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Septerna (SEPN) Institutional Ownership

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$38.51 +0.76 (+2.01%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$38.88 +0.37 (+0.95%)
As of 09/11/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
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Institutional Ownership Changes (13F Filings) for Septerna (NASDAQ:SEPN)

Number of
Institutional Buyers
(last 12 months)
74
Total
Institutional Inflows
(last 12 months)
$716.63M
Number of
Institutional Sellers
(last 12 months)
19
Total
Institutional Outflows
(last 12 months)
$92.84M
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SEPN Institutional Buying and Selling by Quarter

Septerna Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
9/9/2026 First Light Asset Management LLC963,260$32.26M2.0%+31.4%2.064%
9/9/2026 WINTON GROUP Ltd7,182$241K0.0%-18.8%0.015%
9/9/2026 Engineers Gate Manager LP17,350$581K0.0%+5.0%0.037%
9/9/2026 Squarepoint Ops LLC21,219$711K0.0%+17.3%0.045%
8/25/2026 VIRGINIA RETIREMENT SYSTEMS ET Al13,300$445K0.0%N/A0.028%
8/24/2026 California State Teachers Retirement System363,902$12.19M0.0%+31,352.2%0.780%
8/17/2026 Bank of America Corp DE35,875$1.20M0.0%N/A0.077%
8/15/2026 Man Group plc11,469$384K0.0%N/A0.025%
8/15/2026 Jupiter Topco LLC1,307,500$43.72M0.0%N/A2.801%
8/15/2026 Elmind Capital LP49,444$1.66M0.0%N/A0.106%
8/14/2026 ADAR1 Capital Management LLC940,747$31.51M1.4%N/A2.015%
8/14/2026 Primecap Management Co. CA1,167,382$39.10M0.0%N/A2.501%
8/14/2026 Canada Pension Plan Investment Board8,900$298K0.0%N/A0.019%
8/14/2026 Legal & General Group Plc10,062$337K0.0%N/A0.022%
8/14/2026 The Manufacturers Life Insurance Company6,304$211K0.0%N/A0.014%
8/14/2026 Algert Global LLC397,487$13.31M0.2%+1,789.6%0.852%
8/10/2026 TRV GP V LLC6,215,591$208.16M0.0%N/A13.788%
8/10/2026 TRV GP VI LLC4,211,659$141.05M0.1%N/A9.343%
8/7/2026 BlackRock Inc.1,932,088$64.71M0.0%N/A4.286%
8/7/2026 Deutsche Bank AG21,873$733K0.0%N/A0.049%
8/6/2026 Bank of New York Mellon Corp56,176$1.88M0.0%N/A0.125%
8/6/2026 State of Wyoming16,379$549K0.1%N/A0.036%
5/19/2026 Bank of America Corp DE25,973$624K0.0%-30.9%0.058%
5/19/2026Janus Henderson Group PLC890,754$21.33M0.0%N/A1.976%
5/18/2026 ADAR1 Capital Management LLC1,089,818$26.19M1.5%-5.9%2.418%
5/16/2026 First Light Asset Management LLC732,860$17.61M1.6%+18.0%1.626%
5/15/2026 Rangeley Capital LLC39,800$956K0.9%-39.5%0.088%
5/14/2026 Renaissance Technologies LLC37,700$906K0.0%N/A0.084%
5/14/2026 Public Employees Retirement System of Ohio3,374$81K0.0%-68.2%0.007%
5/7/2026 Swiss National Bank22,100$531K0.0%N/A0.049%
5/5/2026 Bank of New York Mellon Corp58,709$1.41M0.0%+6.1%0.131%
4/27/2026 Y Intercept Hong Kong Ltd25,770$619K0.0%N/A0.057%
4/25/2026 Strs Ohio17,200$413K0.0%+17.8%0.038%
3/3/2026 Caitong International Asset Management Co. Ltd3,170$88K0.0%N/A0.007%
2/26/2026 Seven Fleet Capital Management LP11,445$319K0.2%N/A0.026%
2/19/2026 Invesco Ltd.162,014$4.52M0.0%-8.5%0.362%
2/18/2026 XTX Topco Ltd23,315$650K0.0%N/A0.052%
2/18/2026 VARCOV Co.22,634$631K0.2%N/A0.051%
2/18/2026 Virtus Investment Advisers LLC10,457$292K0.1%N/A0.023%
2/18/2026 Tudor Investment Corp ET AL18,053$503K0.0%N/A0.040%
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2/18/2026 Numerai GP LLC45,866$1.28M0.2%N/A0.102%
2/18/2026 Perceptive Advisors LLC433,160$12.08M0.2%-20.0%0.968%
2/18/2026 Millennium Management LLC107,463$3.00M0.0%-72.0%0.240%
2/18/2026 Balyasny Asset Management L.P.3,571$100K0.0%N/A0.008%
