Rhythm Pharmaceuticals (RYTM) Institutional Ownership

$86.84 -3.68 (-4.07%)

Closing price 04:00 PM Eastern

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$87.08 +0.24 (+0.28%)

As of 05:03 PM Eastern

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Number of Institutional Buyers (last 12 months): 183
Total Institutional Inflows (last 12 months): $1.57B

Number of Institutional Sellers (last 12 months): 106
Total Institutional Outflows (last 12 months): $45.34B

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RYTM Institutional Buying and Selling by Quarter

Rhythm Pharmaceuticals Major Shareholders & Ownership History

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Reporting Date	Major Shareholder Name	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
5/18/2026	Rock Springs Capital Management LP	689,748	$59.99M	3.5%	-0.8%	1.006%
5/18/2026	Exome Asset Management LLC	40,581	$3.53M	1.8%	N/A	0.059%
5/16/2026	The Manufacturers Life Insurance Company	50,769	$4.42M	0.0%	-14.8%	0.074%
5/16/2026	First Light Asset Management LLC	87,181	$7.58M	0.7%	-70.5%	0.127%
5/16/2026	SummitTX Capital L.P.	165,599	$14.40M	0.4%	+105.1%	0.242%
5/16/2026	Lazard Asset Management LLC	32,888	$2.86M	0.0%	+28.6%	0.048%
5/16/2026	Castleark Management LLC	52,279	$4.55M	0.2%	-18.9%	0.076%
5/16/2026	Orbimed Advisors LLC	314,100	$27.32M	0.5%	+31.0%	0.458%
5/15/2026	Granahan Investment Management LLC	77,709	$6.76M	0.3%	+45.4%	0.113%
5/15/2026	Entropy Technologies LP	10,318	$897K	0.0%	+314.0%	0.015%
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5/14/2026	Renaissance Technologies LLC	258,011	$22.44M	0.0%	-24.4%	0.376%
5/14/2026	Siren L.L.C.	725,511	$63.10M	1.7%	+45.1%	1.059%
5/14/2026	Inceptionr LLC	4,379	$381K	0.1%	N/A	0.006%
5/14/2026	Sei Investments Co.	40,685	$3.54M	0.0%	+8.7%	0.059%
5/13/2026	First Trust Advisors LP	85,506	$7.44M	0.0%	-3.4%	0.125%
5/8/2026	PNC Financial Services Group Inc.	6,938	$603K	0.0%	+48.9%	0.010%
5/7/2026	WCM Investment Management LLC	80,620	$7.01M	0.0%	+79.9%	0.118%
5/7/2026	Dimensional Fund Advisors LP	19,151	$1.67M	0.0%	-40.2%	0.028%
5/7/2026	AlphaCentric Advisors LLC	9,297	$809K	0.8%	+84.0%	0.014%
5/7/2026	Swiss National Bank	112,200	$9.76M	0.0%	+0.8%	0.164%
5/5/2026	Bank of New York Mellon Corp	293,298	$25.51M	0.0%	-2.6%	0.428%
5/5/2026	Hillsdale Investment Management Inc.	40,300	$3.51M	0.1%	-4.7%	0.059%
5/4/2026	Principal Financial Group Inc.	5,637	$490K	0.0%	-9.1%	0.008%
5/4/2026	Chicago Partners Investment Group LLC	3,125	$266K	0.0%	+14.1%	0.005%
5/1/2026	Fifth Third Bancorp	5,260	$457K	0.0%	N/A	0.008%
5/1/2026	Candriam S.C.A.	464,340	$40.38M	0.2%	+61.3%	0.680%
4/30/2026	Hsbc Holdings PLC	14,307	$1.23M	0.0%	N/A	0.021%
4/28/2026	Abel Hall LLC	4,015	$349K	0.1%	+87.6%	0.006%
4/25/2026	Strs Ohio	28,914	$2.52M	0.0%	+141.0%	0.042%
4/22/2026	Pictet Asset Management Holding SA	667,046	$57.33M	0.1%	+8.5%	0.977%
4/16/2026	SG Americas Securities LLC	18,760	$1.63M	0.0%	+59.8%	0.027%
4/16/2026	E. Ohman J or Asset Management AB	4,409	$383K	0.0%	-33.1%	0.006%
3/17/2026	Rockefeller Capital Management L.P.	11,771	$1.26M	0.0%	+32.7%	0.017%
2/19/2026	Invesco Ltd.	291,150	$31.17M	0.0%	+102.8%	0.436%
2/18/2026	Empowered Funds LLC	4,164	$446K	0.0%	+94.1%	0.006%
2/18/2026	XTX Topco Ltd	10,433	$1.12M	0.0%	N/A	0.016%
2/18/2026	Voloridge Investment Management LLC	60,575	$6.48M	0.0%	-83.6%	0.091%
2/18/2026	Virtus Investment Advisers LLC	6,017	$644K	0.2%	-14.7%	0.009%
2/18/2026	Wellington Management Group LLP	250,156	$26.78M	0.0%	+922.0%	0.375%
2/18/2026	SummitTX Capital L.P.	80,729	$8.64M	0.3%	+580.2%	0.121%
Read now. Do not delete. You’ve been warned. (Ad) Three Nobel Prize Winners expose this once-in-a-generation wealth shift: “Don’t Say I Didn’t Warn You” Porter Stansberry exposes how the convergence of three immense forces is about to rewrite everything about the American way of life: how you work, save, invest… it’s all about to change. Don’t be left behind. Click here now.
2/18/2026	Orbimed Advisors LLC	239,800	$25.67M	0.5%	+11.5%	0.359%
2/18/2026	Opaleye Management Inc.	330,000	$35.32M	4.6%	-28.5%	0.494%
2/18/2026	Perceptive Advisors LLC	2,546,391	$272.57M	4.9%	-99.4%	3.816%
2/18/2026	Millennium Management LLC	186,709	$19.99M	0.0%	+17.7%	0.280%
2/18/2026	Man Group plc	9,558	$1.02M	0.0%	-92.6%	0.014%
