Septerna (SEPN) Institutional Ownership $9.48 +0.42 (+4.64%) Closing price 04:00 PM EasternExtended Trading$9.46 -0.03 (-0.26%) As of 07:50 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Ownership Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock Institutional Ownership Changes (13F Filings) for Septerna (NASDAQ:SEPN)Number ofInstitutional Buyers(last 12 months)58TotalInstitutional Inflows(last 12 months)$808.35MNumber ofInstitutional Sellers(last 12 months)2TotalInstitutional Outflows(last 12 months)$1.43M Get SEPN Insider Trade Alerts Want to know when executives and insiders are buying or selling Septerna stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily. Email Address Skip Chart & View Institutional Buying and Selling Data SEPN Institutional Buying and Selling by Quarter Septerna Major Shareholders & Ownership History Export to ExcelReporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails5/16/2025 Woodline Partners LP582,585$3.37M0.0%+94.2%1.309% 5/16/2025 Goldman Sachs Group Inc.1,449,399$8.39M0.0%-13.4%3.256% 5/16/2025 Checkpoint Capital L.P.824,878$4.78M2.6%N/A1.853% 5/16/2025 BVF Inc. IL4,396,124$25.45M1.0%+79.3%9.875% 5/16/2025 ADAR1 Capital Management LLC720,848$4.17M0.8%N/A1.619% 5/15/2025 Driehaus Capital Management LLC3,122,608$18.08M0.2%+20.6%7.015% 5/14/2025 Stonepine Capital Management LLC68,084$394K0.4%N/A0.153% 5/14/2025 Stoneridge Investment Partners LLC18,477$107K0.1%N/A0.042% 5/12/2025 Nuveen LLC23,961$139K0.0%N/A0.054% 5/12/2025 Swiss National Bank30,100$174K0.0%N/A0.068% Get the Latest News and Ratings for SEPN and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Septerna and its competitors with MarketBeat's FREE daily newsletter. 5/9/2025 Deutsche Bank AG15,968$92K0.0%+53.3%0.036% 5/9/2025 TRV GP VI LLC4,211,659$24.39M58.1%+33.6%9.461% 5/9/2025 Chicago Partners Investment Group LLC10,954$63K0.0%N/A0.025% 5/9/2025 Charles Schwab Investment Management Inc.118,451$686K0.0%-15.2%0.266% 5/8/2025 XTX Topco Ltd37,350$216K0.0%N/A0.084% 5/6/2025 KLP Kapitalforvaltning AS8,400$49K0.0%N/A0.019% 4/8/2025 Rhumbline Advisers23,318$135K0.0%+16.6%0.052% 2/28/2025 Universal Beteiligungs und Servicegesellschaft mbH102,749$2.35M0.0%N/A0.231% 2/17/2025 Woodline Partners LP300,000$6.87M0.0%N/A0.676% 2/17/2025 Zimmer Partners LP10,000$229K0.0%N/A0.023% 2/17/2025 Soleus Capital Management L.P.675,409$15.47M1.0%N/A1.521% 2/17/2025Nuveen Asset Management LLC23,961$549K0.0%N/A0.054% 2/17/2025 OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC12,118$278K0.0%N/A0.027% 2/17/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.10,519$241K0.0%N/A0.024% 2/17/2025 Janus Henderson Group PLC1,096,302$25.11M0.0%N/A2.469% 2/17/2025 Deutsche Bank AG10,419$239K0.0%N/A0.023% 2/17/2025 Deerfield Management Company L.P. Series C861,814$19.74M0.4%N/A1.941% 2/17/2025 Driehaus Capital Management LLC2,589,553$59.30M0.5%N/A5.832% 2/17/2025 Deep Track Capital LP1,912,929$43.81M1.6%N/A4.308% 2/17/2025 Casdin Capital LLC553,268$12.67M0.8%N/A1.246% 2/17/2025 BVF Inc. IL2,452,024$56.15M1.9%N/A5.523% 2/17/2025 Bank of America Corp DE78,744$1.80M0.0%N/A0.177% 2/17/2025 BNP Paribas Financial Markets2,251$52K0.0%N/A0.005% 2/17/2025 Alyeska Investment Group L.P.35,000$802K0.0%N/A0.079% 2/17/2025 ArrowMark Colorado Holdings LLC147,886$3.39M0.0%N/A0.333% 2/14/2025 RA Capital Management L.P.6,995,858$160.21M2.1%N/A15.756% 2/14/2025 Jane Street Group LLC26,208$600K0.0%N/A0.059% 2/14/2025 Samsara BioCapital LLC2,768,520$63.40M8.6%N/A6.235% 2/14/2025 Soros Fund Management LLC10,000$229K0.0%N/A0.023% 2/14/2025 Northern Trust Corp147,776$3.38M0.0%N/A0.333% Trump’s Exec Order #14154 could be a “Millionaire-Maker” (Ad)Former Presidential Advisor, Jim Rickards, says Trump could “rewire our economy and hand millions of Americans a chance at true financial independence in the months ahead.” We recently sat down with Rickards to capture all the key details on tape. For the moment, you can watch this interview free of charge – just click here.2/14/2025 The Manufacturers Life Insurance Company22,095$506K0.0%N/A0.050% 2/14/2025 Adage Capital Partners GP L.L.C.300,000$6.87M0.0%N/A0.676% 2/14/2025 Price T Rowe Associates Inc. MD518,588$11.88M0.0%N/A1.168% 2/14/2025 Avoro Capital Advisors LLC1,110,000$25.42M0.4%N/A2.500% 2/14/2025 Tower Research Capital LLC TRC1,093$25K0.0%N/A0.002% 2/14/2025 TRV GP V LLC6,215,591$142.34M48.4%N/A13.999% 2/14/2025 TRV GP VI LLC3,152,456$72.19M61.7%N/A7.100% 2/14/2025 MetLife Investment Management LLC11,555$265K0.0%N/A0.026% 2/13/2025 Walleye Capital LLC20,204$463K0.0%N/A0.046% 2/13/2025 Barclays PLC28,785$659K0.0%N/A0.065% 2/13/2025 Summit Investment Advisors Inc.1,944$45K0.0%N/A0.004% 2/13/2025 Legal & General Group Plc1,840$42K0.0%N/A0.004% 2/13/2025 Invesco Ltd.12,154$278K0.0%N/A0.027% 2/13/2025 Wells Fargo & Company MN10,651$244K0.0%N/A0.024% 2/12/2025 Geode Capital Management LLC380,577$8.72M0.0%N/A0.857% 2/12/2025 JPMorgan Chase & Co.38,015$871K0.0%N/A0.086% 2/11/2025 Corebridge Financial Inc.9,236$212K0.0%N/A0.021% 2/11/2025 Vanguard Group Inc.985,032$22.56M0.0%N/A2.219% 2/7/2025 PNC Financial Services Group Inc.2,680$61K0.0%N/A0.006% 2/6/2025 Lindbrook Capital LLC21,000$481K0.0%N/A0.047% 2/6/2025 M&T Bank Corp16,394$376K0.0%N/A0.037% 2/6/2025 Charles Schwab Investment Management Inc.139,616$3.20M0.0%N/A0.314% 2/4/2025 Bank of New York Mellon Corp38,093$872K0.0%N/A0.086% 1/31/2025 New York State Common Retirement Fund1,400$32K0.0%N/A0.003% 1/30/2025 Rhumbline Advisers19,995$458K0.0%N/A0.045% 1/17/2025 SG Americas Securities LLC8,095$185K0.0%N/A0.018% (Data available from 1/1/2016 forward) SEPN Institutional Ownership - Frequently Asked Questions Who are the largest shareholders of SEPN shares? During the previous two years, 59 institutional investors and hedge funds held shares of Septerna. The most heavily invested institutionals were RA Capital Management L.P. ($160.21M), TRV GP V LLC ($142.34M), Samsara BioCapital LLC ($63.40M), Deep Track Capital LP ($43.81M), BVF Inc. IL ($25.45M), Avoro Capital Advisors LLC ($25.42M), and Janus Henderson Group PLC ($25.11M).Learn more on SEPN's institutional investors. Which institutional investors have been buying Septerna stock? Of the 58 institutional investors that purchased Septerna stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: RA Capital Management L.P. ($7.00M), TRV GP V LLC ($6.22M), BVF Inc. IL ($4.40M), TRV GP VI LLC ($4.21M), Driehaus Capital Management LLC ($3.12M), Samsara BioCapital LLC ($2.77M), and Deep Track Capital LP ($1.91M). How much institutional buying is happening at Septerna? Institutional investors have bought a total of 39,461,264 shares in the last 24 months. This purchase volume represents approximately $808.35M in transactions. Which Septerna major shareholders have been selling company stock? The following institutional investors have sold Septerna stock in the last 24 months: Goldman Sachs Group Inc. ($224.96K), and Charles Schwab Investment Management Inc. ($21.17K). How much institutional selling is happening at Septerna? Institutional investors have sold a total of 246,123 shares in the last 24 months. This volume of shares sold represents approximately $1.43M in transactions. 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