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Spero Therapeutics (SPRO) Institutional Ownership

Spero Therapeutics logo
$2.21 -0.07 (-3.07%)
Closing price 06/22/2026 04:00 PM Eastern
Extended Trading
$2.19 -0.02 (-0.90%)
As of 06:22 AM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.
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Institutional Ownership Changes (13F Filings) for Spero Therapeutics (NASDAQ:SPRO)

Current
Institutional Ownership
Percentage
25.60%
Number of
Institutional Buyers
(last 12 months)
20
Total
Institutional Inflows
(last 12 months)
$24.20M
Number of
Institutional Sellers
(last 12 months)
10
Total
Institutional Outflows
(last 12 months)
$4.08M
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SPRO Institutional Buying and Selling by Quarter

Spero Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
5/19/2026 Anson Funds Management LP421,956$987K0.1%-32.5%0.729%
5/15/2026 OMERS ADMINISTRATION Corp39,400$92K0.0%-70.0%0.068%
5/14/2026 Renaissance Technologies LLC1,189,235$2.78M0.0%-7.1%2.054%
2/18/2026 XTX Topco Ltd15,175$35K0.0%-55.1%0.027%
2/18/2026 Quadrature Capital Ltd37,799$88K0.0%N/A0.067%
2/18/2026 Millennium Management LLC24,107$56K0.0%N/A0.043%
2/18/2026 Intrepid Family Office LLC165,000$384K0.3%+50.0%0.293%
2/18/2026 Ionic Capital Management LLC195,939$457K0.1%-6.1%0.348%
2/17/2026 Anson Funds Management LP625,062$1.46M0.1%-61.0%1.109%
2/16/2026 Squarepoint Ops LLC119,434$278K0.0%N/A0.212%
2/16/2026 OMERS ADMINISTRATION Corp131,127$306K0.0%N/A0.233%
2/13/2026 State Street Corp210,151$490K0.0%+10.1%0.373%
2/12/2026 GSK plc9,190,606$21.41M2.7%N/A16.313%
2/12/2026 Renaissance Technologies LLC1,279,522$2.98M0.0%-11.9%2.271%
2/12/2026 Informed Momentum Co LLC218,084$508K0.1%-22.8%0.387%
1/9/2026 Assenagon Asset Management S.A.18,636$43K0.0%-49.6%0.033%
11/17/2025 Ionic Capital Management LLC208,725$392K0.0%+39.2%0.370%
11/17/2025 Anson Funds Management LP1,603,569$3.02M0.2%-0.7%2.846%
11/14/2025 ADAR1 Capital Management LLC115,539$217K0.0%-19.7%0.205%
11/14/2025 Shay Capital LLC63,667$120K0.0%N/A0.113%
11/14/2025 Two Sigma Investments LP49,399$93K0.0%N/A0.088%
11/13/2025 Arrowstreet Capital Limited Partnership150,516$283K0.0%N/A0.267%
11/12/2025 Dimensional Fund Advisors LP28,994$55K0.0%N/A0.052%
11/7/2025 GSA Capital Partners LLP106,894$201K0.0%N/A0.190%
11/7/2025Vanguard Group Inc.1,989,855$3.74M0.0%+2.0%3.536%
10/7/2025 Assenagon Asset Management S.A.36,993$70K0.0%N/A0.066%
8/15/2025 Bridgeway Capital Management LLC114,800$333K0.0%-25.8%0.204%
8/13/2025 Stonepine Capital Management LLC156,888$455K0.4%N/A0.281%
8/13/2025 Invesco Ltd.14,968$43K0.0%N/A0.027%
8/13/2025 Quadrature Capital Ltd31,205$90K0.0%N/A0.056%
8/12/2025 XTX Topco Ltd34,551$100K0.0%N/A0.062%
8/8/2025 Geode Capital Management LLC510,699$1.48M0.0%-2.7%0.913%
7/28/2025 Axxcess Wealth Management LLC32,548$94K0.0%N/A0.058%
7/7/2025 Capital Asset Advisory Services LLC32,548$94K0.0%N/A0.058%
5/28/2025Anson Funds Management LP3,798,932$2.74M0.4%-1.1%6.795%
5/21/2025Acadian Asset Management LLC871,212$626K0.0%-16.2%1.558%
5/14/2025Anson Funds Management LP7,638,818$5.50M0.8%+98.9%13.662%
5/7/2025Mackenzie Financial Corp209,031$151K0.0%+11.4%0.374%
2/20/2025Mackenzie Financial Corp187,559$193K0.0%+487.9%0.344%
2/17/2025Squarepoint Ops LLC55,051$57K0.0%N/A0.101%
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2/17/2025Anson Funds Management LP3,839,886$3.96M0.4%+2.4%7.043%
2/14/2025Jane Street Group LLC52,869$54K0.0%N/A0.097%
2/14/2025Northern Trust Corp86,447$89K0.0%-22.5%0.159%
2/14/2025Three Seasons Wealth LLC30,000$31K0.0%N/A0.055%
2/13/2025XTX Topco Ltd30,138$31K0.0%N/A0.055%
2/13/2025Renaissance Technologies LLC1,105,591$1.14M0.0%+13.4%2.028%
2/13/2025ADAR1 Capital Management LLC801,277$825K0.2%+7.8%1.470%
2/12/2025JPMorgan Chase & Co.61,624$63K0.0%+26,011.9%0.113%
2/11/2025Prudential Financial Inc.49,200$51K0.0%N/A0.090%
2/11/2025Virtu Financial LLC46,046$47K0.0%N/A0.084%
2/10/2025Monimus Capital Management LP310,908$320K0.3%N/A0.570%
2/6/2025Atlas Venture Life Science Advisors LLC305,255$314K0.0%-24.2%0.560%
11/16/2024Geode Capital Management LLC481,187$645K0.0%-2.2%0.891%
8/9/2024Renaissance Technologies LLC975,952$1.27M0.0%+14.2%1.808%
8/9/2024Atlas Venture Life Science Advisors LLC535,336$696K0.1%-11.9%0.992%
8/6/2024Acadian Asset Management LLC1,071,860$1.39M0.0%+40.6%1.985%
5/20/2024Virtu Financial LLC18,180$31K0.0%N/A0.034%
5/16/2024Murchinson Ltd.873,910$1.50M0.1%+1.3%1.622%
5/14/2024Anson Funds Management LP3,750,450$6.45M0.4%-12.7%6.959%
5/10/2024Acadian Asset Management LLC762,598$1.31M0.0%+121.8%1.415%
5/10/2024Vanguard Group Inc.1,653,432$2.84M0.0%+0.6%3.068%
5/6/2024Atlas Venture Life Science Advisors LLC607,613$1.05M0.1%-40.0%1.128%
2/14/2024ADAR1 Capital Management LLC1,067,711$1.57M0.6%N/A2.015%
11/15/2023Rock Springs Capital Management LP57,373$69K0.0%-91.4%0.109%
11/14/2023AWM Investment Company Inc.333,400$403K0.1%-13.0%0.632%
11/13/2023Acadian Asset Management LLC272,024$327K0.0%+56.8%0.516%
8/14/2023Anson Funds Management LP3,444,862$5.00M0.8%+3.0%6.537%
8/11/2023AWM Investment Company Inc.383,400$556K0.1%-70.5%0.729%
8/11/2023Atlas Venture Life Science Advisors LLC1,013,438$1.47M0.2%-1.7%1.928%
8/7/2023Acadian Asset Management LLC173,539$250K0.0%N/A0.330%
8/7/2023Royce & Associates LP22,851$33K0.0%N/A0.043%
8/3/2023Mackenzie Financial Corp17,198$25K0.0%N/A0.033%
7/27/2023Virtu Financial LLC22,195$32K0.0%N/A0.042%
5/15/2023Anson Funds Management LP3,344,862$4.85M0.8%+10.8%6.363%
4/17/2023Bourgeon Capital Management LLC25,600$37K0.0%+95.4%0.049%
2/14/2023AWM Investment Company Inc.1,300,400$2.25M0.3%-43.5%3.708%
11/16/2022Alphabet Inc.889,979$1.78M0.1%N/A2.538%
11/16/2022Anson Funds Management LP1,473,872$2.95M0.3%N/A4.203%
11/15/2022Murchinson Ltd.762,700$1.53M0.4%N/A2.175%
11/15/2022BVF Inc. IL1,929,376$3.86M0.2%-37.6%5.501%
10/21/2022Weitzel Financial Services Inc.14,200$28K0.0%N/A0.040%
8/9/2022Kingsbury Capital Investment Advisors LLC60,844$45K0.1%N/A0.185%
7/27/2022Assenagon Asset Management S.A.131,020$97K0.0%+466.6%0.399%
5/17/2022Rock Springs Capital Management LP990,913$8.62M0.2%+4.8%3.025%
5/16/2022Eversept Partners LP59,639$519K0.0%N/A0.182%
5/16/2022Granahan Investment Management LLC113,322$986K0.0%-70.1%0.346%
5/11/2022GSA Capital Partners LLP25,916$225K0.0%N/A0.079%
5/6/2022Sentinel Pension Advisors Inc.42,000$365K0.1%+39.1%0.128%
5/5/2022New York State Common Retirement Fund17,123$149K0.0%-68.1%0.052%
5/3/2022Bourgeon Capital Management LLC63,096$549K0.1%+23.1%0.193%
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4/25/2022Assenagon Asset Management S.A.23,123$201K0.0%N/A0.071%


