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Septerna (SEPN) Competitors

Septerna logo
$26.30 -0.65 (-2.41%)
Closing price 05/18/2026 04:00 PM Eastern
Extended Trading
$26.28 -0.02 (-0.08%)
As of 07:25 AM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

SEPN vs. TVTX, AMRX, CRNX, MANE, and CPRX

Should you buy Septerna stock or one of its competitors? MarketBeat compares Septerna with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Septerna include Travere Therapeutics (TVTX), Amneal Pharmaceuticals (AMRX), Crinetics Pharmaceuticals (CRNX), MANE (MANE), and Catalyst Pharmaceuticals (CPRX). These companies are all part of the "pharmaceutical products" industry.

How does Septerna compare to Travere Therapeutics?

Septerna (NASDAQ:SEPN) and Travere Therapeutics (NASDAQ:TVTX) are both medical companies, but which is the better business? We will contrast the two businesses based on the strength of their valuation, risk, earnings, dividends, analyst recommendations, institutional ownership, profitability and media sentiment.

Travere Therapeutics has a net margin of -4.00% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Travere Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Travere Therapeutics -4.00%-26.16%-3.71%

In the previous week, Septerna had 11 more articles in the media than Travere Therapeutics. MarketBeat recorded 16 mentions for Septerna and 5 mentions for Travere Therapeutics. Travere Therapeutics' average media sentiment score of 1.19 beat Septerna's score of -0.06 indicating that Travere Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Travere Therapeutics
3 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Travere Therapeutics has higher revenue and earnings than Septerna. Travere Therapeutics is trading at a lower price-to-earnings ratio than Septerna, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M25.80-$48.88M-$0.81N/A
Travere Therapeutics$490.73M8.13-$25.55M-$0.23N/A

Septerna has a beta of 2.21, meaning that its stock price is 121% more volatile than the broader market. Comparatively, Travere Therapeutics has a beta of 1.13, meaning that its stock price is 13% more volatile than the broader market.

Septerna currently has a consensus target price of $43.13, suggesting a potential upside of 63.97%. Travere Therapeutics has a consensus target price of $47.83, suggesting a potential upside of 11.53%. Given Septerna's stronger consensus rating and higher probable upside, research analysts clearly believe Septerna is more favorable than Travere Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80
Travere Therapeutics
1 Sell rating(s)
2 Hold rating(s)
10 Buy rating(s)
0 Strong Buy rating(s)
2.69

Summary

Septerna beats Travere Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Septerna compare to Amneal Pharmaceuticals?

Amneal Pharmaceuticals (NASDAQ:AMRX) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the better investment? We will contrast the two companies based on the strength of their dividends, institutional ownership, valuation, profitability, earnings, risk, analyst recommendations and media sentiment.

Amneal Pharmaceuticals has a net margin of 4.01% compared to Septerna's net margin of -49.88%. Septerna's return on equity of -12.72% beat Amneal Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Amneal Pharmaceuticals4.01% -313.96% 7.49%
Septerna -49.88%-12.72%-8.87%

In the previous week, Septerna had 10 more articles in the media than Amneal Pharmaceuticals. MarketBeat recorded 16 mentions for Septerna and 6 mentions for Amneal Pharmaceuticals. Amneal Pharmaceuticals' average media sentiment score of 0.74 beat Septerna's score of -0.06 indicating that Amneal Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Amneal Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Septerna
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Amneal Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Amneal Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Amneal Pharmaceuticals$3.02B1.26$72.06M$0.3831.37
Septerna$45.95M25.80-$48.88M-$0.81N/A

31.8% of Amneal Pharmaceuticals shares are held by institutional investors. 17.3% of Amneal Pharmaceuticals shares are held by company insiders. Comparatively, 4.3% of Septerna shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term.

Amneal Pharmaceuticals has a beta of 1.32, suggesting that its stock price is 32% more volatile than the broader market. Comparatively, Septerna has a beta of 2.21, suggesting that its stock price is 121% more volatile than the broader market.

