Go Pro
→ Elon Warns 'America Will Go Bankrupt'. Trump's Plan Inside. (From American Hartford Gold) (Ad)tc pixel Free SEPN Stock Alerts

Septerna (SEPN) Institutional Ownership

Septerna logo
$37.71 -0.34 (-0.89%)
Closing price 04:00 PM Eastern
Extended Trading
$37.66 -0.05 (-0.15%)
As of 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
Compare

Institutional Ownership Changes (13F Filings) for Septerna (NASDAQ:SEPN)

Number of
Institutional Buyers
(last 12 months)
73
Total
Institutional Inflows
(last 12 months)
$704.48M
Number of
Institutional Sellers
(last 12 months)
19
Total
Institutional Outflows
(last 12 months)
$92.84M
Get SEPN Insider Trade Alerts

Want to know when executives and insiders are buying or selling Septerna stock? Sign up for InsiderTrades.com's daily newsletter to get the latest insider transactions delivered to your inbox daily.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.
Skip Chart & View Institutional Buying and Selling Data

SEPN Institutional Buying and Selling by Quarter

Septerna Major Shareholders & Ownership History

Export
Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
9/9/2026First Light Asset Management LLC963,260$32.26M2.0%+31.4%2.064%
9/9/2026WINTON GROUP Ltd7,182$241K0.0%-18.8%0.015%
9/9/2026Engineers Gate Manager LP17,350$581K0.0%+5.0%0.037%
9/9/2026Squarepoint Ops LLC21,219$711K0.0%+17.3%0.045%
8/25/2026VIRGINIA RETIREMENT SYSTEMS ET Al13,300$445K0.0%N/A0.028%
8/17/2026Bank of America Corp DE35,875$1.20M0.0%N/A0.077%
8/15/2026Man Group plc11,469$384K0.0%N/A0.025%
8/15/2026Jupiter Topco LLC1,307,500$43.72M0.0%N/A2.801%
8/15/2026Elmind Capital LP49,444$1.66M0.0%N/A0.106%
8/14/2026ADAR1 Capital Management LLC940,747$31.51M1.4%N/A2.015%
8/14/2026Primecap Management Co. CA1,167,382$39.10M0.0%N/A2.501%
8/14/2026Canada Pension Plan Investment Board8,900$298K0.0%N/A0.019%
8/14/2026Legal & General Group Plc10,062$337K0.0%N/A0.022%
8/14/2026The Manufacturers Life Insurance Company6,304$211K0.0%N/A0.014%
8/14/2026Algert Global LLC397,487$13.31M0.2%+1,789.6%0.852%
8/10/2026TRV GP V LLC6,215,591$208.16M0.0%N/A13.788%
8/10/2026TRV GP VI LLC4,211,659$141.05M0.1%N/A9.343%
8/7/2026BlackRock Inc.1,932,088$64.71M0.0%N/A4.286%
8/7/2026Deutsche Bank AG21,873$733K0.0%N/A0.049%
8/6/2026Bank of New York Mellon Corp56,176$1.88M0.0%N/A0.125%
8/6/2026State of Wyoming16,379$549K0.1%N/A0.036%
5/19/2026Bank of America Corp DE25,973$624K0.0%-30.9%0.058%
5/19/2026Janus Henderson Group PLC890,754$21.33M0.0%N/A1.976%
5/18/2026ADAR1 Capital Management LLC1,089,818$26.19M1.5%-5.9%2.418%
5/16/2026First Light Asset Management LLC732,860$17.61M1.6%+18.0%1.626%
5/15/2026Rangeley Capital LLC39,800$956K0.9%-39.5%0.088%
5/14/2026Renaissance Technologies LLC37,700$906K0.0%N/A0.084%
5/14/2026Public Employees Retirement System of Ohio3,374$81K0.0%-68.2%0.007%
5/7/2026Swiss National Bank22,100$531K0.0%N/A0.049%
5/5/2026Bank of New York Mellon Corp58,709$1.41M0.0%+6.1%0.131%
4/27/2026Y Intercept Hong Kong Ltd25,770$619K0.0%N/A0.057%
4/25/2026Strs Ohio17,200$413K0.0%+17.8%0.038%
3/3/2026Caitong International Asset Management Co. Ltd3,170$88K0.0%N/A0.007%
2/26/2026Seven Fleet Capital Management LP11,445$319K0.2%N/A0.026%
2/19/2026Invesco Ltd.162,014$4.52M0.0%-8.5%0.362%
2/18/2026XTX Topco Ltd23,315$650K0.0%N/A0.052%
2/18/2026VARCOV Co.22,634$631K0.2%N/A0.051%
2/18/2026Virtus Investment Advisers LLC10,457$292K0.1%N/A0.023%
2/18/2026Tudor Investment Corp ET AL18,053$503K0.0%N/A0.040%
2/18/2026Numerai GP LLC45,866$1.28M0.2%N/A0.102%
How options let you do more with less capital (Ad)