2/18/2026	Janus Henderson Group PLC	1,126,125	$120.59M	0.1%	-3.0%	1.687%
2/18/2026	Caption Management LLC	4,614	$494K	0.0%	-83.3%	0.007%
2/18/2026	Cinctive Capital Management LP	3,225	$345K	0.0%	-90.8%	0.005%
2/18/2026	Balyasny Asset Management L.P.	72,282	$7.74M	0.0%	-79.3%	0.108%
2/17/2026	Guggenheim Capital LLC	12,401	$1.33M	0.0%	+442.7%	0.019%
2/17/2026	Logos Global Management LP	190,000	$20.34M	1.2%	-5.0%	0.285%
2/17/2026	ADAR1 Capital Management LLC	51,349	$5.50M	0.4%	+3.6%	0.077%
2/17/2026	PDT Partners LLC	59,436	$6.36M	0.4%	-31.0%	0.089%
2/17/2026	AQR Capital Management LLC	70,046	$7.50M	0.0%	-12.2%	0.105%
2/17/2026	Abel Hall LLC	2,140	$229K	0.1%	N/A	0.003%
2/17/2026	EFG International AG	29,291	$3.14M	0.1%	N/A	0.044%
2/17/2026	Lazard Asset Management LLC	25,571	$2.74M	0.0%	-15.4%	0.038%
2/17/2026	First Light Asset Management LLC	295,844	$31.67M	2.4%	+63.9%	0.443%
2/17/2026	RA Capital Management L.P.	6,666,837	$713.62M	7.3%	+17.3%	9.989%
2/17/2026	Quantedge Capital Pte Ltd	5,600	$599K	0.3%	-68.5%	0.008%
2/17/2026	Jump Financial LLC	6,759	$723K	0.0%	N/A	0.010%
2/17/2026	Price T Rowe Associates Inc. MD	1,560,847	$167.07M	0.0%	+11.5%	2.339%
2/17/2026	Rock Springs Capital Management LP	695,010	$74.39M	3.8%	-3.1%	1.041%
2/17/2026	Integral Health Asset Management LLC	475,000	$50.84M	2.5%	+115.9%	0.712%
2/17/2026	Adage Capital Partners GP L.L.C.	621,585	$66.53M	0.1%	+14.3%	0.931%
2/17/2026	California State Teachers Retirement System	53,537	$5.73M	0.0%	+9.4%	0.080%
2/17/2026	Russell Investments Group Ltd.	134,180	$14.36M	0.0%	-14.9%	0.201%
2/17/2026	Atom Investors LP	22,929	$2.45M	0.2%	N/A	0.034%
2/17/2026	Granahan Investment Management LLC	53,452	$5.72M	0.2%	+7.5%	0.080%
2/17/2026	State of Wisconsin Investment Board	36,079	$3.86M	0.0%	-11.5%	0.054%
2/17/2026	Artisan Partners Limited Partnership	263,591	$28.22M	0.0%	+11.3%	0.395%
2/17/2026	Fred Alger Management LLC	9,301	$996K	0.0%	-24.6%	0.014%
2/17/2026	ExodusPoint Capital Management LP	75,141	$8.04M	0.1%	N/A	0.113%
2/17/2026	Royal Bank of Canada	1,676	$180K	0.0%	-98.7%	0.003%
2/17/2026	Magnetar Financial LLC	29,598	$3.17M	0.0%	N/A	0.044%
2/17/2026	Persistent Asset Partners Ltd	1,446	$155K	0.1%	N/A	0.002%
2/17/2026	Polar Capital Holdings Plc	1,185,392	$126.88M	0.5%	-4.8%	1.776%
2/16/2026	Squarepoint Ops LLC	32,829	$3.51M	0.0%	N/A	0.049%
2/16/2026	Sofinnova Investments Inc.	271,394	$29.05M	1.2%	+9.9%	0.407%
2/16/2026	Verition Fund Management LLC	4,504	$482K	0.0%	N/A	0.007%
2/16/2026	NEXTBio Capital Management LP	67,586	$7.23M	4.2%	N/A	0.101%
2/16/2026	Nicholas Investment Partners LP	34,710	$3.72M	0.3%	N/A	0.052%
2/16/2026	First Turn Management LLC	146,303	$15.66M	1.8%	N/A	0.219%
2/16/2026	Kennedy Capital Management LLC	39,887	$4.27M	0.1%	+0.8%	0.060%
2/16/2026	Entropy Technologies LP	2,492	$267K	0.0%	-70.7%	0.004%
2/16/2026	Arax Advisory Partners	381	$41K	0.0%	-51.2%	0.001%
2/16/2026	Barclays PLC	131,436	$14.07M	0.0%	-7.7%	0.197%
2/13/2026	The Manufacturers Life Insurance Company	59,609	$6.37M	0.0%	-2.1%	0.089%
2/13/2026	CANADA LIFE ASSURANCE Co	5,797	$621K	0.0%	-59.7%	0.009%
2/13/2026	Stifel Financial Corp	13,247	$1.42M	0.0%	-8.4%	0.020%
Read now. Do not delete. You’ve been warned. (Ad) Three Nobel Prize Winners expose this once-in-a-generation wealth shift: “Don’t Say I Didn’t Warn You” Porter Stansberry exposes how the convergence of three immense forces is about to rewrite everything about the American way of life: how you work, save, invest… it’s all about to change. Don’t be left behind. Click here now.
2/13/2026	Smartleaf Asset Management LLC	399	$43K	0.0%	+39.5%	0.001%
2/13/2026	Morgan Stanley	651,402	$69.73M	0.0%	+40.0%	0.976%
2/13/2026	Rafferty Asset Management LLC	55,526	$5.94M	0.0%	-0.4%	0.083%
2/13/2026	First Trust Advisors LP	88,505	$9.47M	0.0%	+9.4%	0.133%
2/13/2026	Headlands Technologies LLC	8,632	$924K	0.1%	N/A	0.013%
2/13/2026	Charles Schwab Investment Management Inc.	532,447	$56.99M	0.0%	+0.9%	0.798%
2/13/2026	Police & Firemen s Retirement System of New Jersey	14,183	$1.52M	0.0%	-2.9%	0.021%
2/13/2026	State Street Corp	2,198,615	$235.34M	0.0%	+8.4%	3.294%
2/13/2026	UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	549,020	$58.77M	0.0%	+25.5%	0.823%
2/13/2026	Wells Fargo & Company MN	72,617	$7.77M	0.0%	+54.1%	0.109%

