Siren, L.L.C. Top Holdings and 13F Report (2025) About Siren, L.L.C.Investment ActivitySiren, L.L.C. has $4.23 billion in total holdings as of June 30, 2025.Siren, L.L.C. owns shares of 110 different stocks, but just 34 companies or ETFs make up 80% of its holdings.Approximately 9.42% of the portfolio was purchased this quarter.About 13.71% of the portfolio was sold this quarter.This quarter, Siren, L.L.C. has purchased 116 new stocks and bought additional shares in 18 stocks.Siren, L.L.C. sold shares of 36 stocks and completely divested from 24 stocks this quarter.Largest Holdings Scholar Rock $453,000,628Kymera Therapeutics $311,323,747Erasca $193,479,469Revolution Medicines $174,471,000BeOne Medicines AG $170,162,100 Largest New Holdings this Quarter 00654F105 - ADARx Pharmaceuticals, Inc. $38,400,332 HoldingK08588103 - Ascendis Pharma A/S $29,617,900 HoldingG2646Y104 - Damora Therapeutics Inc $19,152,000 Holding92941V407 - Yarrow Bioscience, Inc. $15,201,000 Holding78392B206 - SK hynix Inc. $14,732,000 Holding Largest Purchases this Quarter Tyra Biosciences 2,670,887 shares (about $58.41M)ADARx Pharmaceuticals, Inc. 1,925,794 shares (about $38.40M)Arrowhead Pharmaceuticals 575,000 shares (about $37.63M)Ascendis Pharma A/S 130,000 shares (about $29.62M)Amylyx Pharmaceuticals 1,000,000 shares (about $29.10M) Largest Sales this Quarter Veradermics, Incorporated 331,075 shares (about $40.14M)Abivax SA 388,000 shares (about $38.42M)Xenon Pharmaceuticals 600,258 shares (about $22.32M)Kymera Therapeutics 150,932 shares (about $16.87M)Edgewise Therapeutics 380,450 shares (about $15.45M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSiren, L.L.C. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSRRKScholar Rock$453,000,628$9,664,000 ▼-2.1%9,375,01310.7%HealthcareKYMRKymera Therapeutics$311,323,747$16,872,688 ▼-5.1%2,784,8987.4%HealthcareERASErasca$193,479,469$26,388,000 ▲15.8%13,197,7814.6%HealthcareRVMDRevolution Medicines$174,471,000$10,263,000 ▼-5.6%850,0004.1%HealthcareBeOne Medicines AG$170,162,1000.0%465,0004.0%SPONSORED ADSTNGXTango Therapeutics$169,262,821$15,087,689 ▲9.8%6,784,0814.0%HealthcareVeradermics, Incorporated$160,544,768$40,136,222 ▼-20.0%1,324,2993.8%COMMON STOCKARWRArrowhead Pharmaceuticals$149,911,654$37,633,750 ▲33.5%2,290,4763.5%HealthcareEWTXEdgewise Therapeutics$113,849,667$15,446,270 ▼-11.9%2,804,1792.7%HealthcareRYTMRhythm Pharmaceuticals$103,429,674$4,760,750 ▼-4.4%1,086,2752.4%HealthcareBicara Therapeutics Inc$102,410,272$1,861,000 ▼-1.8%5,502,9702.4%COMParabilis Medicines Inc$96,620,0430.0%2,992,2592.3%COMLXRXLexicon Pharmaceuticals$83,290,6140.0%44,303,5182.0%HealthcareSpyre Therapeutics Inc$77,331,280$8,903,000 ▼-10.3%868,5981.8%COM NEWTYRATyra Biosciences$74,268,049$58,412,299 ▲368.4%3,395,8871.8%HealthcareHemab Therapeutics Holdings Inc$72,974,687$8,616,727 ▲13.4%2,366,2351.7%COM SHSAMLXAmylyx Pharmaceuticals$72,185,053$29,100,000 ▲67.5%2,480,5861.7%HealthcareELVNEnliven Therapeutics$67,621,472$13,717,528 ▼-16.9%1,475,1631.6%HealthcareSepterna, Inc.