Would you rather spend $5,000 buying 100 shares of a $50 stock, or control those same 100 shares for a fraction of the cost? That's the core advantage options offer traders at every level. The Beginner's Guide to Options breaks down leverage, income strategies, and real trade examples in plain English — including a little-known approach many traders use to reduce costs and improve profit potential. Download your free copy before this offer expires.tc pixel

Claim your free copy of The Beginner's Guide to Options now
2/18/2026Perceptive Advisors LLC433,160$12.08M0.2%-20.0%0.968%
2/18/2026Millennium Management LLC107,463$3.00M0.0%-72.0%0.240%
2/18/2026Balyasny Asset Management L.P.3,571$100K0.0%N/A0.008%
2/18/2026BVF Inc. IL1,720,782$47.98M1.6%-57.1%3.844%
2/17/2026Logos Global Management LP23,548$657K0.0%-71.8%0.053%
2/17/2026ADAR1 Capital Management LLC1,157,611$32.27M2.4%-1.6%2.586%
2/17/2026AQR Capital Management LLC7,826$218K0.0%N/A0.017%
2/17/2026First Light Asset Management LLC620,811$17.31M1.3%N/A1.387%
2/17/2026Trexquant Investment LP44,005$1.23M0.0%N/A0.098%
2/17/2026Jump Financial LLC8,399$234K0.0%N/A0.019%
2/17/2026Price T Rowe Associates Inc. MD25,443$710K0.0%-7.2%0.057%
2/17/2026Public Employees Retirement System of Ohio10,594$295K0.0%N/A0.024%
2/17/2026Russell Investments Group Ltd.15,310$427K0.0%+707.5%0.034%
2/17/2026Atom Investors LP9,791$273K0.0%N/A0.022%
2/17/2026ExodusPoint Capital Management LP37,867$1.06M0.0%N/A0.085%
2/17/2026Graham Capital Management L.P.8,971$250K0.0%N/A0.020%
2/16/2026Squarepoint Ops LLC14,847$414K0.0%N/A0.033%
2/16/2026Barclays PLC38,147$1.06M0.0%+26.7%0.085%
2/13/2026Marshall Wace LLP226,901$6.33M0.0%N/A0.507%
2/13/2026Kalehua Capital Management LLC194,544$5.42M5.0%N/A0.435%
2/13/2026Bank of Nova Scotia8,300$231K0.0%N/A0.019%
2/13/2026Jacobs Levy Equity Management Inc.61,370$1.71M0.0%+71.5%0.137%
2/13/2026Siren L.L.C.2,000,000$55.76M1.7%-9.2%4.467%
2/13/2026State Street Corp540,028$15.06M0.0%+28.9%1.206%
2/13/2026Dynamic Technology Lab Private Ltd10,810$301K0.1%N/A0.024%
2/13/2026Caitong International Asset Management Co. Ltd1,901$53K0.1%N/A0.004%
2/13/2026Wells Fargo & Company MN26,529$740K0.0%+31.7%0.059%
2/12/2026Federated Hermes Inc.78,905$2.20M0.0%N/A0.176%
2/12/2026New York State Common Retirement Fund5,600$156K0.0%+93.1%0.013%
2/12/2026Nuveen LLC25,798$719K0.0%+7.7%0.058%
2/12/2026Group One Trading LLC944$26K0.0%-111.8%0.002%
2/11/2026Primecap Management Co. CA546,100$15.23M0.0%N/A1.220%
2/11/2026Deutsche Bank AG14,879$415K0.0%+5.3%0.033%
2/11/2026Franklin Resources Inc.16,852$470K0.0%N/A0.038%
2/11/2026Los Angeles Capital Management LLC18,550$517K0.0%N/A0.041%
2/10/2026Goldman Sachs Group Inc.2,715,129$75.70M0.0%+86.6%6.065%
2/10/2026Intech Investment Management LLC13,283$370K0.0%N/A0.030%
2/9/2026Geode Capital Management LLC572,734$15.97M0.0%+5.0%1.279%
2/6/2026Global Retirement Partners LLC1,256$35K0.0%N/A0.003%
2/6/2026Covestor Ltd1,941$54K0.0%-46.4%0.004%
2/5/2026Baader Bank Aktiengesellschaft10,000$279K0.0%N/A0.022%
2/2/2026Strs Ohio14,600$407K0.0%N/A0.033%
1/29/2026China Universal Asset Management Co. Ltd.10,296$287K0.0%N/A0.023%
1/26/2026Mirae Asset Global Investments Co. Ltd.2,176$61K0.0%N/A0.005%
1/1/2026JPMorgan Chase & Co.8,736$164K0.0%-13.5%0.020%
11/17/2025Jacobs Levy Equity Management Inc.35,778$673K0.0%N/A0.080%
11/17/2025PharVision Advisers LLC11,932$224K0.1%+17.5%0.027%
11/17/2025VR Adviser LLC610,808$11.49M0.6%+13.0%1.364%
11/17/2025Verition Fund Management LLC20,131$379K0.0%N/A0.045%
11/17/2025Quarry LP1,736$33K0.0%-51.8%0.004%
A new kind of civil war is coming after election day? (Ad)

