Oruka Therapeutics (ORKA) Competitors

$60.61 0.00 (0.00%)

Closing price 05/22/2026 04:00 PM Eastern

Extended Trading

$60.87 +0.26 (+0.43%)

As of 05/22/2026 06:12 PM Eastern

ORKA vs. ASND, SMMT, BBIO, RGC, and AXSM

Should you buy Oruka Therapeutics stock or one of its competitors? MarketBeat compares Oruka Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Oruka Therapeutics include Ascendis Pharma A/S (ASND), Summit Therapeutics (SMMT), BridgeBio Pharma (BBIO), Regencell Bioscience (RGC), and Axsome Therapeutics (AXSM). These companies are all part of the "pharmaceutical products" industry.

How does Oruka Therapeutics compare to Ascendis Pharma A/S?

Oruka Therapeutics (NASDAQ:ORKA) and Ascendis Pharma A/S (NASDAQ:ASND) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their dividends, risk, earnings, profitability, valuation, analyst recommendations, institutional ownership and media sentiment.

56.4% of Oruka Therapeutics shares are owned by institutional investors. 23.5% of Oruka Therapeutics shares are owned by insiders. Comparatively, 40.0% of Ascendis Pharma A/S shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

In the previous week, Oruka Therapeutics had 11 more articles in the media than Ascendis Pharma A/S. MarketBeat recorded 15 mentions for Oruka Therapeutics and 4 mentions for Ascendis Pharma A/S. Oruka Therapeutics' average media sentiment score of 0.61 beat Ascendis Pharma A/S's score of 0.50 indicating that Oruka Therapeutics is being referred to more favorably in the media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Oruka Therapeutics	3 Very Positive mention(s)	1 Positive mention(s)	1 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive
Ascendis Pharma A/S	0 Very Positive mention(s)	0 Positive mention(s)	3 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive

Oruka Therapeutics has higher earnings, but lower revenue than Ascendis Pharma A/S. Oruka Therapeutics is trading at a lower price-to-earnings ratio than Ascendis Pharma A/S, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Oruka Therapeutics	N/A	N/A	-$105.43M	-$1.94	N/A
Ascendis Pharma A/S	$814.57M	18.92	-$258M	$8.67	28.49

Oruka Therapeutics presently has a consensus target price of $120.80, indicating a potential upside of 99.31%. Ascendis Pharma A/S has a consensus target price of $295.39, indicating a potential upside of 19.57%. Given Oruka Therapeutics' higher possible upside, equities analysts plainly believe Oruka Therapeutics is more favorable than Ascendis Pharma A/S.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Oruka Therapeutics	1 Sell rating(s)	0 Hold rating(s)	10 Buy rating(s)	0 Strong Buy rating(s)	2.82
Ascendis Pharma A/S	1 Sell rating(s)	0 Hold rating(s)	16 Buy rating(s)	2 Strong Buy rating(s)	3.00

Ascendis Pharma A/S has a net margin of 57.87% compared to Oruka Therapeutics' net margin of 0.00%. Ascendis Pharma A/S's return on equity of 0.00% beat Oruka Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Oruka Therapeutics	N/A	-26.16%	-25.00%
Ascendis Pharma A/S	57.87%	N/A	-8.37%

Oruka Therapeutics has a beta of -0.2, indicating that its share price is 120% less volatile than the broader market. Comparatively, Ascendis Pharma A/S has a beta of 0.41, indicating that its share price is 59% less volatile than the broader market.

Summary

Ascendis Pharma A/S beats Oruka Therapeutics on 11 of the 16 factors compared between the two stocks.

How does Oruka Therapeutics compare to Summit Therapeutics?

Summit Therapeutics (NASDAQ:SMMT) and Oruka Therapeutics (NASDAQ:ORKA) are both medical companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, institutional ownership, dividends, media sentiment, risk, valuation, profitability and analyst recommendations.