$66,521,000$7,826,000 ▼-10.5%1,700,0001.6%COMRCUSArcus Biosciences$62,519,7070.0%2,420,4301.5%HealthcareRLAYRelay Therapeutics$58,896,717$6,985,783 ▼-10.6%3,262,9761.4%HealthcareIRONDisc Medicine$58,154,7290.0%888,4011.4%HealthcareSLDBSolid Biosciences$55,601,6280.0%7,690,4051.3%HealthcareSTOKStoke Therapeutics$51,879,0220.0%1,995,3471.2%HealthcareCOGTCogent Biosciences$51,529,114$8,005,000 ▼-13.4%1,609,2791.2%HealthcareTSHATaysha Gene Therapies$47,952,8400.0%9,846,5791.1%HealthcareCYTKCytokinetics$46,727,026$3,295,500 ▼-6.6%708,9521.1%HealthcareORICOric Pharmaceuticals$45,234,846$4,849,200 ▲12.0%3,358,1921.1%HealthcareOLMAOlema Pharmaceuticals$41,964,0390.0%4,856,9491.0%HealthcareDyne Therapeutics, Inc.$39,133,204$4,833,000 ▲14.1%2,429,1250.9%COMADARx Pharmaceuticals, Inc.$38,400,332$38,400,332 ▲New Holding1,925,7940.9%COMRemitly Global Inc$32,933,4030.0%1,543,2710.8%COMSLNSilence Therapeutics$31,564,386$4,629,631 ▼-12.8%2,887,8670.7%HealthcareMSFTMicrosoft$29,748,200$1,795,150 ▼-5.7%58,0000.7%TechnologyAscendis Pharma A/S$29,617,900$29,617,900 ▲New Holding130,0000.7%ORD SHSDNLIDenali Therapeutics$28,865,9240.0%1,396,5130.7%HealthcarePalvella Therapeutics Inc$28,618,406$6,896,500 ▼-19.4%207,4850.7%COMDbv Technologies SA$27,712,899$5,870,322 ▲26.9%2,356,5390.7%SPONSORED ADSCGEMCullinan Therapeutics$27,528,844$1,535,000 ▼-5.3%1,793,4100.7%HealthcareGOOGLAlphabet$27,526,400$3,440,800 ▼-11.1%80,0000.7%Communication ServicesGPCRStructure Therapeutics$27,297,6780.0%872,9670.6%HealthcareXENEXenon Pharmaceuticals$26,713,800$22,323,595 ▼-45.5%718,3060.6%HealthcareKailera Therapeutics Inc$25,287,1460.0%2,214,2860.6%COMMON STOCKAgenus Inc$24,023,282$13,455,279 ▲127.3%2,419,2630.6%COM NEWNVDANVIDIA$22,267,050$570,950 ▲2.6%97,5000.5%TechnologySeaport Therapeutics Inc$22,092,5240.0%1,095,3160.5%COMMON STOCKTRVITrevi Therapeutics$21,822,090$3,765,845 ▼-14.7%1,523,8890.5%HealthcareRapport Therapeutics, Inc.$21,553,3580.0%641,4690.5%COMMonopar Therapeutics Inc.$21,520,3010.0%270,1180.5%COM NEWTSMTaiwan Semiconductor Manufacturing$20,528,550$136,857 ▲0.7%45,0000.5%TechnologyDamora Therapeutics Inc$19,152,000$19,152,000 ▲New Holding900,0000.5%COM SHSAbivax SA$18,615,760$38,419,760 ▼-67.4%188,0000.4%SPONSORED ADSANNXAnnexon$18,440,939$419,134 ▼-2.2%4,359,5600.4%HealthcareENTXEntera Bio$17,460,000$15,316,910 ▲714.7%6,000,0000.4%HealthcareZURAZura Bio$15,537,0430.0%3,734,8660.4%HealthcareYarrow Bioscience, Inc.