Spero Therapeutics (SPRO) Short Interest Ratio & Short Volume $0.66 +0.01 (+1.06%) Closing price 03:58 PM EasternExtended Trading$0.66 0.00 (-0.45%) As of 04:08 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Short Interest Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Short Interest DataSpero Therapeutics (SPRO) has a short interest of 801,300 shares, representing 1.54% of the float (the number of shares available for trading by the public). This marks a 60.87% increase in short interest from the previous month. The short interest ratio (days to cover) is 4.8, indicating that it would take 4.8 days of the average trading volume of 185,770 shares to cover all short positions.Current Short Interest801,300 sharesPrevious Short Interest498,100 sharesChange Vs. Previous Month+60.87%Dollar Volume Sold Short$596,487.72Short Interest Ratio4.8 Days to CoverLast Record DateApril 15, 2025Outstanding Shares55,901,000 sharesShort Percent of Float1.54%Today's Trading Volume26,320 sharesAverage Trading Volume185,770 sharesToday's Volume Vs. Average14% Short Selling Spero Therapeutics? Sign up to receive the latest short interest report for Spero Therapeutics and its competitors with MarketBeat's FREE newsletter. Email Address Skip Charts & View Short Interest HistoryShort Interest ChartDays to Cover ChartShort Percent of Float ChartSPRO Short Interest Over TimeSPRO Days to Cover Over TimeSPRO Percentage of Float Shorted Over Time Spero Therapeutics Short Interest History Export to ExcelReport DateTotal Shares Sold ShortDollar Volume Sold ShortChange from Previous ReportPercentage of Float ShortedDays to CoverPrice on Report Date 4/15/2025801,300 shares $596,487.72 +60.9%1.5%4.8 $0.74 3/31/2025498,100 shares $358,632.00 +13.9%1.0%2.6 $0.72 3/15/2025437,300 shares $342,143.52 +3.0%0.8%2.2 $0.78 2/28/2025424,700 shares $329,397.32 -1.1%0.8%2 $0.78 2/15/2025429,600 shares $350,124.00 +14.0%0.8%1.9 $0.82 1/31/2025376,800 shares $322,766.88 +6.4%N/A1.5 $0.86 1/15/2025354,100 shares $317,698.52 -14.2%N/A1.2 $0.90 12/31/2024412,600 shares $424,978.00 -8.6%N/A1.4 $1.03 12/15/2024451,200 shares $482,784.00 -8.6%N/A1.7 $1.07 11/30/2024493,800 shares $562,932.00 -9.7%N/A2 $1.14 Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 11/15/2024546,800 shares $645,224.00 -12.5%N/A2.3 $1.18 10/31/2024625,200 shares $768,996.00 +61.5%N/A3 $1.23 10/15/2024387,100 shares $464,520.00 +0.7%N/A3.2 $1.20 9/30/2024384,300 shares $514,962.00 -0.2%N/A3 $1.34 9/15/2024385,200 shares $527,724.00 -5.8%N/A3.4 $1.37 8/31/2024409,100 shares $560,467.00 +8.6%N/A3.1 $1.37 8/15/2024376,700 shares $455,807.00 +5.8%N/A2.9 $1.21 7/31/2024355,900 shares $501,819.00 -8.8%N/A2.6 $1.41 7/15/2024390,300 shares $563,983.50 -7.1%N/A2.7 $1.45 6/30/2024420,000 shares $546,000.00 -3.3%N/A2.5 $1.30 6/15/2024434,200 shares $590,512.00 -10.3%N/A2.3 $1.36 5/31/2024483,900 shares $687,138.00 -2.1%N/A1.7 $1.42 5/15/2024494,200 shares $800,604.00 +5.6%N/A1.6 $1.62 4/30/2024468,100 shares $664,702.00 -8.8%N/A1.5 $1.42 4/15/2024513,200 shares $785,196.00 -21.5%N/A1.6 $1.53 3/31/2024653,800 shares $1.12 million +6.5%N/A2.1 $1.72 3/15/2024613,900 shares $1.10 million +8.9%N/A2 $1.79 2/29/2024564,000 shares $930,600.00 -8.9%N/A2.8 $1.65 2/15/2024619,000 shares $940,880.00 -12.5%N/A3.2 $1.52 1/31/2024707,100 shares $1.07 million +4.0%N/A3.8 $1.52 1/15/2024680,200 shares $986,290.00 -13.8%N/A4 $1.45 12/31/2023789,000 shares $1.16 million -19.2%N/A4.5 $1.47 12/15/2023976,500 shares $1.26 million -9.6%N/A6 $1.29 11/30/20231,080,000 shares $1.23 million -4.4%N/A6.2 $1.14 11/15/20231,130,000 shares $1.29 million -10.3%N/A4.7 $1.14 10/31/20231,260,000 shares $1.36 million -3.1%N/A4.8 $1.08 10/15/20231,300,000 shares $1.47 million -3.7%N/A4.1 $1.13 9/30/20231,350,000 shares $1.63 million -5.6%N/A4.2 $1.21 9/15/20231,430,000 shares $1.83 million +25.4%N/A4.3 $1.28 8/31/20231,140,000 shares $1.71 million No ChangeN/A3.2 $1.50Watch This Robotics Demo Before July 23rd (Ad)Jeff Brown, the tech legend who picked shares of Nvidia in 2016 before they jumped by more than 22,000%... Just did a demo of what Nvidia’s CEO said will be "the first multitrillion-dollar robotics industry." Click here to watch the demo… 8/15/20231,140,000 shares $1.53 million -2.6%N/A3.8 $1.35 7/31/20231,170,000 shares $1.91 million No ChangeN/A3.9 $1.63 7/15/20231,170,000 shares $1.77 million -4.9%N/A4.2 $1.51 6/30/20231,230,000 shares $1.78 million +40.4%N/A4 $1.45 6/15/2023876,300 shares $1.38 million -0.6%N/A1.8 $1.57 5/31/2023881,800 shares $1.53 million -9.5%N/A1.7 $1.74 5/15/2023974,400 shares $1.82 million -32.8%N/A1.7 $1.87 4/30/20231,450,000 shares $2.57 million -21.6%N/A2.5 $1.77 4/15/20231,850,000 shares $3.18 million +17.1%N/A3.3 $1.72 3/31/20231,580,000 shares $2.29 million +67.6%N/A2.8 $1.45 3/15/2023942,700 shares $1.39 million +142.0%N/A2.1 $1.47 2/28/2023389,500 shares $576,460.00 +35.5%N/A0.9 $1.48 2/15/2023287,400 shares $514,446.00 -38.6%N/A0.7 $1.79 1/31/2023468,200 shares $866,170.00 -29.9%N/A0.8 $1.85 1/15/2023667,900 shares $1.34 million -21.4%N/A1.1 $2.00 12/30/2022849,400 shares $1.47 million -14.6%N/A1.1 $1.73 12/15/2022994,200 shares $1.69 million -23.5%N/A0.4 $1.70 11/30/20221,300,000 shares $2.52 million -13.9%N/A0.2 $1.94 11/15/20221,510,000 shares $2.84 million +22.8%5.5%0.2 $1.88 10/31/20221,230,000 shares $2.41 million -15.8%4.5%0.2 $1.96 10/15/20221,460,000 shares $2.89 million -32.4%5.4%0.2 $1.98 9/30/20222,160,000 shares $4.32 million +177.9%8.0%0.3 $2.00 9/15/2022777,200 shares $753,884.00 +182.0%2.9%0.1 $0.97 8/31/2022275,600 shares $222,381.64 -32.9%1.0%0.1 $0.81 8/15/2022410,600 shares $371,059.22 +1.1%1.5%1.3 $0.90 7/31/2022406,100 shares $297,346.42 -27.2%1.6%1.1 $0.73 7/15/2022557,800 shares $440,662.00 +34.9%2.3%0.8 $0.79 6/30/2022413,600 shares $306,477.60 -70.9%1.7%0.6 $0.74 6/15/20221,420,000 shares $1.36 million -9.0%5.8%1.9 $0.96 5/31/20221,560,000 shares $1.84 million -5.5%6.4%2.3 $1.18 5/15/20221,650,000 shares $2.82 million -55.3%6.8%2.6 $1.71 4/30/20223,690,000 shares $17.93 million +6.7%14.6%6.3 $4.86 4/15/20223,460,000 shares $21.14 million +6.5%13.7%16.7 $6.11 3/31/20223,250,000 shares $28.28 million +4.2%13.1%16.5 $8.70 3/15/20223,120,000 shares $25.40 million +5.4%12.6%18.6 $8.14 2/28/20222,960,000 shares $28.42 million +5.7%11.9%20.8 $9.60 2/15/20222,800,000 shares $27.94 million +12.0%11.3%19.6 $9.98 1/31/20222,500,000 shares $29.68 million +4.6%10.1%18.6 $11.87 1/15/20222,390,000 shares $31.55 million +4.4%9.4%21.1 $13.20 12/31/20212,290,000 shares $36.66 million -1.7%9.0%23.2 $16.01 12/15/20212,330,000 shares $30.64 million -0.9%9.2%24.5 $13.15 11/30/20212,350,000 shares $33.49 million -2.5%9.3%23.9 $14.25 11/15/20212,410,000 shares $39.55 million -3.6%9.5%22.4 $16.41 10/29/20212,500,000 shares $43.90 million No Change9.9%21 $17.56 10/15/20212,500,000 shares $42.55 million -1.2%9.9%21.4 $17.02 9/30/20212,530,000 shares $46.58 million -1.9%10.0%20.4 $18.41 9/15/20212,580,000 shares $47.81 million -4.1%10.2%16.4 $18.53 8/31/20212,690,000 shares $51.78 million +1.9%10.9%15.8 $19.25 8/13/20212,640,000 shares $35.69 million No Change10.7%16.5 $13.52 7/30/20212,640,000 shares $35.22 million No Change11.6%17 $13.34Watch This Robotics Demo Before July 23rd (Ad)Jeff Brown, the tech legend who picked shares of Nvidia in 2016 before they jumped by more than 22,000%... Just did a demo of what Nvidia’s CEO said will be "the first multitrillion-dollar robotics industry." Click here to watch the demo… 7/15/20212,640,000 shares $37.73 million +10.0%12.1%16.6 $14.29 