| 3/5/2020 | Nuveen Asset Management LLC | 38,397 | $0.37M | 0.0% | -12.5% | 0.201% | |
| 2/20/2020 | Geode Capital Management LLC | 119,452 | $1.15M | 0.0% | +2.3% | 0.624% | |
| 2/14/2020 | BVF Inc. IL | 845,405 | $8.13M | 0.6% | -10.0% | 4.420% | |
| 2/14/2020 | Bank of America Corp DE | 18,226 | $0.18M | 0.0% | +21.7% | 0.095% | |
| 2/14/2020 | Jacobs Levy Equity Management Inc. | 45,853 | $0.44M | 0.0% | +355.6% | 0.240% | |
| 2/14/2020 | Goldman Sachs Group Inc. | 31,546 | $0.30M | 0.0% | +128.5% | 0.165% | |
| 2/14/2020 | UBS Group AG | 14,267 | $0.14M | 0.0% | +29.1% | 0.075% | |
| 2/13/2020 | Oxford Asset Management LLP | 58,868 | $0.57M | 0.0% | -21.3% | 0.308% | |
| 2/13/2020 | Stifel Financial Corp | 30,027 | $0.29M | 0.0% | +131.9% | 0.157% | |
| 2/13/2020 | Renaissance Technologies LLC | 338,203 | $3.25M | 0.0% | +33.8% | 1.768% | |
| 2/12/2020 | Panagora Asset Management Inc. | 41,033 | $0.39M | 0.0% | -19.1% | 0.214% | |
| 2/10/2020 | Barclays PLC | 11,361 | $0.11M | 0.0% | +106.3% | 0.059% | |
| 2/7/2020 | FMR LLC | 98,952 | $0.95M | 0.0% | -42.0% | 0.517% | |
| 2/6/2020 | State Street Corp | 208,591 | $2.01M | 0.0% | +5.8% | 1.090% | |
| 1/29/2020 | Russell Investments Group Ltd. | 5,868 | $55K | 0.0% | N/A | 0.031% | |
| 1/21/2020 | Janney Montgomery Scott LLC | 13,500 | $0.13M | 0.0% | N/A | 0.071% | |
| 11/27/2019 | Orbimed Advisors LLC | 140,709 | $1.49M | 0.0% | -72.3% | 0.736% | |
| 11/27/2019 | Granahan Investment Management Inc. MA | 147,543 | $1.56M | 0.1% | +6.7% | 0.771% | |
| 11/27/2019 | Barclays PLC | 5,508 | $58K | 0.0% | -18.9% | 0.029% | |
| 11/27/2019 | California State Teachers Retirement System | 16,997 | $0.18M | 0.0% | +7.7% | 0.089% | |
| 11/27/2019 | Stifel Financial Corp | 12,949 | $0.14M | 0.0% | N/A | 0.068% | |
| 11/27/2019 | State Street Corp | 197,226 | $2.09M | 0.0% | +16.3% | 1.031% | |
| 11/5/2019 | D.A. Davidson & CO. | 12,000 | $0.13M | 0.0% | +20.0% | 0.064% | |
| 10/23/2019 | Rhumbline Advisers | 15,042 | $0.16M | 0.0% | +10.9% | 0.081% | |
| 8/14/2019 | Marshall Wace LLP | 17,699 | $0.20M | 0.0% | +475.8% | 0.095% | |
| 8/14/2019 | Novo Holdings A S | 465,983 | $5.36M | 0.8% | N/A | 2.498% | |
| 8/14/2019 | Vanguard Group Inc. | 437,204 | $5.03M | 0.0% | +4.5% | 2.344% | |
| 8/13/2019 | BlackRock Inc. | 656,778 | $7.56M | 0.0% | +56.0% | 3.520% | |
| 8/13/2019 | D.A. Davidson & CO. | 10,000 | $0.12M | 0.0% | N/A | 0.054% | |
| 8/13/2019 | Northern Trust Corp | 93,750 | $1.08M | 0.0% | +6.1% | 0.502% | |
| 8/12/2019 | Renaissance Technologies LLC | 214,903 | $2.47M | 0.0% | +89.7% | 1.226% | |
