| 2/24/2021 | Virtu Financial LLC | 27,736 | $0.11M | 0.0% | N/A | 0.272% | |
| 2/24/2021 | Alyeska Investment Group L.P. | 842,554 | $3.27M | 0.0% | +11.9% | 8.272% | |
| 2/16/2021 | Alyeska Investment Group L.P. | 842,554 | $3.27M | 0.0% | +11.9% | 8.272% | |
| 2/12/2021 | Ikarian Capital LLC | 400,000 | $1.55M | 0.1% | N/A | 3.927% | |
| 2/10/2021 | Renaissance Technologies LLC | 319,130 | $1.24M | 0.0% | -21.9% | 3.133% | |
| 11/13/2020 | Ardsley Advisory Partners LP | 20,000 | $65K | 0.0% | N/A | 0.200% | |
| 11/9/2020 | Acadian Asset Management LLC | 83,052 | $0.27M | 0.0% | +22.2% | 0.830% | |
| 11/6/2020 | BlackRock Inc. | 41,411 | $0.13M | 0.0% | +23.8% | 0.414% | |
| 9/15/2020 | Two Sigma Advisers LP | 80,950 | $0.36M | 0.0% | +122.7% | 0.849% | |
| 8/14/2020 | Alyeska Investment Group L.P. | 725,984 | $3.22M | 0.1% | -1.7% | 7.763% | |
|
| 5/15/2020 | Two Sigma Investments LP | 64,269 | $0.18M | 0.0% | N/A | 0.687% | |
| 5/15/2020 | Two Sigma Advisers LP | 36,350 | $0.10M | 0.0% | N/A | 0.389% | |
| 5/15/2020 | Alyeska Investment Group L.P. | 738,288 | $2.07M | 0.0% | N/A | 7.894% | |
| 5/13/2020 | Viking Global Investors LP | 587,444 | $1.65M | 0.0% | +156.2% | 6.281% | |
| 5/13/2020 | Federated Hermes Inc. | 1,615,000 | $4.52M | 0.0% | +171.4% | 17.269% | |
| 5/8/2020 | Oppenheimer & Co. Inc. | 18,941 | $53K | 0.0% | N/A | 0.203% | |
| 5/1/2020 | UBS Group AG | 37,999 | $0.11M | 0.0% | +1,002.1% | 0.406% | |
| 4/8/2020 | Marquette Asset Management LLC | 18,848 | $53K | 0.0% | N/A | 0.202% | |
| 2/14/2020 | First Republic Investment Management Inc. | 22,579 | $94K | 0.0% | N/A | 0.580% | |
| 2/13/2020 | Renaissance Technologies LLC | 199,920 | $0.83M | 0.0% | +3.3% | 5.139% | |
| 2/4/2020 | Virtu Financial LLC | 11,183 | $47K | 0.0% | N/A | 0.287% | |
| 8/14/2019 | Vanguard Group Inc. | 1,779,024 | $0.65M | 0.0% | +1.9% | 54.321% | |
| 8/13/2019 | BlackRock Inc. | 125,916 | $46K | 0.0% | -31.3% | 3.845% | |
| 8/13/2019 | Polaris Venture Management Co. V L.L.C. | 130,571 | $0.67M | 0.5% | -92.9% | 3.987% | |
| 8/12/2019 | Renaissance Technologies LLC | 1,845,873 | $0.68M | 0.0% | +19.8% | 56.363% | |
| 8/1/2019 | Wedbush Securities Inc. | 67,270 | $25K | 0.0% | +158.7% | 2.051% | |
| 2/8/2019 | BlackRock Inc. | 186,738 | $93K | 0.0% | -9.9% | 0.622% | |
| 11/13/2018 | Renaissance Technologies LLC | 1,107,025 | $0.90M | 0.0% | +107.4% | 3.707% | |
| 11/9/2018 | FMR LLC | 4,328,450 | $3.52M | 0.0% | -3.3% | 14.496% | |
| 11/9/2018 | BlackRock Inc. | 207,281 | $0.17M | 0.0% | -33.3% | 0.694% | |
| 8/13/2018 | Renaissance Technologies LLC | 533,861 | $0.49M | 0.0% | +37.6% | 1.790% | |
| 8/9/2018 | BlackRock Inc. | 310,903 | $0.28M | 0.0% | -19.1% | 1.042% | |
| 5/15/2018 | Sofinnova Ventures Inc | 1,866,126 | $4.95M | 0.8% | N/A | 6.262% | |
| 5/11/2018 | Dimensional Fund Advisors LP | 114,449 | $0.30M | 0.0% | +33.5% | 0.384% | |
| 2/14/2018 | Viking Global Investors LP | 1,384,300 | $4.85M | 0.0% | -22.1% | 4.652% | |
| 2/14/2018 | Deutsche Bank AG | 56,999 | $0.20M | 0.0% | N/A | 0.192% | |
| 2/13/2018 | Renaissance Technologies LLC | 279,400 | $0.98M | 0.0% | +143.2% | 0.939% | |
| 2/9/2018 | Artal Group S.A. | 500,000 | $1.75M | 0.0% | +100.0% | 1.680% | |
| 2/9/2018 | BlackRock Inc. | 366,047 | $1.28M | 0.0% | -29.8% | 1.230% | |
