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Septerna (SEPN) Financials

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$24.69 +0.82 (+3.44%)
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Annual Income Statements for Septerna

Annual Income Statements for Septerna

This table shows Septerna's income and expenses over time, based on annual financial data. All values are USD millions unless otherwise specified.

Metric 2023 2024 2025
Period end date 12/31/2023 12/31/2024 12/31/2025
Net Income / (Loss) Attributable to Common Shareholders		 4.75 -72 -49
Consolidated Net Income / (Loss)		 4.18 -72 -49
Net Income / (Loss) Continuing Operations		 4.19 -72 -49
Total Pre-Tax Income 		4.87 -72 -49
Total Operating Income		 2.08 -81 -68
Total Gross Profit		 0.15 1.08 46
Total Revenue		 0.15 1.08 46
Operating Revenue		 0.15 1.08 46
Total Cost of Revenue		 0.00 0.00 0.00
Total Operating Expenses		 -1.92 82 114
Selling, General & Admin Expense		 9.72 17 29
Research & Development Expense		 36 65 98
Other Special Charges / (Income)		 -48 0.00 -13
Total Other Income / (Expense), net		 2.79 8.53 19
Interest & Investment Income		 2.79 8.62 20
Other Income / (Expense), net		 - -0.09 -0.10
Income Tax Expense		 0.69 -0.50 0.01
Basic Earnings per Share		 $0.29 ($7.26) ($1.10)
Weighted Average Basic Shares Outstanding		 1.93M 9.89M 44.26M
Diluted Earnings per Share		 $0.29 ($7.26) ($1.10)
Weighted Average Diluted Shares Outstanding		 2.18M 9.89M 44.26M
Weighted Average Basic & Diluted Shares Outstanding		 - 44.44M 44.91M

Quarterly Income Statements for Septerna

This table shows Septerna's income and expenses over time, based on quarterly financial data. All values are USD millions unless otherwise specified.

Metric Q3 2023 Q1 2024 Q2 2024 Q3 2024 Q4 2024 Q1 2025 Q2 2025 Q3 2025 Q4 2025
Period end date 9/30/2023 3/31/2024 6/30/2024 9/30/2024 12/31/2024 3/31/2025 6/30/2025 9/30/2025 12/31/2025
Net Income / (Loss) Attributable to Common Shareholders		 -11 -14 -16 -20 -21 -21 -25 8.37 -11
Consolidated Net Income / (Loss)		 -11 -14 -16 -21 -21 -21 -25 8.17 -11
Net Income / (Loss) Continuing Operations		 -11 -14 -17 -21 -20 -21 -25 8.17 -11
Total Pre-Tax Income 		-11 -14 -17 -21 -21 -21 -25 8.17 -11
Total Operating Income		 -12 -15 -18 -23 -25 -26 -29 2.61 -16
Total Gross Profit		 0.03 0.32 0.37 0.18 0.21 0.22 0.12 21 24
Total Revenue		 0.03 0.32 0.37 0.18 0.21 0.22 0.12 21 24
Operating Revenue		 0.03 0.32 0.37 0.18 0.21 0.22 0.12 21 24
Total Operating Expenses		 12 16 18 23 25 26 29 19 40
Selling, General & Admin Expense		 2.79 2.65 3.40 4.89 5.61 6.86 6.91 7.12 8.28
Research & Development Expense		 9.28 13 15 18 19 19 22 24 32
Total Other Income / (Expense), net		 1.10 1.23 1.52 1.89 3.89 4.43 4.14 5.56 5.30
Interest & Investment Income		 1.10 1.28 1.53 1.90 3.91 4.46 4.17 5.57 5.34
Other Income / (Expense), net		 -0.00 -0.05 -0.02 -0.01 -0.02 -0.03 -0.03 -0.01 -0.04
Income Tax Expense		 0.00 0.09 0.11 -0.14 -0.56 0.00 0.00 0.00 0.01
Basic Earnings per Share		 ($5.45) ($6.35) ($7.03) ($8.40) $14.52 ($0.49) ($0.56) $0.18 ($0.23)
Weighted Average Basic Shares Outstanding		 2.01M 2.23M 2.34M 2.44M 9.89M 43.94M 44.17M 44.34M 44.26M
Diluted Earnings per Share		 ($5.45) ($6.35) ($7.03) ($8.40) $14.52 ($0.49) ($0.56) $0.18 ($0.23)
Weighted Average Diluted Shares Outstanding		 2.01M 2.23M 2.34M 2.44M 9.89M 43.94M 44.17M 45.60M 44.26M
Weighted Average Basic & Diluted Shares Outstanding		 - - - 44.40M 44.44M 44.56M 44.59M 44.77M 44.91M