| 8/12/2019 | Fosun International Ltd | 86,596 | $0.96M | 0.1% | -16.2% | 0.494% | |
| 8/10/2019 | Charles Schwab Investment Management Inc. | 25,118 | $0.29M | 0.0% | +30.7% | 0.143% | |
| 8/10/2019 | Artal Group S.A. | 540,000 | $6.22M | 0.3% | -10.0% | 3.081% | |
| 8/8/2019 | AWM Investment Company Inc. | 598,315 | $6.89M | 1.3% | +6.4% | 3.415% | |
| 8/8/2019 | Acadian Asset Management LLC | 2,204 | $25K | 0.0% | N/A | 0.013% | |
| 8/7/2019 | JPMorgan Chase & Co. | 164,389 | $1.83M | 0.0% | +9.2% | 0.938% | |
| 8/6/2019 | Wells Fargo & Company MN | 13,660 | $0.16M | 0.0% | +187.9% | 0.078% | |
| 6/16/2019 | FMR LLC | 389,252 | $4.99M | 0.0% | -20.3% | 2.222% | |
| 6/16/2019 | Marshall Wace LLP | 3,074 | $39K | 0.0% | N/A | 0.018% | |
| 5/10/2019 | Fosun International Ltd | 103,362 | $1.25M | 0.1% | -36.3% | 0.593% | |
| 4/12/2019 | Virtu Financial LLC | 10,465 | $0.13M | 0.0% | N/A | 0.061% | |
| 4/1/2019 | Deutsche Bank AG | 11,031 | $67K | 0.0% | -35.4% | 0.064% | |
| 2/26/2019 | FMR LLC | 488,552 | $3.01M | 0.0% | -21.0% | 2.839% | |
| 2/19/2019 | UBS Oconnor LLC | 168,018 | $1.03M | 0.1% | -1.2% | 0.977% | |
| 2/15/2019 | UBS Oconnor LLC | 168,018 | $1.03M | 0.1% | -1.2% | 0.976% | |
| 2/15/2019 | IHT Wealth Management LLC | 18,715 | $0.12M | 0.0% | N/A | 0.109% | |
| 2/14/2019 | Bank of America Corp DE | 83,009 | $0.51M | 0.0% | +2,036.1% | 0.482% | |
| 2/14/2019 | Two Sigma Investments LP | 27,454 | $0.17M | 0.0% | N/A | 0.160% | |
| 2/13/2019 | Geode Capital Management LLC | 91,842 | $0.56M | 0.0% | +4.4% | 0.534% | |
| 2/12/2019 | Northern Trust Corp | 96,833 | $0.60M | 0.0% | +1.1% | 0.563% | |
| 2/11/2019 | Bank of New York Mellon Corp | 36,716 | $0.23M | 0.0% | +31.9% | 0.213% | |
| 2/8/2019 | BlackRock Inc. | 393,630 | $2.42M | 0.0% | +5.7% | 2.288% | |
| 2/8/2019 | PNC Financial Services Group Inc. | 15,800 | $98K | 0.0% | +58.0% | 0.092% | |
| 1/31/2019 | Rhumbline Advisers | 10,010 | $62K | 0.0% | N/A | 0.058% | |
| 1/31/2019 | Fosun International Ltd | 162,362 | $1.04M | 0.1% | N/A | 0.943% | |
| 12/13/2018 | Vanguard Group Inc | 455,416 | $4.79M | 0.0% | +264.8% | 2.646% | |
| 11/23/2018 | Vanguard Group Inc. | 455,416 | $4.79M | 0.0% | +264.8% | 2.504% | |
| 11/15/2018 | Point72 Asset Management L.P. | 44,000 | $0.46M | 0.0% | N/A | 0.242% | |
| 11/14/2018 | EcoR1 Capital LLC | 892,741 | $9.38M | 0.8% | N/A | 4.908% | |
| 11/14/2018 | Highland Capital Management LP | 20,000 | $0.21M | 0.0% | N/A | 0.110% | |
| 11/13/2018 | Renaissance Technologies LLC | 12,000 | $0.13M | 0.0% | N/A | 0.066% | |
| 11/13/2018 | Stonepine Capital Management LLC | 226,444 | $2.38M | 1.4% | N/A | 1.316% | |