6/30/20212,400,000 shares $33.50 million -23.1%9.9%14.5 $13.96 6/15/20213,120,000 shares $47.55 million -1.0%12.9%22.1 $15.24 5/28/20213,150,000 shares $45.68 million -3.4%13.0%20.3 $14.50 5/14/20213,260,000 shares $42.28 million -2.1%N/A19.9 $12.97 4/30/20213,330,000 shares $45.59 million -2.1%N/A17.5 $13.69 4/15/20213,400,000 shares $44.81 million +0.6%N/A14 $13.18 3/31/20213,380,000 shares $46.04 million +50.9%N/A12.9 $13.62 3/15/20212,240,000 shares $37.50 million +1.8%N/A6.7 $16.74 2/26/20212,200,000 shares $40.44 million -1.8%N/A6.6 $18.38 2/12/20212,240,000 shares $45.52 million -0.4%N/A6.6 $20.32 1/29/20212,250,000 shares $40.95 million +0.9%N/A6.4 $18.20 1/15/20212,230,000 shares $37.08 million -0.9%N/A7.3 $16.63 12/31/20202,250,000 shares $45.52 million +17.8%N/A7.3 $20.23 12/15/20201,910,000 shares $34.02 million -2.1%N/A6.2 $17.81 11/30/20201,950,000 shares $32.62 million +1.6%N/A5.9 $16.73 11/15/20201,920,000 shares $27.49 million +2.7%N/A5 $14.32 10/30/20201,870,000 shares $25.13 million +3.3%N/A5.1 $13.44 10/15/20201,810,000 shares $24.63 million +1.7%N/A5.2 $13.61 9/30/20201,780,000 shares $19.86 million -6.3%N/A5.4 $11.16 9/15/20201,900,000 shares $18.98 million +49.6%N/A6.4 $9.99 8/31/20201,270,000 shares $13.80 million +18.7%8.5%5.3 $10.87 8/14/20201,070,000 shares $13.38 million +2.9%7.2%6.7 $12.50 7/31/20201,040,000 shares $12.17 million +8.0%7.0%6.2 $11.70 7/15/2020963,100 shares $12.96 million +11.1%6.7%5 $13.46 6/30/2020866,900 shares $11.49 million +39.1%6.0%4.6 $13.25 6/15/2020623,200 shares $7.45 million +8.0%4.3%3.7 $11.95 5/29/2020577,300 shares $6.82 million -0.9%4.0%3.6 $11.82 5/15/2020582,300 shares $6.95 million +5.1%4.1%3.9 $11.93 SPRO Short Interest - Frequently Asked Questions What is Spero Therapeutics' current short interest? Short interest is the volume of Spero Therapeutics shares that have been sold short but have not yet been covered or closed out. As of April 15th, investors have sold 801,300 shares of SPRO short. 1.54% of Spero Therapeutics' shares are currently sold short. Learn More on Spero Therapeutics' current short interest. What is a good short interest ratio for Spero Therapeutics? The short interest ratio, also known as the "days to cover ratio", is calculated by dividing the number of shares of a stock sold short divided by its average trading volume. A short interest ratio ranging between 1 and 4 generally indicates strong positive sentiment about a stock and a lack of short sellers. A short interest ratio of 10 or greater indicates strong pessimism about a stock. SPRO shares currently have a short interest ratio of 5.0. Learn More on Spero Therapeutics's short interest ratio. Which institutional investors are shorting Spero Therapeutics? As of the most recent reporting period, the following institutional investors, funds, and major shareholders have reported short positions of Spero Therapeutics: Citadel Advisors LLC, and Concourse Financial Group Securities Inc.. These positions are disclosed in Form 13F filings with the Securities and Exchange Commission. What is a good short interest percentage for Spero Therapeutics? Companies that have a short interest as a percentage of float below 10% indicates positive investor sentiment and few short sellers. Stocks with a short interest percentage above 10% is considered high, suggesting some investors are pessimistic about the stock. Companies with a short interest percentage of 20% or more indicates widespread negative sentiment. 