Annual Cash Flow Statements for Septerna

This table details how cash moves in and out of Septerna's business through operations, investing, and financing, using annual figures. All values are USD millions unless otherwise specified.

Metric 2023 2024 2025
Period end date 12/31/2023 12/31/2024 12/31/2025
Net Change in Cash & Equivalents		 58 150 -117
Net Cash From Operating Activities		 -39 -67 110
Net Cash From Continuing Operating Activities		 -39 -67 123
Net Income / (Loss) Continuing Operations		 4.18 -72 -49
Consolidated Net Income / (Loss)		 4.18 -72 -49
Depreciation Expense		 0.85 1.40 1.60
Amortization Expense		 0.00 -1.41 -3.45
Non-Cash Adjustments To Reconcile Net Income		 -46 5.03 11
Changes in Operating Assets and Liabilities, net		 2.19 -0.69 163
Net Cash From Investing Activities		 22 -161 -229
Net Cash From Continuing Investing Activities		 22 -161 -242
Purchase of Property, Plant & Equipment		 -2.88 -2.10 -0.52
Purchase of Investments		 0.00 -213 -451
Sale and/or Maturity of Investments		 0.00 32 210
Net Cash From Financing Activities		 75 378 1.69
Net Cash From Continuing Financing Activities		 75 378 1.69
Issuance of Preferred Equity		 75 75 0.00
Issuance of Common Equity		 0.00 303 0.72
Other Financing Activities, net		 0.00 0.05 0.97
Cash Income Taxes Paid		 0.08 0.23 0.00

Quarterly Cash Flow Statements for Septerna

This table details how cash moves in and out of Septerna's business through operations, investing, and financing, using quarterly figures. All values are USD millions unless otherwise specified.

Metric Q4 2023 Q1 2024 Q2 2024 Q3 2024 Q4 2024 Q1 2025 Q2 2025 Q3 2025 Q4 2025
Period end date 12/31/2023 3/31/2024 6/30/2024 9/30/2024 12/31/2024 3/31/2025 6/30/2025 9/30/2025 12/31/2025
Net Change in Cash & Equivalents		 -10 -7.14 50 -43 150 -28 -21 131 -199
Net Cash From Operating Activities		 -8.80 -17 -13 -17 -21 -23 -20 169 -15
Net Cash From Continuing Operating Activities		 -8.80 -17 -13 -17 -21 -23 -20 169 -2.49
Net Income / (Loss) Continuing Operations		 35 -14 -16 -21 -21 -21 -25 8.17 -11
Consolidated Net Income / (Loss)		 35 -14 -16 -21 -21 -21 -25 8.17 -11
Depreciation Expense		 0.24 0.32 0.33 0.36 0.39 0.40 0.41 0.40 0.40
Amortization Expense		 - -0.07 -0.16 -0.37 -0.81 -0.97 -0.98 -0.62 -0.89
Non-Cash Adjustments To Reconcile Net Income		 -47 0.69 0.71 1.63 2.00 1.54 2.79 -11 17
Changes in Operating Assets and Liabilities, net		 3.04 -3.48 2.57 2.09 -1.87 -2.84 2.33 172 -8.36
Net Cash From Investing Activities		 -1.24 9.57 -12 -25 -133 -4.87 -0.79 -38 -185
Net Cash From Continuing Investing Activities		 -1.24 9.57 -12 -25 -133 -4.87 -0.79 -38 -198
Purchase of Property, Plant & Equipment		 -1.24 -0.76 -0.15 -0.58 -0.61 -0.38 -0.06 -0.01 -0.07
Purchase of Investments		 - -12 -20 -34 -148 -50 -64 -110 -227
Sale and/or Maturity of Investments		 - 0.00 7.91 9.43 15 45 63 59 42
Net Cash From Financing Activities		 - 0.00 75 -1.32 304 0.07 0.34 0.26 1.02
Net Cash From Continuing Financing Activities		 - 0.00 75 -1.32 304 0.07 0.34 0.26 1.02
Other Financing Activities, net		 - 0.00 -0.05 -1.26 1.36 0.07 0.34 0.26 0.30

