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Septerna (SEPN) Competitors

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$38.83 0.00 (0.00%)
Closing price 08/7/2026 04:00 PM Eastern
Extended Trading
$38.84 +0.01 (+0.03%)
As of 08/7/2026 07:34 PM Eastern
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SEPN vs. MIRM, CGON, XENE, DNTH, and LGND

Should you buy Septerna stock or one of its competitors? MarketBeat compares Septerna with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Septerna include Mirum Pharmaceuticals (MIRM), CG Oncology (CGON), Xenon Pharmaceuticals (XENE), Dianthus Therapeutics (DNTH), and Ligand Pharmaceuticals (LGND). These companies are all part of the "biotechnology" industry.

How does Septerna compare to Mirum Pharmaceuticals?

Septerna (NASDAQ:SEPN) and Mirum Pharmaceuticals (NASDAQ:MIRM) are both healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, valuation, institutional ownership, media sentiment, analyst recommendations, dividends, earnings and profitability.

Septerna currently has a consensus target price of $45.89, indicating a potential upside of 18.18%. Mirum Pharmaceuticals has a consensus target price of $137.33, indicating a potential upside of 36.45%. Given Mirum Pharmaceuticals' stronger consensus rating and higher probable upside, analysts plainly believe Mirum Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Mirum Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.93

Mirum Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Mirum Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M38.09-$48.88M-$0.81N/A
Mirum Pharmaceuticals$521.31M12.54-$23.36M-$14.55N/A

Septerna has a net margin of -49.88% compared to Mirum Pharmaceuticals' net margin of -139.18%. Septerna's return on equity of -12.72% beat Mirum Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Mirum Pharmaceuticals -139.18%-36.28%-8.54%

Septerna has a beta of 2.29, indicating that its stock price is 129% more volatile than the broader market. Comparatively, Mirum Pharmaceuticals has a beta of 0.52, indicating that its stock price is 48% less volatile than the broader market.

In the previous week, Mirum Pharmaceuticals had 28 more articles in the media than Septerna. MarketBeat recorded 35 mentions for Mirum Pharmaceuticals and 7 mentions for Septerna. Septerna's average media sentiment score of 0.53 beat Mirum Pharmaceuticals' score of 0.11 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Mirum Pharmaceuticals
6 Very Positive mention(s)
3 Positive mention(s)
6 Neutral mention(s)
3 Negative mention(s)
1 Very Negative mention(s)
Neutral

Summary

Mirum Pharmaceuticals beats Septerna on 8 of the 14 factors compared between the two stocks.

How does Septerna compare to CG Oncology?

CG Oncology (NASDAQ:CGON) and Septerna (NASDAQ:SEPN) are both healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their valuation, institutional ownership, analyst recommendations, profitability, dividends, risk, media sentiment and earnings.

CG Oncology has a beta of 0.23, suggesting that its stock price is 77% less volatile than the broader market. Comparatively, Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market.

Septerna has a net margin of -49.88% compared to CG Oncology's net margin of -3,602.68%. Septerna's return on equity of -12.72% beat CG Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
CG Oncology-3,602.68% -26.58% -25.34%
Septerna -49.88%-12.72%-8.87%

Septerna has higher revenue and earnings than CG Oncology. Septerna is trading at a lower price-to-earnings ratio than CG Oncology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
CG Oncology$4.04M1,647.74-$160.99M-$2.69N/A
Septerna$45.95M38.09-$48.88M-$0.81N/A

CG Oncology presently has a consensus target price of $83.18, suggesting a potential upside of 10.76%. Septerna has a consensus target price of $45.89, suggesting a potential upside of 18.18%. Given Septerna's stronger consensus rating and higher possible upside, analysts plainly believe Septerna is more favorable than CG Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
CG Oncology
1 Sell rating(s)
2 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.71
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

26.6% of CG Oncology shares are held by institutional investors. 4.8% of CG Oncology shares are held by insiders. Comparatively, 5.8% of Septerna shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

In the previous week, CG Oncology had 22 more articles in the media than Septerna. MarketBeat recorded 29 mentions for CG Oncology and 7 mentions for Septerna. Septerna's average media sentiment score of 0.53 beat CG Oncology's score of 0.03 indicating that Septerna is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
CG Oncology
7 Very Positive mention(s)
1 Positive mention(s)
5 Neutral mention(s)
3 Negative mention(s)
1 Very Negative mention(s)
Neutral
Septerna
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Septerna beats CG Oncology on 12 of the 17 factors compared between the two stocks.