2/18/2026 BVF Inc. IL1,720,782$47.98M1.6%-57.1%3.844%
2/17/2026 Logos Global Management LP23,548$657K0.0%-71.8%0.053%
2/17/2026 ADAR1 Capital Management LLC1,157,611$32.27M2.4%-1.6%2.586%
2/17/2026 AQR Capital Management LLC7,826$218K0.0%N/A0.017%
2/17/2026 First Light Asset Management LLC620,811$17.31M1.3%N/A1.387%
2/17/2026 Trexquant Investment LP44,005$1.23M0.0%N/A0.098%
2/17/2026 Jump Financial LLC8,399$234K0.0%N/A0.019%
2/17/2026 Price T Rowe Associates Inc. MD25,443$710K0.0%-7.2%0.057%
2/17/2026 Public Employees Retirement System of Ohio10,594$295K0.0%N/A0.024%
2/17/2026 Russell Investments Group Ltd.15,310$427K0.0%+707.5%0.034%
2/17/2026 Atom Investors LP9,791$273K0.0%N/A0.022%
2/17/2026 ExodusPoint Capital Management LP37,867$1.06M0.0%N/A0.085%
2/17/2026 Graham Capital Management L.P.8,971$250K0.0%N/A0.020%
2/16/2026 Squarepoint Ops LLC14,847$414K0.0%N/A0.033%
2/16/2026 Barclays PLC38,147$1.06M0.0%+26.7%0.085%
2/13/2026 Marshall Wace LLP226,901$6.33M0.0%N/A0.507%
2/13/2026 Kalehua Capital Management LLC194,544$5.42M5.0%N/A0.435%
2/13/2026 Bank of Nova Scotia8,300$231K0.0%N/A0.019%
2/13/2026 Jacobs Levy Equity Management Inc.61,370$1.71M0.0%+71.5%0.137%
2/13/2026 Siren L.L.C.2,000,000$55.76M1.7%-9.2%4.467%
2/13/2026 State Street Corp540,028$15.06M0.0%+28.9%1.206%
2/13/2026 Dynamic Technology Lab Private Ltd10,810$301K0.1%N/A0.024%
2/13/2026 Caitong International Asset Management Co. Ltd1,901$53K0.1%N/A0.004%
2/13/2026 Wells Fargo & Company MN26,529$740K0.0%+31.7%0.059%
2/12/2026 Federated Hermes Inc.78,905$2.20M0.0%N/A0.176%
2/12/2026 New York State Common Retirement Fund5,600$156K0.0%+93.1%0.013%
2/12/2026 Nuveen LLC25,798$719K0.0%+7.7%0.058%
2/12/2026 Group One Trading LLC944$26K0.0%-111.8%0.002%
2/11/2026 Primecap Management Co. CA546,100$15.23M0.0%N/A1.220%
2/11/2026 Deutsche Bank AG14,879$415K0.0%+5.3%0.033%
2/11/2026 Franklin Resources Inc.16,852$470K0.0%N/A0.038%
2/11/2026 Los Angeles Capital Management LLC18,550$517K0.0%N/A0.041%
2/10/2026 Goldman Sachs Group Inc.2,715,129$75.70M0.0%+86.6%6.065%
2/10/2026 Intech Investment Management LLC13,283$370K0.0%N/A0.030%
2/9/2026 Geode Capital Management LLC572,734$15.97M0.0%+5.0%1.279%
2/6/2026 Global Retirement Partners LLC1,256$35K0.0%N/A0.003%
2/6/2026 Covestor Ltd1,941$54K0.0%-46.4%0.004%
2/5/2026 Baader Bank Aktiengesellschaft10,000$279K0.0%N/A0.022%
2/2/2026 Strs Ohio14,600$407K0.0%N/A0.033%
1/29/2026 China Universal Asset Management Co. Ltd.10,296$287K0.0%N/A0.023%
1/26/2026 Mirae Asset Global Investments Co. Ltd.2,176$61K0.0%N/A0.005%
1/1/2026 JPMorgan Chase & Co.8,736$164K0.0%-13.5%0.020%
11/17/2025 Jacobs Levy Equity Management Inc.35,778$673K0.0%N/A0.080%
11/17/2025 PharVision Advisers LLC11,932$224K0.1%+17.5%0.027%
11/17/2025 VR Adviser LLC610,808$11.49M0.6%+13.0%1.364%
11/17/2025 Verition Fund Management LLC20,131$379K0.0%N/A0.045%
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11/17/2025 Quarry LP1,736$33K0.0%-51.8%0.004%
11/17/2025 Millennium Management LLC384,200$7.23M0.0%+639.6%0.858%
11/17/2025 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,791$184K0.0%-16.3%0.022%
11/17/2025 Checkpoint Capital L.P.283,158$5.33M1.8%-51.7%0.632%
11/17/2025 Bank of America Corp DE51,495$969K0.0%-48.1%0.115%
11/14/2025 ADAR1 Capital Management LLC1,176,491$22.13M2.1%+38.9%2.628%
11/14/2025 Longaeva Partners L.P.57,064$1.07M0.2%N/A0.127%
11/14/2025 Two Sigma Investments LP92,334$1.74M0.0%+18.9%0.206%
11/14/2025 Avoro Capital Advisors LLC1,337,500$25.16M0.3%+8.1%2.987%
11/13/2025 Invesco Ltd.177,070$3.33M0.0%+1,396.4%0.397%