Annual Balance Sheets for Septerna

This table presents Septerna's assets and liabilities at the end of each period, using annual balance sheet data. All values are USD millions unless otherwise specified.

Metric 2023 2024 2025
Period end date 12/31/2023 12/31/2024 12/31/2025
Total Assets		 131 457 596
Total Current Assets		 113 357 411
Cash & Equivalents		 88 238 121
Short-Term Investments		 0.00 113 270
Accounts Receivable		 23 0.17 10
Prepaid Expenses		 1.42 5.73 9.52
Plant, Property, & Equipment, net		 4.67 5.09 4.43
Total Noncurrent Assets		 14 95 181
Long-Term Investments		 0.00 70 158
Other Noncurrent Operating Assets		 14 25 23
Total Liabilities & Shareholders' Equity		 131 457 596
Total Liabilities		 20 37 214
Total Current Liabilities		 6.91 13 87
Accounts Payable		 2.64 3.20 10
Accrued Expenses		 4.28 7.80 12
Current Deferred Revenue		 - 0.00 62
Other Current Liabilities		 0.00 1.85 2.21
Total Noncurrent Liabilities		 13 24 127
Noncurrent Deferred Revenue		 - 0.00 106
Other Noncurrent Operating Liabilities		 13 24 21
Commitments & Contingencies		 0.00 0.00 0.00
Redeemable Noncontrolling Interest		 149 0.00 0.00
Total Equity & Noncontrolling Interests		 -38 420 382
Total Preferred & Common Equity		 -38 420 382
Preferred Stock		 0.00 0.00 0.00
Total Common Equity		 -38 420 382
Common Stock		 8.20 538 549
Retained Earnings		 -47 -118 -167
Accumulated Other Comprehensive Income / (Loss)		 0.00 0.06 0.62

Quarterly Balance Sheets for Septerna

This table presents Septerna's assets and liabilities at the end of each period, using quarterly balance sheet data. All values are USD millions unless otherwise specified.

Metric Q3 2024 Q1 2025 Q2 2025 Q3 2025
Period end date 9/30/2024 3/31/2025 6/30/2025 9/30/2025
Total Assets		 174 434 415 607
Total Current Assets		 133 342 334 492
Cash & Equivalents		 88 210 189 320
Short-Term Investments		 42 126 137 154
Accounts Receivable		 0.21 0.25 0.15 8.65
Prepaid Expenses		 2.67 6.21 7.43 8.69
Plant, Property, & Equipment, net		 5.41 5.04 4.69 4.32
Total Noncurrent Assets		 35 87 76 111
Long-Term Investments		 6.98 62 53 87
Other Noncurrent Operating Assets		 28 24 24 23
Total Liabilities & Shareholders' Equity		 174 434 415 607
Total Liabilities		 38 34 38 218
Total Current Liabilities		 13 11 15 75
Accounts Payable		 6.13 4.35 6.54 3.73
Accrued Expenses		 5.99 4.35 6.56 7.83
Current Deferred Revenue		 - - - 62
Other Current Liabilities		 1.12 1.94 2.03 2.12
Total Noncurrent Liabilities		 24 23 23 143
Noncurrent Deferred Revenue		 - - - 121
Other Noncurrent Operating Liabilities		 24 23 23 22
Commitments & Contingencies		 0.00 0.00 0.00 0.00
Redeemable Noncontrolling Interest		 224 0.00 0.00 0.00
Total Equity & Noncontrolling Interests		 -87 400 378 389
Total Preferred & Common Equity		 -87 400 378 389
Preferred Stock		 - 0.00 0.00 0.00
Total Common Equity		 -87 400 378 389
Common Stock		 10 540 542 545
Retained Earnings		 -98 -140 -165 -157
Accumulated Other Comprehensive Income / (Loss)		 0.18 0.20 0.18 0.38

