Pacific Biosciences of California, Inc. (NASDAQ:PACB), commonly known as PacBio, is a biotechnology company specializing in high-resolution, single-molecule real-time (SMRT) DNA sequencing solutions. Founded in 2004 and headquartered in Menlo Park, California, PacBio has developed next-generation sequencing technologies that enable researchers to generate long, accurate reads for comprehensive genomic analysis. Its platforms are designed to deliver insights into complex regions of the genome that are difficult to resolve with short-read sequencing methods.
The company’s flagship products include the Sequel II and Revio Systems, which leverage SMRT Sequencing chemistry and zero-mode waveguide (ZMW) technology to produce highly accurate long reads. PacBio offers a suite of reagents, library preparation kits and software tools—such as SMRT Link—for data management and analysis. These integrated solutions support applications in de novo genome assembly, structural variant detection, full-length transcript sequencing and epigenetic profiling.
PacBio serves a diverse global customer base encompassing academic institutions, pharmaceutical and biotechnology companies, agricultural and environmental research organizations, and government laboratories. Its sequencing platforms are deployed across North America, Europe, Asia-Pacific and other regions, with strategic partnerships aimed at expanding access to advanced genomics in both research and clinical settings. The company’s technologies have been instrumental in projects ranging from human genome reference improvement to agricultural trait discovery and infectious disease surveillance.
Led by Chief Executive Officer Christian Henry and a seasoned management team drawn from the life sciences and technology sectors, PacBio remains committed to advancing genomic science through ongoing investment in research and development. The company continues to enhance throughput, accuracy and ease of use in its sequencing systems, positioning itself at the forefront of precision medicine, agricultural genomics and biological discovery worldwide.
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