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Spero Therapeutics (SPRO) Institutional Ownership

Spero Therapeutics logo
$1.22 0.00 (0.00%)
As of 08/21/2026 04:00 PM Eastern
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Institutional Ownership Changes (13F Filings) for Spero Therapeutics (NASDAQ:SPRO)

Current
Institutional Ownership
Percentage
25.60%
Number of
Institutional Buyers
(last 12 months)
19
Total
Institutional Inflows
(last 12 months)
$27.32M
Number of
Institutional Sellers
(last 12 months)
8
Total
Institutional Outflows
(last 12 months)
$3.93M
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SPRO Institutional Buying and Selling by Quarter

Spero Therapeutics Major Shareholders & Ownership History

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Reporting DateMajor Shareholder NameShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
8/20/2026 Susquehanna Fundamental Investments LLC16,095$36K0.0%N/A0.028%
8/7/2026 BlackRock Inc.594,404$1.31M0.0%N/A1.027%
8/7/2026 Alphabet Inc.889,979$1.97M0.0%N/A1.537%
8/6/2026 Global Retirement Partners LLC25,000$55K0.0%N/A0.043%
8/6/2026 GSA Capital Partners LLP285,906$632K0.0%N/A0.494%
5/19/2026 Anson Funds Management LP421,956$987K0.1%-32.5%0.729%
5/15/2026 OMERS ADMINISTRATION Corp39,400$92K0.0%-70.0%0.068%
5/14/2026 Renaissance Technologies LLC1,189,235$2.78M0.0%-7.1%2.054%
2/18/2026 XTX Topco Ltd15,175$35K0.0%-55.1%0.027%
2/18/2026 Quadrature Capital Ltd37,799$88K0.0%N/A0.067%
2/18/2026 Millennium Management LLC24,107$56K0.0%N/A0.043%
2/18/2026 Intrepid Family Office LLC165,000$384K0.3%+50.0%0.293%
2/18/2026 Ionic Capital Management LLC195,939$457K0.1%-6.1%0.348%
2/17/2026 Anson Funds Management LP625,062$1.46M0.1%-61.0%1.109%
2/16/2026 Squarepoint Ops LLC119,434$278K0.0%N/A0.212%
2/16/2026 OMERS ADMINISTRATION Corp131,127$306K0.0%N/A0.233%
2/13/2026 State Street Corp210,151$490K0.0%+10.1%0.373%
2/12/2026 GSK plc9,190,606$21.41M2.7%N/A16.313%
2/12/2026 Renaissance Technologies LLC1,279,522$2.98M0.0%-11.9%2.271%
2/12/2026 Informed Momentum Co LLC218,084$508K0.1%-22.8%0.387%
1/9/2026 Assenagon Asset Management S.A.18,636$43K0.0%-49.6%0.033%
11/17/2025 Ionic Capital Management LLC208,725$392K0.0%+39.2%0.370%
11/17/2025 Anson Funds Management LP1,603,569$3.02M0.2%-0.7%2.846%
11/14/2025 ADAR1 Capital Management LLC115,539$217K0.0%-19.7%0.205%
11/14/2025 Shay Capital LLC63,667$120K0.0%N/A0.113%
11/14/2025 Two Sigma Investments LP49,399$93K0.0%N/A0.088%
11/13/2025 Arrowstreet Capital Limited Partnership150,516$283K0.0%N/A0.267%
11/12/2025 Dimensional Fund Advisors LP28,994$55K0.0%N/A0.052%
11/7/2025 GSA Capital Partners LLP106,894$201K0.0%N/A0.190%
11/7/2025Vanguard Group Inc.1,989,855$3.74M0.0%+2.0%3.536%
10/7/2025 Assenagon Asset Management S.A.36,993$70K0.0%N/A0.066%
8/15/2025 Bridgeway Capital Management LLC114,800$333K0.0%-25.8%0.204%
8/13/2025 Stonepine Capital Management LLC156,888$455K0.4%N/A0.281%
8/13/2025 Invesco Ltd.14,968$43K0.0%N/A0.027%
8/13/2025 Quadrature Capital Ltd31,205$90K0.0%N/A0.056%
8/12/2025 XTX Topco Ltd34,551$100K0.0%N/A0.062%
8/8/2025 Geode Capital Management LLC510,699$1.48M0.0%-2.7%0.913%
7/28/2025 Axxcess Wealth Management LLC32,548$94K0.0%N/A0.058%
7/7/2025 Capital Asset Advisory Services LLC32,548$94K0.0%N/A0.058%
5/28/2025Anson Funds Management LP3,798,932$2.74M0.4%-1.1%6.795%
