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Septerna (SEPN) Institutional Ownership

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$20.68 +0.53 (+2.63%)
Closing price 04:00 PM Eastern
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$20.12 -0.56 (-2.68%)
As of 07:24 PM Eastern
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Institutional Ownership Changes (13F Filings) for Septerna (NASDAQ:SEPN)

Number of
Institutional Buyers
(last 12 months)
66
Total
Institutional Inflows
(last 12 months)
$823.68M
Number of
Institutional Sellers
(last 12 months)
5
Total
Institutional Outflows
(last 12 months)
$10.89M
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SEPN Institutional Buying and Selling by Quarter

Septerna Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/15/2025Soleus Capital Management L.P.75,456$798K0.1%-90.0%0.169%
8/15/2025Rangeley Capital LLC58,605$619K0.8%+10.7%0.131%
8/15/2025Perceptive Advisors LLC541,450$5.72M0.5%N/A1.215%
8/15/2025Boothbay Fund Management LLC24,142$255K0.0%N/A0.054%
8/15/2025Bank of America Corp DE99,213$1.05M0.0%+758.3%0.223%
8/14/2025VR Adviser LLC540,453$5.71M0.4%N/A1.213%
8/13/2025CW Advisors LLC12,589$133K0.0%N/A0.028%
8/13/2025PharVision Advisers LLC10,152$107K0.2%N/A0.023%
8/13/2025Sio Capital Management LLC584,435$6.18M2.4%-25.9%1.312%
8/13/2025Quadrature Capital Ltd10,125$107K0.0%N/A0.023%
8/12/2025XTX Topco Ltd22,330$236K0.0%-40.2%0.050%
8/12/2025Rhumbline Advisers28,572$302K0.0%+22.5%0.064%
8/12/2025JPMorgan Chase & Co.10,101$107K0.0%+15.0%0.023%
8/11/2025Universal Beteiligungs und Servicegesellschaft mbH222,702$2.35M0.0%+116.7%0.500%
8/8/2025Intech Investment Management LLC12,200$129K0.0%N/A0.027%
8/8/2025Geode Capital Management LLC487,956$5.16M0.0%+19.1%1.095%
5/29/2025Rhumbline Advisers23,318$135K0.0%+16.6%0.052%
5/16/2025Woodline Partners LP582,585$3.37M0.0%+94.2%1.309%
5/16/2025Goldman Sachs Group Inc.1,449,399$8.39M0.0%-13.4%3.253%
5/16/2025Checkpoint Capital L.P.824,878$4.78M2.6%N/A1.853%
5/16/2025BVF Inc. IL4,396,124$25.45M1.0%+79.3%9.875%
5/16/2025ADAR1 Capital Management LLC720,848$4.17M0.8%N/A1.619%
5/15/2025Driehaus Capital Management LLC3,122,608$18.08M0.2%+20.6%7.015%
5/14/2025Stonepine Capital Management LLC68,084$394K0.4%N/A0.153%
5/14/2025Stoneridge Investment Partners LLC18,477$107K0.1%N/A0.042%
5/12/2025Nuveen LLC23,961$139K0.0%N/A0.054%
5/12/2025Swiss National Bank30,100$174K0.0%N/A0.068%
5/9/2025Deutsche Bank AG15,968$92K0.0%+53.3%0.036%
5/9/2025TRV GP VI LLC4,211,659$24.39M58.1%+33.6%9.461%
5/9/2025Chicago Partners Investment Group LLC10,954$63K0.0%N/A0.025%
5/9/2025Charles Schwab Investment Management Inc.118,451$686K0.0%-15.2%0.266%
5/8/2025XTX Topco Ltd37,350$216K0.0%N/A0.084%
5/6/2025KLP Kapitalforvaltning AS8,400$49K0.0%N/A0.019%
4/8/2025Rhumbline Advisers23,318$135K0.0%+16.6%0.052%
2/28/2025Universal Beteiligungs und Servicegesellschaft mbH102,749$2.35M0.0%N/A0.231%
2/17/2025Woodline Partners LP300,000$6.87M0.0%N/A0.676%
2/17/2025Zimmer Partners LP10,000$229K0.0%N/A0.023%
2/17/2025Soleus Capital Management L.P.675,409$15.47M1.0%N/A1.521%
2/17/2025Nuveen Asset Management LLC23,961$549K0.0%N/A0.054%
2/17/2025OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC12,118$278K0.0%N/A0.027%
2/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.10,519$241K0.0%N/A0.024%
2/17/2025Janus Henderson Group PLC1,096,302$25.11M0.0%N/A2.469%
2/17/2025Deutsche Bank AG10,419$239K0.0%N/A0.023%
2/17/2025Deerfield Management Company L.P. Series C861,814$19.74M0.4%N/A1.941%
2/17/2025Driehaus Capital Management LLC2,589,553$59.30M0.5%N/A5.832%
2/17/2025Deep Track Capital LP1,912,929$43.81M1.6%N/A4.308%
2/17/2025Casdin Capital LLC553,268$12.67M0.8%N/A1.246%
2/17/2025BVF Inc. IL2,452,024$56.15M1.9%N/A5.523%
2/17/2025Bank of America Corp DE78,744$1.80M0.0%N/A0.177%
2/17/2025BNP Paribas Financial Markets2,251$52K0.0%N/A0.005%
2/17/2025Alyeska Investment Group L.P.35,000$802K0.0%N/A0.079%
2/17/2025ArrowMark Colorado Holdings LLC147,886$3.39M0.0%N/A0.333%
2/14/2025RA Capital Management L.P.6,995,858$160.21M2.1%N/A15.756%
2/14/2025Jane Street Group LLC26,208$600K0.0%N/A0.059%
2/14/2025Samsara BioCapital LLC2,768,520$63.40M8.6%N/A6.235%
2/14/2025Soros Fund Management LLC10,000$229K0.0%N/A0.023%
2/14/2025Northern Trust Corp147,776$3.38M0.0%N/A0.333%
2/14/2025The Manufacturers Life Insurance Company22,095$506K0.0%N/A0.050%
2/14/2025Adage Capital Partners GP L.L.C.300,000$6.87M0.0%N/A0.676%
2/14/2025Price T Rowe Associates Inc. MD518,588$11.88M0.0%N/A1.168%
2/14/2025Avoro Capital Advisors LLC1,110,000$25.42M0.4%N/A2.500%
2/14/2025Tower Research Capital LLC TRC1,093$25K0.0%N/A0.002%
2/14/2025TRV GP V LLC6,215,591$142.34M48.4%N/A13.999%
2/14/2025TRV GP VI LLC3,152,456$72.19M61.7%N/A7.100%
2/14/2025MetLife Investment Management LLC11,555$265K0.0%N/A0.026%
2/13/2025Walleye Capital LLC20,204$463K0.0%N/A0.046%
2/13/2025Barclays PLC28,785$659K0.0%N/A0.065%
2/13/2025Summit Investment Advisors Inc.1,944$45K0.0%N/A0.004%
2/13/2025Legal & General Group Plc1,840$42K0.0%N/A0.004%
2/13/2025Invesco Ltd.12,154$278K0.0%N/A0.027%
2/13/2025Wells Fargo & Company MN10,651$244K0.0%N/A0.024%
2/12/2025Geode Capital Management LLC380,577$8.72M0.0%N/A0.857%
2/12/2025JPMorgan Chase & Co.38,015$871K0.0%N/A0.086%
2/11/2025Corebridge Financial Inc.9,236$212K0.0%N/A0.021%
2/11/2025Vanguard Group Inc.985,032$22.56M0.0%N/A2.219%
2/7/2025PNC Financial Services Group Inc.2,680$61K0.0%N/A0.006%
2/6/2025Lindbrook Capital LLC21,000$481K0.0%N/A0.047%
2/6/2025M&T Bank Corp16,394$376K0.0%N/A0.037%
2/6/2025Charles Schwab Investment Management Inc.139,616$3.20M0.0%N/A0.314%
2/4/2025Bank of New York Mellon Corp38,093$872K0.0%N/A0.086%
1/31/2025New York State Common Retirement Fund1,400$32K0.0%N/A0.003%
1/30/2025Rhumbline Advisers19,995$458K0.0%N/A0.045%
1/17/2025SG Americas Securities LLC8,095$185K0.0%N/A0.018%
(Data available from 1/1/2016 forward)

