Lowest-Rated StocksLowest-RatedNASDAQ:SION Sionna Therapeutics (SION) Stock Price, News & Analysis $5.96 -1.22 (-16.99%) Closing price 09/18/2026 04:00 PM EasternExtended Trading$6.03 +0.07 (+1.24%) As of 09/18/2026 07:50 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsInsider TradesNews and TrendsOwnershipSEC FilingsShort Interest About Sionna Therapeutics Stock (NASDAQ:SION) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Sionna Therapeutics alerts:Sign Up Key Stats Today's Range$5.90▼$7.1950-Day Range$4.50▼$51.0452-Week Range$4.01▼$54.97Volume3.68 million shsAverage Volume1.30 million shsMarket Capitalization$269.45 millionP/E RatioN/ADividend YieldN/APrice Target$42.33Consensus RatingHold Company Overview Sionna Therapeutics is a clinical-stage biopharmaceutical company focused on developing treatments for cystic fibrosis (CF), a genetic disease that affects the lungs and other organs. The company is developing small-molecule therapies designed to address defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which is responsible for transporting salt and fluids across cell membranes. Sionna’s research is centered on nucleotide-binding domain 1 (NBD1) correctors. These investigational medicines are intended to stabilize and improve the function of defective CFTR proteins, including proteins affected by the common F508del mutation. The company’s approach is designed to potentially form part of combination therapies that target multiple stages of CFTR production, processing and activity. Sionna’s pipeline includes preclinical and clinical-stage programs evaluating the safety, tolerability and pharmacological activity of its CFTR modulators. The company’s goal is to develop oral treatments that may benefit a broad population of people with cystic fibrosis, including patients who have limited treatment options because of the specific mutations they carry.AI Generated. May Contain Errors. Read More Sionna Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks63rd Percentile Overall ScoreSION MarketRank™: Sionna Therapeutics scored higher than 63% of companies evaluated by MarketBeat, and ranked 292nd out of 897 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion4.0 / 5Analyst RatingHold Consensus RatingSionna Therapeutics has received a consensus rating of Hold. The company's average rating score is 2.00, and is based on no strong buy ratings, 1 buy rating, 11 hold ratings, and 1 sell rating.Upside PotentialSionna Therapeutics has a consensus price target of $42.33, representing about 610.3% upside from its current price of $5.96.Amount of Analyst CoverageSionna Therapeutics has been the subject of 11 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Sionna Therapeutics' stock forecast and price target. Earnings and Valuation1.3 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Sionna Therapeutics are expected to grow in the coming year, from ($2.54) to ($2.44) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Sionna Therapeutics is -2.73, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Sionna Therapeutics is -2.73, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioSionna Therapeutics has a P/B Ratio of 0.87. P/B Ratios below 1 indicate that a company could be undervalued with respect to its assets and liabilities. Short Interest2.0 / 5Short Interest LevelBearish Percentage of Shares Shorted10.02% of the float of Sionna Therapeutics has been sold short.Short Interest Ratio / Days to CoverSionna Therapeutics has a short interest ratio ("days to cover") of 2.62, which is generally considered an acceptable ratio of short interest to trading volume.Change versus previous monthShort interest in Sionna Therapeutics has recently increased by 1.20%, indicating that investor sentiment is decreasing. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldSionna Therapeutics does not currently pay a dividend.Dividend GrowthSionna Therapeutics does not have a long track record of dividend growth. News and Social Media2.5 / 5News Sentiment0.00 News SentimentSionna Therapeutics has a news sentiment score of 0.00. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.56 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 14 news articles for Sionna Therapeutics this week, compared to 5 articles on an average week.Search Interest16 people have searched for SION on MarketBeat in the last 30 days. This is an increase of 100% compared to the previous 30 days. Company Ownership0.9 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Sionna Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $18,250,367.00 in company stock.Percentage Held by Insiders5.10% of the stock of Sionna Therapeutics is held by insiders.Percentage Held by InstitutionsSionna Therapeutics has minimal institutional ownership at this time.Read more about Sionna Therapeutics' insider trading history. 