| 11/14/2017 | Alyeska Investment Group L.P. | 754,524 | $3.81M | 0.0% | -10.1% | 3.165% | |
| 11/13/2017 | Dimensional Fund Advisors LP | 83,848 | $0.42M | 0.0% | +44.1% | 0.352% | |
| 11/8/2017 | Artal Group S.A. | 250,000 | $1.26M | 0.0% | N/A | 1.049% | |
| 10/27/2017 | Victory Capital Management Inc. | 90,020 | $0.46M | 0.0% | N/A | 0.378% | |
| 8/15/2017 | EcoR1 Capital LLC | 2,292,659 | $7.80M | 1.4% | No Change | 9.631% | |
| 8/11/2017 | Dimensional Fund Advisors LP | 58,172 | $0.20M | 0.0% | No Change | 0.244% | |
| 8/11/2017 | FMR LLC | 3,557,779 | $12.27M | 0.0% | No Change | 14.945% | |
| 5/18/2017 | Goldman Sachs Group Inc. | 32,074 | $0.11M | 0.0% | -59.1% | 0.135% | |
| 5/15/2017 | Polaris Venture Management Co. V L.L.C. | 1,827,992 | $6.40M | 6.8% | No Change | 7.697% | |
| 5/15/2017 | EcoR1 Capital LLC | 2,292,659 | $8.02M | 2.0% | +134.7% | 9.654% | |
| 5/15/2017 | Bank of America Corp DE | 47,708 | $0.17M | 0.0% | -7.9% | 0.201% | |
| 5/12/2017 | Renaissance Technologies LLC | 38,800 | $0.14M | 0.0% | +1.8% | 0.163% | |
| 5/11/2017 | FMR LLC | 3,557,779 | $12.45M | 0.0% | No Change | 14.981% | |
| 2/15/2017 | EcoR1 Capital LLC | 976,986 | $2.10M | 0.7% | N/A | 4.119% | |
| 2/14/2017 | Alyeska Investment Group L.P. | 1,072,108 | $2.31M | 0.0% | +3.1% | 4.520% | |
| 2/10/2017 | FMR LLC | 3,557,779 | $7.65M | 0.0% | No Change | 15.000% | |
| 11/15/2016 | Tang Capital Management LLC | 279,425 | $0.89M | 0.4% | No Change | 1.178% | |
| 11/14/2016 | Rock Springs Capital Management LP | 433,500 | $1.38M | 0.1% | No Change | 1.828% | |
| 11/9/2016 | Polaris Venture Management Co. V L.L.C. | 1,827,992 | $5.81M | 6.1% | No Change | 7.707% | |
| 11/8/2016 | BlackRock Advisors LLC | 231,813 | $0.74M | 0.0% | -5.2% | 0.977% | |
| 11/1/2016 | Jackson Park Capital LLC | 66,000 | $0.21M | 0.3% | No Change | 0.278% | |
| 8/4/2016 | GSA Capital Partners LLP | 36,498 | $0.10M | 0.0% | N/A | 0.154% | |
| 8/3/2016 | Emerald Acquisition Ltd. | 74,310 | $0.21M | 0.0% | N/A | 0.314% | |
| 7/28/2016 | Jackson Park Capital LLC | 66,000 | $0.18M | 0.3% | N/A | 0.279% | |
| 7/28/2016 | Polaris Venture Management Co. V L.L.C. | 1,827,992 | $5.08M | 5.5% | No Change | 7.717% | |
| 5/16/2016 | Magnetar Financial LLC | 183,806 | $0.72M | 0.0% | -1.3% | 0.776% | |
| 5/16/2016 | Jacobs Levy Equity Management Inc. | 42,004 | $0.17M | 0.0% | N/A | 0.177% | |
| 5/13/2016 | Geode Capital Management LLC | 46,943 | $0.18M | 0.0% | -0.2% | 0.199% | |
| 5/13/2016 | Goldman Sachs Group Inc. | 42,753 | $0.17M | 0.0% | +220.2% | 0.181% | |
| 5/12/2016 | State Street Corp | 68,285 | $0.27M | 0.0% | +51.8% | 0.289% | |
| 5/10/2016 | BlackRock Institutional Trust Company N.A. | 82,461 | $0.33M | 0.0% | -1.1% | 0.349% | |
| 5/10/2016 | BlackRock Fund Advisors | 464,476 | $1.83M | 0.0% | +4.6% | 1.964% | |
| 2/16/2016 | Rock Springs Capital Management LP | 415,196 | $4.08M | 0.3% | +6.7% | 1.756% | |
| 2/16/2016 | Price T Rowe Associates Inc. MD | 1,169,007 | $11.49M | 0.0% | -1.3% | 4.943% | |
| 2/16/2016 | Lord Abbett & CO. LLC | 108,451 | $1.07M | 0.0% | -38.6% | 0.459% | |
| 2/12/2016 | Federated Investors Inc. PA | 161,300 | $1.59M | 0.0% | No Change | 0.682% | |
| 2/11/2016 | RS Investment Management Co. LLC | 1,206,249 | $11.86M | 0.1% | +11.5% | 5.101% | |
