Spero Therapeutics (SPRO) Stock Chart & Stock Price History $2.76 +0.07 (+2.60%) Closing price 05/22/2026 04:00 PM EasternExtended Trading$2.76 0.00 (0.00%) As of 05/22/2026 04:10 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 296.38%, with a year-to-date return of 18.45%. In the past month, the stock has decreased 1.43%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $2.76 with a market cap of $159.80 million and volume of 545,468 shares. Five years ago, the stock traded at $14.50, representing a 80.97% decrease over that period. At the time, it had a market cap of $430.14 million and a volume of 90,541 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. 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Read our full terms of service and privacy policy. 5 Day Performance+6.98%1 Month Performance-1.43%3 Month Performance+23.21%Year-To-Date Performance+18.45%1 Year Performance+296.38%5 Year Performance-80.97% SPRO Stock Chart for Saturday, May, 23, 2026 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization05/22/2026$2.69$2.76+2.60%$2.85$2.69545,468 shs$159.80 million05/21/2026$2.63$2.69+2.28%$2.71$2.56433,185 shs$155.75 million05/20/2026$2.59$2.63+1.54%$2.65$2.55319,553 shs$152.28 million05/19/2026$2.58$2.59+0.39%$2.62$2.50322,198 shs$149.96 million05/18/2026$2.79$2.58-7.53%$2.79$2.57917,114 shs$149.38 million05/15/2026$2.76$2.79+1.09%$2.89$2.69936,323 shs$161.54 million05/14/2026$2.44$2.76+13.11%$2.76$2.371.61 million shs$159.81 million05/13/2026$2.54$2.44-3.94%$2.56$2.43673,527 shs$141.28 million05/12/2026$2.55$2.54-0.39%$2.56$2.48350,890 shs$147.07 million05/11/2026$2.56$2.55-0.39%$2.67$2.54421,175 shs$147.65 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 05/08/2026$2.51$2.56+1.99%$2.58$2.49355,476 shs$145.33 million05/07/2026$2.53$2.51-0.79%$2.62$2.49566,250 shs$145.33 million05/06/2026$2.42$2.53+4.55%$2.57$2.44617,278 shs$146.49 million05/05/2026N/A$2.42$2.59$2.41505,629 shs$140.12 million04/30/2026$2.53$2.51-0.79%$2.58$2.50363,858 shs$145.31 million04/29/2026$2.67$2.53-5.24%$2.66$2.47828,455 shs$146.46 million04/28/2026$2.67$2.67$2.73$2.67219,061 shs$154.57 million04/27/2026$2.74$2.67-2.55%$2.75$2.67322,073 shs$154.57 million04/24/2026$2.80$2.74-2.14%$2.82$2.74346,530 shs$158.62 million04/23/2026$2.86$2.80-2.10%$2.91$2.79297,006 shs$162.10 million04/22/2026$2.80$2.86+2.14%$2.93$2.84318,737 shs$165.57 million Related Companies EIKN Stock Price Chart Candel Therapeutics Stock Price Chart Climb Bio Stock Price Chart Sutro Biopharma Stock Price Chart Arvinas Stock Price Chart Valneva Stock Price Chart Kyverna Therapeutics Stock Price Chart Tectonic Therapeutic Stock Price Chart Aquestive Therapeutics Stock Price Chart Prime Medicine Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. This page (NASDAQ:SPRO) was last updated on 5/23/2026 by MarketBeat.com Staff. 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