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Septerna (SEPN) Competitors

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$30.41 -0.74 (-2.38%)
Closing price 04:00 PM Eastern
Extended Trading
$30.44 +0.03 (+0.10%)
As of 05:19 PM Eastern
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SEPN vs. GRFS, XENE, CGON, APGE, and DNTH

Should you buy Septerna stock or one of its competitors? MarketBeat compares Septerna with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Septerna include Grifols (GRFS), Xenon Pharmaceuticals (XENE), CG Oncology (CGON), Apogee Therapeutics (APGE), and Dianthus Therapeutics (DNTH). These companies are all part of the "pharmaceutical products" industry.

How does Septerna compare to Grifols?

Grifols (NASDAQ:GRFS) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the better business? We will compare the two businesses based on the strength of their dividends, media sentiment, profitability, valuation, analyst recommendations, institutional ownership, earnings and risk.

In the previous week, Septerna had 2 more articles in the media than Grifols. MarketBeat recorded 4 mentions for Septerna and 2 mentions for Grifols. Grifols' average media sentiment score of 1.64 beat Septerna's score of -0.03 indicating that Grifols is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Grifols
2 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Grifols has a net margin of 5.54% compared to Septerna's net margin of -49.88%. Grifols' return on equity of 6.21% beat Septerna's return on equity.

Company Net Margins Return on Equity Return on Assets
Grifols5.54% 6.21% 2.39%
Septerna -49.88%-12.72%-8.87%

Grifols has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Grifols, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Grifols$8.51B0.59$454.82M$0.1938.58
Septerna$45.95M29.83-$48.88M-$0.81N/A

Grifols currently has a consensus target price of $10.00, suggesting a potential upside of 36.43%. Septerna has a consensus target price of $45.00, suggesting a potential upside of 47.98%. Given Septerna's stronger consensus rating and higher probable upside, analysts clearly believe Septerna is more favorable than Grifols.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Grifols
1 Sell rating(s)
3 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.75
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

Grifols has a beta of 0.65, meaning that its share price is 35% less volatile than the broader market. Comparatively, Septerna has a beta of 2.39, meaning that its share price is 139% more volatile than the broader market.

Summary

Grifols beats Septerna on 8 of the 15 factors compared between the two stocks.

How does Septerna compare to Xenon Pharmaceuticals?

Xenon Pharmaceuticals (NASDAQ:XENE) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the better business? We will compare the two businesses based on the strength of their dividends, media sentiment, profitability, valuation, analyst recommendations, institutional ownership, earnings and risk.

Xenon Pharmaceuticals has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Xenon PharmaceuticalsN/A -49.23% -46.42%
Septerna -49.88%-12.72%-8.87%

95.5% of Xenon Pharmaceuticals shares are held by institutional investors. 4.1% of Xenon Pharmaceuticals shares are held by insiders. Comparatively, 4.3% of Septerna shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Xenon Pharmaceuticals has a beta of 0.62, indicating that its share price is 38% less volatile than the broader market. Comparatively, Septerna has a beta of 2.39, indicating that its share price is 139% more volatile than the broader market.

Xenon Pharmaceuticals currently has a consensus target price of $77.20, suggesting a potential upside of 50.75%. Septerna has a consensus target price of $45.00, suggesting a potential upside of 47.98%. Given Xenon Pharmaceuticals' stronger consensus rating and higher probable upside, analysts clearly believe Xenon Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xenon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
14 Buy rating(s)
2 Strong Buy rating(s)
3.00
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

Septerna has higher revenue and earnings than Xenon Pharmaceuticals. Septerna is trading at a lower price-to-earnings ratio than Xenon Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xenon Pharmaceuticals$7.50M660.06-$345.91M-$4.70N/A
Septerna$45.95M29.83-$48.88M-$0.81N/A

In the previous week, Septerna had 2 more articles in the media than Xenon Pharmaceuticals. MarketBeat recorded 4 mentions for Septerna and 2 mentions for Xenon Pharmaceuticals. Xenon Pharmaceuticals' average media sentiment score of 0.85 beat Septerna's score of -0.03 indicating that Xenon Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xenon Pharmaceuticals
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Xenon Pharmaceuticals beats Septerna on 9 of the 17 factors compared between the two stocks.

How does Septerna compare to CG Oncology?

Septerna (NASDAQ:SEPN) and CG Oncology (NASDAQ:CGON) are both medical companies, but which is the superior investment? We will compare the two companies based on the strength of their valuation, earnings, media sentiment, institutional ownership, analyst recommendations, profitability, dividends and risk.

In the previous week, Septerna and Septerna both had 4 articles in the media. Septerna's average media sentiment score of -0.03 beat CG Oncology's score of -0.37 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
CG Oncology
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

CG Oncology has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat CG Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
CG Oncology N/A -23.33%-22.24%

Septerna has a beta of 2.39, indicating that its stock price is 139% more volatile than the broader market. Comparatively, CG Oncology has a beta of 0.31, indicating that its stock price is 69% less volatile than the broader market.

26.6% of CG Oncology shares are held by institutional investors. 4.3% of Septerna shares are held by company insiders. Comparatively, 4.8% of CG Oncology shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Septerna has higher revenue and earnings than CG Oncology. Septerna is trading at a lower price-to-earnings ratio than CG Oncology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M29.83-$48.88M-$0.81N/A
CG Oncology$4.04M1,187.64-$160.99M-$2.33N/A

Septerna presently has a consensus target price of $45.00, indicating a potential upside of 47.98%. CG Oncology has a consensus target price of $81.73, indicating a potential upside of 50.23%. Given CG Oncology's higher possible upside, analysts clearly believe CG Oncology is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80
CG Oncology
1 Sell rating(s)
2 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.71

Summary

Septerna beats CG Oncology on 9 of the 15 factors compared between the two stocks.