How does Septerna compare to Xenon Pharmaceuticals?

Septerna (NASDAQ:SEPN) and Xenon Pharmaceuticals (NASDAQ:XENE) are both healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their risk, analyst recommendations, institutional ownership, media sentiment, valuation, dividends, earnings and profitability.

Septerna has higher revenue and earnings than Xenon Pharmaceuticals. Septerna is trading at a lower price-to-earnings ratio than Xenon Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M38.09-$48.88M-$0.81N/A
Xenon Pharmaceuticals$7.50M816.67-$345.91M-$4.74N/A

95.5% of Xenon Pharmaceuticals shares are held by institutional investors. 5.8% of Septerna shares are held by insiders. Comparatively, 2.9% of Xenon Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Xenon Pharmaceuticals has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Xenon Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Xenon Pharmaceuticals N/A -43.98%-41.72%

Septerna presently has a consensus price target of $45.89, suggesting a potential upside of 18.18%. Xenon Pharmaceuticals has a consensus price target of $77.13, suggesting a potential upside of 21.74%. Given Xenon Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Xenon Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Xenon Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
14 Buy rating(s)
2 Strong Buy rating(s)
3.00

Septerna has a beta of 2.29, meaning that its stock price is 129% more volatile than the broader market. Comparatively, Xenon Pharmaceuticals has a beta of 0.62, meaning that its stock price is 38% less volatile than the broader market.

In the previous week, Xenon Pharmaceuticals had 8 more articles in the media than Septerna. MarketBeat recorded 15 mentions for Xenon Pharmaceuticals and 7 mentions for Septerna. Xenon Pharmaceuticals' average media sentiment score of 0.65 beat Septerna's score of 0.53 indicating that Xenon Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xenon Pharmaceuticals
5 Very Positive mention(s)
0 Positive mention(s)
7 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Xenon Pharmaceuticals beats Septerna on 10 of the 17 factors compared between the two stocks.

How does Septerna compare to Dianthus Therapeutics?

Dianthus Therapeutics (NASDAQ:DNTH) and Septerna (NASDAQ:SEPN) are both healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their earnings, dividends, risk, institutional ownership, valuation, profitability, media sentiment and analyst recommendations.

Dianthus Therapeutics has a beta of 1.22, suggesting that its stock price is 22% more volatile than the broader market. Comparatively, Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market.

In the previous week, Dianthus Therapeutics had 28 more articles in the media than Septerna. MarketBeat recorded 35 mentions for Dianthus Therapeutics and 7 mentions for Septerna. Dianthus Therapeutics' average media sentiment score of 0.54 beat Septerna's score of 0.53 indicating that Dianthus Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Dianthus Therapeutics
10 Very Positive mention(s)
2 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Positive
Septerna
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

47.5% of Dianthus Therapeutics shares are owned by institutional investors. 3.0% of Dianthus Therapeutics shares are owned by company insiders. Comparatively, 5.8% of Septerna shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Septerna has a net margin of -49.88% compared to Dianthus Therapeutics' net margin of -10,096.95%. Septerna's return on equity of -12.72% beat Dianthus Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Dianthus Therapeutics-10,096.95% -22.53% -21.55%
Septerna -49.88%-12.72%-8.87%

Dianthus Therapeutics currently has a consensus target price of $124.27, suggesting a potential upside of 14.10%. Septerna has a consensus target price of $45.89, suggesting a potential upside of 18.18%. Given Septerna's higher probable upside, analysts clearly believe Septerna is more favorable than Dianthus Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Dianthus Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.93
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

Septerna has higher revenue and earnings than Dianthus Therapeutics. Septerna is trading at a lower price-to-earnings ratio than Dianthus Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Dianthus Therapeutics$2.04M2,918.95-$162.34M-$4.15N/A
Septerna$45.95M38.09-$48.88M-$0.81N/A

Summary

Septerna beats Dianthus Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Septerna compare to Ligand Pharmaceuticals?