SEPN Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of SEPN shares?

During the previous two years, 68 institutional investors and hedge funds held shares of Septerna. The most heavily invested institutionals were RA Capital Management L.P. ($160.21M), TRV GP V LLC ($142.34M), Samsara BioCapital LLC ($63.40M), Deep Track Capital LP ($43.81M), BVF Inc. IL ($25.45M), Avoro Capital Advisors LLC ($25.42M), and Janus Henderson Group PLC ($25.11M).Learn more on Septerna's institutional investors.

Which institutional investors have been buying Septerna's stock?

Of the 66 institutional investors that purchased Septerna's stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: RA Capital Management L.P. ($7.00M), TRV GP V LLC ($6.22M), BVF Inc. IL ($4.40M), TRV GP VI LLC ($4.21M), Driehaus Capital Management LLC ($3.12M), Samsara BioCapital LLC ($2.77M), and Deep Track Capital LP ($1.91M).

How much institutional buying is happening at Septerna?

Institutional investors have bought a total of 40,913,845 shares in the last 24 months. This purchase volume represents approximately $823.68M in transactions.

Which of Septerna's major shareholders have been selling company stock?

The following institutional investors have sold Septerna stock in the last 24 months: Soleus Capital Management L.P. ($675.90K), Goldman Sachs Group Inc. ($224.96K), Sio Capital Management LLC ($204.24K), Charles Schwab Investment Management Inc. ($21.17K), and XTX Topco Ltd ($15.02K).

How much institutional selling is happening at Septerna?

Institutional investors have sold a total of 1,141,275 shares in the last 24 months. This volume of shares sold represents approximately $10.89M in transactions.


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This page (NASDAQ:SEPN) was last updated on 10/3/2025 by MarketBeat.com Staff
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