Summit Therapeutics currently has a consensus target price of $26.05, indicating a potential upside of 56.76%. Oruka Therapeutics has a consensus target price of $120.80, indicating a potential upside of 99.31%. Given Oruka Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Oruka Therapeutics is more favorable than Summit Therapeutics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Summit Therapeutics	3 Sell rating(s)	6 Hold rating(s)	7 Buy rating(s)	1 Strong Buy rating(s)	2.35
Oruka Therapeutics	1 Sell rating(s)	0 Hold rating(s)	10 Buy rating(s)	0 Strong Buy rating(s)	2.82

In the previous week, Oruka Therapeutics had 9 more articles in the media than Summit Therapeutics. MarketBeat recorded 15 mentions for Oruka Therapeutics and 6 mentions for Summit Therapeutics. Oruka Therapeutics' average media sentiment score of 0.61 beat Summit Therapeutics' score of 0.55 indicating that Oruka Therapeutics is being referred to more favorably in the news media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Summit Therapeutics	0 Very Positive mention(s)	1 Positive mention(s)	3 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive
Oruka Therapeutics	3 Very Positive mention(s)	1 Positive mention(s)	1 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive

Summit Therapeutics has a beta of -1.25, suggesting that its share price is 225% less volatile than the broader market. Comparatively, Oruka Therapeutics has a beta of -0.2, suggesting that its share price is 120% less volatile than the broader market.

Oruka Therapeutics' return on equity of -26.16% beat Summit Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Summit Therapeutics	N/A	-291.24%	-243.07%
Oruka Therapeutics	N/A	-26.16%	-25.00%

4.6% of Summit Therapeutics shares are owned by institutional investors. Comparatively, 56.4% of Oruka Therapeutics shares are owned by institutional investors. 83.5% of Summit Therapeutics shares are owned by company insiders. Comparatively, 23.5% of Oruka Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Oruka Therapeutics is trading at a lower price-to-earnings ratio than Summit Therapeutics, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Summit Therapeutics	N/A	N/A	-$1.08B	-$1.60	N/A
Oruka Therapeutics	N/A	N/A	-$105.43M	-$1.94	N/A

Summary

Oruka Therapeutics beats Summit Therapeutics on 10 of the 14 factors compared between the two stocks.

How does Oruka Therapeutics compare to BridgeBio Pharma?

Oruka Therapeutics (NASDAQ:ORKA) and BridgeBio Pharma (NASDAQ:BBIO) are both medical companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, profitability, institutional ownership, dividends, risk, earnings, analyst recommendations and valuation.

Oruka Therapeutics currently has a consensus price target of $120.80, suggesting a potential upside of 99.31%. BridgeBio Pharma has a consensus price target of $88.90, suggesting a potential upside of 28.62%. Given Oruka Therapeutics' higher possible upside, equities research analysts plainly believe Oruka Therapeutics is more favorable than BridgeBio Pharma.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Oruka Therapeutics	1 Sell rating(s)	0 Hold rating(s)	10 Buy rating(s)	0 Strong Buy rating(s)	2.82
BridgeBio Pharma	1 Sell rating(s)	1 Hold rating(s)	23 Buy rating(s)	0 Strong Buy rating(s)	2.88

Oruka Therapeutics has a net margin of 0.00% compared to BridgeBio Pharma's net margin of -124.42%. BridgeBio Pharma's return on equity of 0.00% beat Oruka Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Oruka Therapeutics	N/A	-26.16%	-25.00%
BridgeBio Pharma	-124.42%	N/A	-65.81%

Oruka Therapeutics has a beta of -0.2, suggesting that its stock price is 120% less volatile than the broader market. Comparatively, BridgeBio Pharma has a beta of 1.02, suggesting that its stock price is 2% more volatile than the broader market.

