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Septerna (SEPN) Competitors

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$38.69 -0.81 (-2.05%)
Closing price 09/18/2026 04:00 PM Eastern
Extended Trading
$38.72 +0.03 (+0.08%)
As of 09/18/2026 07:30 PM Eastern
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SEPN vs. RYTM, CGON, MIRM, ORKA, and TVTX

Should you buy Septerna stock or one of its competitors? Septerna's main competitors and comparable companies include Rhythm Pharmaceuticals (RYTM), CG Oncology (CGON), Mirum Pharmaceuticals (MIRM), Oruka Therapeutics (ORKA), and Travere Therapeutics (TVTX). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Septerna compare to Rhythm Pharmaceuticals?

Rhythm Pharmaceuticals (NASDAQ:RYTM) and Septerna (NASDAQ:SEPN) are both healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their institutional ownership, dividends, analyst recommendations, media sentiment, risk, profitability, valuation and earnings.

Septerna has a net margin of -24.51% compared to Rhythm Pharmaceuticals' net margin of -85.59%. Septerna's return on equity of -9.57% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Rhythm Pharmaceuticals-85.59% -159.87% -44.00%
Septerna -24.51%-9.57%-6.28%

Rhythm Pharmaceuticals presently has a consensus target price of $140.67, suggesting a potential upside of 43.96%. Septerna has a consensus target price of $52.44, suggesting a potential upside of 35.55%. Given Rhythm Pharmaceuticals' higher possible upside, equities research analysts clearly believe Rhythm Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Rhythm Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.76
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

Septerna has lower revenue, but higher earnings than Rhythm Pharmaceuticals. Septerna is trading at a lower price-to-earnings ratio than Rhythm Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Rhythm Pharmaceuticals$189.76M35.29-$196.54M-$3.11N/A
Septerna$45.95M39.30-$48.88M-$0.54N/A

Rhythm Pharmaceuticals has a beta of 1.97, meaning that its stock price is 97% more volatile than the broader market. Comparatively, Septerna has a beta of 2.3, meaning that its stock price is 130% more volatile than the broader market.

In the previous week, Rhythm Pharmaceuticals had 15 more articles in the media than Septerna. MarketBeat recorded 17 mentions for Rhythm Pharmaceuticals and 2 mentions for Septerna. Septerna's average media sentiment score of 0.67 beat Rhythm Pharmaceuticals' score of 0.38 indicating that Septerna is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Rhythm Pharmaceuticals
3 Very Positive mention(s)
3 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Septerna beats Rhythm Pharmaceuticals on 10 of the 15 factors compared between the two stocks.

How does Septerna compare to CG Oncology?

Septerna (NASDAQ:SEPN) and CG Oncology (NASDAQ:CGON) are both healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, institutional ownership, media sentiment, risk, valuation, dividends, profitability and analyst recommendations.

26.6% of CG Oncology shares are owned by institutional investors. 5.8% of Septerna shares are owned by insiders. Comparatively, 4.8% of CG Oncology shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Septerna presently has a consensus price target of $52.44, indicating a potential upside of 35.55%. CG Oncology has a consensus price target of $87.78, indicating a potential upside of 17.63%. Given Septerna's stronger consensus rating and higher probable upside, equities analysts plainly believe Septerna is more favorable than CG Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
CG Oncology
1 Sell rating(s)
1 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.73

Septerna has a beta of 2.3, meaning that its stock price is 130% more volatile than the broader market. Comparatively, CG Oncology has a beta of 0.24, meaning that its stock price is 76% less volatile than the broader market.

In the previous week, CG Oncology had 6 more articles in the media than Septerna. MarketBeat recorded 8 mentions for CG Oncology and 2 mentions for Septerna. Septerna's average media sentiment score of 0.67 beat CG Oncology's score of 0.56 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
CG Oncology
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Septerna has higher revenue and earnings than CG Oncology. Septerna is trading at a lower price-to-earnings ratio than CG Oncology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M39.30-$48.88M-$0.54N/A
CG Oncology$4.04M1,637.21-$160.99M-$2.69N/A

Septerna has a net margin of -24.51% compared to CG Oncology's net margin of -3,602.68%. Septerna's return on equity of -9.57% beat CG Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-24.51% -9.57% -6.28%
CG Oncology -3,602.68%-25.20%-23.98%

Summary

Septerna beats CG Oncology on 12 of the 17 factors compared between the two stocks.

How does Septerna compare to Mirum Pharmaceuticals?

Mirum Pharmaceuticals (NASDAQ:MIRM) and Septerna (NASDAQ:SEPN) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their profitability, earnings, analyst recommendations, valuation, institutional ownership, dividends, risk and media sentiment.

Mirum Pharmaceuticals currently has a consensus price target of $137.31, indicating a potential upside of 49.53%. Septerna has a consensus price target of $52.44, indicating a potential upside of 35.55%. Given Mirum Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Mirum Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Mirum Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.93
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

Mirum Pharmaceuticals has a beta of 0.49, indicating that its stock price is 51% less volatile than the broader market. Comparatively, Septerna has a beta of 2.3, indicating that its stock price is 130% more volatile than the broader market.

In the previous week, Mirum Pharmaceuticals had 6 more articles in the media than Septerna. MarketBeat recorded 8 mentions for Mirum Pharmaceuticals and 2 mentions for Septerna. Septerna's average media sentiment score of 0.67 beat Mirum Pharmaceuticals' score of 0.62 indicating that Septerna is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Mirum Pharmaceuticals
4 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Septerna has a net margin of -24.51% compared to Mirum Pharmaceuticals' net margin of -139.18%. Septerna's return on equity of -9.57% beat Mirum Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Mirum Pharmaceuticals-139.18% -36.28% -8.54%
Septerna -24.51%-9.57%-6.28%

Mirum Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Mirum Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Mirum Pharmaceuticals$521.31M11.44-$23.36M-$14.55N/A
Septerna$45.95M39.30-$48.88M-$0.54N/A

Summary

Mirum Pharmaceuticals and Septerna tied by winning 7 of the 14 factors compared between the two stocks.

