Septerna (SEPN) Stock Chart & Stock Price History $28.36 +0.44 (+1.58%) Closing price 05/22/2026 04:00 PM EasternExtended Trading$28.36 0.00 (-0.02%) As of 05/22/2026 06:13 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock Septerna Stock Price Performance The Septerna (SEPN) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 208.60%, with a year-to-date return of 1.72%. In the past month, the stock has increased 13.58%, reflecting recent market activity. As of the latest close, Septerna traded at $28.36 with a market cap of $1.28 billion and volume of 346,804 shares. 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Read our full terms of service and privacy policy. 5 Day Performance+7.83%1 Month Performance+13.58%3 Month Performance+1.29%Year-To-Date Performance+1.72%1 Year Performance+208.60% SEPN Stock Chart for Saturday, May, 23, 2026 SEPN Chart by TradingView Septerna Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization05/22/2026$27.92$28.36+1.58%$29.89$27.93346,804 shs$1.28 billion05/21/2026$28.01$27.92-0.32%$28.60$27.49232,419 shs$1.26 billion05/20/2026$26.51$28.01+5.66%$28.06$26.71226,724 shs$1.26 billion05/19/2026$26.30$26.51+0.80%$27.16$25.79366,751 shs$1.20 billion05/18/2026$26.95$26.30-2.41%$27.98$26.00316,921 shs$1.19 billion05/15/2026$28.32$26.95-4.84%$28.81$26.28573,801 shs$1.21 billion05/14/2026$24.75$28.32+14.42%$28.37$24.03555,975 shs$1.28 billion05/13/2026$24.84$24.75-0.36%$25.48$24.23315,749 shs$1.11 billion05/12/2026$23.57$24.84+5.39%$25.99$23.57407,763 shs$1.12 billion05/11/2026$23.87$23.57-1.26%$24.65$23.50132,853 shs$1.06 billion Get the Latest News and Ratings for SEPN and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Septerna and its competitors with MarketBeat's FREE daily newsletter. 05/08/2026$23.98$23.87-0.46%$24.86$23.82208,365 shs$1.08 billion05/07/2026$24.77$23.98-3.20%$25.05$23.44218,326 shs$1.08 billion05/06/2026$24.13$24.77+2.66%$24.90$23.90308,477 shs$1.11 billion05/05/2026N/A$24.13$25.25$23.29298,691 shs$1.08 billion04/30/2026$23.45$23.76+1.32%$24.24$23.12271,707 shs$1.07 billion04/29/2026$24.29$23.45-3.46%$24.57$22.78347,603 shs$1.05 billion04/28/2026$25.09$24.29-3.19%$25.51$23.95280,227 shs$1.09 billion04/27/2026$24.67$25.09+1.70%$25.86$24.58370,792 shs$1.13 billion04/24/2026$24.97$24.67-1.20%$25.40$24.49595,430 shs$1.11 billion04/23/2026$25.86$24.97-3.44%$27.17$24.94337,908 shs$1.12 billion04/22/2026$25.80$25.86+0.23%$26.20$25.34255,588 shs$1.16 billion Related Companies DNTH Stock Chart NNNN Stock Chart CRSP Stock Chart INDV Stock Chart MANE Stock Chart KNSA Stock Chart NAMS Stock Chart TVTX Stock Chart CPRX Stock Chart AMRX Stock Chart Receive SEPN Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Septerna and its competitors with MarketBeat's FREE daily newsletter. This page (NASDAQ:SEPN) was last updated on 5/23/2026 by MarketBeat.com Staff. 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