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Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. SION Stock News HeadlinesSionna Therapeutics, Inc. (NASDAQ:SION) Receives $42.22 Consensus Target Price from AnalystsSeptember 18 at 3:44 AM | americanbankingnews.comSionna Therapeutics (SION) Approves 46% Job Cut. Can a New Trial Make its Cash More Productive?September 17 at 6:36 PM | finance.yahoo.comBank of America: 'Digital Dollar Inevitable'Bank of America just revealed your expiration date. In their Bloomberg interview, they didn't just predict the digital dollar. They gave us the timeline… 2025 to 2030. We're in that window right now. Once the digital dollar launches, every transaction you make will be tracked. Your spending could be controlled. Your accounts could be frozen. Over 4,500 investors have already used this legal backdoor to hold assets CBDCs can't freeze and generate yields the Federal Reserve can't touch.September 20 at 1:00 AM | Decentralized Masters (Ad)INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONSeptember 17 at 10:00 AM | prnewswire.comSionna Therapeutics (NASDAQ:SION) Stock Price Expected to Rise, Wedbush Analyst SaysSeptember 17 at 1:30 AM | americanbankingnews.comStifel Nicolaus Keeps Their Hold Rating on Sionna Therapeutics, Inc. (SION)September 16, 2026 | theglobeandmail.comSION to Cut Workforce by Nearly Half After CF Study Failure, Stock DownSeptember 16, 2026 | finance.yahoo.comINVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SIONSeptember 15, 2026 | globenewswire.comSee More Headlines SION Stock Analysis - Frequently Asked Questions How have SION shares performed this year? Sionna Therapeutics' stock was trading at $41.14 at the beginning of the year. Since then, SION stock has decreased by 85.5% and is now trading at $5.96. How were Sionna Therapeutics' earnings last quarter? Sionna Therapeutics, Inc. (NASDAQ:SION) announced its quarterly earnings data on Thursday, August, 6th. The company reported ($0.66) EPS for the quarter, missing the consensus estimate of ($0.64) by $0.02. When did Sionna Therapeutics IPO? Sionna Therapeutics (SION) raised $180 million in an initial public offering on Friday, February 7th 2025. The company issued 10,588,233 shares at $16.00-$18.00 per share. Who are Sionna Therapeutics' major shareholders? Sionna Therapeutics' top institutional investors include BlackRock Inc. (3.27%), Artia Global Partners LP (0.26%), Walleye Capital LLC (0.22%) and Bank of America Corp DE (0.20%). Insiders that own company stock include Tpg Gp A, Llc, Peter A Thompson, Orbimed Advisors Llc, Bruce Booth, Michael Cloonan, Ra Capital Management, LP and Elena Ridloff. View institutional ownership trends. How do I buy shares of Sionna Therapeutics? Shares of SION stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. Company Calendar Last Earnings8/06/2026Today9/19/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (6d) 1-Year History Sep 25 Dec 25 Mar 26 Jun 26 Sep 26 For the last 6 days, SION's financial health has been in the Green zone, according to TradeSmith. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:SION Previous SymbolNASDAQ:SION CIK2036042 Webwww.sionnatx.com Phone(617) 819-2020FaxN/AEmployees59Year FoundedN/APrice Target and Rating Average Price Target for Sionna Therapeutics$42.33 High Price Target$63.00 Low Price Target$5.00 Potential Upside/Downside+610.3%Consensus RatingHold Rating Score (0-4)2.00 Research Coverage13 Analysts Profitability EPS (Trailing Twelve Months)($2.18) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$75.27 million Net MarginsN/A Pretax MarginN/A Return on Equity-32.94% Return on Assets-31.08% Debt Debt-to-Equity RatioN/A Current Ratio20.05 Quick Ratio20.05 Sales & Book Value Annual SalesN/A Price / SalesN/A Cash FlowN/A Price / Cash FlowN/A Book Value$6.88 per share Price / Book0.87Miscellaneous Outstanding Shares45,210,000Free Float42,906,000Market Cap$269.45 million OptionableN/A Beta0.89 The Best Nuclear Energy Stocks to BuyNuclear energy is entering a new growth cycle as rising power demand, expanding data centers, and renewed policy support bring the sector back into focus. 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