SEPN Institutional Ownership - Frequently Asked Questions

During the previous two years, 123 institutional investors and hedge funds held shares of Septerna. The most heavily invested institutionals were TRV GP V LLC ($208.16M), RA Capital Management L.P. ($160.21M), TRV GP VI LLC ($141.05M), Goldman Sachs Group Inc. ($75.70M), BlackRock Inc. ($64.71M), Samsara BioCapital LLC ($63.40M), and Siren L.L.C. ($55.76M).Learn more on Septerna's institutional investors.

Of the 117 institutional investors that purchased Septerna's stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: TRV GP V LLC ($12.43M), TRV GP VI LLC ($8.42M), RA Capital Management L.P. ($7.00M), BVF Inc. IL ($4.40M), Driehaus Capital Management LLC ($3.12M), Samsara BioCapital LLC ($2.77M), and ADAR1 Capital Management LLC ($1.99M).

Institutional investors have bought a total of 22,841,017 shares in the last 24 months. This purchase volume represents approximately $716.63M in transactions.

Of the 19 institutional investors that sold Septerna's stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: BVF Inc. IL ($2.30M), Checkpoint Capital L.P. ($303.32K), Millennium Management LLC ($276.74K), Siren L.L.C. ($202.51K), Perceptive Advisors LLC ($108.29K), ADAR1 Capital Management LLC ($86.67K), and Logos Global Management LP ($60K).

Institutional investors have sold a total of 3,466,230 shares in the last 24 months. This volume of shares sold represents approximately $92.84M in transactions.


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Institutional ownership data for NASDAQ:SEPN is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 9/9/2026. New 13F filings are added each quarter as they're published.
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