Amneal Pharmaceuticals currently has a consensus price target of $15.00, indicating a potential upside of 25.84%. Septerna has a consensus price target of $43.13, indicating a potential upside of 63.97%. Given Septerna's higher probable upside, analysts plainly believe Septerna is more favorable than Amneal Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Amneal Pharmaceuticals
0 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.88
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

Summary

Amneal Pharmaceuticals beats Septerna on 10 of the 16 factors compared between the two stocks.

How does Septerna compare to Crinetics Pharmaceuticals?

Crinetics Pharmaceuticals (NASDAQ:CRNX) and Septerna (NASDAQ:SEPN) are both medical companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, risk, institutional ownership, valuation, media sentiment, analyst recommendations, dividends and profitability.

Septerna has higher revenue and earnings than Crinetics Pharmaceuticals. Septerna is trading at a lower price-to-earnings ratio than Crinetics Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Crinetics Pharmaceuticals$7.70M475.16-$465.32M-$5.13N/A
Septerna$45.95M25.80-$48.88M-$0.81N/A

Crinetics Pharmaceuticals has a beta of 0.28, meaning that its stock price is 72% less volatile than the broader market. Comparatively, Septerna has a beta of 2.21, meaning that its stock price is 121% more volatile than the broader market.

Crinetics Pharmaceuticals presently has a consensus target price of $76.13, suggesting a potential upside of 119.38%. Septerna has a consensus target price of $43.13, suggesting a potential upside of 63.97%. Given Crinetics Pharmaceuticals' stronger consensus rating and higher possible upside, analysts clearly believe Crinetics Pharmaceuticals is more favorable than Septerna.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Crinetics Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.90
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80

98.5% of Crinetics Pharmaceuticals shares are held by institutional investors. 3.8% of Crinetics Pharmaceuticals shares are held by company insiders. Comparatively, 4.3% of Septerna shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Septerna had 8 more articles in the media than Crinetics Pharmaceuticals. MarketBeat recorded 16 mentions for Septerna and 8 mentions for Crinetics Pharmaceuticals. Crinetics Pharmaceuticals' average media sentiment score of 0.09 beat Septerna's score of -0.06 indicating that Crinetics Pharmaceuticals is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Crinetics Pharmaceuticals
3 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Septerna
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Septerna has a net margin of -49.88% compared to Crinetics Pharmaceuticals' net margin of -2,747.18%. Septerna's return on equity of -12.72% beat Crinetics Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Crinetics Pharmaceuticals-2,747.18% -43.96% -39.61%
Septerna -49.88%-12.72%-8.87%

Summary

Septerna beats Crinetics Pharmaceuticals on 9 of the 16 factors compared between the two stocks.

How does Septerna compare to MANE?

Septerna (NASDAQ:SEPN) and MANE (NYSE:MANE) are both pharmaceutical products companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, media sentiment, valuation, institutional ownership, dividends, analyst recommendations, risk and earnings.

Septerna presently has a consensus target price of $43.13, suggesting a potential upside of 63.97%. MANE has a consensus target price of $100.00, suggesting a potential downside of 0.88%. Given Septerna's higher possible upside, research analysts plainly believe Septerna is more favorable than MANE.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80
MANE
0 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.80

In the previous week, Septerna had 11 more articles in the media than MANE. MarketBeat recorded 16 mentions for Septerna and 5 mentions for MANE. Septerna's average media sentiment score of -0.06 beat MANE's score of -0.47 indicating that Septerna is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
MANE
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

MANE has lower revenue, but higher earnings than Septerna.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M25.80-$48.88M-$0.81N/A
MANEN/AN/AN/AN/AN/A

MANE has a net margin of 0.00% compared to Septerna's net margin of -49.88%. MANE's return on equity of 0.00% beat Septerna's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
MANE N/A N/A N/A

Summary

Septerna beats MANE on 6 of the 9 factors compared between the two stocks.

How does Septerna compare to Catalyst Pharmaceuticals?