$15,201,000$15,201,000 ▲New Holding675,0000.4%COMABSIAbsci$14,806,208$11,847,000 ▼-44.4%1,374,7640.3%HealthcareSK hynix Inc.$14,732,000$14,732,000 ▲New Holding80,0000.3%AMERICAN DEPOSITTBLATaboola.com$14,313,156$13,989,501 ▼-49.4%4,259,8680.3%Communication ServicesGHRSGH Research$14,088,000$14,088,000 ▲New Holding600,0000.3%HealthcareRZLTRezolute$13,779,1080.0%3,328,2870.3%HealthcareenGene Therapeutics Inc.$12,513,3240.0%6,256,6620.3%COMNOWServiceNow$12,060,900$1,340,100 ▼-10.0%90,0000.3%TechnologyInhibikase Therapeutics, Inc.$12,021,7500.0%5,850,0000.3%COM NEWYNDXYandex$11,204,300$1,061,460 ▼-8.7%47,5000.3%TechnologyGenerate Biomedicines Inc$11,056,2820.0%736,1040.3%COM SHSDTDynatrace$10,970,600$2,020,900 ▲22.6%190,0000.3%TechnologyACRSAclaris Therapeutics$10,651,500$10,651,500 ▲New Holding2,025,0000.3%HealthcareAVGOBroadcom$10,360,105$1,580,355 ▲18.0%29,5000.2%TechnologyCTMXCytomX Therapeutics$9,404,9740.0%3,457,7110.2%HealthcareAADIAadi Bioscience$8,787,5040.0%2,337,1020.2%HealthcareSatellos Bioscience Inc.$7,582,6290.0%892,0740.2%COMIONQIonQ$7,456,2000.0%170,0000.2%TechnologyDSGNDesign Therapeutics$6,576,7750.0%523,2120.2%HealthcareFROGJFrog$6,453,160$2,814,160 ▼-30.4%66,5000.2%TechnologyEloxx Pharmaceuticals Inc$6,124,0000.0%400,0000.1%COM NEWOCSOculis$5,837,5000.0%625,0000.1%HealthcareCrescent Biopharma, Inc.$5,836,000$5,836,000 ▲New Holding400,0000.1%COMAMZNAmazon.com$5,356,725$2,740,650 ▼-33.8%21,5000.1%Consumer DiscretionaryCRWDCrowdStrike$5,295,000$2,647,500 ▲100.0%20,0000.1%TechnologyNeumora Therapeutics Inc$5,066,4010.0%8,497,8220.1%COMvTv Therapeutics Inc$5,026,9200.0%163,0000.1%CL A NEWDDOGDatadog$4,929,300$6,024,700 ▼-55.0%18,0000.1%TechnologyAgomab Therapeutics NV$4,564,8750.0%411,2500.1%SPONSORED ADSOdyssey Therapeutics Inc$4,444,0000.0%200,0000.1%COMMON STOCKIVVDInvivyd$4,350,5000.0%5,000,0000.1%HealthcareJersey Mike's Subs Inc$4,205,000$4,205,000 ▲New Holding250,0000.1%COM SHS CL AIRENIREN$4,088,000$3,066,000 ▼-42.9%100,0000.1%TechnologyOuster, Inc.$4,034,000$1,311,050 ▲48.1%100,0000.1%COM NEWWise Group PLC$4,022,368$4,022,368 ▲New Holding350,9060.1%ORD SHS CLASS ATTMITTM Technologies$3,685,200$3,685,200 ▲New Holding30,0000.1%TechnologyKorro Bio, Inc.$3,445,8850.0%347,7180.1%COMMNDYmonday.com$2,942,250$392,300 ▼-11.8%37,5000.1%TechnologyAeva Technologies, Inc.$2,808,000$765,756 ▲37.5%200,0000.1%COM NEWAmer Sports Inc$2,729,000$2,729,000 ▲New Holding100,0000.1%COM SHSPalisade Bio Inc$2,700,0000.0%2,000,0000.1%COMFHTXFoghorn Therapeutics$2,572,9700.0%720,7200.1%HealthcareGTLBGitLab$2,362,500$3,543,750 ▼-60.0%50,0000.1%TechnologyBACBank of America$2,177,200$2,177,200 ▲New Holding40,0000.1%FinanceSCHWCharles Schwab$1,466,100$1,466,100 ▲New Holding15,0000.0%FinanceShowing largest 100 holdings. 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