SPRO Institutional Ownership - Frequently Asked Questions

During the previous two years, 36 institutional investors and hedge funds held shares of Spero Therapeutics. The most heavily invested institutionals were GSK plc ($21.41M), Vanguard Group Inc. ($3.74M), Renaissance Technologies LLC ($2.78M), Geode Capital Management LLC ($1.48M), Anson Funds Management LP ($987K), Acadian Asset Management LLC ($626K), and Informed Momentum Co LLC ($508K).Learn more on Spero Therapeutics' institutional investors.

25.60% of Spero Therapeutics' stock is owned by institutional investors. Learn more on SPRO's institutional investor holdings.

Of the 31 institutional investors that purchased Spero Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: GSK plc ($9.19M), Anson Funds Management LP ($3.89M), Monimus Capital Management LP ($310.91K), Acadian Asset Management LLC ($309.26K), Renaissance Technologies LLC ($252.43K), Mackenzie Financial Corp ($177.13K), and Squarepoint Ops LLC ($174.49K).

Institutional investors have bought a total of 10,414,643 shares in the last 24 months. This purchase volume represents approximately $24.20M in transactions.

Of the 10 institutional investors that sold Spero Therapeutics' stock in the last 24 months, the following investors and hedge funds have sold the highest volume of shares: Anson Funds Management LP ($1.19M), Renaissance Technologies LLC ($263.53K), OMERS ADMINISTRATION Corp ($91.73K), Informed Momentum Co LLC ($64.36K), Bridgeway Capital Management LLC ($40K), ADAR1 Capital Management LLC ($28.38K), and XTX Topco Ltd ($18.63K).

Institutional investors have sold a total of 1,745,448 shares in the last 24 months. This volume of shares sold represents approximately $4.08M in transactions.


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This page (NASDAQ:SPRO) was last updated on 6/23/2026 by MarketBeat.com Staff.
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