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Septerna (SEPN) Competitors

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$32.21 -1.19 (-3.56%)
Closing price 07/20/2026 04:00 PM Eastern
Extended Trading
$32.22 +0.02 (+0.05%)
As of 07/20/2026 07:34 PM Eastern
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SEPN vs. ERAS, BLTE, TWST, DNTH, and AMRX

Should you buy Septerna stock or one of its competitors? MarketBeat compares Septerna with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Septerna include Erasca (ERAS), Belite Bio (BLTE), Twist Bioscience (TWST), Dianthus Therapeutics (DNTH), and Amneal Pharmaceuticals (AMRX). These companies are all part of the "pharmaceutical products" industry.

How does Septerna compare to Erasca?

Septerna (NASDAQ:SEPN) and Erasca (NASDAQ:ERAS) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, institutional ownership, dividends, risk, valuation, profitability, earnings and media sentiment.

Septerna has higher revenue and earnings than Erasca. Septerna is trading at a lower price-to-earnings ratio than Erasca, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M31.60-$48.88M-$0.81N/A
ErascaN/AN/A-$124.55M-$0.93N/A

Erasca has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Erasca's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Erasca N/A -35.31%-29.49%

67.8% of Erasca shares are owned by institutional investors. 5.8% of Septerna shares are owned by company insiders. Comparatively, 14.2% of Erasca shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Septerna currently has a consensus target price of $45.89, indicating a potential upside of 42.47%. Erasca has a consensus target price of $21.64, indicating a potential upside of 14.96%. Given Septerna's stronger consensus rating and higher probable upside, research analysts clearly believe Septerna is more favorable than Erasca.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Erasca
1 Sell rating(s)
2 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.64

Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market. Comparatively, Erasca has a beta of 0.66, suggesting that its stock price is 34% less volatile than the broader market.

In the previous week, Erasca had 40 more articles in the media than Septerna. MarketBeat recorded 42 mentions for Erasca and 2 mentions for Septerna. Septerna's average media sentiment score of 0.37 beat Erasca's score of 0.13 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Erasca
4 Very Positive mention(s)
3 Positive mention(s)
31 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Neutral

Summary

Septerna beats Erasca on 10 of the 15 factors compared between the two stocks.

How does Septerna compare to Belite Bio?

Septerna (NASDAQ:SEPN) and Belite Bio (NASDAQ:BLTE) are both medical companies, but which is the better business? We will compare the two companies based on the strength of their analyst recommendations, institutional ownership, risk, media sentiment, profitability, valuation, dividends and earnings.

0.5% of Belite Bio shares are owned by institutional investors. 5.8% of Septerna shares are owned by insiders. Comparatively, 13.3% of Belite Bio shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market. Comparatively, Belite Bio has a beta of -1.23, suggesting that its stock price is 223% less volatile than the broader market.

In the previous week, Belite Bio had 4 more articles in the media than Septerna. MarketBeat recorded 6 mentions for Belite Bio and 2 mentions for Septerna. Septerna's average media sentiment score of 0.37 beat Belite Bio's score of 0.27 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Belite Bio
2 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Septerna presently has a consensus target price of $45.89, indicating a potential upside of 42.47%. Belite Bio has a consensus target price of $203.00, indicating a potential upside of 32.82%. Given Septerna's stronger consensus rating and higher probable upside, analysts plainly believe Septerna is more favorable than Belite Bio.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Belite Bio
1 Sell rating(s)
1 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.63

Septerna has higher revenue and earnings than Belite Bio. Belite Bio is trading at a lower price-to-earnings ratio than Septerna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M31.60-$48.88M-$0.81N/A
Belite BioN/AN/A-$77.61M-$2.53N/A

Belite Bio has a net margin of 0.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Belite Bio's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Belite Bio N/A -13.14%-12.88%

Summary

Septerna beats Belite Bio on 12 of the 16 factors compared between the two stocks.

How does Septerna compare to Twist Bioscience?

Septerna (NASDAQ:SEPN) and Twist Bioscience (NASDAQ:TWST) are both medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their media sentiment, institutional ownership, earnings, dividends, profitability, risk, valuation and analyst recommendations.

Twist Bioscience has a net margin of -19.85% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Twist Bioscience's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Twist Bioscience -19.85%-26.73%-19.15%

Septerna presently has a consensus target price of $45.89, indicating a potential upside of 42.47%. Twist Bioscience has a consensus target price of $90.30, indicating a potential upside of 3.26%. Given Septerna's stronger consensus rating and higher probable upside, equities analysts clearly believe Septerna is more favorable than Twist Bioscience.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82
Twist Bioscience
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.70

Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market. Comparatively, Twist Bioscience has a beta of 2.11, suggesting that its stock price is 111% more volatile than the broader market.

In the previous week, Twist Bioscience had 4 more articles in the media than Septerna. MarketBeat recorded 6 mentions for Twist Bioscience and 2 mentions for Septerna. Twist Bioscience's average media sentiment score of 0.55 beat Septerna's score of 0.37 indicating that Twist Bioscience is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Twist Bioscience
1 Very Positive mention(s)
3 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Septerna has higher earnings, but lower revenue than Twist Bioscience. Twist Bioscience is trading at a lower price-to-earnings ratio than Septerna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M31.60-$48.88M-$0.81N/A
Twist Bioscience$376.57M14.46-$77.67M-$1.33N/A

Summary

Septerna beats Twist Bioscience on 10 of the 14 factors compared between the two stocks.