Septerna (NASDAQ:SEPN) and Catalyst Pharmaceuticals (NASDAQ:CPRX) are both medical companies, but which is the better investment? We will compare the two companies based on the strength of their dividends, institutional ownership, valuation, risk, analyst recommendations, media sentiment, earnings and profitability.

79.2% of Catalyst Pharmaceuticals shares are held by institutional investors. 4.3% of Septerna shares are held by company insiders. Comparatively, 10.4% of Catalyst Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Septerna currently has a consensus price target of $43.13, suggesting a potential upside of 63.97%. Catalyst Pharmaceuticals has a consensus price target of $32.17, suggesting a potential upside of 3.00%. Given Septerna's higher probable upside, research analysts plainly believe Septerna is more favorable than Catalyst Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Septerna
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
1 Strong Buy rating(s)
2.80
Catalyst Pharmaceuticals
0 Sell rating(s)
4 Hold rating(s)
1 Buy rating(s)
3 Strong Buy rating(s)
2.88

Septerna has a beta of 2.21, suggesting that its share price is 121% more volatile than the broader market. Comparatively, Catalyst Pharmaceuticals has a beta of 0.72, suggesting that its share price is 28% less volatile than the broader market.

In the previous week, Septerna had 14 more articles in the media than Catalyst Pharmaceuticals. MarketBeat recorded 16 mentions for Septerna and 2 mentions for Catalyst Pharmaceuticals. Catalyst Pharmaceuticals' average media sentiment score of 0.61 beat Septerna's score of -0.06 indicating that Catalyst Pharmaceuticals is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Septerna
1 Very Positive mention(s)
1 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Catalyst Pharmaceuticals
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Catalyst Pharmaceuticals has higher revenue and earnings than Septerna. Septerna is trading at a lower price-to-earnings ratio than Catalyst Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Septerna$45.95M25.80-$48.88M-$0.81N/A
Catalyst Pharmaceuticals$588.99M6.49$214.33M$1.7417.95

Catalyst Pharmaceuticals has a net margin of 37.08% compared to Septerna's net margin of -49.88%. Catalyst Pharmaceuticals' return on equity of 35.76% beat Septerna's return on equity.

Company Net Margins Return on Equity Return on Assets
Septerna-49.88% -12.72% -8.87%
Catalyst Pharmaceuticals 37.08%35.76%31.31%

Summary

Catalyst Pharmaceuticals beats Septerna on 12 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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SEPN vs. The Competition

MetricSepternaMED IndustryMedical SectorNASDAQ Exchange
Market Cap$1.21B$3.31B$6.25B$12.29B
Dividend YieldN/A2.34%2.80%5.32%
P/E Ratio-32.4718.1320.6425.23
Price / Sales25.80289.87554.8579.36
Price / CashN/A55.2727.4837.30
Price / Book3.086.579.666.63
Net Income-$48.88M$24.35M$3.56B$335.59M
7 Day Performance5.88%-2.53%-1.65%-1.20%
1 Month Performance0.65%-3.55%-2.60%-1.16%
1 Year Performance163.79%53.51%30.07%28.10%

Septerna Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
SEPN
Septerna
3.151 of 5 stars
$26.30
-2.4%
$43.13
+64.0%
+167.3%$1.21B$45.95MN/AN/A
TVTX
Travere Therapeutics
1.9177 of 5 stars
$42.84
-1.5%
$47.83
+11.7%
+155.3%$3.98B$490.73MN/A460
AMRX
Amneal Pharmaceuticals
4.487 of 5 stars
$12.60
-1.4%
$15.00
+19.0%
+56.8%$3.96B$3.02B33.168,500
CRNX
Crinetics Pharmaceuticals
2.2437 of 5 stars
$36.91
+1.0%
$76.13
+106.2%
+11.1%$3.89B$7.70MN/A210
MANE
MANE
N/A$104.05
-3.8%
$83.33
-19.9%
N/A$3.89BN/AN/A19

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This page (NASDAQ:SEPN) was last updated on 5/19/2026 by MarketBeat.com Staff.
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