How does Septerna compare to Apogee Therapeutics?

Apogee Therapeutics (NASDAQ:APGE) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the superior business? We will compare the two businesses based on the strength of their risk, institutional ownership, earnings, dividends, media sentiment, valuation, profitability and analyst recommendations.

Apogee Therapeutics presently has a consensus target price of $114.56, indicating a potential upside of 38.01%. Septerna has a consensus target price of $45.00, indicating a potential upside of 47.98%. Given Septerna's stronger consensus rating and higher probable upside, analysts clearly believe Septerna is more favorable than Apogee Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Apogee Therapeutics
1 Sell rating(s)
5 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
2.74
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

79.0% of Apogee Therapeutics shares are held by institutional investors. 24.3% of Apogee Therapeutics shares are held by insiders. Comparatively, 4.3% of Septerna shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Septerna has higher revenue and earnings than Apogee Therapeutics. Septerna is trading at a lower price-to-earnings ratio than Apogee Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Apogee TherapeuticsN/AN/A-$255.84M-$4.33N/A
Septerna$45.95M29.83-$48.88M-$0.81N/A

Apogee Therapeutics has a beta of 0.62, suggesting that its share price is 38% less volatile than the broader market. Comparatively, Septerna has a beta of 2.39, suggesting that its share price is 139% more volatile than the broader market.

In the previous week, Apogee Therapeutics had 3 more articles in the media than Septerna. MarketBeat recorded 7 mentions for Apogee Therapeutics and 4 mentions for Septerna. Apogee Therapeutics' average media sentiment score of 0.62 beat Septerna's score of -0.03 indicating that Apogee Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Apogee Therapeutics
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Apogee Therapeutics has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Apogee Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Apogee TherapeuticsN/A -32.64% -31.25%
Septerna -49.88%-12.72%-8.87%

Summary

Apogee Therapeutics and Septerna tied by winning 8 of the 16 factors compared between the two stocks.

How does Septerna compare to Dianthus Therapeutics?

Dianthus Therapeutics (NASDAQ:DNTH) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the superior business? We will contrast the two companies based on the strength of their profitability, institutional ownership, dividends, valuation, media sentiment, analyst recommendations, earnings and risk.

47.5% of Dianthus Therapeutics shares are owned by institutional investors. 3.0% of Dianthus Therapeutics shares are owned by company insiders. Comparatively, 4.3% of Septerna shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Dianthus Therapeutics had 3 more articles in the media than Septerna. MarketBeat recorded 7 mentions for Dianthus Therapeutics and 4 mentions for Septerna. Dianthus Therapeutics' average media sentiment score of 0.50 beat Septerna's score of -0.03 indicating that Dianthus Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Dianthus Therapeutics
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Septerna
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Dianthus Therapeutics has a beta of 1.18, meaning that its stock price is 18% more volatile than the broader market. Comparatively, Septerna has a beta of 2.39, meaning that its stock price is 139% more volatile than the broader market.

Dianthus Therapeutics currently has a consensus target price of $117.82, indicating a potential upside of 45.06%. Septerna has a consensus target price of $45.00, indicating a potential upside of 47.98%. Given Septerna's higher possible upside, analysts clearly believe Septerna is more favorable than Dianthus Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Dianthus Therapeutics
1 Sell rating(s)
0 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
3.00
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

Septerna has a net margin of -49.88% compared to Dianthus Therapeutics' net margin of -12,998.50%. Septerna's return on equity of -12.72% beat Dianthus Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Dianthus Therapeutics-12,998.50% -27.30% -25.91%
Septerna -49.88%-12.72%-8.87%

Septerna has higher revenue and earnings than Dianthus Therapeutics. Septerna is trading at a lower price-to-earnings ratio than Dianthus Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Dianthus Therapeutics$2.04M2,176.62-$162.34M-$4.13N/A
Septerna$45.95M29.83-$48.88M-$0.81N/A

Summary

Septerna beats Dianthus Therapeutics on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SEPN vs. The Competition

MetricSepternaMED IndustryMedical SectorNASDAQ Exchange
Market Cap$1.40B$3.34B$6.49B$11.99B
Dividend YieldN/A2.30%2.67%5.57%
P/E Ratio-37.5410.3820.2421.95
Price / Sales29.83298.43507.57108.00
Price / CashN/A51.4526.9937.25
Price / Book3.578.0410.286.78
Net Income-$48.88M$23.89M$3.57B$337.51M
7 Day Performance1.43%-5.97%-1.43%-2.72%
1 Month Performance27.40%2.78%3.27%1.87%
1 Year Performance197.85%36.26%23.37%26.61%

Septerna Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SEPN
Septerna
2.3457 of 5 stars
$30.41
-2.4%
$45.00
+48.0%
+205.1%$1.40B$45.95MN/AN/A
GRFS
Grifols
4.5228 of 5 stars
$7.64
-1.4%
$10.00
+31.0%
-13.4%$5.34B$8.51B40.4825,247
XENE
Xenon Pharmaceuticals
3.8124 of 5 stars
$52.35
-2.0%
$77.20
+47.5%
+63.5%$5.29BN/AN/A210
CGON
CG Oncology
2.9046 of 5 stars
$55.51
-6.3%
$81.73
+47.2%
+99.6%$5.22B$5.07MN/A61
APGE
Apogee Therapeutics
3.194 of 5 stars
$78.92
-0.5%
$113.63
+44.0%
+112.1%$5.08BN/AN/A91

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This page (NASDAQ:SEPN) was last updated on 6/8/2026 by MarketBeat.com Staff.
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