RYTM Institutional Ownership - Frequently Asked Questions

During the previous two years, 284 institutional investors and hedge funds held shares of Rhythm Pharmaceuticals. The most heavily invested institutionals were RA Capital Management L.P. ($713.62M), Vanguard Group Inc. ($664.82M), Primecap Management Co. CA ($372.36M), Baker BROS. Advisors LP ($296.87M), Perceptive Advisors LLC ($272.57M), State Street Corp ($235.34M), and Goldman Sachs Group Inc. ($195.98M).Learn more on Rhythm Pharmaceuticals' institutional investors.

Of the 247 institutional investors that purchased Rhythm Pharmaceuticals' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: Vanguard Group Inc. ($2.62M), Westfield Capital Management Co. LP ($1.83M), JPMorgan Chase & Co. ($1.46M), RA Capital Management L.P. ($1.11M), Capital Research Global Investors ($985.09K), Alliancebernstein L.P. ($920.11K), and Price T Rowe Associates Inc. MD ($809.47K).

Institutional investors have bought a total of 16,580,124 shares in the last 24 months. This purchase volume represents approximately $1.57B in transactions.

Of the 106 institutional investors that sold Rhythm Pharmaceuticals' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Perceptive Advisors LLC ($416.69M), Primecap Management Co. CA ($2.31M), Balyasny Asset Management L.P. ($579.35K), Westfield Capital Management Co. LP ($560.46K), Marshall Wace LLP ($363.27K), Voloridge Investment Management LLC ($307.69K), and Comerica Bank ($297.65K).

Institutional investors have sold a total of 424,779,872 shares in the last 24 months. This volume of shares sold represents approximately $45.34B in transactions.

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This page (NASDAQ:RYTM) was last updated on 5/18/2026 by MarketBeat.com Staff.

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Rhythm Pharmaceuticals (RYTM) Institutional Ownership

RYTM Institutional Buying and Selling by Quarter

Rhythm Pharmaceuticals Major Shareholders & Ownership History

RYTM Institutional Ownership - Frequently Asked Questions

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Rhythm Pharmaceuticals (RYTM) Institutional Ownership

Institutional Ownership Changes (13F Filings) for Rhythm Pharmaceuticals (NASDAQ:RYTM)

RYTM Institutional Buying and Selling by Quarter

Rhythm Pharmaceuticals Major Shareholders & Ownership History

RYTM Institutional Ownership - Frequently Asked Questions

Who are the largest shareholders of RYTM shares?

Which institutional investors have been buying Rhythm Pharmaceuticals' stock?

How much institutional buying is happening at Rhythm Pharmaceuticals?

Which of Rhythm Pharmaceuticals' major shareholders have been selling company stock?

How much institutional selling is happening at Rhythm Pharmaceuticals?

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