| 10/01/2026 3:32 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 09/10/2026 4:08 PM | Patni Rajiv (1616200) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 09/03/2026 6:01 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 09/03/2026 6:03 PM | Patni Rajiv (1616200) Reporting Septerna (1984086) Issuer | Form 3 Initial statement of beneficial ownership of securities | |
| 08/25/2026 7:15 AM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 08/14/2026 4:44 PM | Septerna (1984086) Issuer Third Rock Ventures GP V, LP (1977498) Reporting Third Rock Ventures GP VI, L.P. (1977499) Reporting Third Rock Ventures V, L.P. (1778071) Reporting Third Rock Ventures VI, L.P. (1931056) Reporting TRV GP V, LLC (1990717) Reporting TRV GP VI, LLC (1990716) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 08/14/2026 4:11 PM | Kolchinsky Peter (1384859) Reporting RA Capital Healthcare Fund LP (1315082) Reporting RA CAPITAL MANAGEMENT, L.P. (1346824) Reporting RA Capital Nexus Fund III, L.P. (1883840) Reporting Septerna (1984086) Issuer Shah Rajeev M. (1619841) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 08/14/2026 4:14 PM | RA CAPITAL MANAGEMENT, L.P. (1346824) Filed by Septerna (1984086) Subject | Form SCHEDULE 13D/A | |
| 08/14/2026 6:32 AM | DRIEHAUS CAPITAL MANAGEMENT LLC (938206) Filed by Septerna (1984086) Subject | Form SCHEDULE 13G/A | |
| 08/13/2026 6:00 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 08/12/2026 5:55 PM | RA Capital Nexus Fund III, L.P. (1883840) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
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| 08/12/2026 6:06 PM | RA Capital Healthcare Fund LP (1315082) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 08/11/2026 3:28 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 08/10/2026 3:03 PM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 08/10/2026 3:06 PM | Septerna (1984086) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |
| 08/05/2026 6:00 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/17/2026 6:00 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 07/15/2026 3:23 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 07/02/2026 6:00 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:52 PM | Kolchinsky Peter (1384859) Reporting RA Capital Healthcare Fund LP (1315082) Reporting RA CAPITAL MANAGEMENT, L.P. (1346824) Reporting RA Capital Nexus Fund III, L.P. (1883840) Reporting Septerna (1984086) Issuer Shah Rajeev M. (1619841) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Septerna (1984086) Issuer Simson Jake (1863094) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Ezekowitz Alan (1780209) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Gottesdiener Keith Michael (1615856) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Septerna (1984086) Issuer Tong Jeffrey K (1479701) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Coulie Bernard (1808895) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Septerna (1984086) Issuer Sharp Shalini (1377202) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:00 PM | Bassan Abraham (1864485) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 6:01 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/30/2026 3:30 PM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 06/26/2026 3:02 PM | Kim Jae B. (1819159) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/24/2026 6:24 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/22/2026 3:16 PM | Kim Jae B. (1819159) Reporting Septerna (1984086) Subject | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/16/2026 7:31 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 06/12/2026 3:42 PM | Septerna (1984086) Subject Shaikhly Samira (2040363) Reporting | Form 144 Notice of proposed sale of securities pursuant to Rule 144 | |
| 06/03/2026 6:11 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/28/2026 6:02 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 05/11/2026 3:05 PM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 04/30/2026 3:32 PM | Septerna (1984086) Filer | Form ARS | |
| 04/30/2026 3:21 PM | Septerna (1984086) Filer | Form DEF 14A | |
| 04/17/2026 6:00 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 04/13/2026 7:30 AM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
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| 03/10/2026 3:31 PM | Septerna (1984086) Filer | Form S-3ASR | |
| 03/09/2026 4:09 PM | Septerna (1984086) Filer | Form S-8 Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans | |
| 03/09/2026 3:08 PM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 03/09/2026 3:11 PM | Septerna (1984086) Filer | Form 10-K Annual report pursuant to Section 13 or 15(d) | |
| 03/04/2026 6:00 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 03/02/2026 6:00 AM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 02/20/2026 4:28 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:01 PM | Septerna (1984086) Issuer Wilson Mark Andrew (1808356) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:03 PM | Finer Jeffrey (2040376) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:05 PM | Bhatt Elizabeth (1748622) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:08 PM | Kim Jae B. (1819159) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:10 PM | Labrucherie Gil M (1394875) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:13 PM | Septerna (1984086) Issuer Shaikhly Samira (2040363) Reporting | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:15 PM | Klein Uwe (2040350) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 02/10/2026 6:17 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 01/15/2026 3:16 PM | Septerna (1984086) Issuer Wilson Mark Andrew (1808356) Reporting | Form 3 Initial statement of beneficial ownership of securities | |
| 01/12/2026 7:30 AM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 01/08/2026 3:31 PM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 11/13/2025 7:13 PM | Long Daniel D. (2040349) Reporting Septerna (1984086) Issuer | Form 4 Statement of changes in beneficial ownership of securities | |
| 11/10/2025 7:42 AM | Septerna (1984086) Filer | Form 8-K Current report pursuant to Section 13 or 15(d) | |
| 11/10/2025 7:44 AM | Septerna (1984086) Filer | Form 10-Q General form for quarterly reports under Section 13 or 15(d) | |