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5/21/2025Acadian Asset Management LLC871,212$626K0.0%-16.2%1.558%
5/14/2025Anson Funds Management LP7,638,818$5.50M0.8%+98.9%13.662%
5/7/2025Mackenzie Financial Corp209,031$151K0.0%+11.4%0.374%
2/20/2025Mackenzie Financial Corp187,559$193K0.0%+487.9%0.344%
2/17/2025Squarepoint Ops LLC55,051$57K0.0%N/A0.101%
2/17/2025Anson Funds Management LP3,839,886$3.96M0.4%+2.4%7.043%
2/14/2025Jane Street Group LLC52,869$54K0.0%N/A0.097%
2/14/2025Northern Trust Corp86,447$89K0.0%-22.5%0.159%
2/14/2025Three Seasons Wealth LLC30,000$31K0.0%N/A0.055%
2/13/2025XTX Topco Ltd30,138$31K0.0%N/A0.055%
2/13/2025Renaissance Technologies LLC1,105,591$1.14M0.0%+13.4%2.028%
2/13/2025ADAR1 Capital Management LLC801,277$825K0.2%+7.8%1.470%
2/12/2025JPMorgan Chase & Co.61,624$63K0.0%+26,011.9%0.113%
2/11/2025Prudential Financial Inc.49,200$51K0.0%N/A0.090%
2/11/2025Virtu Financial LLC46,046$47K0.0%N/A0.084%
2/10/2025Monimus Capital Management LP310,908$320K0.3%N/A0.570%
2/6/2025Atlas Venture Life Science Advisors LLC305,255$314K0.0%-24.2%0.560%
11/16/2024Geode Capital Management LLC481,187$645K0.0%-2.2%0.891%
8/9/2024Renaissance Technologies LLC975,952$1.27M0.0%+14.2%1.808%
8/9/2024Atlas Venture Life Science Advisors LLC535,336$696K0.1%-11.9%0.992%
8/6/2024Acadian Asset Management LLC1,071,860$1.39M0.0%+40.6%1.985%
5/20/2024Virtu Financial LLC18,180$31K0.0%N/A0.034%
5/16/2024Murchinson Ltd.873,910$1.50M0.1%+1.3%1.622%
5/14/2024Anson Funds Management LP3,750,450$6.45M0.4%-12.7%6.959%
5/10/2024Acadian Asset Management LLC762,598$1.31M0.0%+121.8%1.415%
5/10/2024Vanguard Group Inc.1,653,432$2.84M0.0%+0.6%3.068%
5/6/2024Atlas Venture Life Science Advisors LLC607,613$1.05M0.1%-40.0%1.128%
2/14/2024ADAR1 Capital Management LLC1,067,711$1.57M0.6%N/A2.015%
11/15/2023Rock Springs Capital Management LP57,373$69K0.0%-91.4%0.109%
11/14/2023AWM Investment Company Inc.333,400$403K0.1%-13.0%0.632%
11/13/2023Acadian Asset Management LLC272,024$327K0.0%+56.8%0.516%
8/14/2023Anson Funds Management LP3,444,862$5.00M0.8%+3.0%6.537%
8/11/2023AWM Investment Company Inc.383,400$556K0.1%-70.5%0.729%
8/11/2023Atlas Venture Life Science Advisors LLC1,013,438$1.47M0.2%-1.7%1.928%
8/7/2023Acadian Asset Management LLC173,539$250K0.0%N/A0.330%
8/7/2023Royce & Associates LP22,851$33K0.0%N/A0.043%
8/3/2023Mackenzie Financial Corp17,198$25K0.0%N/A0.033%
7/27/2023Virtu Financial LLC22,195$32K0.0%N/A0.042%
5/15/2023Anson Funds Management LP3,344,862$4.85M0.8%+10.8%6.363%
4/17/2023Bourgeon Capital Management LLC25,600$37K0.0%+95.4%0.049%
2/14/2023AWM Investment Company Inc.1,300,400$2.25M0.3%-43.5%3.708%
11/16/2022Alphabet Inc.889,979$1.78M0.1%N/A2.538%
11/16/2022Anson Funds Management LP1,473,872$2.95M0.3%N/A4.203%
11/15/2022Murchinson Ltd.762,700$1.53M0.4%N/A2.175%
11/15/2022BVF Inc. IL1,929,376$3.86M0.2%-37.6%5.501%
10/21/2022Weitzel Financial Services Inc.14,200$28K0.0%N/A0.040%
8/9/2022Kingsbury Capital Investment Advisors LLC60,844$45K0.1%N/A0.185%
7/27/2022Assenagon Asset Management S.A.131,020$97K0.0%+466.6%0.399%
5/17/2022Rock Springs Capital Management LP990,913$8.62M0.2%+4.8%3.025%
5/16/2022Eversept Partners LP59,639$519K0.0%N/A0.182%
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5/16/2022Granahan Investment Management LLC113,322$986K0.0%-70.1%0.346%
5/11/2022GSA Capital Partners LLP25,916$225K0.0%N/A0.079%