Annual Metrics And Ratios for Septerna

This table displays calculated financial ratios and metrics derived from Septerna's official financial filings.

Metric 2023 2024 2025
Period end date 12/31/2023 12/31/2024 12/31/2025
DEI Shares Outstanding		 0.00 - 44,774,192.00
DEI Adjusted Shares Outstanding		 0.00 - 44,774,192.00
DEI Earnings Per Adjusted Shares Outstanding		 0.00 - -1.09
Growth Metrics		 - - -
Profitability Metrics		 - - -
Net Operating Profit after Tax (NOPAT)		 1.78 -57 -48
Return On Investment Capital (ROIC_SIMPLE)		 -4.64% -13.47% -12.52%
Earnings before Interest and Taxes (EBIT)		 2.08 -81 -68
Earnings before Interest, Taxes, Depreciation and Amortization (EBITDA)		 2.92 -81 -70
Valuation Ratios		 - - -
Leverage & Solvency		 - - -
Liquidity Ratios		 - - -
Cash Flow Metrics		 - - -
Free Cash Flow to Firm (FCFF)		 0.00 -33 118
Efficiency Ratios		 - - -
Capital & Investment Metrics		 - - -
Invested Capital		 22 -0.74 -167
Increase / (Decrease) in Invested Capital		 0.00 -23 -166
Book Value per Share		 ($19.90) $9.46 $8.53
Tangible Book Value per Share		 ($19.90) $9.46 $8.53
Total Capital		 111 420 382
Total Debt		 0.00 0.00 0.00
Total Long-Term Debt		 0.00 0.00 0.00
Net Debt		 -88 -421 -549
Capital Expenditures (CapEx)		 2.88 2.10 0.52
Debt-free, Cash-free Net Working Capital (DFCFNWC)		 17 -6.95 -67
Debt-free Net Working Capital (DFNWC)		 106 344 324
Net Working Capital (NWC)		 106 344 324
Net Nonoperating Expense (NNE)		 -2.40 15 1.07
Net Nonoperating Obligations (NNO)		 -88 -421 -549
Total Depreciation and Amortization (D&A)		 0.85 -0.01 -1.84
Earnings Adjustments		 - - -
Adjusted Basic Earnings per Share		 $0.00 ($7.26) ($1.10)
Adjusted Weighted Average Basic Shares Outstanding		 0.00 9.89M 44.26M
Adjusted Diluted Earnings per Share		 $0.00 ($7.26) ($1.10)
Adjusted Weighted Average Diluted Shares Outstanding		 0.00 9.89M 44.26M
Adjusted Basic & Diluted Earnings per Share		 $0.00 $0.00 $0.00
Adjusted Weighted Average Basic & Diluted Shares Outstanding		 0.00 44.44M 44.91M
Normalized Net Operating Profit after Tax (NOPAT)		 -39 -57 -57
Debt Service Ratios		 - - -
Payout Ratios		 - - -

Quarterly Metrics And Ratios for Septerna

This table displays calculated financial ratios and metrics derived from Septerna's official financial filings.