How does Septerna compare to Oruka Therapeutics?

Septerna (NASDAQ:SEPN) and Oruka Therapeutics (NASDAQ:ORKA) are both healthcare companies, but which is the superior business? We will contrast the two companies based on the strength of their dividends, profitability, media sentiment, earnings, analyst recommendations, institutional ownership, risk and valuation.

In the previous week, Oruka Therapeutics had 13 more articles in the media than Septerna. MarketBeat recorded 15 mentions for Oruka Therapeutics and 2 mentions for Septerna. Septerna's average media sentiment score of 0.67 beat Oruka Therapeutics' score of 0.26 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Oruka Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Septerna has a beta of 2.3, suggesting that its share price is 130% more volatile than the broader market. Comparatively, Oruka Therapeutics has a beta of -0.34, suggesting that its share price is 134% less volatile than the broader market.

Septerna presently has a consensus target price of $52.44, indicating a potential upside of 35.55%. Oruka Therapeutics has a consensus target price of $133.00, indicating a potential upside of 40.06%. Given Oruka Therapeutics' higher probable upside, analysts clearly believe Oruka Therapeutics is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Oruka Therapeutics
1 Sell rating(s)
0 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.82

Oruka Therapeutics has a net margin of 0.00% compared to Septerna's net margin of -24.51%. Septerna's return on equity of -9.57% beat Oruka Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-24.51% -9.57% -6.28%
Oruka Therapeutics N/A -21.65%-20.88%

Septerna has higher revenue and earnings than Oruka Therapeutics. Septerna is trading at a lower price-to-earnings ratio than Oruka Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M39.30-$48.88M-$0.54N/A
Oruka TherapeuticsN/AN/A-$105.43M-$2.03N/A

56.4% of Oruka Therapeutics shares are held by institutional investors. 5.8% of Septerna shares are held by company insiders. Comparatively, 23.5% of Oruka Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Summary

Septerna beats Oruka Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Septerna compare to Travere Therapeutics?

Septerna (NASDAQ:SEPN) and Travere Therapeutics (NASDAQ:TVTX) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their valuation, profitability, earnings, risk, analyst recommendations, institutional ownership, media sentiment and dividends.

Travere Therapeutics has a net margin of -7.35% compared to Septerna's net margin of -24.51%. Septerna's return on equity of -9.57% beat Travere Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-24.51% -9.57% -6.28%
Travere Therapeutics -7.35%-55.15%-6.88%

Travere Therapeutics has higher revenue and earnings than Septerna. Travere Therapeutics is trading at a lower price-to-earnings ratio than Septerna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M39.30-$48.88M-$0.54N/A
Travere Therapeutics$490.73M12.06-$25.55M-$0.46N/A

Septerna has a beta of 2.3, indicating that its stock price is 130% more volatile than the broader market. Comparatively, Travere Therapeutics has a beta of 1.05, indicating that its stock price is 5% more volatile than the broader market.

Septerna currently has a consensus price target of $52.44, indicating a potential upside of 35.55%. Travere Therapeutics has a consensus price target of $68.00, indicating a potential upside of 8.35%. Given Septerna's stronger consensus rating and higher probable upside, equities research analysts plainly believe Septerna is more favorable than Travere Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Travere Therapeutics
1 Sell rating(s)
1 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.75

In the previous week, Travere Therapeutics had 35 more articles in the media than Septerna. MarketBeat recorded 37 mentions for Travere Therapeutics and 2 mentions for Septerna. Septerna's average media sentiment score of 0.67 beat Travere Therapeutics' score of 0.34 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Travere Therapeutics
16 Very Positive mention(s)
7 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Septerna beats Travere Therapeutics on 9 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SEPN vs. The Competition

MetricSepternaBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$1.81B$3.90B$7.24B$13.19B
Dividend YieldN/A3.64%2.57%12.81%
P/E Ratio-71.6514.23274.9325.38
Price / Sales39.301,419.61646.0189.45
Price / CashN/A108.9076.2551.42
Price / Book4.5415.4510.466.33
Net Income-$48.88M-$22.86M$3.49B$358.33M
7 Day Performance0.47%-1.21%0.59%1.12%
1 Month Performance-5.15%-3.29%-1.74%-2.39%
1 Year Performance146.43%37.74%18.13%5.35%

Septerna Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SEPN
Septerna
3.0057 of 5 stars
$38.69
-2.1%
$52.44
+35.6%
+146.4%$1.81B$45.95MN/A130
RYTM
Rhythm Pharmaceuticals
2.7622 of 5 stars
$101.80
-0.9%
$141.12
+38.6%
+1.7%$6.98B$239.92MN/A140
CGON
CG Oncology
2.8453 of 5 stars
$73.40
-1.7%
$87.78
+19.6%
+102.2%$6.51B$4.04MN/A61
MIRM
Mirum Pharmaceuticals
3.0345 of 5 stars
$99.53
-1.4%
$137.31
+38.0%
+23.5%$6.46B$521.31MN/A140
ORKA
Oruka Therapeutics
3.4315 of 5 stars
$94.31
+1.9%
$133.00
+41.0%
+510.7%$6.24BN/AN/AN/A

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This page (NASDAQ:SEPN) was last updated on 9/20/2026 by MarketBeat.com Staff.
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