In the previous week, Oruka Therapeutics and Oruka Therapeutics both had 15 articles in the media. Oruka Therapeutics' average media sentiment score of 0.61 beat BridgeBio Pharma's score of 0.47 indicating that Oruka Therapeutics is being referred to more favorably in the media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Oruka Therapeutics	3 Very Positive mention(s)	1 Positive mention(s)	1 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive
BridgeBio Pharma	5 Very Positive mention(s)	2 Positive mention(s)	5 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Neutral

56.4% of Oruka Therapeutics shares are held by institutional investors. Comparatively, 99.9% of BridgeBio Pharma shares are held by institutional investors. 23.5% of Oruka Therapeutics shares are held by company insiders. Comparatively, 14.2% of BridgeBio Pharma shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Oruka Therapeutics has higher earnings, but lower revenue than BridgeBio Pharma. Oruka Therapeutics is trading at a lower price-to-earnings ratio than BridgeBio Pharma, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Oruka Therapeutics	N/A	N/A	-$105.43M	-$1.94	N/A
BridgeBio Pharma	$502.08M	26.96	-$724.93M	-$3.74	N/A

Summary

Oruka Therapeutics and BridgeBio Pharma tied by winning 7 of the 14 factors compared between the two stocks.

How does Oruka Therapeutics compare to Regencell Bioscience?

Regencell Bioscience (NASDAQ:RGC) and Oruka Therapeutics (NASDAQ:ORKA) are both pharmaceutical products companies, but which is the superior investment? We will compare the two businesses based on the strength of their analyst recommendations, dividends, media sentiment, profitability, valuation, earnings, institutional ownership and risk.

0.1% of Regencell Bioscience shares are owned by institutional investors. Comparatively, 56.4% of Oruka Therapeutics shares are owned by institutional investors. 2.0% of Regencell Bioscience shares are owned by company insiders. Comparatively, 23.5% of Oruka Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Regencell Bioscience's return on equity of 0.00% beat Oruka Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Regencell Bioscience	N/A	N/A	N/A
Oruka Therapeutics	N/A	-26.16%	-25.00%

Regencell Bioscience has a beta of 1.88, meaning that its stock price is 88% more volatile than the broader market. Comparatively, Oruka Therapeutics has a beta of -0.2, meaning that its stock price is 120% less volatile than the broader market.

Oruka Therapeutics has a consensus price target of $120.80, suggesting a potential upside of 99.31%. Given Oruka Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Oruka Therapeutics is more favorable than Regencell Bioscience.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Regencell Bioscience	1 Sell rating(s)	0 Hold rating(s)	0 Buy rating(s)	0 Strong Buy rating(s)	1.00
Oruka Therapeutics	1 Sell rating(s)	0 Hold rating(s)	10 Buy rating(s)	0 Strong Buy rating(s)	2.82

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Regencell Bioscience	N/A	N/A	-$3.58M	N/A	N/A
Oruka Therapeutics	N/A	N/A	-$105.43M	-$1.94	N/A

In the previous week, Oruka Therapeutics had 1 more articles in the media than Regencell Bioscience. MarketBeat recorded 15 mentions for Oruka Therapeutics and 14 mentions for Regencell Bioscience. Oruka Therapeutics' average media sentiment score of 0.61 beat Regencell Bioscience's score of 0.00 indicating that Oruka Therapeutics is being referred to more favorably in the news media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Regencell Bioscience	0 Very Positive mention(s)	1 Positive mention(s)	11 Neutral mention(s)	2 Negative mention(s)	0 Very Negative mention(s)	Neutral
Oruka Therapeutics	3 Very Positive mention(s)	1 Positive mention(s)	1 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive

Summary

Oruka Therapeutics beats Regencell Bioscience on 7 of the 11 factors compared between the two stocks.

How does Oruka Therapeutics compare to Axsome Therapeutics?