| 11/13/2018 | JPMorgan Chase & Co. | 176,483 | $1.86M | 0.0% | +27.3% | 0.970% | |
| 11/13/2018 | Bridgeway Capital Management Inc. | 78,579 | $0.83M | 0.0% | +43.7% | 0.432% | |
| 11/9/2018 | AWM Investment Company Inc. | 540,474 | $5.68M | 0.9% | +284.8% | 2.975% | |
| 11/9/2018 | FMR LLC | 618,206 | $6.50M | 0.0% | -22.7% | 3.402% | |
| 11/9/2018 | Artal Group S.A. | 600,000 | $6.31M | 0.2% | +71.4% | 3.302% | |
| 11/9/2018 | BlackRock Inc. | 372,469 | $3.92M | 0.0% | +8.9% | 2.050% | |
| 11/7/2018 | JPMorgan Chase & Co. | 176,483 | $1.86M | 0.0% | +27.3% | 0.971% | |
| 8/15/2018 | Granahan Investment Management Inc. MA | 151,148 | $2.22M | 0.1% | N/A | 0.832% | |
| 8/14/2018 | Aquilo Capital Management LLC | 416,691 | $6.11M | 5.0% | N/A | 2.293% | |
| 8/13/2018 | VHCP Management II LLC | 474,015 | $6.95M | 2.1% | -2.4% | 3.299% | |
| 8/10/2018 | PNC Financial Services Group Inc. | 10,000 | $0.15M | 0.0% | N/A | 0.070% | |
| 8/9/2018 | BlackRock Inc. | 341,999 | $5.02M | 0.0% | +35.6% | 2.380% | |
| 8/6/2018 | Bank of New York Mellon Corp | 24,689 | $0.36M | 0.0% | +73.9% | 0.172% | |
| 5/16/2018 | Millennium Management LLC | 11,415 | $0.16M | 0.0% | N/A | 0.079% | |
| 5/15/2018 | DAFNA Capital Management LLC | 29,544 | $0.42M | 0.2% | +490.9% | 0.205% | |
| 5/10/2018 | JPMorgan Chase & Co. | 256,353 | $3.65M | 0.0% | +19,604.3% | 1.784% | |
| 5/9/2018 | BlackRock Inc. | 252,301 | $3.60M | 0.0% | +4.7% | 1.756% | |
| 5/7/2018 | BVF Inc. IL | 1,048,958 | $14.95M | 1.5% | +1.9% | 7.300% | |
| 2/15/2018 | Endurant Capital Management LP | 31,100 | $0.37M | 0.1% | N/A | 0.216% | |
| 2/14/2018 | TIAA CREF Investment Management LLC | 8,806 | $0.10M | 0.0% | N/A | 0.061% | |
| 2/14/2018 | California State Teachers Retirement System | 9,511 | $0.11M | 0.0% | N/A | 0.066% | |
| 2/14/2018 | BVF Inc. IL | 1,029,185 | $12.09M | 1.5% | N/A | 7.162% | |
| 2/14/2018 | Deutsche Bank AG | 13,293 | $0.16M | 0.0% | N/A | 0.093% | |
| 2/14/2018 | Rock Springs Capital Management LP | 525,000 | $6.17M | 0.3% | N/A | 3.653% | |
| 2/13/2018 | VHCP Management II LLC | 485,615 | $5.71M | 1.4% | N/A | 3.379% | |
| 2/13/2018 | AWM Investment Company Inc. | 350,000 | $4.11M | 0.8% | N/A | 2.436% | |
| 2/9/2018 | Artal Group S.A. | 350,000 | $4.11M | 0.1% | N/A | 2.436% | |
| 2/9/2018 | BlackRock Inc. | 240,874 | $2.83M | 0.0% | N/A | 1.676% | |
| 2/7/2018 | California Public Employees Retirement System | 25,000 | $0.29M | 0.0% | N/A | 0.174% | |
| 2/5/2018 | Atlas Venture Associates IX LLC | 1,376,968 | $16.18M | 14.3% | N/A | 9.582% | |
| 1/31/2018 | Dean Capital Investments Management LLC | 10,039 | $0.12M | 0.0% | N/A | 0.070% | |