Ligand Pharmaceuticals (NASDAQ:LGND) and Septerna (NASDAQ:SEPN) are both healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their institutional ownership, valuation, earnings, profitability, risk, analyst recommendations, dividends and media sentiment.

In the previous week, Ligand Pharmaceuticals had 22 more articles in the media than Septerna. MarketBeat recorded 29 mentions for Ligand Pharmaceuticals and 7 mentions for Septerna. Ligand Pharmaceuticals' average media sentiment score of 0.57 beat Septerna's score of 0.53 indicating that Ligand Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ligand Pharmaceuticals
7 Very Positive mention(s)
3 Positive mention(s)
13 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
3 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ligand Pharmaceuticals has a beta of 1.13, suggesting that its share price is 13% more volatile than the broader market. Comparatively, Septerna has a beta of 2.29, suggesting that its share price is 129% more volatile than the broader market.

Ligand Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Ligand Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ligand Pharmaceuticals$290.54M20.22$124.45M$9.3531.35
Septerna$45.95M38.09-$48.88M-$0.81N/A

Ligand Pharmaceuticals has a net margin of 67.88% compared to Septerna's net margin of -49.88%. Ligand Pharmaceuticals' return on equity of 20.06% beat Septerna's return on equity.

Company Net Margins Return on Equity Return on Assets
Ligand Pharmaceuticals67.88% 20.06% 11.68%
Septerna -49.88%-12.72%-8.87%

Ligand Pharmaceuticals presently has a consensus target price of $336.57, indicating a potential upside of 14.81%. Septerna has a consensus target price of $45.89, indicating a potential upside of 18.18%. Given Septerna's higher probable upside, analysts clearly believe Septerna is more favorable than Ligand Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ligand Pharmaceuticals
0 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.88
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

91.3% of Ligand Pharmaceuticals shares are held by institutional investors. 5.6% of Ligand Pharmaceuticals shares are held by company insiders. Comparatively, 5.8% of Septerna shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Summary

Ligand Pharmaceuticals beats Septerna on 11 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SEPN vs. The Competition

MetricSepternaBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$1.75B$3.69B$7.00B$12.99B
Dividend YieldN/A3.76%2.58%10.20%
P/E Ratio-47.949.02270.5825.05
Price / Sales38.091,289.00658.42107.93
Price / CashN/A44.9528.8937.44
Price / Book4.5517.5211.186.43
Net Income-$48.88M-$13.25M$3.45B$348.10M
7 Day Performance11.01%4.99%3.39%2.66%
1 Month Performance8.07%-2.14%-0.71%-0.85%
1 Year Performance232.16%61.21%77.30%23.96%

Septerna Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SEPN
Septerna
2.0778 of 5 stars
$38.83
flat
$45.89
+18.2%
+232.2%$1.75B$45.95MN/AN/A
MIRM
Mirum Pharmaceuticals
2.9626 of 5 stars
$104.33
-0.2%
$143.40
+37.4%
+67.8%$6.36B$521.31MN/A140
CGON
CG Oncology
2.2035 of 5 stars
$71.40
+3.3%
$81.73
+14.5%
+202.2%$6.30B$4.04MN/A61
XENE
Xenon Pharmaceuticals
2.5807 of 5 stars
$64.01
+2.8%
$77.20
+20.6%
+89.5%$6.19B$7.50MN/A210
DNTH
Dianthus Therapeutics
2.1008 of 5 stars
$110.92
+4.6%
$117.82
+6.2%
+480.6%$6.06B$2.04MN/A80

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This page (NASDAQ:SEPN) was last updated on 8/10/2026 by MarketBeat.com Staff.
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