLOB), Luminar Technologies (LAZR) and Rambus (RMBS).

Company Calendar

• Last Earnings: 8/11/2025
• Today: 9/15/2025
• Next Earnings (Estimated): 11/04/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - DRUGS
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:KPTI
• CIK: 1503802
• Web: www.karyopharm.com
• Phone: (617) 658-0600
• Fax: N/A
• Employees: 380
• Year Founded: 2008

Price Target and Rating

• Average Price Target for Karyopharm Therapeutics: $34.00
• High Price Target: $75.00
• Low Price Target: $10.00
• Potential Upside/Downside: +427.1%
• Consensus Rating: Moderate Buy
• Rating Score (0-4): 2.80
• Research Coverage: 5 Analysts

Profitability

• EPS (Trailing Twelve Months): ($14.59)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$76.42 million
• Net Margins: -90.02%
• Pretax Margin: -90.02%
• Return on Equity: N/A
• Return on Assets: -84.28%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 0.99
• Quick Ratio: 0.94

Sales & Book Value

• Annual Sales: $145.24 million
• Price / Sales: 0.39
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: ($22.10) per share
• Price / Book: -0.29

Miscellaneous

• Outstanding Shares: 8,670,000
• Free Float: 8,433,000
• Market Cap: $55.92 million
• Optionable: Optionable
• Beta: 0.34