Metric Q3 2023 Q1 2024 Q2 2024 Q3 2024 Q4 2024 Q1 2025 Q2 2025 Q3 2025 Q4 2025
Period end date 9/30/2023 3/31/2024 6/30/2024 9/30/2024 12/31/2024 3/31/2025 6/30/2025 9/30/2025 12/31/2025
DEI Shares Outstanding		 0.00 0.00 0.00 0.00 44,402,742.00 44,442,496.00 44,558,338.00 44,585,135.00 44,774,192.00
DEI Adjusted Shares Outstanding		 0.00 0.00 0.00 0.00 44,402,742.00 44,442,496.00 44,558,338.00 44,585,135.00 44,774,192.00
DEI Earnings Per Adjusted Shares Outstanding		 0.00 0.00 0.00 0.00 -0.46 -0.48 -0.56 0.19 -0.25
Growth Metrics		 - - - - - - - - -
Profitability Metrics		 - - - - - - - - -
Net Operating Profit after Tax (NOPAT)		 -8.43 -11 -13 -16 -17 -18 -20 2.61 -11
Return On Investment Capital (ROIC_SIMPLE)		 - - - 18.06% -4.12% -4.53% -5.37% 0.67% -2.94%
Earnings before Interest and Taxes (EBIT)		 -12 -16 -18 -23 -25 -26 -29 2.61 -16
Earnings before Interest, Taxes, Depreciation and Amortization (EBITDA)		 -12 -15 -18 -23 -25 -27 -30 2.39 -17
Valuation Ratios		 - - - - - - - - -
Leverage & Solvency		 - - - - - - - - -
Liquidity Ratios		 - - - - - - - - -
Cash Flow Metrics		 - - - - - - - - -
Free Cash Flow to Firm (FCFF)		 0.00 0.00 0.00 -15 0.00 -20 -19 175 155
Efficiency Ratios		 - - - - - - - - -
Capital & Investment Metrics		 - - - - - - - - -
Invested Capital		 0.00 0.00 0.00 -0.76 -0.74 2.02 -1.64 -173 -167
Increase / (Decrease) in Invested Capital		 0.00 0.00 0.00 -0.76 0.00 2.02 -1.64 -172 -166
Book Value per Share		 $0.00 $0.00 $0.00 ($35.77) $9.46 $9.01 $8.47 $8.72 $8.53
Tangible Book Value per Share		 $0.00 $0.00 $0.00 ($35.77) $9.46 $9.01 $8.47 $8.72 $8.53
Total Capital		 0.00 0.00 0.00 137 420 400 378 389 382
Total Debt		 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Total Long-Term Debt		 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Net Debt		 0.00 0.00 0.00 -138 -421 -398 -379 -562 -549
Capital Expenditures (CapEx)		 0.00 0.76 0.15 0.58 0.61 0.38 0.06 0.01 0.07
Debt-free, Cash-free Net Working Capital (DFCFNWC)		 0.00 0.00 0.00 -10 -6.95 -4.17 -7.55 -58 -67
Debt-free Net Working Capital (DFNWC)		 0.00 0.00 0.00 120 344 332 319 416 324
Net Working Capital (NWC)		 0.00 0.00 0.00 120 344 332 319 416 324
Net Nonoperating Expense (NNE)		 2.52 3.32 3.80 4.74 3.37 3.34 4.55 -5.56 -0.48
Net Nonoperating Obligations (NNO)		 0.00 0.00 0.00 -138 -421 -398 -379 -562 -549
Total Depreciation and Amortization (D&A)		 0.00 0.24 0.18 -0.01 -0.42 -0.57 -0.57 -0.22 -0.49
Earnings Adjustments		 - - - - - - - - -
Adjusted Basic Earnings per Share		 $0.00 $0.00 $0.00 ($8.40) $14.52 ($0.49) ($0.56) $0.18 ($0.23)
Adjusted Weighted Average Basic Shares Outstanding		 0.00 0.00 0.00 2.44M 9.89M 43.94M 44.17M 44.34M 44.26M
Adjusted Diluted Earnings per Share		 $0.00 $0.00 $0.00 ($8.40) $14.52 ($0.49) ($0.56) $0.18 ($0.23)
Adjusted Weighted Average Diluted Shares Outstanding		 0.00 0.00 0.00 2.44M 9.89M 43.94M 44.17M 45.60M 44.26M
Adjusted Basic & Diluted Earnings per Share		 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00
Adjusted Weighted Average Basic & Diluted Shares Outstanding		 0.00 0.00 0.00 44.40M 44.44M 44.56M 44.59M 44.77M 44.91M
Normalized Net Operating Profit after Tax (NOPAT)		 -8.43 -11 -13 -16 -17 -18 -20 -6.92 -11
Debt Service Ratios		 - - - - - - - - -
Payout Ratios		 - - - - - - - - -