SPRO Institutional Ownership - Frequently Asked Questions

During the previous two years, 40 institutional investors and hedge funds held shares of Spero Therapeutics. The most heavily invested institutionals were GSK plc ($21.41M), Vanguard Group Inc. ($3.74M), Renaissance Technologies LLC ($2.78M), Alphabet Inc. ($1.97M), Geode Capital Management LLC ($1.48M), BlackRock Inc. ($1.31M), and Anson Funds Management LP ($987K).Learn more on Spero Therapeutics' institutional investors.

25.60% of Spero Therapeutics' stock is owned by institutional investors. Learn more on SPRO's institutional investor holdings.

Of the 34 institutional investors that purchased Spero Therapeutics' stock in the last 24 months, the following investors and hedge funds have bought the highest volume of shares: GSK plc ($9.19M), Anson Funds Management LP ($3.89M), Alphabet Inc. ($889.98K), BlackRock Inc. ($594.40K), GSA Capital Partners LLP ($392.80K), Monimus Capital Management LP ($310.91K), and Mackenzie Financial Corp ($177.13K).

Institutional investors have bought a total of 11,923,319 shares in the last 24 months. This purchase volume represents approximately $27.32M in transactions.

The following institutional investors have sold Spero Therapeutics stock in the last 24 months: Anson Funds Management LP ($1.19M), Renaissance Technologies LLC ($263.53K), OMERS ADMINISTRATION Corp ($91.73K), Informed Momentum Co LLC ($64.36K), ADAR1 Capital Management LLC ($28.38K), XTX Topco Ltd ($18.63K), and Assenagon Asset Management S.A. ($18.36K).

Institutional investors have sold a total of 1,691,278 shares in the last 24 months. This volume of shares sold represents approximately $3.93M in transactions.


Related Companies

Institutional ownership data for NASDAQ:SPRO is compiled from quarterly 13F filings submitted to the U.S. Securities and Exchange Commission (SEC), with the most recent received on 8/20/2026. New 13F filings are added each quarter as they're published.
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