Across America, AI-driven backlash is fueling protests, lawsuits, and moratoria that could reshape the political and investment landscape. Whitney Tilson believes tensions may come to a head at midnight on November 4th, the day after the midterm elections, with major implications for your portfolio.tc pixel

Read Whitney Tilson's free analysis on what could happen next.
11/17/2025Millennium Management LLC384,200$7.23M0.0%+639.6%0.858%
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.9,791$184K0.0%-16.3%0.022%
11/17/2025Checkpoint Capital L.P.283,158$5.33M1.8%-51.7%0.632%
11/17/2025Bank of America Corp DE51,495$969K0.0%-48.1%0.115%
11/14/2025ADAR1 Capital Management LLC1,176,491$22.13M2.1%+38.9%2.628%
11/14/2025Longaeva Partners L.P.57,064$1.07M0.2%N/A0.127%
11/14/2025Two Sigma Investments LP92,334$1.74M0.0%+18.9%0.206%
11/14/2025Avoro Capital Advisors LLC1,337,500$25.16M0.3%+8.1%2.987%
11/13/2025Invesco Ltd.177,070$3.33M0.0%+1,396.4%0.397%
11/13/2025UBS Group AG59,046$1.11M0.0%-18.4%0.132%


SEPN Institutional Ownership - Frequently Asked Questions

During the previous two years, 122 institutional investors and hedge funds held shares of Septerna. The most heavily invested institutionals were TRV GP V LLC ($208.16M), RA Capital Management L.P. ($160.21M), TRV GP VI LLC ($141.05M), Goldman Sachs Group Inc. ($75.70M), BlackRock Inc. ($64.71M), Samsara BioCapital LLC ($63.40M), and Siren L.L.C. ($55.76M).Learn more on Septerna's institutional investors.

Of the 116 institutional investors that purchased Septerna's stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: TRV GP V LLC ($12.43M), TRV GP VI LLC ($8.42M), RA Capital Management L.P. ($7.00M), BVF Inc. IL ($4.40M), Driehaus Capital Management LLC ($3.12M), Samsara BioCapital LLC ($2.77M), and ADAR1 Capital Management LLC ($1.99M).

Institutional investors have bought a total of 22,478,272 shares in the last 24 months. This purchase volume represents approximately $704.48M in transactions.

Of the 19 institutional investors that sold Septerna's stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: BVF Inc. IL ($2.30M), Checkpoint Capital L.P. ($303.32K), Millennium Management LLC ($276.74K), Siren L.L.C. ($202.51K), Perceptive Advisors LLC ($108.29K), ADAR1 Capital Management LLC ($86.67K), and Logos Global Management LP ($60K).

Institutional investors have sold a total of 3,466,230 shares in the last 24 months. This volume of shares sold represents approximately $92.84M in transactions.


Related Companies

Institutional ownership data for NASDAQ:SEPN is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 9/9/2026. New 13F filings are added each quarter as they're published.
From Our Partners
Elon Warns "America Will Go Bankrupt". Trump's Plan Inside.
National debt just crossed 40 trillion dollars, and Elon Musk says America is 1,000% going to go bankrupt with...
American Hartford Gold | Sponsoredtc pixel
MILLIONAIRE MASTERCLASS INVITE: Altucher
James Altucher says Elon Musk is preparing an unprecedented project set to surface on December 8th. Altuche...
Paradigm Press | Sponsoredtc pixel
They're not buying gold. They're buying this.
Bank of America raised its stake in a small gold company by 139%. Jane Street increased its position by 159%, ...
Behind the Markets | Sponsoredtc pixel
How options let you do more with less capital
Would you rather spend $5,000 buying 100 shares of a $50 stock, or control those same 100 shares for a fractio...
Base Camp Trading | Sponsoredtc pixel
Trump's New Dollar
Porter Stansberry says President Trump has signed an executive order initiating what he calls a full U.S. doll...
Porter & Company | Sponsoredtc pixel
How Elon’s Empire Ends (and how to profit)
Marc Chaikin, the 60 year Wall Street veteran whose Chaikin Money Flow indicator sits on every Bloomberg termi...
Chaikin Analytics | Sponsoredtc pixel
A “bloodbath” Is Coming
Reports suggest some Silicon Valley billionaires are stockpiling gold, guns, and gas masks - or leaving the co...
TradeSmith | Sponsoredtc pixel
Bank of America: 'Digital Dollar Inevitable'
Bank of America just revealed your expiration date. In their Bloomberg interview, they didn't just predict the...
Decentralized Masters | Sponsoredtc pixel