Financials Breakdown Chart

Key Financial Trends

Here are the top takeaways from Septerna's latest four years of quarterly results, focusing on the last four years of data provided. Items are organized with positives first, then neutral, then negatives.

  • Revenue in Q4 2025 rose to about $24.1 million, up from $21.2 million in Q4 2024, a year-over-year increase of roughly 13%.
  • Q3 2025 produced a positive quarterly net income to common shareholders of about $8.37 million, with basic/diluted earnings per share of $0.18, aided by roughly $5.57 million of investment income.
  • Liquidity remains strong: as of 9/30/2025, cash and equivalents were about $320.0 million and short-term investments about $154.4 million, for total liquid assets near $474.4 million, while total current liabilities were only about $75.3 million.
  • Q4 2025 shows a near 100% gross margin, with Total Gross Profit of about $24.12 million on $24.12 million in revenue (no explicit cost of revenue line shown in the data).
  • The balance sheet shows a solid equity cushion, with Total Equity around $388.7 million against Total Liabilities of about $217.9 million.
  • R&D spending has been rising through 2025 (e.g., Q4 2025 RD expense about $31.9 million), signaling continued investment in pipeline development.
  • Long-term investments remained material (about $87.2 million as of Q3 2025), reflecting a strategic asset base beyond core operations.
  • Financing activities contributed modest cash inflows in late 2025 (net cash from financing activities around $0.3–$1.0 million per quarter; Q4 2025 shown as approximately $1.02 million).
  • Net income to common shareholders in Q4 2025 turned negative again at about −$11.06 million, with EPS of −$0.23, reflecting the heavy R&D spend and other costs.
  • Cash burn remained evident in Q4 2025, with a net decrease in cash and equivalents of about −$199.3 million, driven by sizable investing activity (notably purchases of investments around $227.4 million) and continued operating losses.
05/11/26 09:29 AM ETAI Generated. May Contain Errors.

Septerna Financials - Frequently Asked Questions

According to the most recent income statement we have on file, Septerna's financial year ends in December. Their financial year 2025 ended on December 31, 2025.

Septerna's net income appears to be on an upward trend, with a most recent value of -$48.88 million in 2025, falling from $4.18 million in 2023. The previous period was -$71.80 million in 2024. View Septerna's forecast to see where analysts expect Septerna to go next.

Septerna's total operating income in 2025 was -$68.30 million, based on the following breakdown:
  • Total Gross Profit: $45.95 million
  • Total Operating Expenses: $114.25 million

Over the last 2 years, Septerna's total revenue changed from $151 thousand in 2023 to $45.95 million in 2025, a change of 30,331.1%.

Septerna's total liabilities were at $214.26 million at the end of 2025, a 486.9% increase from 2024, and a 969.9% increase since 2023.

In the past 2 years, Septerna's cash and equivalents has ranged from $88.48 million in 2023 to $238.20 million in 2024, and is currently $120.72 million as of their latest financial filing in 2025.

Over the last 2 years, Septerna's book value per share changed from -19.90 in 2023 to 8.53 in 2025, a change of -142.9%.


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Financial statements for NASDAQ:SEPN last updated on 4/9/2026 by MarketBeat.com Staff. New filings and market data are monitored continuously.
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