Axsome Therapeutics (NASDAQ:AXSM) and Oruka Therapeutics (NASDAQ:ORKA) are both medical companies, but which is the better investment? We will contrast the two companies based on the strength of their risk, analyst recommendations, dividends, valuation, profitability, earnings, institutional ownership and media sentiment.

Axsome Therapeutics has a beta of 0.59, suggesting that its stock price is 41% less volatile than the broader market. Comparatively, Oruka Therapeutics has a beta of -0.2, suggesting that its stock price is 120% less volatile than the broader market.

Axsome Therapeutics currently has a consensus price target of $251.26, indicating a potential upside of 6.48%. Oruka Therapeutics has a consensus price target of $120.80, indicating a potential upside of 99.31%. Given Oruka Therapeutics' higher probable upside, analysts clearly believe Oruka Therapeutics is more favorable than Axsome Therapeutics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Axsome Therapeutics	1 Sell rating(s)	1 Hold rating(s)	18 Buy rating(s)	1 Strong Buy rating(s)	2.90
Oruka Therapeutics	1 Sell rating(s)	0 Hold rating(s)	10 Buy rating(s)	0 Strong Buy rating(s)	2.82

In the previous week, Oruka Therapeutics had 13 more articles in the media than Axsome Therapeutics. MarketBeat recorded 15 mentions for Oruka Therapeutics and 2 mentions for Axsome Therapeutics. Axsome Therapeutics' average media sentiment score of 0.65 beat Oruka Therapeutics' score of 0.61 indicating that Axsome Therapeutics is being referred to more favorably in the media.

Company	Very Positive	Positive	Neutral	Negative	Very Negative	Overall Sentiment
Axsome Therapeutics	1 Very Positive mention(s)	1 Positive mention(s)	0 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive
Oruka Therapeutics	3 Very Positive mention(s)	1 Positive mention(s)	1 Neutral mention(s)	0 Negative mention(s)	0 Very Negative mention(s)	Positive

Oruka Therapeutics has lower revenue, but higher earnings than Axsome Therapeutics. Axsome Therapeutics is trading at a lower price-to-earnings ratio than Oruka Therapeutics, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Axsome Therapeutics	$638.50M	19.02	-$183.17M	-$3.73	N/A
Oruka Therapeutics	N/A	N/A	-$105.43M	-$1.94	N/A

Oruka Therapeutics has a net margin of 0.00% compared to Axsome Therapeutics' net margin of -26.59%. Oruka Therapeutics' return on equity of -26.16% beat Axsome Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Axsome Therapeutics	-26.59%	-267.16%	-28.53%
Oruka Therapeutics	N/A	-26.16%	-25.00%

81.5% of Axsome Therapeutics shares are owned by institutional investors. Comparatively, 56.4% of Oruka Therapeutics shares are owned by institutional investors. 20.6% of Axsome Therapeutics shares are owned by insiders. Comparatively, 23.5% of Oruka Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Summary

Oruka Therapeutics beats Axsome Therapeutics on 9 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding ORKA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.

ORKA vs. The Competition

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Metric	Oruka Therapeutics	MED Industry	Medical Sector	NASDAQ Exchange
Market Cap	$3.66B	$3.03B	$6.43B	$12.32B
Dividend Yield	N/A	1.97%	2.76%	5.28%
P/E Ratio	-31.24	17.79	21.01	25.66
Price / Sales	N/A	784.72	615.84	111.99
Price / Cash	N/A	57.74	43.49	56.67
Price / Book	7.56	5.86	10.37	7.14
Net Income	-$105.43M	$74.99M	$3.57B	$335.98M
7 Day Performance	3.89%	2.55%	6.01%	3.56%
1 Month Performance	-12.20%	-3.05%	3.52%	2.54%
1 Year Performance	453.52%	34.38%	34.13%	35.05%