How does Septerna compare to Dianthus Therapeutics?

Dianthus Therapeutics (NASDAQ:DNTH) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their analyst recommendations, institutional ownership, profitability, valuation, dividends, earnings, risk and media sentiment.

47.5% of Dianthus Therapeutics shares are owned by institutional investors. 3.0% of Dianthus Therapeutics shares are owned by insiders. Comparatively, 5.8% of Septerna shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Dianthus Therapeutics currently has a consensus price target of $117.82, suggesting a potential upside of 16.65%. Septerna has a consensus price target of $45.89, suggesting a potential upside of 42.47%. Given Septerna's higher probable upside, analysts plainly believe Septerna is more favorable than Dianthus Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Dianthus Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.93
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

In the previous week, Dianthus Therapeutics had 2 more articles in the media than Septerna. MarketBeat recorded 4 mentions for Dianthus Therapeutics and 2 mentions for Septerna. Septerna's average media sentiment score of 0.37 beat Dianthus Therapeutics' score of 0.33 indicating that Septerna is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Dianthus Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Septerna
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Septerna has higher revenue and earnings than Dianthus Therapeutics. Septerna is trading at a lower price-to-earnings ratio than Dianthus Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Dianthus Therapeutics$2.04M2,706.70-$162.34M-$4.13N/A
Septerna$45.95M31.60-$48.88M-$0.81N/A

Dianthus Therapeutics has a beta of 1.2, suggesting that its stock price is 20% more volatile than the broader market. Comparatively, Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market.

Septerna has a net margin of -49.88% compared to Dianthus Therapeutics' net margin of -12,998.50%. Septerna's return on equity of -12.72% beat Dianthus Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Dianthus Therapeutics-12,998.50% -27.30% -25.91%
Septerna -49.88%-12.72%-8.87%

Summary

Septerna beats Dianthus Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Septerna compare to Amneal Pharmaceuticals?

Amneal Pharmaceuticals (NASDAQ:AMRX) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their risk, analyst recommendations, earnings, dividends, media sentiment, valuation, profitability and institutional ownership.

Amneal Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Amneal Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amneal Pharmaceuticals$3.02B1.85$72.06M$0.3846.05
Septerna$45.95M31.60-$48.88M-$0.81N/A

In the previous week, Amneal Pharmaceuticals had 5 more articles in the media than Septerna. MarketBeat recorded 7 mentions for Amneal Pharmaceuticals and 2 mentions for Septerna. Amneal Pharmaceuticals' average media sentiment score of 1.12 beat Septerna's score of 0.37 indicating that Amneal Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amneal Pharmaceuticals
4 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

31.8% of Amneal Pharmaceuticals shares are held by institutional investors. 17.3% of Amneal Pharmaceuticals shares are held by insiders. Comparatively, 5.8% of Septerna shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Amneal Pharmaceuticals has a beta of 1.26, suggesting that its stock price is 26% more volatile than the broader market. Comparatively, Septerna has a beta of 2.29, suggesting that its stock price is 129% more volatile than the broader market.

Amneal Pharmaceuticals has a net margin of 4.01% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Amneal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amneal Pharmaceuticals4.01% -313.96% 7.49%
Septerna -49.88%-12.72%-8.87%

Amneal Pharmaceuticals currently has a consensus target price of $16.60, suggesting a potential downside of 5.14%. Septerna has a consensus target price of $45.89, suggesting a potential upside of 42.47%. Given Septerna's stronger consensus rating and higher possible upside, analysts plainly believe Septerna is more favorable than Amneal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amneal Pharmaceuticals
0 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.71
Septerna
1 Sell rating(s)
1 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.82

Summary

Amneal Pharmaceuticals beats Septerna on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SEPN vs. The Competition

MetricSepternaMED IndustryMedical SectorNASDAQ Exchange
Market Cap$1.51B$3.69B$6.89B$12.28B
Dividend YieldN/A2.16%2.67%9.39%
P/E Ratio-39.7620.4927.0623.94
Price / Sales31.60300.39517.5191.94
Price / CashN/A60.3126.6847.25
Price / Book3.787.9210.666.14
Net Income-$48.88M$23.81M$3.60B$331.74M
7 Day Performance-6.75%-1.09%-1.23%-1.81%
1 Month Performance-10.95%2.56%1.10%-1.44%
1 Year Performance161.66%42.16%23.65%16.33%

Septerna Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SEPN
Septerna
2.169 of 5 stars
$32.21
-3.6%
$45.89
+42.5%
+156.7%$1.51B$45.95MN/AN/A
ERAS
Erasca
1.8057 of 5 stars
$19.50
+8.9%
$20.30
+4.1%
+1,154.7%$6.06BN/AN/A120
BLTE
Belite Bio
3.334 of 5 stars
$146.68
-0.2%
$203.00
+38.4%
+150.9%$5.88BN/AN/A10
TWST
Twist Bioscience
2.0931 of 5 stars
$92.53
+2.4%
$87.30
-5.7%
+148.6%$5.76B$376.57MN/A990
DNTH
Dianthus Therapeutics
1.9496 of 5 stars
$101.28
+2.7%
$117.82
+16.3%
+395.1%$5.54B$2.04MN/A80

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This page (NASDAQ:SEPN) was last updated on 7/21/2026 by MarketBeat.com Staff.
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