1.54% of Spero Therapeutics' floating shares are currently sold short. Is Spero Therapeutics' short interest increasing or decreasing? Spero Therapeutics saw a increase in short interest in the month of April. As of April 15th, there was short interest totaling 801,300 shares, an increase of 60.9% from the previous total of 498,100 shares. Changes in short volume can be used to identify positive and negative investor sentiment. Investors that short sell a stock are betting that its price will decline in the future. An increase in short sale volume suggests bearish (negative) sentiment among investors. A decrease on short sale volume suggests bullish (positive) sentiment. How does Spero Therapeutics' short interest compare to its competitors? 1.54% of Spero Therapeutics' shares are currently sold short. Here is how the short interest of companies in the industry of "pharmaceutical products" compare to Spero Therapeutics: Innate Pharma S.A. (0.68%), LifeVantage Co. (17.26%), Nanobiotix S.A. (0.02%), Molecular Partners AG (0.10%), DiaMedica Therapeutics Inc. (0.94%), Tango Therapeutics, Inc. (19.01%), AC Immune SA (2.36%), Journey Medical Co. (2.66%), Fate Therapeutics, Inc. (14.41%), 4D Molecular Therapeutics, Inc. (12.13%), Which stocks are the most shorted right now? As of the most recent reporting period, the following stocks had the largest short interest positions: Invesco QQQ ($21.71 billion), iShares 20+ Year Treasury Bond ETF ($9.48 billion), Strategy Incorporated ($8.92 billion), Charter Communications, Inc. ($3.86 billion), Apollo Global Management, Inc. ($3.86 billion), Capital One Financial Co. ($3.72 billion), Super Micro Computer, Inc. ($3.47 billion), AppLovin Co. ($2.64 billion), VanEck Semiconductor ETF ($2.46 billion), and The Kroger Co. ($2.33 billion). View all of the most shorted stocks. What does it mean to sell short Spero Therapeutics stock? Short selling SPRO is an investing strategy that aims to generate trading profit from Spero Therapeutics as its price is falling. SPRO shares are trading up $0.01 today. To short a stock, an investor borrows shares, sells them and buys the shares back on the public market later to return it to the lender. Short sellers are betting that a stock will decline in price. If the stock does drop after selling, the short seller buys it back at a lower price and returns it to the lender. The difference between the sell price and the buy price is the trader's profit. How does a short squeeze work against Spero Therapeutics? A short squeeze for Spero Therapeutics occurs when it has a large amount of short interest and its stock increases in price. This forces short sellers to cover their short interest positions by buying actual shares of SPRO, which in turn drives the price of the stock up even further. How often is Spero Therapeutics' short interest reported? Short interest is typically published by a stock exchange once per month. However, NASDAQ publishes a report for U.S. stocks, including SPRO, twice per month. The most recent reporting period available is April, 15 2025. More Short Interest Resources from MarketBeat Related Companies Innate Pharma Short Interest LifeVantage Short Interest Nanobiotix Short Interest Molecular Partners Short Interest DiaMedica Therapeutics Short Interest Tango Therapeutics Short Interest AC Immune Short Interest Journey Medical Short Interest Fate Therapeutics Short Interest 4D Molecular Therapeutics Short Interest Short Interest Tools Stocks to Short Largest Short Interest Positions Short Interest Increases Short Interest Decreases Short Interest Reporting Dates This page (NASDAQ:SPRO) was last updated on 5/1/2025 by MarketBeat.com Staff From Our PartnersHow to invest in Elon Musk’s Optimus before its launchElon Musk is set to completely take over the AI industry with Optimus… A breakthrough AI-powered robot that El...InvestorPlace | SponsoredElon Musk’s next move from the Oval Office?No one is closer to President Trump than Tesla CEO Elon Musk. 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