Oruka Therapeutics Competitors List

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Company	MarketRank	Share Price	Analysts' Price Target	1Y Price Performance	Market Cap	Revenue	P/E Ratio	Employee Count	Indicator(s)
ORKA Oruka Therapeutics	3.6424 of 5 stars	$60.61 flat	$120.80 +99.3%	+453.5%	$3.66B	N/A	N/A	N/A	Insider Trade Gap Down
ASND Ascendis Pharma A/S	3.5441 of 5 stars	$240.50 -2.0%	$291.78 +21.3%	+52.5%	$15.31B	$814.57M	27.74	1,189
SMMT Summit Therapeutics	3.0156 of 5 stars	$16.87 -7.0%	$27.58 +63.5%	-35.7%	$14.08B	N/A	N/A	110	Analyst Downgrade
BBIO BridgeBio Pharma	3.504 of 5 stars	$66.13 -5.1%	$88.19 +33.4%	+107.3%	$13.64B	$502.08M	N/A	400	Gap Up
RGC Regencell Bioscience	0.4813 of 5 stars	$28.58 +6.2%	N/A	N/A	$13.31B	N/A	N/A	10	Gap Up

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This page (NASDAQ:ORKA) was last updated on 5/25/2026 by MarketBeat.com Staff.

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Oruka Therapeutics (ORKA) Competitors

ORKA vs. ASND, SMMT, BBIO, RGC, and AXSM

How does Oruka Therapeutics compare to Ascendis Pharma A/S?

Summary

How does Oruka Therapeutics compare to Summit Therapeutics?

Summary

How does Oruka Therapeutics compare to BridgeBio Pharma?

Summary

How does Oruka Therapeutics compare to Regencell Bioscience?

Summary

How does Oruka Therapeutics compare to Axsome Therapeutics?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

ORKA vs. The Competition

Oruka Therapeutics Competitors List

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Stock Ideas and Recommendations

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Oruka Therapeutics (ORKA) Competitors

ORKA vs. ASND, SMMT, BBIO, RGC, and AXSM

How does Oruka Therapeutics compare to Ascendis Pharma A/S?

Do institutionals and insiders believe in ORKA or ASND?

Does the media prefer ORKA or ASND?

Which has better valuation & earnings, ORKA or ASND?

Do analysts prefer ORKA or ASND?

Is ORKA or ASND more profitable?

Which has more risk and volatility, ORKA or ASND?

Summary

How does Oruka Therapeutics compare to Summit Therapeutics?

Do analysts rate SMMT or ORKA?

Does the media refer more to SMMT or ORKA?

Which has more risk & volatility, SMMT or ORKA?

Is SMMT or ORKA more profitable?

Do institutionals & insiders have more ownership in SMMT or ORKA?

Which has better earnings & valuation, SMMT or ORKA?

Summary

How does Oruka Therapeutics compare to BridgeBio Pharma?

Do analysts recommend ORKA or BBIO?

Is ORKA or BBIO more profitable?

Which has more risk & volatility, ORKA or BBIO?

Does the media prefer ORKA or BBIO?

Do institutionals and insiders have more ownership in ORKA or BBIO?

Which has preferable valuation and earnings, ORKA or BBIO?

Summary

How does Oruka Therapeutics compare to Regencell Bioscience?

Do insiders and institutionals hold more shares of RGC or ORKA?

Is RGC or ORKA more profitable?

Which has more volatility & risk, RGC or ORKA?

Do analysts prefer RGC or ORKA?

Which has higher valuation & earnings, RGC or ORKA?

Does the media favor RGC or ORKA?

Summary

How does Oruka Therapeutics compare to Axsome Therapeutics?

Which has more volatility and risk, AXSM or ORKA?

Do analysts prefer AXSM or ORKA?

Does the media prefer AXSM or ORKA?

Which has better earnings & valuation, AXSM or ORKA?

Is AXSM or ORKA more profitable?

Do institutionals and insiders believe in AXSM or ORKA?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

ORKA vs. The Competition

Oruka Therapeutics Competitors List

Related Companies and Tools

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools